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  1. Article: Patologie cronico-degenerative nelle attività assistenziali: i dati nell'Azienda Ospedaliera Universitaria Federico II di Napoli.

    Farina, A / Cavaliere, L / Boggia, B / Esposito, A / Ferrucci, R / Romano, L / Barletta, R / Carbone, U

    Giornale italiano di medicina del lavoro ed ergonomia

    2007  Volume 29, Issue 3 Suppl, Page(s) 615–616

    Abstract: Recent average life increase, as well as new habits and lifestyles assumption, has determined a change in population health profiles, as a result of progressive increase in chronic-degenerative diseases prevalence. Among these latter; musculoskeletal and ...

    Title translation Chronic-degenerative diseases in health care activities: data from health surveillance of Federico II University General Hospital in Naples.
    Abstract Recent average life increase, as well as new habits and lifestyles assumption, has determined a change in population health profiles, as a result of progressive increase in chronic-degenerative diseases prevalence. Among these latter; musculoskeletal and cardiovascular diseases are the most frequent ones. Health care workers also suffered from this change in health profiles. This study, performed thanks to the extension of Health Surveillance to all health care workers, aimed at evaluating chronic-degenerative diseases risk among three main welfare activities (medical, nursing and auxiliary). In conclusion, data showed that nurses, mainly the shift workers, are exposed to a higher risk of chronic-degenerative diseases. All other health care workers have not significant work risk factors, because of a greater burden of aging and lifestyles effects.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Chronic Disease ; Health Care Sector ; Hospitals, General ; Humans ; Italy ; Middle Aged ; Musculoskeletal Diseases/epidemiology ; Occupational Diseases/epidemiology ; Population Surveillance
    Language Italian
    Publishing date 2007-07
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 603103-1
    ISSN 1592-7830 ; 0391-9889
    ISSN 1592-7830 ; 0391-9889
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  2. Article: Prospettive del servizio di coordinamento dei medici competenti dell'AUP Federico II di Napoli nella prevenzione degli infortuni.

    Grieco, L / Carbone, U / Galdi, A / Barone, C / Maniscalco, M / Farinaro, E

    Giornale italiano di medicina del lavoro ed ergonomia

    2002  Volume 24, Issue 3, Page(s) 311

    Title translation Prospects of the coordination service of the responsible physicians of the AUP Federico II di Napoli in the prevention of accidents.
    MeSH term(s) Accidents, Occupational/prevention & control ; Humans ; Italy ; Occupational Medicine ; Risk Factors
    Language Italian
    Publishing date 2002-07
    Publishing country Italy
    Document type Comparative Study ; Journal Article
    ZDB-ID 603103-1
    ISSN 1592-7830 ; 0391-9889
    ISSN 1592-7830 ; 0391-9889
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  3. Article: Facing ethical concerns in the age of precise gene therapy: Outlook on inherited arrhythmias.

    Carbone, Federico / Montecucco, Fabrizio

    World journal of cardiology

    2024  Volume 16, Issue 2, Page(s) 64–66

    Abstract: This editorial, comments on the article by ... ...

    Abstract This editorial, comments on the article by Spartalis
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573665-6
    ISSN 1949-8462
    ISSN 1949-8462
    DOI 10.4330/wjc.v16.i2.64
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  4. Article ; Online: CardioMetabolic medicine, one more last step forward.

    Carbone, Federico

    European heart journal

    2021  Volume 43, Issue 20, Page(s) 1895–1896

    MeSH term(s) Cardiovascular Diseases ; Humans ; Medicine ; Risk Factors
    Language English
    Publishing date 2021-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab713
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  5. Article ; Online: Impulse Control Disorders in Parkinson's Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management.

    Carbone, Federico / Djamshidian, Atbin

    CNS drugs

    2024  

    Abstract: Impulse control disorders in Parkinson's disease are relatively common drug-induced addictive behaviours that are usually triggered by the dopamine agonists pramipexole, ropinirole and rotigotine. This narrative review aimed to provide a comprehensive ... ...

    Abstract Impulse control disorders in Parkinson's disease are relatively common drug-induced addictive behaviours that are usually triggered by the dopamine agonists pramipexole, ropinirole and rotigotine. This narrative review aimed to provide a comprehensive overview of the current knowledge of impulse control disorders in Parkinson's disease. We summarised the prevalence, clinical features, risk factors and potential underlying mechanisms of impulse control disorders in Parkinson's disease. Moreover, recent advances in behavioural and imaging characteristics and management strategies are discussed. Early detection as well as a tailored multidisciplinary approach, which typically includes careful adjustment of the dopaminergic therapy and the treatment of associated neuropsychiatric symptoms, are necessary. In some cases, a continuous delivery of levodopa via a pump or the dopamine D
    Language English
    Publishing date 2024-04-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-024-01087-y
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  6. Article ; Online: The obesity syndemic in the European community: towards a systems thinking approach for preventive policies.

    Frühbeck, Gema / Busetto, Luca / Carbone, Federico

    European heart journal

    2024  

    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae066
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  7. Article ; Online: CAR T therapy from haematological malignancies to aging-related diseases: An ever-expanding universe.

    Ramoni, Davide / Montecucco, Fabrizio / Carbone, Federico

    European journal of clinical investigation

    2024  , Page(s) e14203

    Abstract: Background: Short but impactful, the two-decade story of gene editing allowed a significant breakthrough in the treatment of haematological malignancies. However, despite different generations of chimeric antigen receptor T (CAR T), such a successful ... ...

    Abstract Background: Short but impactful, the two-decade story of gene editing allowed a significant breakthrough in the treatment of haematological malignancies. However, despite different generations of chimeric antigen receptor T (CAR T), such a successful therapy has not yet been replicated in solid tumours and non-oncological diseases.
    Methods: This narrative review discusses how CAR T therapy still faces challenges in overcoming the complexity of the solid tumour microenvironment and the concerns that its long-term activity raises about potential unknown and unpredictable consequences in non-oncological diseases.
    Results: In the most recent studies, the senolytic potential of CAR T is becoming an exciting field of research. Still, experimental but promising results indeed indicate the clearance of senescent cells as an effective strategy to improve exercise capacity and metabolic dysfunction in physiological ageing, with long-term therapeutic and preventive effects. However, an effective expansion of a CAR T population requires a lympho-depleting chemotherapy prior to infusion. While this procedure sounds reasonable for rescue therapy of oncological diseases, it poses genotoxic risks that may not be justified for non-malignant diseases. Those represent the leading gaps for applying CAR T therapy in non-oncological diseases.
    Conclusion: More is expected from current studies on the other classes of CAR cells now under investigation. Engineering NK cells and macrophages are candidates to improve cytotoxic and immunomodulating properties, potentially able to broaden application in solid tumours and non-oncological diseases. Finally, engineering autologous T cells in old individuals may generate biologically deteriorated CAR T clones with impaired function and unpredictable effects on cytokine release.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14203
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  8. Article ; Online: BIOCOVID: A lesson of systemic inflammatory response beyond pneumonia.

    Carbone, Federico / Montecucco, Fabrizio

    European journal of clinical investigation

    2022  Volume 52, Issue 8, Page(s) e13816

    MeSH term(s) Biomarkers ; Humans ; Pneumonia ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13816
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  9. Article ; Online: Hydrogen sulphide: Diabetic cardiomyopathy as the paradigm of its pleiotropic function.

    Carbone, Federico / Montecucco, Fabrizio

    European journal of clinical investigation

    2022  Volume 52, Issue 9, Page(s) e13823

    MeSH term(s) Diabetes Mellitus ; Diabetic Cardiomyopathies ; Humans ; Hydrogen Sulfide
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13823
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  10. Article ; Online: Role of glucagon-like peptide-1 receptor agonists in the treatment of obesity, cardiovascular disease, and cerebrovascular disease.

    Tirandi, Amedeo / Montecucco, Fabrizio / Carbone, Federico / Liberale, Luca

    Polish archives of internal medicine

    2024  Volume 134, Issue 2

    Abstract: Worldwide prevalence of obesity is increasing dramatically, imposing a significant economic burden on our society. Treatment of obesity is challenging, potentially due to different disease phenotypes. Taking into consideration "obesities" rather than " ... ...

    Abstract Worldwide prevalence of obesity is increasing dramatically, imposing a significant economic burden on our society. Treatment of obesity is challenging, potentially due to different disease phenotypes. Taking into consideration "obesities" rather than "obesity," and thus aiming to understand different pathophysiologic mechanisms of individual phenotypes, might help identify more tailored treatment strategies. Glucagon‑like peptide‑1 receptor agonists (GLP‑1RAs), for example, dulaglutide and semaglutide, are routinely prescribed for the treatment of type 2 diabetes mellitus (T2DM) in patients with obesity or those at a high cardiovascular (CV) risk. Indeed, despite having been developed for T2DM, GLP‑1RAs are being increasingly often recognized as antiobesity medications due to their weight loss effects. Furthermore, recent evidence has shown that the extent of CV prevention offered by these drugs goes beyond that associated with their weight loss and pleiotropic effects. For instance, they exert anti‑inflammatory effects on vessels, enhance atherosclerotic plaque stability, reduce local advanced glycation end product receptor expression, lower monocyte‑macrophage adhesion, and antagonize the effect of angiotensin II. In the heart, GLP‑1RAs ameliorate cardiomyocyte survival and myocardial contractility, reduce cardiac hypertrophy, and are one of few drugs that can reduce epicardial fat thickness. In this review, we summarize recent evidence concerning the effects of GLP‑1RAs on obesity / dysmetabolism and on cardio- / cerebrovascular health. We further highlight the possible role of GLP‑1RAs in the treatment of obesity‑related CV diseases by describing the principal molecular mechanisms reported in the current literature.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Hypoglycemic Agents/therapeutic use ; Glucagon-Like Peptide-1 Receptor Agonists ; Obesity/complications ; Obesity/drug therapy ; Cerebrovascular Disorders/drug therapy ; Weight Loss
    Chemical Substances Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor Agonists
    Language English
    Publishing date 2024-01-09
    Publishing country Poland
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16658
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