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Article ; Online: Yi Mai granule improve energy supply of endothelial cells in atherosclerosis via miRNA-125a-5p regulating mitochondrial autophagy through Pink1-Mfn2-Parkin pathway.

Kong, De Zhao / Sun, Peng / Lu, Yi / Yang, Ye / Min, Dong Yu / Zheng, Si Cheng / Yang, Yi / Zhang, Zhe / Yang, Guan Lin / Jiang, Jun Wen

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 1, Page(s) 117114

Abstract: Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine ...

Abstract	Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine formulas used to treat cardiovascular disease for centuries. The Pink1-Mfn2-Parkin pathway, a well-recognized mechanism that mediates mitochondrial autophagy, plays a big part in mitochondrial quality control and the maintenance of heart function. However, the effects of YMG on endothelial dysfunction and mitochondrial autophagy remain unknown. Aim of the study: Here, we focused on the therapeutic effects of YMG in improving mitochondrial autophagy and the mechanism of YMG against cardiovascular disease. Materials and methods: In this study, rats were fed high-fat diet (HFD) for 21 weeks and were given high, medium, and low doses of YMG in stomach. The open field test was used to evaluate the rats' behavior. Atherosclerotic plaques, blood lipids, and cytokine levels were measured. Mitochondrial autophagy changes were observed by Transmission electron microscope (TEM). Human umbilical vein endothelial cells (HUVECs) were injured by angiotensinⅡ(AngⅡ) and were given high, medium, and low doses of YMG medicated serum in cell culture medium. Pink1-Mfn2-Parkin expression and miRNA 125a-5p expression were measured by RT-PCR and Western blot. Results: We demonstrated that the atherosclerosis model group tended to exhibit reduced vitality behaviors. We proved that the atherosclerosis model group showed obvious atherosclerotic plaques, endothelial cells destruction, and high level of blood lipid and cytokines (including hs-CRP, ET). Mitochondria were reduced, and mitophagy was inhibited in aortic cells of the model group. MiRNA-125a-5p was up-regulated; at the same time, Pink1-Mfn2-Parkin-mediated mitochondrial autophagy was prevented. We also proved that AngⅡinjured HUVEC showed obviously low mRNA levels of Pink1, Mfn2, and Parkin. Interestingly, we found that miRNA-125a-5p was significantly down regulated in Ang II-induced HUVECs. In addition, miRNA-125a-5p significantly reduced the protective effect of YiMai Granules against Ang II injury. Conclusion: Our finding indicated that Pink1-Mfn2-Parkin-mediated mitochondrial autophagy plays a crucial role in alleviating atherosclerosis. YMG alleviated atherosclerosis by potentially activating mitochondrial autophagy may via miRNA-125a-5p, regulating Pink1-Mfn2-Parkin pathway, and regulating proinflammatory factors, vasoconstriction cytokine, and blood lipids.
MeSH term(s)	Rats ; Humans ; Animals ; Endothelial Cells/metabolism ; Plaque, Atherosclerotic/metabolism ; Cardiovascular Diseases ; Protein Kinases/metabolism ; Autophagy ; Mitochondria ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cytokines/metabolism ; Lipids/pharmacology ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Cytokines ; Lipids ; MicroRNAs
Language	English
Publishing date	2023-09-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117114
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Article ; Online: Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes

Zha, Zheng / Liu, Yi-Jiang / Liu, Si-Si / Zhang, Nan / Li, Jun-Ling / Qi, Fang / Jin, Liang-Yun / Xue, Bing / Yang, Tao / Fan, Yong-Ping / Zhao, Hui / Wang, Lei

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 3800004

Abstract: Background/ ... ...

Abstract	Background/Aims
MeSH term(s)	Animals ; Astrocytes/metabolism ; Central Nervous System ; Complement C1q/metabolism ; Complement C1q/pharmacology ; Mice ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Myelin Sheath ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	MicroRNAs ; Tumor Necrosis Factor-alpha ; Complement C1q (80295-33-6)
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/3800004
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Article: [ZHENG Wenzhuo's Yi gu (

Zheng, H J / Huang, Z Z

Zhonghua yi shi za zhi (Beijing, China : 1980)

2018 Volume 47, Issue 5, Page(s) 303–306

Abstract: Yi gu ...

Abstract	Yi gu
MeSH term(s)	Books/history ; History, 19th Century ; Medicine, Chinese Traditional
Language	Chinese
Publishing date	2018-06-03
Publishing country	China
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.issn.0255-7053.2017.05.008
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Zs.A 4688: Show issues

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Article: [Yi Wan She--Huzhou medical association in the late Ming Dynasty].

Yao, Y F / Xu, X C / Zheng, H

Zhonghua yi shi za zhi (Beijing, China : 1980)

2022 Volume 52, Issue 2, Page(s) 121–126

Abstract: Yi Wan She, as a medical association in the Huzhou area, was organised by Lu Mingquan, Lu Shilong ... of local affairs. This was recorded in Yi Wan She Cao and Lu Shi San Shi Yi Yan. ...

Abstract	Yi Wan She, as a medical association in the Huzhou area, was organised by Lu Mingquan, Lu Shilong, Jin Desheng and other doctors in the late Ming Dynasty, developing daily medical theoretical discussions. It built up a hospital named Tian, paid deference to ancient medical doctors, and participated in activities to fight epidemics, organised by Hui Min Pharmacy, such as drug delivery, as an association of local affairs. This was recorded in Yi Wan She Cao and Lu Shi San Shi Yi Yan.
MeSH term(s)	China ; Humans ; Physicians
Language	Chinese
Publishing date	2022-05-15
Publishing country	China
Document type	Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20211229-00155
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Article ; Online: Genetic polymorphism of 19 autosomal STR loci in the Yi ethnic minority of Liangshan Yi autonomous prefecture from Sichuan province in China.

Cheng, Jingliang / Song, Binghui / Fu, Jiewen / Zheng, Xiaoli / He, Tao / Fu, Junjiang

Scientific reports

2021 Volume 11, Issue 1, Page(s) 16327

Abstract: The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups in China ... The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi community in China ... To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA Identification System ...

Abstract	The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups in China. The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi community in China. To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA Identification System 20A Kit with 19 autosomal STRs (short tandem repeats) was used. As a result, the total discrimination power (TDP) and the cumulative probability of exclusion (CPE) for these STRs in 1016 unrelated individuals were 0.999999999999999999999897 and 0.9999999597, respectively. Totals of 273 alleles for 19 STRs and 8-22 alleles for each locus were found. The allelic frequencies ranged from 0.0005 to 0.5084. The forensic parameter averages of these STRs were as follows: observed heterozygosity (H
MeSH term(s)	Asian Continental Ancestry Group/genetics ; China ; Ethnic Groups/genetics ; Gene Frequency/genetics ; Genetics, Population/methods ; Humans ; Microsatellite Repeats/genetics ; Minority Groups ; Phylogeny ; Polymorphism, Genetic/genetics
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95883-x
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Article ; Online: Exploring the potential mechanisms of Yi-Yi-Fu-Zi-Bai-Jiang-San therapy on the immune-inflamed phenotype of colorectal cancer via combined network pharmacology and bioinformatics analyses.

Liu, Yong / Liang, Youcheng / Su, Yongjian / Hu, Jiaqi / Sun, Jianbo / Zheng, Mingbin / Huang, Zunnan

Computers in biology and medicine

2023 Volume 166, Page(s) 107432

Abstract: ... will help increase knowledge regarding the characteristics of TME infiltration. Yi-Yi-Fu-Zi-Bai-Jiang-San ...

Abstract	Background: The development and progression of colorectal cancer (CRC) is closely associated with its complex tumor microenvironment (TME). Assessment of the modified pattern of immune cell infiltration (ICI) will help increase knowledge regarding the characteristics of TME infiltration. Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) has been shown to have positive effects on the regulation of the immune microenvironment of CRC. However, its pharmacological targets and molecular mechanisms remain to be elucidated. Methods: Network pharmacological analysis was used to identify the target of YYFZBJS in the TME of CRC. Patients with the immune-inflamed phenotype (IIP) were identified using CRC samples from The Cancer Genome Atlas (TCGA) database. Consensus genes were identified by intersecting YYFZBJS targets, CRC disease targets and differentially expressed genes in the CRC microenvironment. Then, least absolute shrinkage and selection operator (LASSO) Cox analyses were used to identify a prognostic signature from the consensus genes. Cytoscape software was further used to build a unique herb-compound-target network diagram of the important components of YYFZBJS and prognostic gene targets. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was performed using the prognostic gene sets to explore the molecular mechanism of the prognostic genes in drug therapy for CRC IIP patients. Finally, single-cell analysis was performed to validate the expression of the prognostic genes in the TME of CRC using the TISCH2 database. Results: A total of 284 IIP patients were identified from 480 patients with CRC. A total of 35 consensus genes were identified as targets of YYFZBJS in the TME of CRC patients. An eleven-gene prognostic signature, including PIK3CG, C5AR1, PRF1, CAV1, HPGDS, PTGS2, SERPINE1, IDO1, TGFB1, CXCR2 and MMP9, was identified from the consensus genes, with areas under the receiver operating characteristic (ROC) curve (AUCs) values of 0.84 and 0.793 for the training and test cohorts, respectively. In the herb-compound-target network, twenty-four compounds were shown to interact with the 11 prognostic genes, which were significantly enriched in the IL-17 signaling, arachidonic acid metabolism and metabolic pathways. Single-cell analysis of the prognostic genes confirmed that their abnormal expression was associated with the TME of CRC. Conclusion: This study organically integrated network pharmacology and bioinformatics analyses to identify prognostic genes in CRC IIP patients from the targets of YYFZBJS. Although this data mining work was limited to the study of mechanisms related to prognosis based on the immune microenvironment, the methodology provides new perspectives in the search for novel therapeutic targets of traditional Chinese medicines (TCMs) and accurate diagnostic indicators of cancers targeted by TCMs.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.107432
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Zs.A 653: Show issues

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Article ; Online: Increasing prevalence of overweight and obesity in Yi farmers and migrants from 2007 to 2015 in China: the Yi migrant study.

Wang, Ye / Pan, Li / Wan, Shaoping / Yi, Huowuli / Yang, Fang / He, Huijing / Li, Zheng / Zhang, Jia / Wang, Xiaoyang / Yong, Zhengping / Shan, Guangliang

BMC public health

2018 Volume 18, Issue 1, Page(s) 659

Abstract: ... and related factors of overweight and obesity in Yi farmers and migrants in southwest China from 2007 ... prevalence of overweight increased in both groups (from 5.54 to 16.65% in Yi farmers, from 27.91 to 33.61 ... in Yi migrants). Standardized prevalence of obesity increased only in Yi farmers (from 0.37 to 3.13 ...

Abstract	Background: With the social development and lifestyle transition, increasing trends of overweight and obesity prevalence are commonly reported worldwide. Data focusing on overweight and obesity trends in rural residents and rural-to-urban migrants in China are limited. This study aims to assess the changes and related factors of overweight and obesity in Yi farmers and migrants in southwest China from 2007 to 2015, and to assess the disparities in prevalence changes. Methods: Pseudo-panel data was obtained from two cross-sectional studies conducted in Sichuan province, southwest China in 2007 and 2015. Standardized prevalence of overweight and obesity were evaluated by direct method using the 2010 national census population as the standard. Prevalence differences of overweight and obesity were calculated in each group and compared between groups to evaluate the disparity in prevalence changes. Generalized linear mixed model was performed to determine factors related to overweight/obesity. Results: Standardized prevalence of overweight increased in both groups (from 5.54 to 16.65% in Yi farmers, from 27.91 to 33.61% in Yi migrants). Standardized prevalence of obesity increased only in Yi farmers (from 0.37 to 3.13%). Prevalence difference of overweight in Yi farmers was higher than that in Yi migrants (11.11 vs. 5.70), but prevalence differences of obesity were not significantly different between Yi farmers and migrants. Conclusions: Prevalence of overweight and obesity in Yi farmers, and prevalence of overweight in Yi migrants increased from 2007 to 2015. Yi farmers were developing overweight at a greater pace than migrants. More attention should be paid to spread health knowledge and encourage healthy lifestyle in Yi people, especially Yi farmers.
MeSH term(s)	Adult ; Agriculture/statistics & numerical data ; China/epidemiology ; Cross-Sectional Studies ; Farmers/statistics & numerical data ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Rural Population/statistics & numerical data ; Transients and Migrants/statistics & numerical data
Language	English
Publishing date	2018-05-24
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-018-5577-4
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Article ; Online: Ecological and human health hazards of soil heavy metals after wildfire: A case study of Liangshan Yi autonomous prefecture, China.

Rao, Lin / Zheng, Chao / Chen, Jian-Bin / Cai, Jun-Zhuo / Yang, Zhan-Biao / Xu, Xiao-Xun / Lv, Guo-Chun / Xu, Chang-Lian / Wang, Gui-Yin / Man, Yu-Bon / Wong, Ming-Hung / Cheng, Zhang

Chemosphere

2024 Volume 352, Page(s) 141506

Abstract: Soil samples were collected in at different depths from the conflagration area in Liangshan Yi ...

Abstract	Soil samples were collected in at different depths from the conflagration area in Liangshan Yi Autonomous Region, China, to investigate the distribution characteristics and ecological and human health risks of heavy metals after a wildfire. The samples collected comprise wildfire ash (WA) above the soil surface, ash soil (AS) 0-5 cm, and plain soil (PS) 5-15 cm below the soil surface. Additionally, reference soil (RS) was collected from a nearby unburned area at the same latitude as the conflagration area. The results showed that the concentrations of zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd) in the WA and AS were significantly higher than in reference soil (RS) (p < 0.05). Concentrations of Pb in the PS were 2.52 times higher than that in RS (17.9 mg kg
MeSH term(s)	Humans ; Soil ; Environmental Monitoring ; Cadmium ; Lead ; Wildfires ; Risk Assessment ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; China ; Neoplasms
Chemical Substances	Soil ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141506
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Article ; Online: Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification.

Zha, Zheng / Liu, Yi-Jiang / Liu, Si-Si / Zhang, Nan / Li, Jun-Ling / Qi, Fang / Jin, Liang-Yun / Xue, Bing / Yang, Tao / Fan, Yong-Ping / Zhao, Hui / Wang, Lei

Mediators of inflammation

2022 Volume 2022, Page(s) 9241261

Abstract: Methods: The potential active ingredients and corresponding potential targets of BSYS Capsule were obtained from the TCMSP, BATMAN-TCM, Swiss Target Prediction platform, and literature research. Disease targets of CNSD were explored through the ... ...

Abstract	Methods: The potential active ingredients and corresponding potential targets of BSYS Capsule were obtained from the TCMSP, BATMAN-TCM, Swiss Target Prediction platform, and literature research. Disease targets of CNSD were explored through the GeneCards and the DisGeNET databases. The matching targets of BSYS in CNSD were identified from a Venn diagram. The protein-protein interaction (PPI) network was constructed using bioinformatics methods. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the mechanisms of BSYS. Furthermore, the neuroprotective effects of BSYS were evaluated using a cell model of hydrogen peroxide- (H Results: A total of 59 potential bioactive components of BSYS Capsule and 227 intersection targets were obtained. Topological analysis showed that AKT had the highest connectivity degrees in the PPI network. Enrichment analysis revealed that the targets of BSYS in the treatment of CNSD were the PI3K-Akt and MAPK signaling pathway, among other pathways. GO analysis results showed that the targets were associated with various biological processes, including apoptosis, reactive oxygen species metabolic process, and response to oxidative stress, among others. The experimental results demonstrated that BSYS drug-containing serum alleviated the H Conclusion: BSYS Capsule alleviated H
MeSH term(s)	Animals ; Central Nervous System ; Drugs, Chinese Herbal/therapeutic use ; Hydrogen Peroxide/pharmacology ; Medicine, Chinese Traditional/methods ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt
Chemical Substances	Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2022/9241261
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Article ; Online: Association between age at arrival, duration of migration, and overweight/obesity in Chinese rural-to-urban migrants: the Yi migrant study.

Wang, Ye / Pan, Li / Wan, Shao-Ping / Yi, Huo-Wu-Li / Yang, Fang / He, Hui-Jing / Li, Zheng / Zhang, Jia / Yong, Zheng-Ping / Shan, Guang-Liang

Chinese medical journal

2020 Volume 134, Issue 1, Page(s) 60–67

Abstract: ... duration of migration, and the corresponding association with overweight/obesity in Yi migrants in China ... of migration and overweight/obesity (BMI ≥ 25 kg/m2).: Results: A total of 3056 Yi people (1894 Yi farmers ... and 1162 Yi migrants) aged 20 to 80 years were enrolled. After adjusting for age, sex, and ...

Abstract	Background: Urbanization in China is rapidly proceeding, but rural-to-urban migration and its association with overweight and obesity is not well studied. This study aimed to explore the age at arrival, duration of migration, and the corresponding association with overweight/obesity in Yi migrants in China. Methods: A cross-sectional study was conducted in rural and urban areas in 2015 in Sichuan province, China. Demographic characteristics, lifestyle factors, and anthropometry were collected. General linear regression models were used to assess the effect of duration of migration (1-10, 11-20, 21-30, and >30 years) on body mass index (BMI). Multi-variable logistic regression was used to examine the association between duration of migration and overweight/obesity (BMI ≥ 25 kg/m2). Results: A total of 3056 Yi people (1894 Yi farmers and 1162 Yi migrants) aged 20 to 80 years were enrolled. After adjusting for age, sex, and other potential confounders, Yi migrants had 1.71 kg/m2 (95% confidence interval [CI]: 1.36-2.06) higher BMI and a 2.13-fold (95% CI: 1.71-2.65) higher risk of overweight/obesity than Yi farmers. In Yi migrants, stratified by age at arrival, no significant association between duration of migration and overweight/obesity was observed in those who were 0 to 20 years old at arrival. In comparison, in migrants >20 years old at arrival, compared with the reference group (1-10 years), long-term migration (>30 years) was found to be associated with overweight/obesity after adjustment (odds ratio: 1.85, 95% CI: 1.04-3.29). Conclusions: Yi migrants were observed to have greater risk of overweight/obesity than Yi farmers. In Yi migrants, the risk of overweight/obesity increased according to the duration of migration, especially in those who were older upon their arrival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Cross-Sectional Studies ; Humans ; Middle Aged ; Obesity/epidemiology ; Overweight/epidemiology ; Prevalence ; Rural Population ; Transients and Migrants ; Urban Population ; Young Adult
Language	English
Publishing date	2020-08-20
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000000973
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