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  1. Book ; Thesis: BK-Virus spezifische Immunität bei immunsupprimierten Patienten

    Batgi-Laggies, Felix / Korth, Johannes

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Flix Batgi-Laggies geb. Laggies ; 1. Gutachter: Herr Priv.-Doz. Dr. med. J. Korth, 2. Gutachter: Herr Univ.-Prof. Dr. med. M. Koldehoff
    Language German
    Size 70 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2023
    HBZ-ID HT030066448
    Database Catalogue ZB MED Medicine, Health

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    2023 E 1274 order for loan Magazin

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  2. Article ; Online: COVID-19 vaccination in patients receiving dialysis.

    Wilde, Benjamin / Korth, Johannes / Jahn, Michael / Kribben, Andreas

    Nature reviews. Nephrology

    2021  Volume 17, Issue 12, Page(s) 788–789

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Humans ; Renal Dialysis ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00499-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  3. Book ; Thesis: Regulation of Dickkopf-1 in hypoxic endothelial activation

    Korth, Julia

    = (Regulation von Dickkopf-1 in hypoxischer endothelialer Aktivation)

    2008  

    Title variant (Regulation von Dickkopf-1 in hypoxischer endothelialer Aktivation)
    Author's details vorgelegt von Julia Korth
    Language English
    Size 101 Bl., Ill., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 2008
    HBZ-ID HT016140611
    Database Catalogue ZB MED Medicine, Health

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    2009 D 1141 order for loan Magazin

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  4. Article: Comparison of infection and complication rates associated with transvenous vs. subcutaneous defibrillators in patients with stage 4 chronic kidney disease: a multicenter long-term retrospective follow-up.

    Schiedat, Fabian / Meuterodt, Benjamin / Prull, Magnus / Aweimer, Assem / Gotzmann, Michael / O'Connor, Stephen / Perings, Christian / Korth, Johannes / Lawo, Thomas / El-Battrawy, Ibrahim / Hanefeld, Christoph / Mügge, Andreas / Kloppe, Axel

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1397138

    Abstract: Background: Patients with progressive chronic kidney disease (CKD) are at higher risk of infections and complications from cardiac implantable electronic devices (CIED). In patients with a primary or secondary prophylactic indication, implantable ... ...

    Abstract Background: Patients with progressive chronic kidney disease (CKD) are at higher risk of infections and complications from cardiac implantable electronic devices (CIED). In patients with a primary or secondary prophylactic indication, implantable cardiac defibrillators (ICD) can prevent sudden cardiac deaths (SCD). We retrospectively compared transvenous-ICD (TV-ICD) and intermuscularly implanted subcutaneous-ICD (S-ICD) associated infections and complication rates together with hospitalizations in recipients with stage 4 kidney disease.
    Methods: We retrospectively analyzed 70 patients from six German centers with stage 4 CKD who received either a prophylactic TV-ICD with a single right ventricular lead, 49 patients, or a S-ICD, 21 patients. Follow-Ups (FU) were performed bi-annually.
    Results: The TV-ICD patients were significantly older. This group had more patients with a history of atrial arrhythmias and more were prescribed anti-arrhythmic medication compared with the S-ICD group. There were no significant differences for other baseline characteristics. The median and interquartile range of FU durations were 55.2 (57.6-69.3) months. During FU, patients with a TV-ICD system experienced significantly more device associated infections (
    Conclusion: In this long-term FU of patients with stage 4 CKD and an indication for a prophylactic ICD, the S-ICD was associated with significantly fewer device associated infections, complications and hospitalizations compared with TV-ICDs.
    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1397138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Anti-SARS-CoV-2 T-cell Responses After mRNA Vaccination in Belatacept-treated Renal Transplant Patients.

    Dolff, Sebastian / Korth, Johannes / Jahn, Michael / Kribben, Andreas / Witzke, Oliver / Wilde, Benjamin

    Transplantation

    2021  Volume 105, Issue 9, Page(s) e99

    MeSH term(s) Abatacept/therapeutic use ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; RNA, Messenger ; SARS-CoV-2 ; T-Lymphocytes/immunology ; Transplant Recipients ; Vaccination ; Vaccines
    Chemical Substances Immunosuppressive Agents ; RNA, Messenger ; Vaccines ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000003812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  6. Book ; Online ; Thesis: Behandlung der Polyomavirus Nephritis nach Nierentransplantation mit Cidofovir

    Korth, Johannes [Verfasser]

    2013  

    Author's details Johannes Korth
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Ulm. Medizinische Fakultät
    Publishing place Ulm
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Comparison of Mortality Prediction Scores in Intermediate-Care Patients with Liver Cirrhosis at a German University Transplant Centre: A Prospective Study.

    Jahn, Michael / Raschidi, Lea / Özçürümez, Mustafa K / Arzideh, Farhad / Korth, Johannes / Kribben, Andreas / Canbay, Ali / Katsounas, Antonios

    Digestive diseases (Basel, Switzerland)

    2022  Volume 41, Issue 1, Page(s) 96–106

    Abstract: Background and aims: Mortality prediction models help to extract and relate patient data upon admission to intensive or intermediate care units (ImCUs). Considering technical and economic healthcare developments, re-evaluations of score performances are ...

    Abstract Background and aims: Mortality prediction models help to extract and relate patient data upon admission to intensive or intermediate care units (ImCUs). Considering technical and economic healthcare developments, re-evaluations of score performances are required to warrant their validity. This study validates and compares established scoring systems in cirrhotic ImCU patients.
    Methods: Acute Physiology and Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score (SAPS) 2 and 3, Sepsis Organ Failure Assessment (SOFA), Mortality Probability Model at ICU admission (MPMo) II and III, Model for End stage Liver Disease (MELD), CLIF-Consortium Acute-on-Chronic Liver Failure (CLIF-C ACLF), CLIF-Consortium Acute Decompensation (CLIF-C AD), and Intermediate Care Unit Severity Score (ImCUSS) were calculated in patients with cirrhosis (n = 98) at ImCU admission. Discrimination performances were evaluated by area under the receiver operating characteristic curves (AUROCs), calibration performances with calibration belt plots, and their corresponding p values.
    Results: Overall, SAPS 3 and CLIF-C ACLF have shown the best 90-day mortality prediction outcomes with AUROCs of 0.825 and 0.783 along with calibration belt p values of 0.128 and 0.061, respectively. In a subgroup analysis of patients with acute-on-chronic liver failure (ACLF), expanded SAPS 2, SOFA, and SAPS 3 reached the best AUROCs, i.e., 0.760, 0.750, and 0.714, but none of the tested scores reached an acceptable calibration.
    Conclusion: Ninety-day mortality risk prediction of the SAPS 3 and CLIF-C ACLF was accurate in our cohort of patients with liver cirrhosis admitted to ImCUs. A particular challenge remains that is the mortality prediction in patients with ACLF requiring ImCU-level care; here, further developments are needed to generate scores with acceptable predictive performances.
    MeSH term(s) Humans ; Prospective Studies ; Severity of Illness Index ; End Stage Liver Disease ; Universities ; Liver Cirrhosis ; Acute-On-Chronic Liver Failure ; ROC Curve ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000522595
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  8. Article: Durability of Immune Response after Application of a Third Dose of SARS-CoV-2 Vaccination in Liver Transplant Recipients.

    Passenberg, Moritz / Authorsen-Grudmann, Roxane / Frey, Alexandra / Korth, Johannes / Zmudzinski, Jaqueline / Anastasiou, Olympia E / Möhlendick, Birte / Schmidt, Hartmut / Rashidi-Alavijeh, Jassin / Willuweit, Katharina

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Immunogenicity after SARS-CoV-2 vaccination is known to be impaired in liver transplant (LT) recipients, but the results after the application of a third dose show significant improvement in seroconversion rates. In the general population, the antibody ... ...

    Abstract Immunogenicity after SARS-CoV-2 vaccination is known to be impaired in liver transplant (LT) recipients, but the results after the application of a third dose show significant improvement in seroconversion rates. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more robust after the application of three doses. Still, the durability of the antibody response in LT recipients who receive a third dose of SARS-CoV-2 vaccination has not been analyzed yet. We therefore assessed antibody responses in a total of 300 LT recipients and observed antibody titers for six months each after patients had received the second and the third doses of the vaccination, explicitly excluding all patients who had suffered from SARS-CoV-2 infection. The initial antibody response was compared to a control group of 122 healthcare workers. After the application of two doses of the vaccination, 74% of LT recipients (158 out of 213) developed antibodies against SARS-CoV-2; this result depended significantly on whether the patients were taking the medication mycophenolate mofetil, and on the age of the patients. Antibody titers declined significantly within six months from 407 BAU/mL (IQR: 0-1865) to 105 BAU/mL (IQR: 0-145) (
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030572
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  9. Article ; Online: The Tacrolimus Concentration/Dose Ratio Does Not Predict Early Complications After Kidney Transplantation.

    von Samson-Himmelstjerna, Friedrich Alexander / Messtorff, Maja Lucia / Kakavand, Nassim / Eisenberger, Ute / Korth, Johannes / Lange, Ulrich / Kolbrink, Benedikt / Aldag, Leon / Schulze Dieckhoff, Tobias / Feldkamp, Thorsten / Kunzendorf, Ulrich / Harth, Ana / Schulte, Kevin

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11027

    Abstract: Early-on post kidney transplantation, there is a high risk of graft rejection and opportunistic viral infections. A low tacrolimus concentration/dose (C/D) ratio as a surrogate marker of fast tacrolimus metabolism has been established for risk ... ...

    Abstract Early-on post kidney transplantation, there is a high risk of graft rejection and opportunistic viral infections. A low tacrolimus concentration/dose (C/D) ratio as a surrogate marker of fast tacrolimus metabolism has been established for risk stratification 3 months post-transplantation (M3). However, many adverse events occurring earlier might be missed, and stratification at 1 month post-transplantation (M1) has not been investigated. We retrospectively analyzed case data from 589 patients who had undergone kidney transplantation between 2011 and 2021 at three German transplant centers. Tacrolimus metabolism was estimated by use of the C/D ratio at M1, M3, M6, and M12. C/D ratios increased substantially during the year, particularly between M1 and M3. Many viral infections and most graft rejections occurred before M3. Neither at M1 nor at M3 was a low C/D ratio associated with susceptibility to BKV viremia or BKV nephritis. A low C/D ratio at M1 could not predict acute graft rejections or impaired kidney function, whereas at M3 it was significantly associated with subsequent rejections and impairment of kidney function. In summary, most rejections occur before M3, but a low C/D ratio at M1 does not identify patients at risk, limiting the predictive utility of this stratification approach.
    MeSH term(s) Humans ; Tacrolimus/adverse effects ; Kidney Transplantation/adverse effects ; Immunosuppressive Agents/adverse effects ; Retrospective Studies ; Graft Rejection
    Chemical Substances Tacrolimus (WM0HAQ4WNM) ; Immunosuppressive Agents
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11027
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    Zs.A 2358: Show issues Location:
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  10. Article ; Online: Mild versus Severe Liver Injury in SARS-CoV-2 Infection.

    Anastasiou, Olympia E / Korth, Johannes / Herbstreit, Frank / Witzke, Oliver / Lange, Christian M

    Digestive diseases (Basel, Switzerland)

    2020  Volume 39, Issue 1, Page(s) 52–57

    Abstract: Background: Abnormal liver function has been reported in patients with COVID-19 infection. The aim of our study was to report on the prevalence of liver injury in our cohort, to evaluate the association of mild versus severe liver injury with mortality ... ...

    Abstract Background: Abnormal liver function has been reported in patients with COVID-19 infection. The aim of our study was to report on the prevalence of liver injury in our cohort, to evaluate the association of mild versus severe liver injury with mortality in COVID-19 patients and to scrutinize the temporal pattern of viral detection and liver injury.
    Methods: We present data from a German cohort of 147 SARS-CoV-2 infected patients. The patients were divided into 3 groups according to their liver status during treatment. The first group included patients without elevated alanine aminotransferase or bilirubin, the third group patients meeting the biochemical criteria of acute liver failure (ALF), and the second group all other patients.
    Results: Liver injury was detected in 75 (50.7%) and 93 (63%) patients by admission and during treatment, respectively. ALF was associated with the male sex, younger age, and higher BMI. Mortality was associated with the presence of ALF (OR = 9.423, 95% CI: 2.410-36.858) in contrast to milder liver injury (OR 1.101, 95% CI: 0.435-2.791). In 30% of patients with mild liver injury and in 50% of ALF patients, peak liver injury was observed at a time point when the virus was no longer detectable in the respiratory tract.
    Conclusion: Mild liver injury was not associated with worse outcome in our cohort, and the pattern of liver injury did not fit well to the theory of SARS-CoV-2 directly causing liver impairment. Instead, severe liver injury in our cohort was associated multiple-organ failure and acute vascular events.
    MeSH term(s) Adult ; Alanine Transaminase/blood ; Bilirubin/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/mortality ; Cohort Studies ; Correlation of Data ; Female ; Germany/epidemiology ; Hospitalization/statistics & numerical data ; Humans ; Liver Failure, Acute/blood ; Liver Failure, Acute/epidemiology ; Liver Failure, Acute/etiology ; Liver Failure, Acute/virology ; Liver Function Tests/methods ; Liver Function Tests/statistics & numerical data ; Male ; Middle Aged ; Prevalence ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
    Chemical Substances Alanine Transaminase (EC 2.6.1.2) ; Bilirubin (RFM9X3LJ49)
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000510758
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