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Article ; Online: Population-based comparative epidemiological survey of hepatitis B, D, and C among Inuit migrated to Denmark and in high endemic Greenland.

Rex, Karsten Fleischer / Krarup, Henrik B / Laurberg, Peter / Andersen, Stig

Scandinavian journal of gastroenterology

2012 Volume 47, Issue 6, Page(s) 692–701

Abstract: ... 0). Liver biochemistry was elevated in Greenlanders exposed to HDV.: Conclusions: Hepatitis B, D ... Objective: Infection with hepatitis B virus (HBV) is endemic among Arctic populations ... as it is for hepatitis D and C, and details on the influence of delta virus at a population level are ...

Abstract	Objective: Infection with hepatitis B virus (HBV) is endemic among Arctic populations where it may have a benign course. However, the relation of HBV to migration to low endemic areas is unknown, as it is for hepatitis D and C, and details on the influence of delta virus at a population level are lacking. Material and methods: Population-based investigation of Greenlanders living in Denmark (n = 136) and in Greenland (n = 441). We tested for HBsAg, anti-HBs, anti-HBc, HBeAg, anti-HBe, HBV-DNA, HBV genotypes, anti-HDV, HDV-RNA, anti-HCV, HCV-Elisa test, HCV-RNA, aspartate aminotransferase, gamma-glutamyl transferase, bilirubin, and albumin, and performed a physical examination. Results: Participation rate was 52/95% in Denmark/Greenland. Half of participants in Denmark had lived more than half of their lives in Denmark, and 54.5% had been exposed to HBV. This was similar to 53% among Greenlanders living in West Greenland (p = 0.76). HBsAg was positive in 4.4% of Greenlanders in Denmark (n = 6), who all were anti-HBe positive and had low viral load. Serological signs of HBV infection associated with having both parents born in Greenland (p = 0.007) and with IV drug use (p = 0.03). We found serological signs of HDV exposure among participants in Denmark/Greenland in 0.7/1.1% (n = 1/5) and HCV exposure in 1.5/0.0% (n = 2/0). Liver biochemistry was elevated in Greenlanders exposed to HDV. Conclusions: Hepatitis B, D, and C occurrences among Greenlanders in Denmark mirrored that of Greenland. Importantly, previously undetected exposure to delta virus associated with elevated liver biochemistry, and the introduction of delta virus is a liability to Greenlanders and to Greenland.
MeSH term(s)	Adult ; Aged ; DNA, Viral/analysis ; Denmark/epidemiology ; Emigrants and Immigrants ; Endemic Diseases ; Female ; Greenland/epidemiology ; Greenland/ethnology ; Hepacivirus/genetics ; Hepacivirus/immunology ; Hepacivirus/isolation & purification ; Hepatitis Antibodies/blood ; Hepatitis Antigens/blood ; Hepatitis B/blood ; Hepatitis B/ethnology ; Hepatitis B/virology ; Hepatitis B virus/genetics ; Hepatitis B virus/immunology ; Hepatitis B virus/isolation & purification ; Hepatitis C/blood ; Hepatitis C/ethnology ; Hepatitis C/virology ; Hepatitis D/blood ; Hepatitis D/ethnology ; Hepatitis D/virology ; Hepatitis Delta Virus/genetics ; Hepatitis Delta Virus/immunology ; Hepatitis Delta Virus/isolation & purification ; Humans ; Inuits ; Male ; Middle Aged ; Reverse Transcriptase Polymerase Chain Reaction ; Seroepidemiologic Studies ; Viral Load
Chemical Substances	DNA, Viral ; Hepatitis Antibodies ; Hepatitis Antigens
Language	English
Publishing date	2012-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.3109/00365521.2011.634026
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Article ; Online: Physical activity compensates for isoflurane-induced selective impairment of neuronal progenitor cell proliferation in the young adult hippocampus.

Böckmann, Saskia / Iggena, Deetje / Schreyer, Stefanie / Rex, André / Steiner, Barbara

Behavioural brain research

2023 Volume 455, Page(s) 114675

Abstract: General anesthesia is considered a risk factor for postoperative cognitive dysfunction. However, it is unclear what the neuronal and cognitive consequences of general anesthesia are and whether they can be treated. One possible pathomechanism is ... ...

Abstract	General anesthesia is considered a risk factor for postoperative cognitive dysfunction. However, it is unclear what the neuronal and cognitive consequences of general anesthesia are and whether they can be treated. One possible pathomechanism is hippocampal neurogenesis. We investigated how the anesthetic isoflurane affects adult hippocampal neurogenesis and associated cognitive functions and whether the neurogenic stimulus of physical activity reverses isoflurane-induced changes. We exposed young adult mice to isoflurane (ISO) - half had access to a running wheel (ISO-RW). Both groups were compared with a control condition (CTR; CTR-RW). Cell proliferation and survival in the dentate gyrus of the hippocampus were quantified histologically 48 h and 3 weeks after anesthesia by bromodeoxyuridine incorporation. Cell phenotype was determined by expression of neuronal markers, and the extent of continuous endogenous neuronal proliferation was estimated from the number of doublecortin-positive cells. The Morris water maze was used to test hippocampus-dependent functions. We found that isoflurane decreased proliferation of neuronal progenitor cells, whereas survival of mature neurons remained intact. Consistent with intact neuronal survival, spatial memory associated with neurogenesis also proved intact in the Morris water maze despite isoflurane exposure. Physical activity attenuated the observed neuronal changes by preventing the decrease in newborn neuronal progenitor cells and the decline in continuous endogenous neuronal proliferation in isoflurane-treated animals. In conclusion, isoflurane selectively impairs neuronal proliferation but not survival or neurogenesis-linked cognition in adult mice. The observed adverse effects can be attenuated by physical activity, a cost-effective means of preventing the neurogenic consequences of general anesthesia.
Language	English
Publishing date	2023-09-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2023.114675
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Article ; Online: Poxvirus A51R proteins regulate microtubule stability and antagonize a cell-intrinsic antiviral response.

Seo, Dahee / Brito Oliveira, Sabrynna / Rex, Emily A / Ye, Xuecheng / Rice, Luke M / da Fonseca, Flávio Guimarães / Gammon, Don B

Cell reports

2024 Volume 43, Issue 3, Page(s) 113882

Abstract: Numerous viruses alter host microtubule (MT) networks during infection, but how and why they induce these changes is unclear in many cases. We show that the vaccinia virus (VV)-encoded A51R protein is a MT-associated protein (MAP) that directly binds MTs ...

Abstract	Numerous viruses alter host microtubule (MT) networks during infection, but how and why they induce these changes is unclear in many cases. We show that the vaccinia virus (VV)-encoded A51R protein is a MT-associated protein (MAP) that directly binds MTs and stabilizes them by both promoting their growth and preventing their depolymerization. Furthermore, we demonstrate that A51R-MT interactions are conserved across A51R proteins from multiple poxvirus genera, and highly conserved, positively charged residues in A51R proteins mediate these interactions. Strikingly, we find that viruses encoding MT interaction-deficient A51R proteins fail to suppress a reactive oxygen species (ROS)-dependent antiviral response in macrophages that leads to a block in virion morphogenesis. Moreover, A51R-MT interactions are required for VV virulence in mice. Collectively, our data show that poxviral MAP-MT interactions overcome a cell-intrinsic antiviral ROS response in macrophages that would otherwise block virus morphogenesis and replication in animals.
MeSH term(s)	Animals ; Mice ; Reactive Oxygen Species/metabolism ; Virus Replication ; Poxviridae/genetics ; Vaccinia virus/physiology ; Viral Proteins/metabolism ; Microtubules/metabolism ; Antiviral Agents/metabolism
Chemical Substances	Reactive Oxygen Species ; Viral Proteins ; Antiviral Agents
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113882
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Article: Subgenome contributions to quantitative genetic variation in bread wheat and durum wheat populations

Bernardo, Rex

Crop science. 2021 Mar., v. 61, no. 2

2021

Abstract: Bread wheat (Triticum aestivum L.) has the A, B, and D genomes, whereas durum wheat ... Triticum turgidum L. ssp. durum) has the A and B genomes. This study aimed to assess the usefulness of the square ... indicated that the B genome had the largest contribution to variation for milling and baking quality traits ...

Abstract	Bread wheat (Triticum aestivum L.) has the A, B, and D genomes, whereas durum wheat (Triticum turgidum L. ssp. durum) has the A and B genomes. This study aimed to assess the usefulness of the square of predictive ability for subgenome i [rMP₍ᵢ₎²] for estimating subgenome contributions to trait variation and to determine which subgenomes in bread wheat and durum wheat populations had the largest and smallest contributions for different traits. Phenotypic and marker data were obtained for four populations used in published studies to map quantitative trait loci (QTL). Subgenome rMP₍ᵢ₎ was calculated by analyzing only the markers within each subgenome. Clear differences were found in subgenome contributions for several but not all traits in the populations studied. In the Louise × Penawawa bread wheat population, the rMP₍ᵢ₎² values indicated that the B genome had the largest contribution to variation for milling and baking quality traits, and these results were consistent with prior results showing QTL for such traits on chromosome 3B. For yield, no significant differences in subgenome contributions were found in any of the populations. The D genome, despite its lower polymorphism, had the largest rMP₍ᵢ₎² for heading date in the ‘Seri’ × ‘Babax’ bread wheat population. In a bread wheat association mapping panel, the rMP₍ᵢ₎² values were problematic in that their sum exceeded 1.0 and the subgenome rMP₍ᵢ₎ values were not significantly different from the whole‐genome rMP. This result was probably caused by linkage disequilibrium between markers found in different subgenomes in the association mapping panel.
Keywords	Triticum aestivum ; Triticum turgidum ; chromosomes ; durum wheat ; genetic variation ; genome ; linkage disequilibrium ; phenotype ; quantitative traits
Language	English
Dates of publication	2021-03
Size	p. 1002-1012.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	410209-5
ISSN	0011-183X
ISSN	0011-183X
DOI	10.1002/csc2.20372
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Article ; Online: CT Perfusion Does Not Modify the Effect of Reperfusion in Patients with Acute Ischemic Stroke Undergoing Endovascular Treatment in the ESCAPE-NA1 Trial.

Rex, N B / McDonough, R V / Ospel, J M / Kashani, N / Sehgal, A / Fladt, J C / McTaggart, R A / Nogueira, R / Menon, B / Demchuk, A M / Tymianski, M / Hill, M D / Goyal, M

AJNR. American journal of neuroradiology

2023 Volume 44, Issue 9, Page(s) 1045–1049

Abstract: Background and purpose: Although reperfusion is associated with improved outcomes in patients with acute ischemic stroke undergoing endovascular treatment, many patients still do poorly. We investigated whether CTP modifies the effect of near-complete ... ...

Abstract	Background and purpose: Although reperfusion is associated with improved outcomes in patients with acute ischemic stroke undergoing endovascular treatment, many patients still do poorly. We investigated whether CTP modifies the effect of near-complete reperfusion on clinical outcomes, ie, whether poor clinical outcomes despite near-complete reperfusion can be partly or fully explained by CTP findings. Materials and methods: Data are from the Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1) trial. Admission CTP was processed using RAPID software, generating relative CBF and CBV volume maps at standard thresholds. CTP lesion volumes were compared in patients with-versus-without near-complete reperfusion. Associations between each CTP metric and clinical outcome (90-day mRS) were tested using multivariable logistic regression, adjusted for baseline imaging and clinical variables. Treatment-effect modification was assessed by introducing CTP lesion volume × reperfusion interaction terms in the models. Results: CTP lesion volumes and reperfusion status were available in 410/1105 patients. CTP lesion volumes were overall larger in patients without near-complete reperfusion, albeit not always statistically significant. Increased CBF <34%, CBV <34%, CBV <38%, and CBV <42% lesion volumes were associated with worse clinical outcome (ordinal mRS) at 90 days. CTP core lesion volumes did not modify the treatment effect of near-complete recanalization on clinical outcome. Conclusions: CTP did not modify the effect of near-complete reperfusion on clinical outcomes. Thus, CTP cannot explain why some patients with near-complete reperfusion have poor clinical outcomes.
MeSH term(s)	Humans ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/drug therapy ; Ischemic Stroke/surgery ; Stroke/diagnostic imaging ; Stroke/drug therapy ; Stroke/surgery ; Hospitalization ; Reperfusion ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A7954
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Article ; Online: Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial.

Fechner, J / El-Boghdadly, K / Spahn, D R / Motsch, J / Struys, M M R F / Duranteau, O / Ganter, M T / Richter, T / Hollmann, M W / Rossaint, R / Bercker, S / Rex, S / Drexler, B / Schippers, F / Morley, A / Ihmsen, H / Kochs, E

Anaesthesia

2024 Volume 79, Issue 4, Page(s) 410–422

Abstract: Remimazolam, a short-acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management of patients with multiple comorbidities remains unclear. In this phase 3 randomised controlled trial, ... ...

Abstract	Remimazolam, a short-acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management of patients with multiple comorbidities remains unclear. In this phase 3 randomised controlled trial, we compared the anaesthetic efficacy and the incidence of postinduction hypotension during total intravenous anaesthesia with remimazolam vs. propofol. A total of 365 patients (ASA physical status 3 or 4) scheduled for elective surgery were assigned randomly to receive total intravenous anaesthesia with remimazolam (n = 270) or propofol (n = 95). Primary outcome was anaesthetic effect, quantified as the percentage of time with Narcotrend® Index values ≤ 60, during surgery (skin incision to last skin suture), with a non-inferiority margin of -10%. Secondary outcome was the incidence of postinduction hypotensive events. Mean (SD) percentage of time with Narcotrend Index values ≤ 60 during surgery across all patients receiving remimazolam (93% (20.7)) was non-inferior to propofol (99% (4.2)), mean difference (97.5%CI) -6.28% (-8.89-infinite); p = 0.003. Mean (SD) number of postinduction hypotension events was 62 (38.1) and 71 (41.1) for patients allocated to the remimazolam and propofol groups, respectively; p = 0.015. Noradrenaline administration events (requirement for a bolus and/or infusion) were also lower in patients allocated to remimazolam compared with propofol (14 (13.5) vs. 20 (14.6), respectively; p < 0.001). In conclusion, in patients who were ASA physical status 3 or 4, the anaesthetic effect of remimazolam was non-inferior to propofol.
MeSH term(s)	Humans ; Propofol ; Anesthetics ; Benzodiazepines ; Hypotension/chemically induced
Chemical Substances	Propofol (YI7VU623SF) ; remimazolam (7V4A8U16MB) ; Anesthetics ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2024-01-14
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1111/anae.16205
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Article: A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions.

Dagamajalu, Shobha / Rex, D A B / Suchitha, G P / Rai, Akhila B / Kumar, Shreya / Joshi, Shreya / Raju, Rajesh / Prasad, T S Keshava

Journal of cell communication and signaling

2022 Volume 17, Issue 3, Page(s) 1081–1088

Abstract: Discoidin domain receptor 1 (DDR1) is one of the receptors that belong to a family of non-integrin collagen receptors. In common, DDR1 is predominantly found in epithelial and smooth muscle cells and its mainly involved in organogenesis during embryonic ... ...

Abstract	Discoidin domain receptor 1 (DDR1) is one of the receptors that belong to a family of non-integrin collagen receptors. In common, DDR1 is predominantly found in epithelial and smooth muscle cells and its mainly involved in organogenesis during embryonic development. However, it's also overexpressed in several pathological conditions, including cancer and inflammation. The DDR1 is reported in numerous cancers, including breast, prostate, pancreatic, bladder, lung, liver, pituitary, colorectal, skin, gastric, glioblastoma, and inflammation. DDR1 activates through the collagen I, IV, IGF-1/IGF1R, and IGF2/IR, regulating downstream signaling molecules such as MAPKs, PI3K/Akt, and NF-kB in diseases. Despite its biomedical importance, there is a lack of consolidated network map of the DDR1 signaling pathway, which prompted us for curation of literature data pertaining to the DDR1 system following the NetPath criteria. We present here the compiled pathway map comprises 39 activation/inhibition events, 17 catalysis events, 22 molecular associations, 65 gene regulation events, 35 types of protein expression, and two protein translocation events. The detailed DDR1 signaling pathway map is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/ Pathway: https://www.wikipathways.org/index.php/Pathway:WP5288 ).
Language	English
Publishing date	2022-12-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2299380-0
ISSN	1873-961X ; 1873-9601
ISSN (online)	1873-961X
ISSN	1873-9601
DOI	10.1007/s12079-022-00714-x
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Article: A network map of apelin-mediated signaling.

Dagamajalu, Shobha / Rex, D A B / Philem, Pushparani Devi / Rainey, Jan K / Keshava Prasad, T S

Journal of cell communication and signaling

2021 Volume 16, Issue 1, Page(s) 137–143

Abstract: The apelin receptor (APLNR) is a class A (rhodopsin-like) G-protein coupled receptor with a wide distribution throughout the human body. Activation of the apelin/APLNR system regulates AMPK/PI3K/AKT/mTOR and RAF/ERK1/2 mediated signaling pathways. APLNR ... ...

Abstract	The apelin receptor (APLNR) is a class A (rhodopsin-like) G-protein coupled receptor with a wide distribution throughout the human body. Activation of the apelin/APLNR system regulates AMPK/PI3K/AKT/mTOR and RAF/ERK1/2 mediated signaling pathways. APLNR activation orchestrates several downstream signaling cascades, which play diverse roles in physiological effects, including effects upon vasoconstriction, heart muscle contractility, energy metabolism regulation, and fluid homeostasis angiogenesis. We consolidated a network map of the APLNR signaling map owing to its biomedical importance. The curation of literature data pertaining to the APLNR system was performed manually by the NetPath criteria. The described apelin receptor signaling map comprises 35 activation/inhibition events, 38 catalysis events, 4 molecular associations, 62 gene regulation events, 113 protein expression types, and 4 protein translocation events. The APLNR signaling pathway map data is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5067 ).
Language	English
Publishing date	2021-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2299380-0
ISSN	1873-961X ; 1873-9601
ISSN (online)	1873-961X
ISSN	1873-9601
DOI	10.1007/s12079-021-00614-6
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Article: The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions.

Rex, D A B / Suchitha, G P / Palollathil, Akhina / Kanichery, Anagha / Prasad, T S Keshava / Dagamajalu, Shobha

Journal of cell communication and signaling

2022 Volume 16, Issue 4, Page(s) 601–608

Abstract: Urotensin-II is a polypeptide ligand with neurohormone-like activity. It mediates downstream signaling pathways through G-protein-coupled receptor 14 (GPR14) also known as urotensin receptor (UTR). Urotensin-II is the most potent endogenous ... ...

Abstract	Urotensin-II is a polypeptide ligand with neurohormone-like activity. It mediates downstream signaling pathways through G-protein-coupled receptor 14 (GPR14) also known as urotensin receptor (UTR). Urotensin-II is the most potent endogenous vasoconstrictor in mammals, promoting cardiovascular remodelling, cardiac fibrosis, and cardiomyocyte hypertrophy. It is also involved in other physiological and pathological activities, including neurosecretory effects, insulin resistance, atherosclerosis, kidney disease, and carcinogenic effects. Moreover, it is a notable player in the process of inflammatory injury, which leads to the development of inflammatory diseases. Urotensin-II/UTR expression stimulates the accumulation of monocytes and macrophages, which promote the adhesion molecules expression, chemokines activation and release of inflammatory cytokines at inflammatory injury sites. Therefore, urotensin-II turns out to be an important therapeutic target for the treatment options and management of associated diseases. The main downstream signaling pathways mediated through this urotensin-II /UTR system are RhoA/ROCK, MAPKs and PI3K/AKT. Due to the importance of urotensin-II systems in biomedicine, we consolidated a network map of urotensin-II /UTR signaling. The described signaling map comprises 33 activation/inhibition events, 31 catalysis events, 15 molecular associations, 40 gene regulation events, 60 types of protein expression, and 11 protein translocation events. The urotensin-II signaling pathway map is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5158 ). The availability of comprehensive urotensin-II signaling in the public resource will help understand the regulation and function of this pathway in normal and pathological conditions. We believe this resource will provide a platform to the scientific community in facilitating the identification of novel therapeutic drug targets for diseases associated with urotensin-II signaling.
Language	English
Publishing date	2022-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2299380-0
ISSN	1873-961X ; 1873-9601
ISSN (online)	1873-961X
ISSN	1873-9601
DOI	10.1007/s12079-022-00672-4
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Article: SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19.

Rex, D A B / Dagamajalu, Shobha / Kandasamy, Richard K / Raju, Rajesh / Prasad, T S Keshava

Journal of cell communication and signaling

2021 Volume 15, Issue 4, Page(s) 601–608

Abstract: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been declared a pandemic by WHO. The clinical manifestation and disease progression in COVID-19 patients varies from minimal symptoms ... ...

Abstract	Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been declared a pandemic by WHO. The clinical manifestation and disease progression in COVID-19 patients varies from minimal symptoms to severe respiratory issues with multiple organ failure. Understanding the mechanism of SARS-CoV-2 interaction with host cells will provide key insights into the effective molecular targets for the development of novel therapeutics. Recent studies have identified virus-mediated phosphorylation or activation of some major signaling pathways, such as ERK1/2, JNK, p38, PI3K/AKT and NF-κB signaling, that potentially elicit the cytokine storm that serves as a major cause of tissue injuries. Several studies highlight the aggressive inflammatory response particularly 'cytokine storm' in SARS-CoV-2 patients. A depiction of host molecular dynamics triggered by SARS-CoV-2 in the form of a network of signaling molecules will be helpful for COVID-19 research. Therefore, we developed the signaling pathway map of SARS-CoV-2 infection using data mined from the recently published literature. This integrated signaling pathway map of SARS-CoV-2 consists of 326 proteins and 73 reactions. These include information pertaining to 1,629 molecular association events, 30 enzyme catalysis events, 43 activation/inhibition events, and 8,531 gene regulation events. The pathway map is publicly available through WikiPathways: https://www.wikipathways.org/index.php/Pathway:WP5115 .
Language	English
Publishing date	2021-06-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2299380-0
ISSN	1873-961X ; 1873-9601
ISSN (online)	1873-961X
ISSN	1873-9601
DOI	10.1007/s12079-021-00632-4
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