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  1. Article ; Online: Self-amplifying RNA vaccines against antigenically distinct SARS-CoV-2 variants.

    Herfst, Sander / de Vries, Rory D

    The Lancet. Infectious diseases

    2023  Volume 24, Issue 4, Page(s) 330–331

    MeSH term(s) Humans ; COVID-19/prevention & control ; SARS-CoV-2/genetics ; mRNA Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
    Chemical Substances mRNA Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00734-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5743: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: COVID-19 vaccine effectiveness and evolving variants: understanding the immunological footprint.

    Zaeck, Luca M / GeurtsvanKessel, Corine H / de Vries, Rory D

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 5, Page(s) 395–396

    MeSH term(s) Humans ; COVID-19 Vaccines ; Vaccine Efficacy ; COVID-19/prevention & control
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00140-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7041: Show issues Location:
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  3. Article ; Online: mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach.

    de Vries, Rory D

    mSphere

    2020  Volume 5, Issue 2

    Abstract: Rory de Vries works in the field of viral pathogenesis and focuses on interactions between ...

    Abstract Rory de Vries works in the field of viral pathogenesis and focuses on interactions between respiratory viruses (or corresponding vaccines) and the host immune system. In this mSphere of Influence article, he reflects on how the articles "Predominant infection of CD150
    MeSH term(s) Host Microbial Interactions/immunology ; Humans ; Measles/immunology ; Measles/virology ; Measles virus/immunology ; Measles virus/pathogenicity
    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00105-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antibodies face the challenge against human respiratory syncytial virus.

    de Vries, Rory D / de Swart, Rik L

    Cell host & microbe

    2023  Volume 31, Issue 1, Page(s) 135–136

    Abstract: In the December 22 issue of Cell, Bartsch et al. describe functional profiling of the antibody response to respiratory syncytial virus in human adults vaccinated with an experimental adenovirus-based prefusion-stabilized HRSV-F vaccine and subsequently ... ...

    Abstract In the December 22 issue of Cell, Bartsch et al. describe functional profiling of the antibody response to respiratory syncytial virus in human adults vaccinated with an experimental adenovirus-based prefusion-stabilized HRSV-F vaccine and subsequently intranasally challenged with HRSV. The authors identified various antibody effector functions as humoral correlates of protection.
    MeSH term(s) Humans ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/prevention & control ; Antibodies, Viral ; Antibodies, Neutralizing ; Viral Fusion Proteins
    Chemical Substances Antibodies, Viral ; Antibodies, Neutralizing ; Viral Fusion Proteins
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2022.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity.

    de Vries, Rory D

    Signal transduction and targeted therapy

    2020  Volume 5, Issue 1, Page(s) 224

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Epitopes, T-Lymphocyte ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome ; T-Lymphocytes
    Chemical Substances Epitopes, T-Lymphocyte
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-020-00338-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The implications of mpox breakthrough infections on future vaccination strategies.

    Shamier, Marc C / Zaeck, Luca M / de Vries, Rory D / GeurtsvanKessel, Corine H

    The Lancet. Infectious diseases

    2023  Volume 24, Issue 1, Page(s) 6–8

    MeSH term(s) Humans ; Breakthrough Infections ; Mpox (monkeypox) ; Vaccination
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00518-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: ADCC: An underappreciated correlate of cross-protection against influenza?

    de Vries, Rory D / Hoschler, Katja / Rimmelzwaan, Guus F

    Frontiers in immunology

    2023  Volume 14, Page(s) 1130725

    Abstract: In this short review, we summarized the results obtained with an assay to detect influenza virus-specific antibodies that mediate ADCC, which was developed and evaluated within the framework of the IMI-funded project "FLUCOP". HA-specific ADCC mediating ... ...

    Abstract In this short review, we summarized the results obtained with an assay to detect influenza virus-specific antibodies that mediate ADCC, which was developed and evaluated within the framework of the IMI-funded project "FLUCOP". HA-specific ADCC mediating antibodies were detected in serum samples from children and adults pre- and post-vaccination with monovalent, trivalent, or quadrivalent seasonal influenza vaccines, or following infection with H1N1pdm09 virus. Additionally, using chimeric influenza HA proteins, the presence of HA-stalk-specific ADCC mediating antibodies after vaccination and natural infection with H1N1pdm09 virus was demonstrated. With serum samples obtained from children that experienced a primary infection with an influenza B virus, we showed that primary infection induces HA-specific ADCC-mediating antibodies that cross-reacted with HA from influenza B viruses from the heterologous lineage. These cross-reactive antibodies were found to be directed to the HA stalk region. Antibodies directed to the influenza B virus HA head mediated low levels of ADCC. Finally, vaccination with a recombinant modified vaccinia virus Ankara expressing the HA gene of a clade 1 A(H5N1) highly pathogenic avian influenza virus led to the induction of ADCC-mediating antibodies, which cross-reacted with H5 viruses of antigenically distinct clades. Taken together, it is clear that virus-specific antibodies induced by infection or vaccination have immunological functionalities in addition to neutralization. These functionalities could contribute to protective immunity. The functional profiling of vaccine-induced antibodies may provide further insight into the effector functions of virus-specific antibodies and their contribution to virus-specific immunity.
    MeSH term(s) Adult ; Child ; Animals ; Humans ; Influenza, Human ; Influenza Vaccines ; Influenza A Virus, H5N1 Subtype ; Hemagglutinin Glycoproteins, Influenza Virus ; Antibodies, Viral ; Vaccinia virus ; Influenza B virus ; Recombinant Proteins ; Vaccines, Combined ; Antibody-Dependent Cell Cytotoxicity
    Chemical Substances Influenza Vaccines ; Hemagglutinin Glycoproteins, Influenza Virus ; Antibodies, Viral ; Recombinant Proteins ; Vaccines, Combined
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1130725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluating novel COVID-19 vaccines in the current chapter of the pandemic.

    GeurtsvanKessel, Corine H / de Vries, Rory D

    The Lancet. Infectious diseases

    2022  Volume 22, Issue 12, Page(s) 1652–1654

    MeSH term(s) Humans ; Pandemics/prevention & control ; COVID-19 Vaccines ; COVID-19/prevention & control ; Influenza Vaccines ; Influenza, Human/prevention & control ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines ; Vaccines
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00517-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Antibodies face the challenge against human respiratory syncytial virus

    de Vries, Rory D. / de Swart, Rik L.

    Cell Host and Microbe

    2023  Volume 31, Issue 1

    Abstract: In the December 22 issue of Cell, Bartsch et al. describe functional profiling of the antibody response to respiratory syncytial virus in human adults vaccinated with an experimental adenovirus-based prefusion-stabilized HRSV-F vaccine and subsequently ... ...

    Abstract In the December 22 issue of Cell, Bartsch et al. describe functional profiling of the antibody response to respiratory syncytial virus in human adults vaccinated with an experimental adenovirus-based prefusion-stabilized HRSV-F vaccine and subsequently intranasally challenged with HRSV. The authors identified various antibody effector functions as humoral correlates of protection.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2278004-X
    ISSN 1931-3128
    ISSN 1931-3128
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 6578: Show issues Location:
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  10. Article: The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic.

    Petrone, Linda / Sette, Alessandro / de Vries, Rory D / Goletti, Delia

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: Neutralizing antibodies are considered a correlate of protection against SARS-CoV-2 infection and severe COVID-19, although they are not the only contributing factor to immunity: T-cell responses are considered important in protecting against severe ... ...

    Abstract Neutralizing antibodies are considered a correlate of protection against SARS-CoV-2 infection and severe COVID-19, although they are not the only contributing factor to immunity: T-cell responses are considered important in protecting against severe COVID-19 and contributing to the success of vaccination effort. T-cell responses after vaccination largely mirror those of natural infection in magnitude and functional capacity, but not in breadth, as T-cells induced by vaccination exclusively target the surface spike glycoprotein. T-cell responses offer a long-lived line of defense and, unlike humoral responses, largely retain reactivity against the SARS-CoV-2 variants. Given the increasingly recognized role of T-cell responses in protection against severe COVID-19, the circulation of SARS-CoV-2 variants, and the potential implementation of novel vaccines, it becomes imperative to continuously monitor T-cell responses. In addition to "classical" T-cell assays requiring the isolation of peripheral blood mononuclear cells, simple whole-blood-based interferon-γ release assays have a potential role in routine T-cell response monitoring. These assays could be particularly useful for immunocompromised people and other clinically vulnerable populations, where interactions between cellular and humoral immunity are complex. As we continue to live alongside COVID-19, the importance of considering immunity as a whole, incorporating both humoral and cellular responses, is crucial.
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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