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Book ; Online ; E-Book: Atlas of Human Semen Examination

Paoli, Donatella / Lombardo, Francesco / Lenzi, Andrea

(Trends in Andrology and Sexual Medicine,)

2020

Abstract: This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling ... ...

Author's details	by Donatella Paoli, Francesco Lombardo, Andrea Lenzi
Series title	Trends in Andrology and Sexual Medicine,
Abstract	This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technicians in the field of andrology as well as practitioners and clinicians in andrology, urology, pathology, IVF and other ART programs.
Keywords	Andrology ; Reproductive medicine ; Pathology ; Reproductive Medicine ; Andrologia ; Semen ; Diagnòstic
Subject code	341.75471608247
Language	English
Size	1 online resource (VII, 106 p. 172 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-39998-2 ; 3-030-39997-4 ; 978-3-030-39998-6 ; 978-3-030-39997-9
DOI	10.1007/978-3-030-39998-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Confirmation of the Pathogenetic Role of the CCDC88C Gene in Early-Onset Pure Spastic Paraplegia.

Caputo, Donatella / Cetica, Valentina / Paoli, Silvia / Rosati, Anna / Lazzeri, Simone

Movement disorders : official journal of the Movement Disorder Society

2023 Volume 38, Issue 8, Page(s) 1561–1562

MeSH term(s)	Humans ; Mutation/genetics ; Spastic Paraplegia, Hereditary/genetics ; Paraplegia/genetics ; Pedigree ; Microfilament Proteins/genetics ; Intracellular Signaling Peptides and Proteins/genetics
Chemical Substances	CCDC88C protein, human ; Microfilament Proteins ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Letter
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29459
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Article: Comment on Boitrelle et al. The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis.

Pallotti, Francesco / Lombardo, Francesco / Paoli, Donatella

Life (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: We wish to congratulate Boitrelle and colleagues for their comprehensive critical review on the Sixth Edition of the WHO Laboratory Manual for Human semen examination [ ... ]. ...

Abstract	We wish to congratulate Boitrelle and colleagues for their comprehensive critical review on the Sixth Edition of the WHO Laboratory Manual for Human semen examination [...].
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12071044
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Article ; Online: Comment on Boitrelle et al. The Sixth Edition of the WHO Manual for Human Semen Analysis

Francesco Pallotti / Francesco Lombardo / Donatella Paoli

Life, Vol 12, Iss 7, p

A Critical Review and SWOT Analysis. Life 2021, 11 , 1368

2022 Volume 1044

Abstract: We wish to congratulate Boitrelle and colleagues for their comprehensive critical review on the Sixth Edition of the WHO Laboratory Manual for Human semen examination [.] ...

Abstract	We wish to congratulate Boitrelle and colleagues for their comprehensive critical review on the Sixth Edition of the WHO Laboratory Manual for Human semen examination [.]
Keywords	n/a ; Science ; Q
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A decade of WHO 2010: total sperm number temporal trend and role of lifestyle factors.

Cargnelutti, Francesco / Pallotti, Francesco / Carlini, Tania / Faja, Fabiana / Vestri, Anna Rita / Fegatelli, Danilo Alunni / Lenzi, Andrea / Lombardo, Francesco / Paoli, Donatella

Asian journal of andrology

2023

Abstract: After a huge decline in sperm concentration between 1938 and 1991 was reported, many researchers investigated the possibility of a worsening of human sperm quality. Despite massive efforts, published evidence is still controversial. Similarly, the role ... ...

Abstract	After a huge decline in sperm concentration between 1938 and 1991 was reported, many researchers investigated the possibility of a worsening of human sperm quality. Despite massive efforts, published evidence is still controversial. Similarly, the role of lifestyle factors on semen parameters is debated. We conducted a monocentric Italian study to evaluate the total sperm number trend over the last 10 years (from 2010 to 2019). Additionally, we evaluated the association between lifestyle factors and total sperm number in order to identify possible damaging factors. We performed a retrospective study analyzing subjects aged 18-55 years who had their semen analyzed between 2010 and 2019. A total of 3329 subjects were included: 1655 subjects referred to our department (Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy) for idiopathic infertility and 1674 subjects referred for preconceptional or andrological screening with no confirmed andrological diseases. Semen samples were examined according to World Health Organization (WHO) 2010 criteria by two seminologists with the same training and the same equipment. For statistical evaluations, only total sperm number (×10 6 per ejaculate) was taken into consideration. We detected no significant changes in mean total sperm number during the last decade, in either the entire population or the two subgroups (infertile group and control group). In a multivariate analysis total sperm number was significantly associated with the history of infertility, body mass index (BMI) and cigarette smoking. Our results suggest that infertile men are "vulnerable" subjects, particularly susceptible to several negative factors, many of which still remain unknown. Our study highlights the need for studies addressing men's lifestyle in order to find and reduce deleterious agents.
Language	English
Publishing date	2023-01-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202297
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Article ; Online: Environmental disruptors and testicular cancer.

Faja, Fabiana / Esteves, Sandro / Pallotti, Francesco / Cicolani, Gaia / Di Chiano, Silvia / Delli Paoli, Enrico / Lenzi, Andrea / Lombardo, Francesco / Paoli, Donatella

Endocrine

2022 Volume 78, Issue 3, Page(s) 429–435

Abstract: Purpose: Testicular cancer (TC) is the most common malignancy among young adult males. The etiology is multifactorial, and both environmental and genetic factors play an essential role in the origin and development of this tumor. In particular, exposure ...

Abstract	Purpose: Testicular cancer (TC) is the most common malignancy among young adult males. The etiology is multifactorial, and both environmental and genetic factors play an essential role in the origin and development of this tumor. In particular, exposure to environmental endocrine disruptors (EEDs), resulting from industrialization and urbanization, seems crucial both in pre-and postnatal life. However, the lack of long-term studies on a wide caseload and the difficulty in evaluating their toxic effects in vivo make it challenging to establish a causal link. This review aims to discuss the main human epidemiological studies currently available in the literature to define a possible association between these chemicals and TC. Methods: A comprehensive Medline/PubMed and Embase search was performed, selecting all relevant, peer-reviewed papers in English published from 2002 to January 2022. Other relevant papers were selected from the reference lists. Results: To date, literature evidence is limited due to the scarcity and heterogeneity of human studies and shows controversial data, highlighting the complexity of the topic. However, most human epidemiological studies seem to point toward a correlation between EEDs exposure and TC. Conclusion: Although the molecular mechanisms are not yet fully understood, the role of EEDs in TC onset is plausible, but several factors, such as the individual genetic background, the exposure time, and the complex mechanism of action of these chemicals, do not allow defining the causal link with certainty and make further studies necessary to investigate this complex topic.
MeSH term(s)	Male ; Young Adult ; Humans ; Testicular Neoplasms/chemically induced ; Testicular Neoplasms/epidemiology ; Endocrine Disruptors/toxicity ; Neoplasms, Germ Cell and Embryonal ; Environmental Exposure/adverse effects
Chemical Substances	Endocrine Disruptors
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-022-03171-z
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Article ; Online: CD137

Gelibter, Alain / Asquino, Angela / Strigari, Lidia / Zizzari, Ilaria Grazia / Tuosto, Lucrezia / Scirocchi, Fabio / Pace, Angelica / Siringo, Marco / Tramontano, Elisa / Bianchini, Serena / Bellati, Filippo / Botticelli, Andrea / Paoli, Donatella / Santini, Daniele / Nuti, Marianna / Rughetti, Aurelia / Napoletano, Chiara

Journal of translational medicine

2024 Volume 22, Issue 1, Page(s) 329

Abstract: Background: Immune checkpoint inhibitors (ICIs), administered alone or combined with chemotherapy, are the standard of care in advanced non-oncogene addicted Non-Small Cell Lung Cancer (NSCLC). Despite these treatments' success, most long-term survival ... ...

Abstract	Background: Immune checkpoint inhibitors (ICIs), administered alone or combined with chemotherapy, are the standard of care in advanced non-oncogene addicted Non-Small Cell Lung Cancer (NSCLC). Despite these treatments' success, most long-term survival benefit is restricted to approximately 20% of patients, highlighting the need to identify novel biomarkers to optimize treatment strategies. In several solid tumors, immune soluble factors, the activatory CD137 Methods: The levels of T cells, MDSCs and soluble factors were evaluated in 89 metastatic NSCLC patients who underwent ICIs as first- or second-line treatment. T cell analysis was performed by cytoflurimetry evaluating Tregs and different CD137 Results: In both groups of patients, high levels of circulating CD137 Conclusion: High levels of CD137
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; T-Lymphocytes, Regulatory ; Lung Neoplasms/pathology ; Prognosis ; Biomarkers ; Immunotherapy/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-05142-6
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Article: Cryopreservation of Sperm: Effects on Chromatin and Strategies to Prevent Them.

Paoli, Donatella / Pelloni, Marianna / Lenzi, Andrea / Lombardo, Francesco

Advances in experimental medicine and biology

2019 Volume 1166, Page(s) 149–167

Abstract: Cryopreservation is a technique that can keep sperm alive indefinitely, enabling the conservation of male fertility. It involves the cooling of semen samples and their storage at -196 °C in liquid nitrogen. At this temperature all metabolic processes are ...

Abstract	Cryopreservation is a technique that can keep sperm alive indefinitely, enabling the conservation of male fertility. It involves the cooling of semen samples and their storage at -196 °C in liquid nitrogen. At this temperature all metabolic processes are arrested. Sperm cryopreservation is of fundamental importance for patients undergoing medical or surgical treatments that could induce sterility, such as cancer patients about to undergo genotoxic chemotherapy or radiotherapy, as it offers these patients not only the hope of future fertility but also psychological support in dealing with the various stages of the treatment protocols.Despite its importance for assisted reproduction technology (ART) and its success in terms of babies born, this procedure can cause cell damage and impaired sperm function. Various studies have evaluated the impact of cryopreservation on chromatin structure, albeit with contradictory results. Some, but not all, authors found significant sperm DNA damage after cryopreservation. However, studies attempting to explain the mechanisms involved in the aetiology of cryopreservation-induced DNA damage are still limited. Some reported an increase in sperm with activated caspases after cryopreservation, while others found an increase in the percentage of oxidative DNA damage. There is still little and contradictory information on the mechanism of the generation of DNA fragmentation after cryopreservation. A number of defensive strategies against cryoinjuries have been proposed in the last decade. Most studies focused on supplementing cryoprotectant medium with various antioxidant molecules, all aimed at minimising oxidative damage and thus improving sperm recovery. Despite the promising results, identification of the ideal antioxidant treatment method is still hampered by the heterogeneity of the studies, which describe the use of different antioxidant regimens at different concentrations or in different combinations. For this reason, additional studies are needed to further investigate the use of antioxidants, individually and in combination, in the cryopreservation of human sperm, to determine the most beneficial conditions for optimal sperm recovery and preservation of fertility.
MeSH term(s)	Chromatin/chemistry ; Chromatin/pathology ; Cryopreservation/methods ; Cryopreservation/standards ; Cryoprotective Agents ; DNA Fragmentation ; Humans ; Male ; Semen Preservation/methods ; Semen Preservation/standards ; Spermatozoa/pathology
Chemical Substances	Chromatin ; Cryoprotective Agents
Language	English
Publishing date	2019-07-12
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-21664-1_9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction to: Effects of endocrine disruptors on fetal testis development, male puberty, and transition age.

Cargnelutti, Francesco / Di Nisio, Andrea / Pallotti, Francesco / Sabovic, Iva / Spaziani, Matteo / Tarsitano, Maria Grazia / Paoli, Donatella / Foresta, Carlo

Endocrine

2021 Volume 72, Issue 2, Page(s) 591–595

Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-020-02581-1
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Article ; Online: 4BNT162b2 mRNA COVID-19 vaccine and semen: What do we know?

Olana, Soraya / Mazzilli, Rossella / Salerno, Gerardo / Zamponi, Virginia / Tarsitano, Maria Grazia / Simmaco, Maurizio / Paoli, Donatella / Faggiano, Antongiulio

Andrology

2022 Volume 10, Issue 6, Page(s) 1023–1029

Abstract: Background: The effects of an mRNA COVID-19 vaccine on spermatozoa parameters are not known. The aim of this study was to evaluate the effect of the BNT162b2 mRNA COVID-19 vaccine on human semen, comparing spermatozoa parameters before and after vaccine ...

Abstract	Background: The effects of an mRNA COVID-19 vaccine on spermatozoa parameters are not known. The aim of this study was to evaluate the effect of the BNT162b2 mRNA COVID-19 vaccine on human semen, comparing spermatozoa parameters before and after vaccine inoculation. Materials and methods: In this single-center prospective study, voluntary subjects who received mRNA vaccines from February to July 2021 were enrolled. The study population included male subjects aged between 18 and 45 years who completed the BNT162b2 mRNA COVID-19 vaccine cycle. All subjects were evaluated before the first dose of vaccine (T0) and after 3 months (T1) with semen analysis and further analysis of seminal plasma, including colorimetric determination of reactive oxygen metabolites (d-ROM test), electrolytes, and interleukin 6 (IL-6) assessment by enzyme-linked immunosorbent assay technology. Results: The experimental sample included 47 subjects (age: 29.3 ± 6.0 years, range 24-32; body mass index: 23.15 ± 2.5 kg/m Discussion and conclusion: In this study, no significant differences in spermatozoa parameters before and after vaccine inoculations were found. Furthermore, oxidative stress analysis,, the activity of the cell membrane, and IL-6, as a marker of inflammation, was not affected by the mRNA COVID-19 vaccine. These results suggest that this vaccine is safe for male semen quality.
MeSH term(s)	Adolescent ; Adult ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Interleukin-6/metabolism ; Male ; Middle Aged ; Prospective Studies ; RNA, Messenger/metabolism ; Semen/metabolism ; Semen Analysis ; Young Adult
Chemical Substances	COVID-19 Vaccines ; Interleukin-6 ; RNA, Messenger ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-06-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13199
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