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  1. Article ; Online: PRKAG2 Gene Mutation Indicating Myocardial Hypertrophy and Wolff-Parkinson-White Syndrome in a 28-Year-Old Woman.

    Xu, Yi-Lin / Li, Jing-Hui / Lan, Tian / Lu, Min-Jie

    European heart journal. Cardiovascular Imaging

    2024  

    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeae016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5614: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF-1α/CXCR4 pathway.

    Zhang, Mei-Feng / Wang, Jing-Hui / Sun, Si / Xu, Yi-Tong / Wan, Dong / Feng, Shan / Tian, Zhen / Zhu, Hui-Feng

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 128, Page(s) 155362

    Abstract: Background: Stroke is a leading cause of disability and death worldwide. Currently, there is a lack of clinically effective treatments for the brain damage following ischemic stroke. Catalpol is a bioactive compound derived from the traditional Chinese ... ...

    Abstract Background: Stroke is a leading cause of disability and death worldwide. Currently, there is a lack of clinically effective treatments for the brain damage following ischemic stroke. Catalpol is a bioactive compound derived from the traditional Chinese medicine Rehmannia glutinosa and shown to be protective in various neurological diseases. However, the potential roles of catalpol against ischemic stroke are still not completely clear.
    Purpose: This study aimed to further elucidate the protective effects of catalpol against ischemic stroke.
    Methods: A rat permanent middle cerebral artery occlusion (pMCAO) and oxygen-glucose deprivation (OGD) model was established to assess the effect of catalpol in vivo and in vitro, respectively. Behavioral tests were used to examine the effects of catalpol on neurological function of ischemic rats. Immunostaining was performed to evaluate the proliferation, migration and differentiation of neural stem cells (NSCs) as well as the angiogenesis in each group. The protein level of related molecules was detected by western-blot. The effects of catalpol on cultured NSCs as well as brain microvascular endothelial cells (BMECs) subjected to OGD in vitro were also examined by similar methods.
    Results: Catalpol attenuated the neurological deficits and improved neurological function of ischemic rats. It stimulated the proliferation of NSCs in the subventricular zone (SVZ), promoted their migration to the ischemic cortex and differentiation into neurons or glial cells. At the same time, catalpol increased the cerebral vessels density and the number of proliferating cerebrovascular endothelial cells in the infracted cortex of ischemic rats. The level of SDF-1α and CXCR4 in the ischemic cortex was found to be enhanced by catalpol treatment. Catalpol was also shown to promote the proliferation and migration of cultured NSCs as well as the proliferation of BMECs subjected to OGD insult in vitro. Interestingly, the impact of catalpol on cultured cells was inhibited by CXCR4 inhibitor AMD3100. Moreover, the culture medium of BMECs containing catalpol promoted the proliferation of NSCs, which was also suppressed by AMD3100.
    Conclusion: Our data demonstrate that catalpol exerts neuroprotective effects by promoting neurogenesis and angiogenesis via the SDF-1α/CXCR4 pathway, suggesting the therapeutic potential of catalpol in treating cerebral ischemia.
    MeSH term(s) Animals ; Iridoid Glucosides/pharmacology ; Receptors, CXCR4/metabolism ; Neurogenesis/drug effects ; Chemokine CXCL12/metabolism ; Male ; Rats, Sprague-Dawley ; Rehmannia/chemistry ; Ischemic Stroke/drug therapy ; Infarction, Middle Cerebral Artery/drug therapy ; Neural Stem Cells/drug effects ; Cell Proliferation/drug effects ; Rats ; Neuroprotective Agents/pharmacology ; Neovascularization, Physiologic/drug effects ; Cell Movement/drug effects ; Cell Differentiation/drug effects ; Endothelial Cells/drug effects ; Disease Models, Animal ; Signal Transduction/drug effects ; Cells, Cultured ; Angiogenesis
    Chemical Substances Iridoid Glucosides ; catalpol (2415-24-9) ; Receptors, CXCR4 ; Chemokine CXCL12 ; Cxcr4 protein, rat ; Neuroprotective Agents ; CXCL12 protein, rat
    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155362
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Prophylactic Epidural Blood Patch or Prophylactic Epidural Infusion of Hydroxyethyl Starch in Preventing Post-Dural Puncture Headache - A Retrospective Study.

    Fan, Yan-Ting / Zhao, Tian-Yun / Chen, Jing-Hui / Tang, Yan-Li / Song, Xing-Rong

    Pain physician

    2023  Volume 26, Issue 5, Page(s) 485–493

    Abstract: Background: Post-dural puncture headache (PDPH) is particularly likely to happen in patients under obstetric care due to an unintentional dural puncture (UDP). There is as yet no ideal strategy for preventing UDP-induced PDPH.: Objectives: The ... ...

    Abstract Background: Post-dural puncture headache (PDPH) is particularly likely to happen in patients under obstetric care due to an unintentional dural puncture (UDP). There is as yet no ideal strategy for preventing UDP-induced PDPH.
    Objectives: The primary objective of this study was to assess whether a prophylactic epidural blood patch (EBP) or prophylactic epidural infusion of hydroxyethyl starch (HES) is effective in preventing PDPH for parturients with UDP compared with conservative treatments.
    Study design: Retrospective analysis from a single center's inpatient data.
    Setting: Department of Anesthesiology at a single center.
    Methods: A retrospective study was conducted of a single center's inpatient data from January 2017 through March 2020. The study included parturients with UDP during neuraxial anesthesia. The interventions of UDP included conservative treatment, prophylactic EBP, and prophylactic epidural infusion of HES. The incidence of PDPH, the use of intravenous aminophylline, therapeutic EBP, symptom onset, duration of headache, and duration of hospital stay were compared.
    Results: A total of 85 patients were analyzed. The incidences of PDPH were 84%, 52.6% and 54.5% with conservative, prophylactic EBP, and prophylactic epidural HES treatments, respectively. Compared with the conservative treatment, prophylactic EBP and prophylactic epidural HES treatment significantly reduced the incidence of PDPH (P < 0.05). No significant difference was found between the prophylactic EBP and prophylactic epidural HES groups. Compared with the conservative treatment group, therapeutic EBP was significantly less used in the prophylactic EBP and prophylactic epidural HES groups (P < 0.05). Prophylactic EBP shortened the length of hospital stay of parturients with UDP (P < 0.05) while prophylactic epidural HES showed no statistical difference compared with conservative treatment. No severe complications, such as central nervous system and puncture site infection or nerve injury, were found in those patients.
    Limitations: Retrospective nature and single center data with a relatively small sample size.
    Conclusions: Prophylactic management with EBP and epidural infusion of HES has an effect in preventing the occurrence of PDPH; prophylactic EBP significantly shortened hospital stay length in parturients with UDP.
    Key words: Unintentional dural puncture, epidural blood patch, hydroxyethyl starch, post-dural puncture headache, parturient.
    MeSH term(s) Pregnancy ; Female ; Humans ; Post-Dural Puncture Headache/prevention & control ; Retrospective Studies ; Blood Patch, Epidural ; Starch ; Uridine Diphosphate
    Chemical Substances Starch (9005-25-8) ; Uridine Diphosphate (58-98-0)
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146393-1
    ISSN 2150-1149 ; 1533-3159
    ISSN (online) 2150-1149
    ISSN 1533-3159
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5930: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Association between QRS voltages and amyloid burden in patients with cardiac amyloidosis.

    Li, Jing-Hui / Li, Changcheng / Zheng, Yucong / Yang, Kai / Huang, Yan / Zhang, Huixin / Li, Xianmei / Chen, Xiuyu / Dai, Linlin / Lan, Tian / Sun, Yang / Lu, Minjie / Zhao, Shihua

    Chinese medical journal

    2024  Volume 137, Issue 3, Page(s) 365–367

    MeSH term(s) Humans ; Amyloidosis ; Amyloid ; Cardiomyopathies
    Chemical Substances Amyloid
    Language English
    Publishing date 2024-01-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002965
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    Zs.B 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Ua VI Zs.425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Adolescent hepatic lenticular degeneration cirrhosis: A rare case of Wilson's disease.

    Zhang, Qin / Ding, Hui / Li, Jing / Tian, Bin

    Asian journal of surgery

    2023  

    Language English
    Publishing date 2023-08-29
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.08.109
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    Zs.B 2831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Isolation and structure determination of superbcyclin A, a cyclic nonapeptide from Dianthus superbus

    Zhang, Qing / Yang, Jing-Hui / Du, Yu-Lan / Fu, Xu-Yang / Liu, Wu-Yang / Zeng, Yi-Qin / Liu, Shu-Hui / Tian, Jun-Mian / Gao, Jin-Ming

    Phytochemical Society of Europe Phytochemistry Letters. 2023 June, v. 55 p.160-163

    2023  

    Abstract: To explore the bioactive phytochemical constituents of Dianthus superbus, whole plants of D. superbus were collected and chemically investigated. A rare Caryophyllaceae-type cyclic nonapeptide, named superbcyclin A, was isolated. Its structure was ... ...

    Abstract To explore the bioactive phytochemical constituents of Dianthus superbus, whole plants of D. superbus were collected and chemically investigated. A rare Caryophyllaceae-type cyclic nonapeptide, named superbcyclin A, was isolated. Its structure was determined on the basis of spectroscopic data and analytical evidence. The absolute configurations of the amino acid residues were identified by advanced Marfey’s analysis.
    Keywords Dianthus superbus ; amino acids ; phytochemicals ; spectral analysis ; Cyclic nonapeptide ; Superbcyclin A ; Isolation ; Structure determination
    Language English
    Dates of publication 2023-06
    Size p. 160-163.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2023.05.005
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Boosting CO

    Jing, Xiao-Ting / Zhu, Zhejiaji / Chen, Li-Wei / Liu, Di / Huang, Hui-Zi / Tian, Wen-Jing / Yin, An-Xiang

    ACS applied materials & interfaces

    2023  Volume 15, Issue 16, Page(s) 20317–20324

    Abstract: Electrochemical ... ...

    Abstract Electrochemical CO
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c02578
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  8. Article ; Online: Phytoecdysteroids from Dianthus superbus L.: Structures and anti-neuroinflammatory evaluation.

    Hou, Xue-Li / Gao, Yu-Qi / Yang, Jing-Hui / Liu, Han-Wu / Bai, Meng-Meng / Wu, Zhen-Hai / Li, Chun-Huan / Tian, Jun-Mian / Gao, Jin-Ming

    Phytochemistry

    2023  Volume 212, Page(s) 113710

    Abstract: Six undescribed ... ...

    Abstract Six undescribed C
    MeSH term(s) Dianthus/chemistry ; Ecdysterone/pharmacology ; Molecular Docking Simulation ; Neuroinflammatory Diseases ; Ecdysteroids/pharmacology
    Chemical Substances Ecdysterone (5289-74-7) ; Ecdysteroids
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 1586: Show issues
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  9. Article ; Online: Engineering and Characterization of 3-Aminotyrosine-Derived Red Fluorescent Variants of Circularly Permutated Green Fluorescent Protein.

    Zhang, Hao / Tian, Xiaodong / Zhang, Jing / Ai, Hui-Wang

    Biosensors

    2024  Volume 14, Issue 1

    Abstract: Introducing 3-aminotyrosine (aY), a noncanonical amino acid (ncAA), into green fluorescent protein (GFP)-like chromophores shows promise for achieving red-shifted fluorescence. However, inconsistent results, including undesired green fluorescent species, ...

    Abstract Introducing 3-aminotyrosine (aY), a noncanonical amino acid (ncAA), into green fluorescent protein (GFP)-like chromophores shows promise for achieving red-shifted fluorescence. However, inconsistent results, including undesired green fluorescent species, hinder the effectiveness of this approach. In this study, we optimized expression conditions for an aY-derived cpGFP (aY-cpGFP). Key factors like rich culture media and oxygen restriction pre- and post-induction enabled high-yield, high-purity production of the red-shifted protein. We also engineered two variants of aY-cpGFP with enhanced brightness by mutating a few amino acid residues surrounding the chromophore. We further investigated the sensitivity of the aY-derived protein to metal ions, reactive oxygen species (ROS), and reactive nitrogen species (RNS). Incorporating aY into cpGFP had minimal impact on metal ion reactivity but increased the response to RNS. Expanding on these findings, we examined aY-cpGFP expression in mammalian cells and found that reductants in the culture media significantly increased the red-emitting product. Our study indicates that optimizing expression conditions to promote a reduced cellular state proved effective in producing the desired red-emitting product in both
    MeSH term(s) Animals ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/chemistry ; Escherichia coli/genetics ; Amino Acids ; Culture Media ; Mammals ; Tyrosine/analogs & derivatives
    Chemical Substances Green Fluorescent Proteins (147336-22-9) ; 3-aminotyrosine (300-34-5) ; Amino Acids ; Culture Media ; Tyrosine (42HK56048U)
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14010054
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  10. Article ; Online: Astragaloside IV targeting autophagy of T cells improves inflammation of asthma.

    Yang, Qing-Qing / Zhang, Hong-Ying / Duan, Xiao-Hong / Li, Mi-Hui / Sun, Jing / Tian, Li-Xia / Dong, Jing-Cheng / Kong, Ling-Wen

    Journal of Asian natural products research

    2024  , Page(s) 1–15

    Abstract: Astragaloside IV (AST) has been confirmed to have antiasthmatic effects. However, the underline mechanism is unclear. The study aimed to explore the treatment mechanism of AST based on autophagy of memory T cells. AST treatment significantly decreased ... ...

    Abstract Astragaloside IV (AST) has been confirmed to have antiasthmatic effects. However, the underline mechanism is unclear. The study aimed to explore the treatment mechanism of AST based on autophagy of memory T cells. AST treatment significantly decreased the number of T effector cells in asthma mice blood and the
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2023.2294069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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