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Article ; Online: Mechanisms of action of Fu Fang Gang Liu liquid in treating condyloma acuminatum by network pharmacology and experimental validation.

Fan, Zhu / Wang, Shuxin / Xu, Chenchen / Yang, Jiao / Cui, Bingnan

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 128

Abstract: ... by the anomalous proliferation of keratinocytes caused by human papillomavirus (HPV) infection. Fu Fang Gang Liu ...

Abstract	Background: Condyloma acuminatum (CA) is a sexually transmitted disease characterized by the anomalous proliferation of keratinocytes caused by human papillomavirus (HPV) infection. Fu Fang Gang Liu liquid (FFGL) is an effective externally administered prescription used to treat CA; however, its molecular mechanism remains unclear. This study aimed to identify and experimentally validate the major active ingredients and prospective targets of FFGL. Methods: Network pharmacology, transcriptomics, and enrichment analysis were used to identify the active ingredients and prospective targets of FFGL, which were confirmed through subsequent experimental validation using mass spectrometry, molecular docking, western blotting, and in vitro assays. Results: The network pharmacology analysis revealed that FFGL contains a total of 78 active compounds, which led to the screening of 610 compound-related targets. Among them, 59 overlapped with CA targets and were considered to be targets with potential therapeutic effects. The protein-protein interaction network analysis revealed that protein kinase B (Akt) serine/threonine kinase 1 was a potential therapeutic target. To further confirm this result, we performed ribonucleic acid sequencing (RNA-seq) assays on HPV 18 Conclusion: FFGL reduced HPV 18
MeSH term(s)	Humans ; Proto-Oncogene Proteins c-akt ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Protein Serine-Threonine Kinases ; Fluorouracil
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-03960-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fu Fang Gang Liu aqueous extract inhibits the proliferation of HeLa cells by causing deoxyribonucleic acid damage.

Fan, Zhu / Wang, Shuxin / Xu, Chenchen / Yang, Jiao / Huang, Xiahe / Xu, Honglin / Wang, Yingchun / Meng, Wenxiang / Cui, Bingnan

Journal of ethnopharmacology

2022 Volume 304, Page(s) 116083

Abstract: Ethnopharmacological relevance: Fu Fang Gang Liu (FFGL) is an effective formula for treating wart ...

Abstract	Ethnopharmacological relevance: Fu Fang Gang Liu (FFGL) is an effective formula for treating wart proliferation caused by human papillomavirus (HPV) infection and has the potential to treat HPV-related cancers. However, scientific evidence of its anti-tumor activity against cervical cancer, the most common cancer caused by HPV, is lacking. Aim of the study: To clarify the anti-tumor effect of an FFGL aqueous extract on human cervical cancer and its possible mechanism of cell cycle arrest in HeLa cells. Materials and methods: The anti-proliferative effect of FFGL on cervical cancer cells was assessed using the cell counting kit-8 assay. The proportion of apoptotic cells, cell cycle distribution, and cell division rate were determined using flow cytometry. Quantitative proteomics was used to identify differentially expressed proteins after FFGL treatment, and bioinformatics analysis was used to identify key nodal proteins affected by FFGL. Immunofluorescence and western blot analyses were used to explore changes in the expression of related proteins in the cell cycle and DNA damage pathways to elucidate the potential mechanism of action of FFGL against HeLa cell proliferation. Results: FFGL inhibited cervical cancer cell proliferation and caused cell cycle arrest. According to quantitative proteomics, CyclinB1 may play an important role in the anti-proliferative effect of FFGL on HeLa cells. Additional experiments showed that FFGL aqueous extract caused ATM-mediated DNA damage, further phosphorylated CHK2, led to the inactivation of Cdc25C, inhibited the activity of the CDK1/CyclinB1 complex, and resulted in cell cycle arrest. Conclusions: FFGL can inhibit cervical cancer cell proliferation. Furthermore, it can increase CDK1 phosphorylation, block the cell cycle by causing DNA damage, and inhibit HeLa cell proliferation.
MeSH term(s)	Female ; Humans ; HeLa Cells ; Uterine Cervical Neoplasms/pathology ; Papillomavirus Infections ; Cell Proliferation ; DNA ; Apoptosis
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-12-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.116083
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Zs.A 1494: Show issues

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Article ; Online: Triterpene saponins from Guo-gang-long attenuate collagen-induced arthritis via regulating A20 and inhibiting MAPK pathway.

Xiong, Hui / Luo, Miao / Ju, Yankun / Zhao, Zhongqiu / Zhang, Man / Xu, Ran / Ren, Yongshen / Yang, Guangzhong / Mei, Zhinan

Journal of ethnopharmacology

2021 Volume 269, Page(s) 113707

Abstract: ... gang-long", is a traditional Chinese folk medicine that has been used clinically in China ... for the treatment of arthritis. Our previous study described that triterpene saponins isolated from "Guo-gang-long ... could inhibit the inflammatory response. However, the potential mechanism of "Guo-gang-long" on treatment ...

Abstract	Ethnopharmacological relevance: The stems of Entada phaseoloides (L.) Merr commonly named "Guo-gang-long", is a traditional Chinese folk medicine that has been used clinically in China for the treatment of arthritis. Our previous study described that triterpene saponins isolated from "Guo-gang-long" could inhibit the inflammatory response. However, the potential mechanism of "Guo-gang-long" on treatment of arthritis, and whether the triterpene saponins responsible for its anti-arthritic effect are unclear. Aim: To investigate the function and mechanisms of the triterpene saponins from E. phaseoloides (ES) in collagen-induced arthritis (CIA) rats. Materials and methods: The chemical components of ES were analyzed by HPLC. Anti-arthritic activity of ES was investigated in CIA rats, which was established by immunization with bovine type II collagen. Three doses of ES (25, 50 and 100 mg/kg) were administrated using oral gavage to CIA rats daily for 3 weeks. The anti-arthritic activity of ES was evaluated by clinical arthritis scoring, paw swelling and mechanical sensitivity, as well as histological changes in CIA rats. The impacts of ES on the regulation of the ubiquintin-editing enzyme A20 and MAPK signaling pathway, and production of pro-inflammatory cytokines in CIA rats were examined by Western blot, quantitative real-time PCR, ELISA, and immunohistochemical staining, respectively. Results: ES treatment relieved the paw swelling, hyperalgesia and joint destruction, and prevented the progression of arthritis in CIA rats. Meanwhile, ES suppressed the excessive mRNA levels and protein expression of TNF-α and IL-17 in synovial tissues and hind paw joints, and reduced the production of IL-1β, TNF-α and IL-17 in serum. Furthermore, ES up-regulated A20 and suppressed the phosphorylation of p38 and ERK1/2 in hind paw joints, as well as inhibiting the activation of spinal p38 in CIA rats. Conclusion: ES could relieve rheumatic symptoms and prevent the development of rheumatoid arthritis. The effects of ES may be mediated by reducing proinflammatory cytokine levels, up-regulating A20 expression, reducing p38 and ERK1/2 activation in periphery, and inhibiting of phospho-p38 in spinal cord.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antirheumatic Agents/isolation & purification ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/metabolism ; China ; Cytokines/drug effects ; Cytokines/genetics ; Cytokines/metabolism ; Edema/drug therapy ; Fabaceae/chemistry ; Hindlimb/drug effects ; Hindlimb/pathology ; Joints/drug effects ; Joints/pathology ; MAP Kinase Signaling System/drug effects ; Male ; Medicine, Chinese Traditional/methods ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats, Wistar ; Saponins/chemistry ; Saponins/isolation & purification ; Saponins/pharmacology ; Saponins/therapeutic use ; Spinal Cord/metabolism ; Spleen/drug effects ; Spleen/metabolism ; Synovial Membrane/drug effects ; Synovial Membrane/metabolism ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Triterpenes/pharmacology ; Triterpenes/therapeutic use ; Tumor Necrosis Factor alpha-Induced Protein 3/drug effects ; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism ; Rats
Chemical Substances	Anti-Inflammatory Agents ; Antirheumatic Agents ; Cytokines ; Plant Extracts ; Saponins ; Triterpenes ; TNFAIP3 protein, rat (EC 3.4.19.12) ; Tumor Necrosis Factor alpha-Induced Protein 3 (EC 3.4.19.12)
Language	English
Publishing date	2021-01-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113707
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Zs.A 1494: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Triterpene saponins from Guo-gang-long attenuate collagen-induced arthritis via regulating A20 and inhibiting MAPK pathway

Xiong, Hui / Luo, Miao / Ju, Yankun / Zhao, Zhongqiu / Zhang, Man / Xu, Ran / Ren, Yongshen / Yang, Guangzhong / Mei, Zhinan

Journal of ethnopharmacology. 2021 Apr. 06, v. 269

2021

Abstract: The stems of Entada phaseoloides (L.) Merr commonly named “Guo-gang-long”, is a traditional Chinese ... described that triterpene saponins isolated from “Guo-gang-long” could inhibit the inflammatory response ... However, the potential mechanism of “Guo-gang-long” on treatment of arthritis, and whether the triterpene saponins ...

Abstract	The stems of Entada phaseoloides (L.) Merr commonly named “Guo-gang-long”, is a traditional Chinese folk medicine that has been used clinically in China for the treatment of arthritis. Our previous study described that triterpene saponins isolated from “Guo-gang-long” could inhibit the inflammatory response. However, the potential mechanism of “Guo-gang-long” on treatment of arthritis, and whether the triterpene saponins responsible for its anti-arthritic effect are unclear.To investigate the function and mechanisms of the triterpene saponins from E. phaseoloides (ES) in collagen-induced arthritis (CIA) rats.The chemical components of ES were analyzed by HPLC. Anti-arthritic activity of ES was investigated in CIA rats, which was established by immunization with bovine type II collagen. Three doses of ES (25, 50 and 100 mg/kg) were administrated using oral gavage to CIA rats daily for 3 weeks. The anti-arthritic activity of ES was evaluated by clinical arthritis scoring, paw swelling and mechanical sensitivity, as well as histological changes in CIA rats. The impacts of ES on the regulation of the ubiquintin-editing enzyme A20 and MAPK signaling pathway, and production of pro-inflammatory cytokines in CIA rats were examined by Western blot, quantitative real-time PCR, ELISA, and immunohistochemical staining, respectively.ES treatment relieved the paw swelling, hyperalgesia and joint destruction, and prevented the progression of arthritis in CIA rats. Meanwhile, ES suppressed the excessive mRNA levels and protein expression of TNF-α and IL-17 in synovial tissues and hind paw joints, and reduced the production of IL-1β, TNF-α and IL-17 in serum. Furthermore, ES up-regulated A20 and suppressed the phosphorylation of p38 and ERK1/2 in hind paw joints, as well as inhibiting the activation of spinal p38 in CIA rats.ES could relieve rheumatic symptoms and prevent the development of rheumatoid arthritis. The effects of ES may be mediated by reducing proinflammatory cytokine levels, up-regulating A20 expression, reducing p38 and ERK1/2 activation in periphery, and inhibiting of phospho-p38 in spinal cord.
Keywords	Entada phaseoloides ; Western blotting ; blood serum ; cattle ; collagen ; immunization ; immunohistochemistry ; inflammation ; interleukin-17 ; phosphorylation ; protein synthesis ; quantitative polymerase chain reaction ; rheumatoid arthritis ; somatosensory disorders ; spinal cord ; traditional medicine ; triterpenoid saponins ; China
Language	English
Dates of publication	2021-0406
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113707
Database	NAL-Catalogue (AGRICOLA)

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Article: Overfeeding influence on antioxidant capacity of serum, liver, gut, and breast muscle in Gang Goose and Tianfu Meat Goose

Wei, R.X / Song, Q / Hu, S.Q / Xu, H.Y / Liu, H.H / Kang, B / Li, L / Zeng, X.Y / Chen, L / Han, C.C

Journal of applied poultry research. 2020 June, v. 29, no. 2

2020

Abstract: ... liver, gut, and breast muscle in Gang Goose and Tianfu Meat Goose. Fifty-five Gang Geese and 55 Tianfu ... higher than those of Gang Goose (P < 0.05). Overfeeding had no significant effect on the meat quality ...

Abstract	This study was conducted to research the effect of overfeeding on antioxidant capacity of serum, liver, gut, and breast muscle in Gang Goose and Tianfu Meat Goose. Fifty-five Gang Geese and 55 Tianfu Meat Geese were separated respectively into a control group and an overfed group randomly (15 birds in control group, 40 birds in overfed group); all birds were slaughtered after overfeeding for 3 wk. After overfeeding, the concentration of triglyceride, insulin, and glucose increased in serum (P < 0.05), the liver weight and fat content in liver increased, and the moisture content in liver decreased (P < 0.05) in both breeds. The liver weight, ratio of liver to body, and fat content in liver of Tianfu Meat Goose were higher than those of Gang Goose (P < 0.05). Overfeeding had no significant effect on the meat quality of breast muscle (P > 0.05). The activities of total glutathione peroxidase (TGP), superoxide dismutase, and catalase (CAT) in serum of the control group were higher than those in the overfed group (P < 0.05); the activities of total glutathione peroxidase, CAT, and the total antioxidant capacity in liver of the control group were higher than those in the overfed group (P < 0.05); there was no significant difference between the overfed group and the control group in the malonyldialdehyde (MAD) content of liver and serum (P > 0.05). The malonyldialdehyde content of intestine in the overfed group was higher than that in the control group (P < 0.05). In conclusion, the oxidative stress occurred in the serum, liver, and intestine after overfeeding.
Keywords	antioxidant activity ; blood serum ; breast muscle ; breeds ; catalase ; geese ; glucose ; glutathione peroxidase ; insulin ; intestines ; lipid content ; liver ; meat quality ; overfeeding ; oxidative stress ; poultry meat ; superoxide dismutase ; triacylglycerols ; water content
Language	English
Dates of publication	2020-06
Size	p. 455-464.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1193887-0
ISSN	1537-0437 ; 1056-6171
ISSN (online)	1537-0437
ISSN	1056-6171
DOI	10.1016/j.japr.2020.02.003
Database	NAL-Catalogue (AGRICOLA)

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Z 5902: Show issues

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Book: Xin yi jin gang jing

Xu, Xingwu / Hou, Naihui

(Gu ji jin zhu xin yi cong shu ; 古籍今注新譯叢書)

1997

Title variant	Jin gang jing ; 金剛經
Author's details	Xu xing wu zhu yi; hou nai hui jiao yue
Series title	Gu ji jin zhu xin yi cong shu 古籍今注新譯叢書
Language	Chinese
Size	2, 2, 186 p, 22 cm
Edition	Chu ban
Publisher	San min shu ju
Publishing place	Tai bei
Document type	Book
ISBN	9571425281 ; 9789571425283
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online ; Conference proceedings: Proceedings of the 2022 International Conference on Artificial Intelligence, Internet and Digital Economy (ICAID 2022)

Radojević, Nebojša / Xu, Gang / Md Mansur, Datuk Dr Hj Kasim Hj

(Atlantis Highlights in Intelligent Systems ; 7)

2023

Author's details	edited by Nebojša Radojević, Gang Xu, Datuk Dr Hj Kasim Hj Md Mansur
Series title	Atlantis Highlights in Intelligent Systems ; 7
Keywords	Business ; Management science ; Business information services ; Entrepreneurship ; New business enterprises ; Artificial intelligence ; Business—Data processing
Subject code	650
Language	English
Size	1 Online-Ressource (XX, 1238 p. 373 illus., 265 illus. in color)
Edition	1st ed. 2023
Publisher	Atlantis Press International BV ; Imprint: Atlantis Press
Publishing place	Dordrecht
Document type	Book ; Online ; Conference proceedings
HBZ-ID	HT021682051
ISBN	978-94-6463-010-7 ; 9789464630091 ; 94-6463-010-8 ; 9464630094
DOI	10.2991/978-94-6463-010-7
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Ming yi Li Shizhen yu "Ben cao gang mu"

Zhu, Baohua / Xu, Lihua

1998

Title translation	Famous physician Li Shizhen and his "Ben cao gang mu".
Author's details	zhu bian Zhu Baohua, Xu Lihua
MeSH term(s)	Materia Medica ; Medicine, Chinese Traditional
Language	Chinese
Size	4, 408 p. ;, 19 cm.
Edition	Di 1 ban.
Publisher	Zhongguo Zhong yi yao chu ban she ; jing xiao zhe Xin hua shu dian zong dian Beijing fa xing suo
Publishing place	Beijing
Document type	Book
ISBN	9787800896149 ; 7800896145
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Letter to the Editor:

Wen, Jing / Tang, Xu-Gang

High altitude medicine & biology

2024

Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Letter
ZDB-ID	2076262-8
ISSN	1557-8682 ; 1527-0297
ISSN (online)	1557-8682
ISSN	1527-0297
DOI	10.1089/ham.2024.0032
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Zs.A 5674: Show issues

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Article ; Online: A new strategy for the treatment of refractory ascites in patients with hepatitis B-related liver cirrhosis.

Xu, Wenjing / Wang, Gang

Asian journal of surgery

2024

Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.03.134
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Zs.B 2831: Show issues

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