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Article: Use of an immunocapture device to detect cytokine release in discrete brain regions.

Frank, Matthew G / Baratta, Michael V

2023 Volume 19, Issue 4, Page(s) 703–704

Language	English
Publishing date	2023-10-16
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.382237
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measuring Readiness to Change Substance Use, Alcohol Use, and Cannabis Use: An Experimental Manipulation of Cognitive Effort.

Schwebel, Frank J / Chavez, Jude G / Pearson, Matthew R

Substance use & misuse

2023 Volume 58, Issue 8, Page(s) 1062–1068

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Cannabis ; Substance-Related Disorders/psychology ; Alcohol Drinking/psychology ; Self Report ; Motivation ; Hallucinogens ; Cognition
Chemical Substances	Hallucinogens
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2023.2205539
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Article ; Online: Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP:TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of COVID-19.

Frank, Matthew G / Fleshner, Monika / Maier, Steven F

Brain, behavior, and immunity

2023 Volume 111, Page(s) 259–269

Abstract: ... in support of an alternate mechanism whereby structural proteins (e.g., spike and spike S1 subunit) derived ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an array of neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection (PASC; post-acute sequelae of SARS-CoV-2 infection). Neuroinflammatory processes are considered key factors in the etiology of these symptoms. Several mechanisms underpinning the development of inflammatory events in the brain have been proposed including SARS-CoV-2 neurotropism and peripheral inflammatory responses (i.e., cytokine storm) to infection, which might produce neuroinflammation via immune-to-brain signaling pathways. In this review, we explore evidence in support of an alternate mechanism whereby structural proteins (e.g., spike and spike S1 subunit) derived from SARS-CoV-2 virions function as pathogen-associated molecular patterns (PAMPs) to elicit proinflammatory immune responses in the periphery and/or brain via classical Toll-Like Receptor (TLR) inflammatory pathways. We propose that SARS-CoV-2 structural proteins might directly produce inflammatory processes in brain independent of and/or in addition to peripheral proinflammatory effects, which might converge to play a causal role in the development of neurologic/neuropsychiatric symptoms in COVID-19.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Neuroinflammatory Diseases ; Post-Acute COVID-19 Syndrome ; Signal Transduction
Language	English
Publishing date	2023-04-27
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2023.04.009
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Article ; Online: A short-chain acyl-CoA synthetase that supports branched-chain fatty acid synthesis in Staphylococcus aureus.

Whaley, Sarah G / Frank, Matthew W / Rock, Charles O

The Journal of biological chemistry

2023 Volume 299, Issue 4, Page(s) 103036

Abstract: Staphylococcus aureus controls its membrane biophysical properties using branched-chain fatty acids (BCFAs). The branched-chain acyl-CoA precursors, utilized to initiate fatty acid synthesis, are derived from branched-chain ketoacid dehydrogenase (Bkd), ... ...

Abstract	Staphylococcus aureus controls its membrane biophysical properties using branched-chain fatty acids (BCFAs). The branched-chain acyl-CoA precursors, utilized to initiate fatty acid synthesis, are derived from branched-chain ketoacid dehydrogenase (Bkd), a multiprotein complex that converts α-keto acids to their corresponding acyl-CoAs; however, Bkd KO strains still contain BCFAs. Here, we show that commonly used rich medias contain substantial concentrations of short-chain acids, like 2-methylbutyric and isobutyric acids, that are incorporated into membrane BCFAs. Bkd-deficient strains cannot grow in defined medium unless it is supplemented with either 2-methylbutyric or isobutyric acid. We performed a screen of candidate KO strains and identified the methylbutyryl-CoA synthetase (mbcS gene; SAUSA300_2542) as required for the incorporation of 2-methylbutyric and isobutyric acids into phosphatidylglycerol. Our mass tracing experiments show that isobutyric acid is converted to isobutyryl-CoA that flows into the even-chain acyl-acyl carrier protein intermediates in the type II fatty acid biosynthesis elongation cycle. Furthermore, purified MbcS is an ATP-dependent acyl-CoA synthetase that selectively catalyzes the activation of 2-methylbutyrate and isobutyrate. We found that butyrate and isovalerate are poor MbcS substrates and activity was not detected with acetate or short-chain dicarboxylic acids. Thus, MbcS functions to convert extracellular 2-methylbutyric and isobutyric acids to their respective acyl-CoAs that are used by 3-ketoacyl-ACP synthase III (FabH) to initiate BCFA biosynthesis.
MeSH term(s)	Isobutyrates ; Staphylococcus aureus/genetics ; Staphylococcus aureus/metabolism ; Ligases ; Fatty Acids/metabolism
Chemical Substances	isobutyric acid (8LL210O1U0) ; Isobutyrates ; Ligases (EC 6.-) ; Fatty Acids
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.103036
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Article ; Online: Use of adeno-associated viruses for transgenic modulation of microglia structure and function: A review of technical considerations and challenges.

Ball, Jayson B / Frank, Matthew G / Green-Fulgham, Suzanne M / Watkins, Linda R

Brain, behavior, and immunity

2024 Volume 118, Page(s) 368–379

Abstract: Microglia play a central role in the etiology of many neuropathologies. Transgenic tools are a powerful experiment approach to gain reliable and specific control over microglia function. Adeno-associated virus (AAVs) vectors are already an indispensable ... ...

Abstract	Microglia play a central role in the etiology of many neuropathologies. Transgenic tools are a powerful experiment approach to gain reliable and specific control over microglia function. Adeno-associated virus (AAVs) vectors are already an indispensable tool in neuroscience research. Despite ubiquitous use of AAVs and substantial interest in the role of microglia in the study of central nervous system (CNS) function and disease, transduction of microglia using AAVs is seldom reported. This review explores the challenges and advancements made in using AAVs for expressing transgenes in microglia. First, we will examine the functional anatomy of the AAV capsid, which will serve as a basis for subsequent discussions of studies exploring the relationship between capsid mutations and microglia transduction efficacy. After outlining the functional anatomy of AAVs, we will consider the experimental evidence demonstrating AAV-mediated transduction of microglia and microglia-like cell lines followed by an examination of the most promising experimental approaches identified in the literature. Finally, technical limitations will be considered in future applications of AAV experimental approaches.
MeSH term(s)	Animals ; Dependovirus/genetics ; Transduction, Genetic ; Microglia/metabolism ; Animals, Genetically Modified ; Transgenes ; Genetic Vectors
Language	English
Publishing date	2024-03-11
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2024.03.005
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

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Article ; Online: STAR Has Better Discrimination for Mortality than ERS/ATS COPD Severity Classification.

Bhatt, Surya P / Nakhmani, Arie / Fortis, Spyridon / Strand, Matthew J / Silverman, Edwin K / Wilson, Carla G / Sciurba, Frank C / Bodduluri, Sandeep

American journal of respiratory and critical care medicine

2024

Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202311-2172LE
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Article ; Online: Branched-chain amino acid metabolism controls membrane phospholipid structure in Staphylococcus aureus.

Frank, Matthew W / Whaley, Sarah G / Rock, Charles O

The Journal of biological chemistry

2021 Volume 297, Issue 5, Page(s) 101255

Abstract: Branched-chain amino acids (primarily isoleucine) are important regulators of virulence and are converted to precursor molecules used to initiate fatty acid synthesis in Staphylococcus aureus. Defining how bacteria control their membrane phospholipid ... ...

Abstract	Branched-chain amino acids (primarily isoleucine) are important regulators of virulence and are converted to precursor molecules used to initiate fatty acid synthesis in Staphylococcus aureus. Defining how bacteria control their membrane phospholipid composition is key to understanding their adaptation to different environments. Here, we used mass tracing experiments to show that extracellular isoleucine is preferentially metabolized by the branched-chain ketoacid dehydrogenase complex, in contrast to valine, which is not efficiently converted to isobutyryl-CoA. This selectivity creates a ratio of anteiso:iso C
MeSH term(s)	Acyl Carrier Protein/genetics ; Acyl Carrier Protein/metabolism ; Amino Acids, Branched-Chain/genetics ; Amino Acids, Branched-Chain/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Phospholipids/genetics ; Phospholipids/metabolism ; Staphylococcus aureus/genetics ; Staphylococcus aureus/metabolism
Chemical Substances	Acyl Carrier Protein ; Amino Acids, Branched-Chain ; Bacterial Proteins ; Phospholipids
Language	English
Publishing date	2021-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.101255
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Article ; Online: Near field communication (NFC) device: Evaluation of MRI issues.

Sautter, Matthew / Sautter, Nicholas / Shellock, Frank G

Magnetic resonance imaging

2022 Volume 92, Page(s) 82–87

Abstract: Objective: Near field communication (NFC) is a wireless, short-range, secure communication technology that may be used for healthcare-related applications. An NFC device was recently developed that was intended for implantation in the dorsal fascia, ... ...

Abstract	Objective: Near field communication (NFC) is a wireless, short-range, secure communication technology that may be used for healthcare-related applications. An NFC device was recently developed that was intended for implantation in the dorsal fascia, above the interosseous compartment of the hand. This implant uses a ferrite rod to increase the distance of communication between devices. The purpose of this investigation was to evaluate MRI issues for this NFC device using standardized techniques and well-accepted methodology. Methods: The NFC device (Vivokey Spark 2, Cryptobionic Implant, Vivokey Technologies, www.vivokey.com) was assessed for magnetic field interactions (force and torque) at 3-Tesla, magnetic field interactions according to the simulated intended use of the implant, MRI-related heating at 1.5-Tesla/64-MHz and 3-Tesla/128-MHz, functional change associated with MRI conditions at 1.5-Tesla/64-MHz and 3-Tesla/128-MHz, and artifacts at 3-Tesla. Results: The mean deflection angle was 90° ± 0 and torque was "positive". However, tests evaluating the simulated intended use of the NFC device demonstrated no movement, displacement, or rotational alignment. The highest temperature changes at 1.5-Tesla/64-MHz and 3-Tesla/128-MHz were 1.7 °C and 1.9 °C, respectively. There was no change in the operational capabilities of the NFC device related to the MRI exposures. Artifacts were relatively large in comparison to the size of the NFC device. Conclusions: The findings indicated that the particular NFC device that underwent evaluation is "MR Conditional" for a patient undergoing MRI at 1.5-Tesla or 3-Tesla, operating the scanner in the Normal Operating Mode (i.e., default whole-body averaged SAR of 2.0-W/kg). Notably, this is the first NFC device evaluated for MRI-related issues.
MeSH term(s)	Artifacts ; Communication ; Humans ; Magnetic Fields ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging
Language	English
Publishing date	2022-06-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2022.06.002
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Article ; Online: Evaluation of clinical prediction models (part 1): from development to external validation.

Collins, Gary S / Dhiman, Paula / Ma, Jie / Schlussel, Michael M / Archer, Lucinda / Van Calster, Ben / Harrell, Frank E / Martin, Glen P / Moons, Karel G M / van Smeden, Maarten / Sperrin, Matthew / Bullock, Garrett S / Riley, Richard D

BMJ (Clinical research ed.)

2024 Volume 384, Page(s) e074819

MeSH term(s)	Humans ; Models, Statistical ; Prognosis
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2023-074819
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Article ; Online: Delayed Infection After Cervical Disc Arthroplasty: A Case Report and Review of the Literature.

Federico, Vincent P / Zavras, Athan G / Vucicevic, Rajko S / Salazar, Luis M / An, Howard S / Colman, Matthew W / Phillips, Frank M

Clinical spine surgery

2024

Abstract: Study design: Case report and literature review.: Objective: To report the relatively rare complication of delayed infection after cervical disc arthroplasty (CDA).: Background: Delayed infection of the M6 device has been a rarely reported ... ...

Abstract	Study design: Case report and literature review. Objective: To report the relatively rare complication of delayed infection after cervical disc arthroplasty (CDA). Background: Delayed infection of the M6 device has been a rarely reported complication, with all cases described outside of the United States. The reliability of positive intraoperative cultures remains an ongoing debate. Methods: Cases were reviewed, and findings were summarized. A literature review was performed and discussed, with special consideration to current reports of delayed M6 infection, etiology, and utility of intraoperative cultures. Results: We present a case of delayed infection 6 years after primary 1-level CDA with the M6 device. At revision surgery, gross purulence was encountered. Intraoperative cultures finalized with Staphylococcus epidermidis and Cutibacterium acnes. The patient was revised with removal of the M6 and conversion to anterior cervical discectomy and fusion. A prolonged course of intravenous antibiotics was followed by an oral course for suppression. At the final follow-up, the patient's preoperative symptoms had resolved. Conclusion: Delayed infection after CDA is a rare complication, with ongoing debate regarding the reliability of positive cultures. We describe an infected M6 and demonstrate the utility of implant removal, conversion to anterior cervical discectomy and fusion, and long-term antibiotics as definitive treatment. Level of evidence: Level V-case report and literature review.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2849646-2
ISSN	2380-0194 ; 2380-0186
ISSN (online)	2380-0194
ISSN	2380-0186
DOI	10.1097/BSD.0000000000001618
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