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  1. Article: Thrombotic Complications after COVID-19 Vaccination: Diagnosis and Treatment Options.

    Guetl, Katharina / Raggam, Reinhard Bernd / Gary, Thomas

    Biomedicines

    2022  Volume 10, Issue 6

    Abstract: Coronavirus disease 2019 (COVID-19) vaccines were developed a few months after the emergence of the pandemic. The first cases of vaccine-induced thrombotic complications after the use of adenoviral vector vaccines ChAdOx1 nCoV-19 by AstraZeneca, and Ad26. ...

    Abstract Coronavirus disease 2019 (COVID-19) vaccines were developed a few months after the emergence of the pandemic. The first cases of vaccine-induced thrombotic complications after the use of adenoviral vector vaccines ChAdOx1 nCoV-19 by AstraZeneca, and Ad26.COV2.S by Johnson & Johnson/Janssen, were announced shortly after the initiation of a global vaccination program. In these cases, the occurrence of thrombotic events at unusual sites-predominantly located in the venous vascular system-in association with concomitant thrombocytopenia were observed. Since this new entity termed vaccine-induced thrombotic thrombocytopenia (VITT) shows similar pathophysiologic mechanisms as heparin-induced thrombocytopenia (HIT), including the presence of antibodies against heparin/platelet factor 4 (PF4), standard routine treatment for thrombotic events-arterial or venous-are not appropriate and may also cause severe harm in affected patients. Thrombotic complications were also rarely documented after vaccination with mRNA vaccines, but a typical VITT phenomenon has, to date, not been established for these vaccines. The aim of this review is to give a concise and feasible overview of diagnostic and therapeutic strategies in COVID-19 vaccine-induced thrombotic complications.
    Language English
    Publishing date 2022-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10061246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Post-Traumatic Aneurysms of the Superficial Temporal Artery.

    Gressenberger, Paul / Gütl, Katharina / Jud, Philipp

    Deutsches Arzteblatt international

    2021  Volume 118, Issue 5, Page(s) 70

    MeSH term(s) Humans ; Intracranial Aneurysm/diagnostic imaging ; Temporal Arteries/diagnostic imaging ; Temporal Arteries/surgery
    Language English
    Publishing date 2021-03-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0101
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  3. Article: Klinischer Schnappschuss. Posttraumatische Aneurysmen der Arteria temporalis superficialis

    Gressenberger, Paul / Gütl, Katharina / Jud, Philipp

    Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

    2021  Volume 118, Issue 5, Page(s) 70

    Language German
    Document type Article
    ZDB-ID 1453475-7
    ISSN 0012-1207
    Database Current Contents Medicine

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  4. Article ; Online: Long-Term Outcomes of the 150 mm Drug-Coated Balloon Cohort from the IN.PACT Global Study.

    Brodmann, Marianne / Lansink, Wouter / Guetl, Katharina / Micari, Antonio / Menk, Jeremiah / Zeller, Thomas

    Cardiovascular and interventional radiology

    2022  Volume 45, Issue 9, Page(s) 1276–1287

    Abstract: Purpose: Data on the long-term safety and effectiveness of drug-coated balloons (DCBs) for the treatment of long femoropopliteal atherosclerotic lesions in the real-world setting are rare. This study reports 3 year and 5 year outcomes of the pre- ... ...

    Abstract Purpose: Data on the long-term safety and effectiveness of drug-coated balloons (DCBs) for the treatment of long femoropopliteal atherosclerotic lesions in the real-world setting are rare. This study reports 3 year and 5 year outcomes of the pre-specified 150 mm balloon sub-cohort of the IN.PACT Global Study.
    Methods: The IN.PACT Global Study was a prospective, multicentre, international, single-arm study evaluating the performance of the IN.PACT Admiral DCB in real-world patients with femoropopliteal atherosclerotic disease. This pre-specified 150 mm DCB cohort analysis comprised 107 participants (111 lesions) with all target lesions treated with at least one 150 mm DCB.
    Results: Mean lesion length was 20.3 ± 9.2 cm; 18.0% had in-stent restenosis, 58.6% were totally occluded, and 17.1% were severely calcified. Through 60 months, the Kaplan-Meier estimate of freedom from clinically driven target lesion revascularization (CD-TLR) was 72.7% [95% confidence interval (CI):62.4%-80.5%]. The safety composite endpoint (freedom from device/procedure-related death through 30 days; freedom from target limb major amputation and clinically driven target vessel revascularization through 5 years) was 70.5%. The cumulative incidence of major amputation was 1.0% and all-cause mortality was 18.4% through 60 months. Freedom from CD-TLR rates in the provisional stented and non-stented subgroups through 36 months were 64.0% [95% CI: 46.1%-77.3%] and 81.9% [95% CI: 69.7%-89.6%] (log-rank p = 0.074), respectively.
    Conclusions: The results demonstrate sustained long-term safety of the 150 mm IN.PACT Admiral DCB for long femoropopliteal atherosclerotic lesions in real-world patients. In particular, the results show that DCB angioplasty is an effective revascularization modality in long complex lesions.
    Clinicaltrials: gov identifier: NCT01609296.
    Level of evidence: Level 3, Cohort Study.
    MeSH term(s) Angioplasty, Balloon ; Cardiovascular Agents ; Coated Materials, Biocompatible ; Cohort Studies ; Femoral Artery/diagnostic imaging ; Humans ; Paclitaxel ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/therapy ; Popliteal Artery/diagnostic imaging ; Prospective Studies ; Time Factors ; Vascular Access Devices ; Vascular Patency
    Chemical Substances Cardiovascular Agents ; Coated Materials, Biocompatible ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-022-03214-y
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    Zs.A 1378: Show issues Location:
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  5. Article ; Online: Standard Balloon Angioplasty Versus Serranator Serration Balloon Angioplasty for the Treatment of Below-the-Knee Artery Occlusive Disease: A Single-Center Subanalysis From the PRELUDE-BTK Prospective Study.

    Guetl, Katharina / Muster, Viktoria / Schweiger, Leyla / Tang, William C / Patel, Kaushal / Brodmann, Marianne

    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

    2022  , Page(s) 15266028221134891

    Abstract: Background: Endovascular interventions in infrapopliteal occlusive artery disease are becoming more complex, and this frequently tests the standard method of treatment, plain old balloon angioplasty (POBA). The potential that serration angioplasty could ...

    Abstract Background: Endovascular interventions in infrapopliteal occlusive artery disease are becoming more complex, and this frequently tests the standard method of treatment, plain old balloon angioplasty (POBA). The potential that serration angioplasty could produce a more acceptable tibial artery lumen was assessed in this study.
    Aim: The aim of this single-center subgroup analysis was to compare acute angiographic results after endovascular treatment using the Serranator serration balloon catheter in patients participating in the PRELUDE-BTK trial with POBA of the infrapopliteal arteries. A secondary objective was to assess post-treatment hemodynamic improvements.
    Methods: Our center enrolled 15 subjects and treated 17 lesions within the multicenter prospective core laboratory-adjudicated PRELUDE-BTK study. A 25 lesions analyzed separately were treated with POBA and then compared with the Serranator subset. In both cohorts, lesions were treated with either plain angioplasty or Serranator as a stand-alone therapy; subsequent methods, such as drug elution technologies, were not used. Acute angiographic results were analyzed by the SynvaCor angiographic core laboratory. To assess volumetric flow rates, data were analyzed with a fluid flow simulation software and compared against Poiseuille's Law.
    Results: Final residual stenosis was 17.2%±8.2% in the Serranator group versus 33.7%±15.7% in the POBA group. The mean lumen diameter (MLD) gain for the Serranator group and the POBA group was 1.64±0.41 mm and 1.33±0.63 mm, respectively. The average atmospheric balloon inflation pressure was 5 ATM in the Serranator group versus 9 ATM in the POBA group. Neither group required a bailout stent; however, it was notable that there were significantly more chronic total occlusions (CTOs) treated in the Serranator group at 41.2% versus 12% in the POBA group. Regarding the effectiveness in improving hemodynamic blood flow for non-CTO lesions, the calculated average ratio of post-treatment to pre-treatment flow rates in the Serranator group was 238% than that for the POBA group. For CTO cases where pre-treatment flow rate was zero, final residual stenosis was used as the parameter for comparison. The Serranator group showed a 62% improvement in final residual stenosis over POBA.
    Conclusion: Endovascular treatment of the infrapopliteal arteries by use of the Serranator serration balloon provides a novel and promising method of action compared with standard balloon angioplasty and, thus, may have a leading role in complex below-the-knee arterial lesions.
    Clinical impact: The Serranator device might help to adequately address issues with conventional routine techniques for the treatment of complex lesions in infrapopliteal arteries in patients with advanced stages of PAD and critical limb ischemia. Integrating modern technologies such as the Serranator balloon catheter into clinical routine is mandatory in order to gain a more favorable outcome in these severely diseased patients and, particularly, to reduce mortality and morbidity.
    Language English
    Publishing date 2022-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006618-1
    ISSN 1545-1550 ; 1526-6028
    ISSN (online) 1545-1550
    ISSN 1526-6028
    DOI 10.1177/15266028221134891
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  6. Article ; Online: SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia treated with immunoglobulin and argatroban.

    Guetl, Katharina / Gary, Thomas / Raggam, Reinhard B / Schmid, Johannes / Wölfler, Albert / Brodmann, Marianne

    Lancet (London, England)

    2021  Volume 397, Issue 10293, Page(s) e19

    MeSH term(s) Antithrombins/therapeutic use ; Arginine/analogs & derivatives ; Arginine/therapeutic use ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Middle Aged ; Pipecolic Acids/therapeutic use ; Purpura, Thrombocytopenic/chemically induced ; Purpura, Thrombocytopenic/drug therapy ; Purpura, Thrombocytopenic/immunology ; SARS-CoV-2 ; Sulfonamides/therapeutic use
    Chemical Substances Antithrombins ; COVID-19 Vaccines ; Immunoglobulins, Intravenous ; Immunologic Factors ; Pipecolic Acids ; Sulfonamides ; Arginine (94ZLA3W45F) ; argatroban (IY90U61Z3S)
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01238-1
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  7. Article: Endovascular Thrombolysis in Hypothenar Hammer Syndrome: A Systematic Review.

    Jud, Philipp / Pregartner, Gudrun / Berghold, Andrea / Rief, Peter / Muster, Viktoria / Gütl, Katharina / Brodmann, Marianne / Hafner, Franz

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 745776

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2021-12-15
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.745776
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  8. Article: Lower Lean Mass Is Associated with Greater Arterial Stiffness in Patients with Lower Extremity Artery Disease.

    Muster, Viktoria / Gütl, Katharina / Pregartner, Gudrun / Berghold, Andrea / Schweiger, Leyla / Jud, Philipp / Brodmann, Marianne / Seinost, Gerald

    Journal of personalized medicine

    2021  Volume 11, Issue 9

    Abstract: Background: Arterial stiffness is independently associated with lower extremity artery disease (LEAD). Although obesity is already known as an independent cardiovascular risk factor, it was found that, paradoxically, in patients diagnosed with ... ...

    Abstract Background: Arterial stiffness is independently associated with lower extremity artery disease (LEAD). Although obesity is already known as an independent cardiovascular risk factor, it was found that, paradoxically, in patients diagnosed with cardiovascular disease, an increase in body mass index (BMI) was associated with a decrease in mortality. However, the underlying mechanism of this paradoxical association remain uncertain. In this study, we firstly hypothesize that arterial stiffness correlates with body mass; secondly, the underlying mechanism of the association for patients with LEAD is individual body composition, in particular, lean mass.
    Methods: The present study was performed as a single-center, prospective, observational analysis. A total of 412 patients with current or previously diagnosed LEAD (Rutherford Classification 2-4) were included, the cfPWV and AIx were measured as indices of arterial stiffness, and a body composition assessment was performed.
    Results: In male patients, there was a significantly negative correlation between the AIx and lean mass coefficient (
    Conclusion: For patients with peripheral arterial disease, our data show that lower lean mass in male patients is associated with increased arterial stiffness as measured by the AIx. Therefore, progressive resistance training may be beneficial for the reduction in arterial stiffness in PAD patients in secondary prevention.
    Language English
    Publishing date 2021-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11090911
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  9. Article ; Online: [No title information]

    Gressenberger, Paul / Portugaller, Rupert Horst / Gütl, Katharina / Muster, Viktoria / Jud, Philipp / Schmid, Johannes / Tiesenhausen, Kurt / Brodmann, Marianne / Gary, Thomas

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2020  Volume 18, Issue 11, Page(s) 1322–1324

    Title translation Persistierende Beckenvenenthrombose nach Cyanacrylatverschluss der Vena saphena magna.
    Language German
    Publishing date 2020-11-30
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14258_g
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    Zs.A 6148: Show issues Location:
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  10. Article ; Online: Persistent iliac vein thrombosis after cyanoacrylate closure of the great saphenous vein.

    Gressenberger, Paul / Portugaller, Rupert Horst / Gütl, Katharina / Muster, Viktoria / Jud, Philipp / Schmid, Johannes / Tiesenhausen, Kurt / Brodmann, Marianne / Gary, Thomas

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2020  Volume 18, Issue 11, Page(s) 1322–1324

    MeSH term(s) Cyanoacrylates ; Humans ; Iliac Vein ; Saphenous Vein ; Thrombosis ; Treatment Outcome ; Varicose Veins ; Venous Insufficiency
    Chemical Substances Cyanoacrylates
    Language English
    Publishing date 2020-09-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14258
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