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  1. Article ; Online: A Co-MOF-derived flower-like CoS@S,N-doped carbon matrix for highly efficient overall water splitting.

    Bereketova, Akerke / Nallal, Muthuchamy / Yusuf, Mohammad / Jang, Sanha / Selvam, Karthick / Park, Kang Hyun

    RSC advances

    2021  Volume 11, Issue 27, Page(s) 16823–16833

    Abstract: In this study, we constructed a highly effective, low-cost, non-noble-metal-based electrocatalyst to replace Pt catalysts, with a CoS@SNC catalyst being successfully synthesized. The obtained nanocatalyst was ... ...

    Abstract In this study, we constructed a highly effective, low-cost, non-noble-metal-based electrocatalyst to replace Pt catalysts, with a CoS@SNC catalyst being successfully synthesized. The obtained nanocatalyst was characterized
    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra01883c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparison of voxel S-value methods for personalized voxel-based dosimetry of

    Kim, Keon Min / Lee, Min Sun / Suh, Min Seok / Selvam, Haniff Shazwan Muhd Safwan / Tan, Teik Hin / Cheon, Gi Jeong / Kang, Keon Wook / Lee, Jae Sung

    Medical physics

    2022  Volume 49, Issue 3, Page(s) 1888–1901

    Abstract: Purpose: Voxel-based dosimetry is potentially accurate than organ-based dosimetry because it considers the anatomical variations in each individual and the heterogeneous radioactivity distribution in each organ. Here, voxel-based dosimetry for : ... ...

    Abstract Purpose: Voxel-based dosimetry is potentially accurate than organ-based dosimetry because it considers the anatomical variations in each individual and the heterogeneous radioactivity distribution in each organ. Here, voxel-based dosimetry for
    Methods: The administered activity of
    Results: The accuracy of the multiple VSV approach increased with the number of dose kernels. The average dose estimation errors of a single VSV with density correction and 20 VSVs were less than 6% in most cases, although organ-based dosimetry using OLINDA/EXM yielded an error of up to 123%. The advantages of the single VSV method with density correction and the 20 VSVs over organ-based dosimetry were most evident in bone marrow and bone-metastatic tumors with heterogeneous medium properties.
    Conclusion: The single VSV method with density correction and multiple VSV method with 20 dose kernels enabled fast and accurate radiation dose estimation. Accordingly, voxel-based dosimetry methods can be useful for managing administration activity and for investigating tumor dose responses to further increase the therapeutic efficacy of
    MeSH term(s) Monte Carlo Method ; Positron-Emission Tomography ; Radiometry/methods ; Radionuclide Imaging ; Radiopharmaceuticals ; Tomography, X-Ray Computed
    Chemical Substances Radiopharmaceuticals ; copper dotatate CU-64
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.15444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cu-Catalyzed Chan-Evans-Lam Coupling Reactions of 2-Nitroimidazole with Aryl Boronic Acids: An Effort toward New Bioactive Agents against S. pneumoniae.

    Raju, Selvam / Sheridan, Patrick E / Hauer, Alanna K / Garrett, Allyn E / McConnell, Danielle E / Thornton, Justin A / Stokes, Sean L / Emerson, Joseph P

    Chemistry & biodiversity

    2022  Volume 19, Issue 8, Page(s) e202200327

    Abstract: ... of newly arylated azomycin derivatives were screened against S. pneumoniae, where 1-(4-(benzyloxy)phenyl)-2 ...

    Abstract The coupling of phenylboronic acids with poorly-activated imidazoles is studied as a model system to explore the use of copper-catalyzed Chan-Evans-Lam (CEL) coupling for targeted C-N bond forming reactions. Optimized CEL reaction conditions are reported for four phenanthroline-based ligand systems, where the ligand 4,5-diazafluoren-9-one (dafo, L2) with 1 molar equivalent of potassium carbonate yielded the highest reactivity. The substrate 2-nitroimidazole (also known as azomycin) has documented antimicrobial activity against a range of microbes. Here N-arylation of 2-nitroimidazole with a range of aryl boronic acids has been successfully developed by copper(II)-catalyzed CEL reactions. Azomycin and a range of newly arylated azomycin derivatives were screened against S. pneumoniae, where 1-(4-(benzyloxy)phenyl)-2-nitro-1H-imidazole (3d) was demonstrated to have a minimal inhibition concentration value of 3.3 μg/mL.
    MeSH term(s) Boronic Acids/chemistry ; Catalysis ; Copper/chemistry ; Ligands ; Nitroimidazoles/pharmacology
    Chemical Substances Boronic Acids ; Ligands ; Nitroimidazoles ; Copper (789U1901C5) ; azomycin (K8E96XL55D)
    Language English
    Publishing date 2022-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202200327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Photocatalytic transfer hydrogenolysis of allylic alcohols on Pd/TiO2: A Shortcut to (S)-(+)-lavandulol.

    Saito, Susumu / Takada, Yuki / Caner, Joaquim / Kaliyamoorthy, Selvam / Naka, Hiroshi

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2017  

    Abstract: ... synthesis of (S)-(+)-lavandulol from (R)-(-)-carvone by avoiding otherwise necessary protection/deprotection ...

    Abstract We report herein a regio- and stereoselective photocatalytic hydrogenolysis of allylic alcohols to form unsaturated hydrocarbons employing a palladium(II)-loaded titanium oxide; the reaction proceeds at room temperature under light irradiation without stoichiometric generation of salt wastes. Olefin and saturated alcohol moieties tolerated the reaction conditions. Hydrogen atoms were selectively incorporated into less sterically congested carbons of the allylic functionalities. This protocol allowed a short-step synthesis of (S)-(+)-lavandulol from (R)-(-)-carvone by avoiding otherwise necessary protection/deprotection steps.
    Language English
    Publishing date 2017-10-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201704099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation of Febrile Seizure Risk Following Ancestral Monovalent COVID-19 mRNA Vaccination Among U.S. Children Aged 2-5 Years

    Forshee, Richard A / Smith, Elizabeth R / Wan, Zhiruo / Amend, Kandace L / Secora, Alex / Djibo, Djeneba Audrey / Kazemi, Kamran / Song, Jennifer / Parlett, Lauren E / Seeger, John D / Selvam, Nandini / McMahill-Walraven, Cheryl N / Hu, Mao / Chillarige, Yoganand / Anderson, Steven A

    medRxiv

    Abstract: Importance The United States Food and Drug Administration noted a potential safety concern for seizure in children aged 2-5 years receiving the ancestral monovalent COVID-19 mRNA vaccines. Objective To evaluate febrile seizure risk following monovalent ... ...

    Abstract Importance The United States Food and Drug Administration noted a potential safety concern for seizure in children aged 2-5 years receiving the ancestral monovalent COVID-19 mRNA vaccines. Objective To evaluate febrile seizure risk following monovalent COVID-19 mRNA vaccination among children aged 2-5 years. Design, Setting, and Participants The primary analysis evaluated children who had a febrile seizure outcome in the 0-1 days following COVID-19 vaccination. A self-controlled case series analysis was performed in three commercial insurance databases to compare the risk of seizure in the risk interval (0-1 days) to a control interval (8-63 days). Exposure Receipt of dose 1 and/or dose 2 of monovalent COVID-19 mRNA vaccinations. Main Outcomes and Measures The primary outcome was febrile seizure (0-1 day risk interval). Analysis A conditional Poisson regression model was used to compare outcome rates in risk and control intervals and estimate incidence rate ratios (IRR) and 95% confidence intervals (CIs). Meta-analyses were used to pool results across databases. Results The primary meta-analysis found a statistically significant increased incidence of febrile seizure, in the 0-1 days following mRNA-1273 vaccination compared to the control interval (IRR: 2.52, 95% CI: 1.35 to 4.69, risk difference (RD)/100,000 doses = 3.22 (95%CI -0.31 to 6.75)). For the BNT162b2 vaccination, the IRR was elevated but not statistically significant (IRR: 1.41, 95%CI: 0.48 to 4.11, RD/100,000 doses = -0.25 (95%CI -2.75 to 2.24). Conclusions and Relevance Among children aged 2-5 years, the analysis showed a small elevated incidence rate ratio of febrile seizures in the 0-1 days following the mRNA-1273 vaccination. Based on the current body of scientific evidence, the safety profile of the monovalent mRNA vaccines remains favorable for use in young children.
    Keywords covid19
    Language English
    Publishing date 2024-03-19
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.03.12.24304127
    Database COVID19

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  6. Article ; Online: Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

    Loganathan, Settu / Shivakumar, Muthugounder Subaramanian / Karthi, S. / Nathan, Sengottayan Senthil / Selvam, Kuppusamy

    Toxicology reports. 2021, v. 8 p.64-72

    2021  

    Abstract: ... that the NP’s are rod shaped with 50–80 nm size and also energy dispersive spectra (EDaX) spectra showed ...

    Abstract In around the world, mosquito control is considered a most important because of the incapable of synthetic insecticides and the ecological pollution about by them. In this manner, need the eco-friendly insecticides to efficient control the mosquito disease is the need of the hour. We synthesized the eco-friendly of zinc oxide nanoparticles (ZnO-NPs) using the Knoxia sumatrensis aqueous leaf extract (Ks-ALE) as a reducing and stabilizing agent. The synthesis of ZnO-NPs was confirmed by UV with an absorption peak at 354 nm. ZnO-NPs crystal structure was analyzed by X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) spectra revealed the chloride, cyclic alcohols, sulfonamies, carboxylic acids, oximes, phosphines, alkenes and alcohol & phenol. Field emission-scanning electron microscopy (FE-SEM) showed that the NP’s are rod shaped with 50–80 nm size and also energy dispersive spectra (EDaX) spectra showed presence of zinc. Antioxidant assay showed superior activity and evidenced by DPPH, ABTS and H₂O₂ radical assays. Furthermore, the ZnO-NPs exhibited strong activity in MCF-7 cell line with IC₅₀ value is 58.87 μg/mL. Mosquito larvicidal activity of ZnO-NPs produced significant activity and excellent larvicidal activity was noticed in Cx. quinquefasciatus with LC₅₀ 0.08, mg/mL and LC₉₀19.46 mg/mL. This study suggests that synthesized ZnO-NPs using Knoxia sumatrensis leaf extract have good biological activities and it makes them an ideal candidate for pharmacological studies.
    Keywords Culicidae ; Fourier transform infrared spectroscopy ; Knoxia ; X-ray diffraction ; absorption ; alkenes ; chlorides ; crystal structure ; energy ; human cell lines ; larvicides ; leaf extracts ; mosquito control ; oximes ; phenol ; pollution ; zinc ; zinc oxide ; K. sumatrensis ; FE-SEM ; Antioxidant ; AO/EtBr ; Cx. quinquefasciatus
    Language English
    Size p. 64-72.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Creative Commons Attribution 4.0 Generic (CC BY-NC-ND 4.0) ; Resource is Open Access
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2020.12.018
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Alterations of Spermatozoa Proteomic Profile in Men with Hodgkin’s Disease Prior to Cancer Therapy

    Ana D. Martins / Ashok Agarwal / Saradha Baskaran / Peter Natesan Pushparaj / Gulfam Ahmad / Manesh Kumar Panner Selvam

    The World Journal of Men's Health, Vol 38, Iss 4, Pp 521-

    2020  Volume 534

    Abstract: Purpose: Hodgkin’s disease (HD) is a type of cancer affecting men in the reproductive age ...

    Abstract Purpose: Hodgkin’s disease (HD) is a type of cancer affecting men in the reproductive age with potential consequences on their fertility status. This study aims to analyze sperm parameters, alterations in proteomic profiles and validate selected protein biomarkers of spermatozoa in men with HD undergoing sperm banking before cancer therapy. Materials and Methods: Semen analysis was carried out in healthy fertile donors (control, n=42), and patients diagnosed with HD (patients, n=38) before cancer therapy. We compared proteomic profiles of spermatozoa from donors (n=3) and patients (n=3) using LTQ-Orbitrap Elite hybrid MS system. Results: A total of 1,169 proteins were identified by global proteomic in both groups. The ingenuity pathway analysis revealed that differentially expressed proteins involved in capacitation, acrosome reaction, binding of sperm to the zona pellucida, sperm motility, regulation of sperm DNA damage, and apoptosis were significantly downregulated in HD patients. Validation of proteins implicated in sperm fertility potential by Western Blot demonstrated that peroxiredoxin 2 (PRDX 2) was underexpressed (p=0.015), and transferrin (p=0.045) and SERPIN A5 (p=0.010) protein levels were overexpressed in spermatozoa of men with HD. Conclusions: Findings of this study indicates that the key proteins involved in sperm fertility potential are significantly altered in men with HD, which provides substantial explanation for the observed low sperm quality in HD subjects prior to cancer therapy. Furthermore, our results suggest PRDX 2, transferrin and SERPIN A5 as possible candidate proteins for assessing sperm quality in HD patients prior to cancer therapy.
    Keywords hodgkin disease ; infertility ; mass spectrometry ; proteomics ; spermatozoa ; transferrin ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Korean Society for Sexual Medicine and Andrology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Going vertical. Dignity's play for U.S. HealthWorks illustrates push for integrated care.

    Selvam, Ashok

    Modern healthcare

    2012  Volume 42, Issue 28, Page(s) 8–9

    MeSH term(s) Ambulatory Care Facilities ; California ; Delivery of Health Care, Integrated ; Health Facility Merger ; Organizational Case Studies ; United States
    Language English
    Publishing date 2012-07-09
    Publishing country United States
    Document type News
    ZDB-ID 187602-8
    ISSN 0160-7480
    ISSN 0160-7480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.

    Lv, Zongyang / Rickman, Kimberly A / Yuan, Lingmin / Williams, Katelyn / Selvam, Shanmugam Panneer / Woosley, Alec N / Howe, Philip H / Ogretmen, Besim / Smogorzewska, Agata / Olsen, Shaun K

    Molecular cell

    2017  Volume 65, Issue 4, Page(s) 699–714.e6

    Abstract: ... residues is unknown. Here, we report the structure of S. pombe Uba1 in complex with Ubc15, a Ub E2 ...

    Abstract Ubiquitin (Ub) E1 initiates the Ub conjugation cascade by activating and transferring Ub to tens of different E2s. How Ub E1 cooperates with E2s that differ substantially in their predicted E1-interacting residues is unknown. Here, we report the structure of S. pombe Uba1 in complex with Ubc15, a Ub E2 with intrinsically low E1-E2 Ub thioester transfer activity. The structure reveals a distinct Ubc15 binding mode that substantially alters the network of interactions at the E1-E2 interface compared to the only other available Ub E1-E2 structure. Structure-function analysis reveals that the intrinsically low activity of Ubc15 largely results from the presence of an acidic residue at its N-terminal region. Notably, Ub E2 N termini are serine/threonine rich in many other Ub E2s, leading us to hypothesize that phosphorylation of these sites may serve as a novel negative regulatory mechanism of Ub E2 activity, which we demonstrate biochemically and in cell-based assays.
    MeSH term(s) Binding Sites ; Cell Line ; Humans ; Models, Molecular ; Phosphorylation ; Protein Binding ; Protein Interaction Domains and Motifs ; Schizosaccharomyces/enzymology ; Schizosaccharomyces/genetics ; Schizosaccharomyces pombe Proteins/chemistry ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Structure-Activity Relationship ; Transfection ; Ubiquitin/metabolism ; Ubiquitin-Activating Enzymes/chemistry ; Ubiquitin-Activating Enzymes/genetics ; Ubiquitin-Activating Enzymes/metabolism ; Ubiquitin-Conjugating Enzymes/chemistry ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
    Chemical Substances Schizosaccharomyces pombe Proteins ; UBA1 protein, human ; Ubiquitin ; ptr3 protein, S pombe ; UBE2G2 protein, human (EC 2.3.2.23) ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ubiquitin-Activating Enzymes (EC 6.2.1.45)
    Language English
    Publishing date 2017-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2017.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intussusception risk after rotavirus vaccination in U.S. infants.

    Yih, W Katherine / Lieu, Tracy A / Kulldorff, Martin / Martin, David / McMahill-Walraven, Cheryl N / Platt, Richard / Selvam, Nandini / Selvan, Mano / Lee, Grace M / Nguyen, Michael

    The New England journal of medicine

    2014  Volume 370, Issue 6, Page(s) 503–512

    Abstract: ... in three U.S. health plans that participate in the Mini-Sentinel program sponsored ...

    Abstract Background: International postlicensure studies have identified an increased risk of intussusception after vaccination with the second-generation rotavirus vaccines RotaTeq (RV5, a pentavalent vaccine) and Rotarix (RV1, a monovalent vaccine). We studied this association among infants in the United States.
    Methods: The study included data from infants 5.0 to 36.9 weeks of age who were enrolled in three U.S. health plans that participate in the Mini-Sentinel program sponsored by the Food and Drug Administration. Potential cases of intussusception and vaccine exposures from 2004 through mid-2011 were identified through procedural and diagnostic codes. Medical records were reviewed to confirm the occurrence of intussusception and the status with respect to rotavirus vaccination. The primary analysis used a self-controlled risk-interval design that included only vaccinated children. The secondary analysis used a cohort design that included exposed and unexposed person-time.
    Results: The analyses included 507,874 first doses and 1,277,556 total doses of RV5 and 53,638 first doses and 103,098 total doses of RV1. The statistical power for the analysis of RV1 was lower than that for the analysis of RV5. The number of excess cases of intussusception per 100,000 recipients of the first dose of RV5 was significantly elevated, both in the primary analysis (attributable risk, 1.1 [95% confidence interval, 0.3 to 2.7] for the 7-day risk window and 1.5 [95% CI, 0.2 to 3.2] for the 21-day risk window) and in the secondary analysis (attributable risk, 1.2 [95% CI, 0.2 to 3.2] for the 21-day risk window). No significant increase in risk was seen after dose 2 or 3. The results with respect to the primary analysis of RV1 were not significant, but the secondary analysis showed a significant risk after dose 2.
    Conclusions: RV5 was associated with approximately 1.5 (95% CI, 0.2 to 3.2) excess cases of intussusception per 100,000 recipients of the first dose. The secondary analysis of RV1 suggested a potential risk, although the study of RV1 was underpowered. These risks must be considered in light of the demonstrated benefits of rotavirus vaccination. (Funded by the Food and Drug Administration.).
    MeSH term(s) Cohort Studies ; Humans ; Immunization, Secondary ; Infant ; Intussusception/epidemiology ; Intussusception/etiology ; Risk ; Rotavirus Vaccines/administration & dosage ; Rotavirus Vaccines/adverse effects ; United States/epidemiology ; Vaccines, Attenuated/administration & dosage ; Vaccines, Attenuated/adverse effects
    Chemical Substances RIX4414 vaccine ; RotaTeq ; Rotavirus Vaccines ; Vaccines, Attenuated
    Language English
    Publishing date 2014-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1303164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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