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Book ; Online: Das neue Volk Gottes in Hispanien

Marschner, Patrick Sebastian

Die Bibel in der christlich-iberischen Historiographie vom 8. bis zum 12. Jahrhundert

2023

Keywords	Bible, Biblical typology, historical writing, Iberian Peninsula, Middle Ages, cultural and religious 'Other', transculturality, Christian-Musslim relations, strategies of identification, ethnonyms ; Ã FOS 2012 -- HUMANITIES (6) -- History, Archaeology (601) -- History, Archaeology (6010) -- Medieval history (601012) ; Ã FOS 2012 -- HUMANITIES (6) -- Philosophy, Ethics, Religion (603) -- Theology (6032) -- Old Testament studies (603201) ; Ã FOS 2012 -- HUMANITIES (6) -- Philosophy, Ethics, Religion (603) -- Theology (6032) -- New Testament studies (603214) ; Ã FOS 2012 -- HUMANITIES (6) -- Linguistics and Literature (602) -- Linguistics and Literature (6020) -- Classical philology (602024) ; Bibel, Bibeltypologie, Geschichtsschreibung, Iberische Halbinsel, Mittelalter, kulturell-religiös "Andere", Transkulturalität, Christlich-Muslimische Beziehungen, Identifikationsstrategien, Ethnonyme ; Ã FOS 2012 -- GEISTESWISSENSCHAFTEN (6) -- Geschichte, ArchÃ¤ologie (601) -- Geschichte, ArchÃ¤ologie (6010) -- Mittelalterliche Geschichte (601012) ; Ã FOS 2012 -- GEISTESWISSENSCHAFTEN (6) -- Philosophie, Ethik, Religion (603) -- Theologie (6032) -- Alttestamentliche Bibelwissenschaft (603201) ; Ã FOS 2012 -- GEISTESWISSENSCHAFTEN (6) -- Philosophie, Ethik, Religion (603) -- Theologie (6032) -- Neutestamentliche Bibelwissenschaft (603214) ; Ã FOS 2012 -- GEISTESWISSENSCHAFTEN (6) -- Sprach- und Literaturwissenschaften (602) -- Sprach- und Literaturwissenschaften (6020) -- Klassische Philologie (602024)
Language	German
Size	1 Online-Ressource
Publisher	LIT Verlag GmbH and Company KG
Document type	Book ; Online
Note	German
HBZ-ID	HT030374665
ISBN	9783643661562 ; 3643661568
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Induktionschemotherapie mit Cisplatin und Gemcitabin, gefolgt von Radiochemotherapie bei Nasopharynxkarzinomen.

Luttke, Moritz / Späth, Richard / Marschner, Sebastian / Walter, Franziska

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

2020 Volume 196, Issue 8, Page(s) 740–742

Title translation	Induction Chemotherapy with Gemcitabine and Cisplatin followed by Radiochemotherapy in locally advanced Nasopharyngeal Carcinoma.
MeSH term(s)	Chemoradiotherapy ; Cisplatin/therapeutic use ; Deoxycytidine/analogs & derivatives ; Humans ; Induction Chemotherapy ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Neoplasms
Chemical Substances	Deoxycytidine (0W860991D6) ; gemcitabine (B76N6SBZ8R) ; Cisplatin (Q20Q21Q62J)
Language	German
Publishing date	2020-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84983-2
ISSN	1439-099X ; 0179-7158 ; 0039-2073
ISSN (online)	1439-099X
ISSN	0179-7158 ; 0039-2073
DOI	10.1007/s00066-020-01644-6
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Article ; Online: Dental management before radiotherapy of the head and neck region: 4-year single-center experience.

Hoffmann, Lea / Marschner, Sebastian N / Kakoschke, Tamara K / Hickel, Reinhard / Sabbagh, Hisham / Wölfle, Uta C

Clinical and experimental dental research

2022 Volume 8, Issue 6, Page(s) 1478–1486

Abstract: Objective: To review our experience with a standardized dental management approach in patients with planned radiotherapy of the head and neck region based on preradiation and follow-up data.: Material and methods: Records of patients who underwent ... ...

Abstract	Objective: To review our experience with a standardized dental management approach in patients with planned radiotherapy of the head and neck region based on preradiation and follow-up data. Material and methods: Records of patients who underwent radiotherapy between June 2016 and November 2020 were reviewed. Data on dental findings and therapeutic recommendations were extracted from a prospectively managed database. Hospital records were used to obtain follow-up data. Results: Two hundred eighty-one patient records were identified. After the exclusion of 81 patients because of incomplete data, 200 patients were included in the study. Dental findings relevant to radiotherapy were found in 144 cases (72.0%). Teeth extractions were recommended in 112 (56.0%) patients. Follow-up data were available for 172 (86.0%) patients (mean follow-up: 16.8 ± 10.7 months). Radiodermatitis was the most frequently observed sequela of radiotherapy (42.4%), followed by dysphagia (38.4%) and stomatitis (36.6%). Osteoradionecrosis was observed in only 2.3% of the patients. Conclusion: Dental findings relevant to planned radiotherapy were frequent and in many cases resulted in recommendations for teeth extraction. Based on our standardized dental management protocol, we observed low rates of late oral complications after radiotherapy of the head and neck region.
MeSH term(s)	Humans ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/complications ; Osteoradionecrosis/epidemiology ; Osteoradionecrosis/etiology ; Tooth Extraction/adverse effects ; Neck ; Dental Care
Language	English
Publishing date	2022-09-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2829558-4
ISSN	2057-4347 ; 2057-4347
ISSN (online)	2057-4347
ISSN	2057-4347
DOI	10.1002/cre2.662
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Deep learning based automatic segmentation of organs-at-risk for 0.35 T MRgRT of lung tumors.

Ribeiro, Marvin F / Marschner, Sebastian / Kawula, Maria / Rabe, Moritz / Corradini, Stefanie / Belka, Claus / Riboldi, Marco / Landry, Guillaume / Kurz, Christopher

Radiation oncology (London, England)

2023 Volume 18, Issue 1, Page(s) 135

Abstract: Background and purpose: Magnetic resonance imaging guided radiotherapy (MRgRT) offers treatment plan adaptation to the anatomy of the day. In the current MRgRT workflow, this requires the time consuming and repetitive task of manual delineation of ... ...

Abstract	Background and purpose: Magnetic resonance imaging guided radiotherapy (MRgRT) offers treatment plan adaptation to the anatomy of the day. In the current MRgRT workflow, this requires the time consuming and repetitive task of manual delineation of organs-at-risk (OARs), which is also prone to inter- and intra-observer variability. Therefore, deep learning autosegmentation (DLAS) is becoming increasingly attractive. No investigation of its application to OARs in thoracic magnetic resonance images (MRIs) from MRgRT has been done so far. This study aimed to fill this gap. Materials and methods: 122 planning MRIs from patients treated at a 0.35 T MR-Linac were retrospectively collected. Using an 80/19/23 (training/validation/test) split, individual 3D U-Nets for segmentation of the left lung, right lung, heart, aorta, spinal canal and esophagus were trained. These were compared to the clinically used contours based on Dice similarity coefficient (DSC) and Hausdorff distance (HD). They were also graded on their clinical usability by a radiation oncologist. Results: Median DSC was 0.96, 0.96, 0.94, 0.90, 0.88 and 0.78 for left lung, right lung, heart, aorta, spinal canal and esophagus, respectively. Median 95th percentile values of the HD were 3.9, 5.3, 5.8, 3.0, 2.6 and 3.5 mm, respectively. The physician preferred the network generated contours over the clinical contours, deeming 85 out of 129 to not require any correction, 25 immediately usable for treatment planning, 15 requiring minor and 4 requiring major corrections. Conclusions: We trained 3D U-Nets on clinical MRI planning data which produced accurate delineations in the thoracic region. DLAS contours were preferred over the clinical contours.
MeSH term(s)	Humans ; Deep Learning ; Retrospective Studies ; Tomography, X-Ray Computed/methods ; Radiotherapy Planning, Computer-Assisted/methods ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/radiotherapy ; Organs at Risk ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2224965-5
ISSN	1748-717X ; 1748-717X
ISSN (online)	1748-717X
ISSN	1748-717X
DOI	10.1186/s13014-023-02330-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of online MR-guided multi-fraction stereotactic ablative radiotherapy in lung tumours.

Hering, Svenja / Nieto, Alexander / Marschner, Sebastian / Hofmaier, Jan / Schmidt-Hegemann, Nina-Sophie / da Silva Mendes, Vanessa / Landry, Guillaume / Niyazi, Maximilian / Manapov, Farkhad / Belka, Claus / Corradini, Stefanie / Eze, Chukwuka

Clinical and translational radiation oncology

2024 Volume 45, Page(s) 100736

Abstract: Background: The aim of this prospective observational study was to evaluate the dosimetry benefits, changes in pulmonary function, and clinical outcome of online adaptive MR-guided SBRT.: Methods: From 11/2020-07/2022, 45 consecutive patients with 59 ...

Abstract	Background: The aim of this prospective observational study was to evaluate the dosimetry benefits, changes in pulmonary function, and clinical outcome of online adaptive MR-guided SBRT. Methods: From 11/2020-07/2022, 45 consecutive patients with 59 lesions underwent multi-fraction SBRT (3-8 fractions) at our institution. Patients were eligible if they had biopsy-proven NSCLC or lung cancer/metastases diagnosed via clinical imaging. Endpoints were local control (LC) and overall survival (OS). We evaluated PTV/GTV dose coverage, organs at risk exposure, and changes in pulmonary function (PF). Acute toxicity was classified per the National Cancer Institute-Common Terminology Criteria for Adverse Events version 5.0. Results: The median PTV was 14.4 cm Conclusions: Online adaptive MR-guided SBRT is an effective, safe and generally well tolerated treatment option for lung tumours achieving encouraging local control rates with significantly improved target volume coverage.
Language	English
Publishing date	2024-01-30
Publishing country	Ireland
Document type	Journal Article
ISSN	2405-6308
ISSN (online)	2405-6308
DOI	10.1016/j.ctro.2024.100736
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Book ; Online ; Thesis: RadioMorph

Marschner, Sebastian [Verfasser] / Belka, Claus [Akademischer Betreuer]

retrospektive, prätherapeutische CT-basierte morphologische Analyse des Primärtumors und der regionalen Lymphknoten bei Patienten mit Plattenepithelkarzinomen des Kopf- und Halsbereiches

2020

Author's details	Sebastian Marschner ; Betreuer: Claus Belka
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Differences in organic matter properties and microbial activity between bulk and rhizosphere soil from the top- and subsoils of three forest stands

Herre, Michael / Heitkötter, Julian / Heinze, Stefanie / Rethemeyer, Janet / Preusser, Sebastian / Kandeler, Ellen / Marschner, Bernd

Geoderma. 2022 Mar. 01, v. 409

2022

Abstract: The distribution of soil organic carbon (SOC) in subsoil is much more heterogeneous than in topsoils. This is largely caused by more localized inputs of fresh substrates and nutrients that mainly derive from rhizodeposition creating hotspots of microbial ...

Abstract	The distribution of soil organic carbon (SOC) in subsoil is much more heterogeneous than in topsoils. This is largely caused by more localized inputs of fresh substrates and nutrients that mainly derive from rhizodeposition creating hotspots of microbial activity. To elucidate the role of rhizosphere soil as an important input path for substrates into deeper soil layers, we investigated differences of organic matter distribution and microbial degradation in the rhizosphere soil and the surrounding bulk topsoil as well as in the subsoil. In addition, we considered the effect of different parent materials on SOC dynamics by analyzing soils developed in pleistocene sand, triassic sandstone and loess all covered with similarly aged beech forest within the same climatic region. Besides basic soil parameters, basal respiration, microbial biomass (Cₘᵢc) and ¹⁴C content were determined. Further, extracellular enzymes involved in C-, N- and P-cycling were analyzed. Differences in the microbial community were investigated using a taxon-specific real time qPCR approach. The results revealed significant differences of the microbial community composition between bulk and rhizosphere in top- and subsoil at the investigated sample sites. The mean SOC contents were 322% and 475% higher in the rhizosphere soil in both the top- and subsoil, respectively. The microbial biomass (Cₘᵢc) in the rhizosphere was up to 80% higher in the topsoil and on average 200% higher in the subsoil (SOC normalized), compared to the respective bulk soil. The qPCR results for all samples showed a higher diversity and abundance in the rhizosphere compared to the respective bulk samples and a shift in community composition with increasing soil depth. Total activity of the analyzed extracellular enzymes involved in different nutrient cycles differed significantly between bulk and rhizosphere soil and revealed that the microbial community in the rhizosphere subsoil can effectively utilize substrates even under scarce availability. The SOC normalized basal respiration at the Pleistocene sand and Loess sites and K₂SO₄-extractable C were higher in the subsoil compared to the topsoil showing more labile C in deeper soil layers with younger ¹⁴C in the rhizosphere. These results show that the rhizosphere at the investigated forest sites is a hotspot for microbial activity, which is more pronounced in the subsoil where the relevance of these hotspots is important for C turnover.
Keywords	Fagus ; Pleistocene epoch ; biodegradation ; climatic zones ; community structure ; forests ; loess ; microbial activity ; microbial biomass ; microbial communities ; rhizodeposition ; rhizosphere ; sand ; sandstone ; soil depth ; soil organic carbon ; subsoil ; topsoil
Language	English
Dates of publication	2022-0301
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	281080-3
ISSN	1872-6259 ; 0016-7061
ISSN (online)	1872-6259
ISSN	0016-7061
DOI	10.1016/j.geoderma.2021.115589
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Radiotherapy in oligometastatic prostate cancer-a pattern of care survey among members of the German Society for Radiation Oncology (DEGRO).

Rogowski, Paul / Trapp, Christian / von Bestenbostel, Rieke / Konnerth, Dinah / Marschner, Sebastian / Schmidt Hegemann, Nina-Sophie / Belka, Claus / Li, Minglun

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

2022 Volume 198, Issue 8, Page(s) 727–734

Abstract: Purpose: Due to improved imaging, oligometastatic prostate cancer (OMPC) is diagnosed more frequently. Growing evidence shows that patients with a limited number of metastases benefit from primary-directed radiotherapy (PDT) as well as from metastasis- ... ...

Abstract	Purpose: Due to improved imaging, oligometastatic prostate cancer (OMPC) is diagnosed more frequently. Growing evidence shows that patients with a limited number of metastases benefit from primary-directed radiotherapy (PDT) as well as from metastasis-directed radiotherapy (MDT). This survey investigates the current treatment practice for OMPC among German-speaking radiation oncologists. Methods: Members of the German Society for Radiation Oncology (Deutsche Gesellschaft für Radioonkologie [DEGRO]) were surveyed regarding their current treatment practice via an anonymous online questionnaire sent by email. The survey included six general items and 14 specific items regarding treatment characteristics. Questionnaires with at least 50% of questions completed were considered for further analysis. Results: A total of 204 responses were received (15% response rate), 167 were considered for further analysis. Most respondents stated to be specialized in treating prostate cancer patients and to treat 10-30 patients with OMPC per annum; 97% considered PSMA-PET/CT necessary to define oligometastatic disease. Opinions differed regarding the use of systemic therapies: 63% of the respondents aimed to defer systemic therapy using radiotherapy in OMPC, whereas 37% considered systemic therapy necessary. In the setting of synchronous OMPC, 97% recommended PDT with or without a combination of MDT and/or systemic therapy. For metachronous nodal or bone oligometastatic recurrence, 98 and 99%, respectively, would opt for MDT. The majority would combine MDT with systemic therapy in patients with metachronous oligorecurrence. Respondents recommended normofractionation, hypofractionation, and SBRT for lymph node metastases in 49, 27, and 24%, respectively. No consensus existed regarding the field size for MDT of lymph node metastases. Most respondents preferred > 5 fractions for treatment of bone metastases. Conclusion: Local radiotherapy for PDT and MDT is routinely used among respondents of this survey, representing 12% of all German-speaking radiation oncologists. The timing of systemic therapy, fractionation schedules, and field sizes are handled differently and remain an area of active investigation.
MeSH term(s)	Humans ; Lymphatic Metastasis/radiotherapy ; Male ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiation Oncology ; Surveys and Questionnaires
Language	English
Publishing date	2022-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84983-2
ISSN	1439-099X ; 0179-7158 ; 0039-2073
ISSN (online)	1439-099X
ISSN	0179-7158 ; 0039-2073
DOI	10.1007/s00066-022-01925-2
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Article ; Online: Correction: A deep image-to-image network organ segmentation algorithm for radiation treatment planning: principles and evaluation.

Marschner, Sebastian / Datar, Manasi / Gaasch, Aurélie / Xu, Zhoubing / Grbic, Sasa / Chabin, Guillaume / Geiger, Bernhard / Rosenman, Julian / Corradini, Stefanie / Niyazi, Maximilian / Heimann, Tobias / Möhler, Christian / Vega, Fernando / Belka, Claus / Thieke, Christian

Radiation oncology (London, England)

2022 Volume 17, Issue 1, Page(s) 149

Language	English
Publishing date	2022-08-23
Publishing country	England
Document type	Published Erratum
ZDB-ID	2224965-5
ISSN	1748-717X ; 1748-717X
ISSN (online)	1748-717X
ISSN	1748-717X
DOI	10.1186/s13014-022-02110-6
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Article ; Online: Factors influencing local control after MR-guided stereotactic body radiotherapy (MRgSBRT) for adrenal metastases.

Ugurluer, Gamze / Schneiders, Famke L / Corradini, Stefanie / Boldrini, Luca / Kotecha, Rupesh / Kelly, Patrick / Portelance, Lorraine / Camilleri, Philip / Ben-David, Merav A / Poiset, Spencer / Marschner, Sebastian N / Panza, Giulia / Kutuk, Tugce / Palacios, Miguel A / Castelluccia, Alessandra / Zoto Mustafayev, Teuta / Atalar, Banu / Senan, Suresh / Ozyar, Enis

Clinical and translational radiation oncology

2024 Volume 46, Page(s) 100756

Abstract: Purpose: Stereotactic body radiotherapy (SBRT) is an effective treatment for adrenal gland metastases, but it is technically challenging and there are concerns about toxicity. We performed a multi-institutional pooled retrospective analysis to study ... ...

Abstract	Purpose: Stereotactic body radiotherapy (SBRT) is an effective treatment for adrenal gland metastases, but it is technically challenging and there are concerns about toxicity. We performed a multi-institutional pooled retrospective analysis to study clinical outcomes and toxicities after MR-guided SBRT (MRgSBRT) using for adrenal gland metastases. Methods and materials: Clinical and dosimetric data of patients treated with MRgSBRT on a 0.35 T MR-Linac at 11 institutions between 2016 and 2022 were analyzed. Local control (LC), local progression-free survival (LPFS), distant progression-free survival (DPFS) and overall survival (OS) were estimated using Kaplan-Meier method and log-rank test. Results: A total of 255 patients (269 adrenal metastases) were included. Metastatic pattern was solitary in 25.9 % and oligometastatic in 58.0 % of patients. Median total dose was 45 Gy (range, 16-60 Gy) in a median of 5 fractions, and the median BED10 was 100 Gy (range, 37.5-132.0 Gy). Adaptation was done in 87.4 % of delivered fractions based on the individual clinicians' judgement. The 1- and 2- year LPFS rates were 94.0 % (95 % CI: 90.7-97.3 %) and 88.3 % (95 % CI: 82.4-94.2 %), respectively and only 2 patients (0.8 %) experienced grade 3 + toxicity. No local recurrences were observed after treatment to a total dose of BED10 > 100 Gy, with single fraction or fractional dose of > 10 Gy. Conclusions: This is a large retrospective multi-institutional study to evaluate the treatment outcomes and toxicities with MRgSBRT in over 250 patients, demonstrating the need for frequent adaptation in 87.4 % of delivered fractions to achieve a 1- year LPFS rate of 94 % and less than 1 % rate of grade 3 + toxicity. Outcomes analysis in 269 adrenal lesions revealed improved outcomes with delivery of a BED
Language	English
Publishing date	2024-02-29
Publishing country	Ireland
Document type	Journal Article
ISSN	2405-6308
ISSN (online)	2405-6308
DOI	10.1016/j.ctro.2024.100756
Database	MEDical Literature Analysis and Retrieval System OnLINE

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