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  1. Article: The Research Progress on the Interaction between Mammalian Gut Microbiota and the Host's Metabolism Homeostasis during Hibernation.

    Zhang, Zhepei / Song, Fengcheng / Wang, Linjuan / Yuan, Zhengrong

    Metabolites

    2024  Volume 14, Issue 3

    Abstract: Hibernating mammals confront seasonal and harsh environmental shifts, prompting a cycle of pre-hibernation feeding and subsequent winter fasting. These adaptive practices induce diverse physiological adjustments within the animal's body. With the gut ... ...

    Abstract Hibernating mammals confront seasonal and harsh environmental shifts, prompting a cycle of pre-hibernation feeding and subsequent winter fasting. These adaptive practices induce diverse physiological adjustments within the animal's body. With the gut microbiota's metabolic activity being heavily reliant on the host's diet, this cycle's primary impact is on this microbial community. When the structure and composition of the gut microbiota changes, corresponding alterations in the interactions occur between these microorganisms and their host. These successive adaptations significantly contribute to the host's capacity to sustain relatively stable metabolic and immune functions in severe environmental conditions. A thorough investigation into the reciprocal interplay between the host and gut microbiota during hibernation-induced adaptive changes holds promise for unveiling new insights. Understanding the underlying mechanisms driving these interactions may potentially unlock innovative approaches to address extreme pathological conditions in humans.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14030134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin-Proteasome Degradation of SIRT1.

    Huang, Min / Wang, Junfeng / Zhang, Zhengrong / Zuo, Xueliang

    Biochemical genetics

    2024  

    Abstract: There are nearly 1.15 million new cases of colon cancer, as well as 586,858 deaths from colon cancer worldwide in 2020. The aim of this study is to reveal whether ZMIZ1 can control the fate of colon cancer cells and the mechanism by which it functions. ... ...

    Abstract There are nearly 1.15 million new cases of colon cancer, as well as 586,858 deaths from colon cancer worldwide in 2020. The aim of this study is to reveal whether ZMIZ1 can control the fate of colon cancer cells and the mechanism by which it functions. Specific shRNA transfection was used to knock down the expression of ZMIZ1 in colon cancer cell lines (HCT116 and HT29), and cell proliferation was detected using EdU and CCK-8 reagents, apoptosis by flow cytometry, and autophagy by western blot. The interaction of ZMIZ1 and SIRT1 was analyzed. Knockdown of ZMIZ1 significantly inhibited autophagy and proliferation, and induced apoptosis of HCT116 and HT29 cells. The mRNA level of SIRT1 was not affected by ZMIZ1 knockdown, but the protein level of SIRT1 was significantly decreased and the protein level of the SIRT1-specific substrate, acetylated FOXO3a, was reduced. Immunoprecipitation assays identified the interaction between SIRT1 and ZMIZ1 in HCT116 and HT29 cells. ZMIZ1 increased intracellular ubiquitination of SIRT1. Knockdown or pharmacological inhibition of SIRT1 neutralized the effects of ZMIZ knockdown on proliferation, autophagy and apoptosis in HCT116 and HT29 cells. ZMIZ1 may control the fate of colon cancer cells through the SIRT1/FOXO3a axis. Targeting ZMIZ1 would be beneficial for the treatment of colon cancer.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2168-4
    ISSN 1573-4927 ; 0006-2928
    ISSN (online) 1573-4927
    ISSN 0006-2928
    DOI 10.1007/s10528-023-10573-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Environmental surveillance reveals co-circulation of distinctive lineages of enteroviruses in southwest China's border cities, 2020-2022.

    Tang, Jingjing / Zhang, Xiaodie / Zhang, Jie / Zhao, Zhixian / Ding, Zhengrong

    Journal of applied microbiology

    2024  Volume 135, Issue 3

    Abstract: Aims: Enteroviruses are significant human pathogens associated with a range of mild to severe diseases. This study aims to understand the diversity and genetic characterization of enteroviruses circulated in southwest China's border cities by using ... ...

    Abstract Aims: Enteroviruses are significant human pathogens associated with a range of mild to severe diseases. This study aims to understand the diversity and genetic characterization of enteroviruses circulated in southwest China's border cities by using environmental surveillance.
    Methods and results: A total of 96 sewage samples were collected in three border cities and a port located in Yunnan Province, China from July 2020 to June 2022. After cell culture and VP1 sequencing, a total of 590 enterovirus isolates were identified, belonging to 21 types. All PV strains were Sabin-like with ≤6 nucleotide mutations in the VP1 coding region. Echovirus 6, echovirus 21 (a rare serotype in previous studies), and coxsackievirus B5 were the predominant serotypes, which accounted for 21.19%, 18.31%, and 13.39% of the total isolates, respectively. The prevalence of the common serotypes varied across different border cities and periods. Phylogenetic analysis revealed the presence of multiple evolutionary lineages for E21, E6, and E30, some of which formed distinct branches.
    Conclusions: High diversity of enteroviruses and distinct lineages of predominant serotypes circulated in southwest China's border cities.
    MeSH term(s) Humans ; Cities ; Phylogeny ; China/epidemiology ; Enterovirus ; Enterovirus Infections/epidemiology ; Enterovirus B, Human/genetics ; Antigens, Viral/genetics ; Environmental Monitoring/methods
    Chemical Substances Antigens, Viral
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1093/jambio/lxae060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Decomposition analysis on the equity of health examination utilization for the middle-aged and elderly people in China: based on longitudinal CHARLS data from 2011 to 2018.

    Su, Min / Zhang, Tianjiao / Zhang, Weile / Li, Zhengrong / Fan, Xiaojing

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 998

    Abstract: Background: This study aimed to investigate the utilization rate and equity of health examination service among the middle-aged and elderly population in China from 2011 to 2018. The contribution of various determinants to the inequity in health ... ...

    Abstract Background: This study aimed to investigate the utilization rate and equity of health examination service among the middle-aged and elderly population in China from 2011 to 2018. The contribution of various determinants to the inequity in health examination service utilization was also examined.
    Methods: Data from the China Health and Retirement Longitudinal Survey (CHARLS) were analyzed to assess the health examination service utilization rate among the middle-aged and elderly population. A concentration curve and concentration index were employed to measure the equity of health examination service utilization and decomposed into its determining factors. Horizontal inequity index was applied to evaluate the trends in equity of health examination service.
    Results: The health examination service utilization rates among the middle-aged and elderly population were 29.45%, 20.69%, 25.40%, and 32.05% in 2011, 2013, 2015, and 2018, respectively. The concentration indexes for health examination service utilization were 0.0080 (95% CI: - 0.0084, 0.0244), 0.0155 (95% CI: - 0.0054, 0.0363), 0.0095 (95% CI: - 0.0088, 0.0277), and - 0.0100 (95% CI: - 0.0254, 0.0054) from 2011 to 2018, respectively. The horizontal inequity index was positive from 2011 to 2018, evidencing a pro-rich inequity trend. Age, residence, education, region, and economic status were the major identified contributors influencing the equity of health examination service utilization.
    Conclusions: A pro-rich inequity existed in health examination service utilization among the middle-aged and elderly population in China. Reducing the wealth and regional gap, providing equal educational opportunities, and strengthening the capacity for chronic disease prevention and control are crucial for reducing the inequity in health examination service utilization.
    MeSH term(s) Middle Aged ; Humans ; Aged ; Retirement ; Healthcare Disparities ; Socioeconomic Factors ; China ; Longitudinal Studies
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-18068-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: WITHDRAWN: Analysis of the Efficacy of Drilling Decompression Autologous Bone Marrow and Allogeneic Bone Grafting in the Treatment of HIV-positive Patients with Early Osteonecrosis of the Femoral Head

    Shengtao, Li / Jie, Wang / Rui, Ma / Changsong, Zhao / Yu, Pu / Min, He / Zhengrong, Gao / Xuemin, Quan / Qiang, Zhang

    Current HIV research

    2023  

    Language English
    Publishing date 2023-11-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2192348-6
    ISSN 1873-4251 ; 1570-162X
    ISSN (online) 1873-4251
    ISSN 1570-162X
    DOI 10.2174/011570162X253808231025111220
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6102: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article ; Online: Event-Triggered Adaptive Neural Network Sensor Failure Compensation for Switched Interconnected Nonlinear Systems With Unknown Control Coefficients.

    Zhang, Jing / Xiang, Zhengrong

    IEEE transactions on neural networks and learning systems

    2022  Volume 33, Issue 10, Page(s) 5241–5252

    Abstract: In this article, a decentralized adaptive neural network (NN) event-triggered sensor failure compensation control issue is investigated for nonlinear switched large-scale systems. Due to the presence of unknown control coefficients, output interactions, ... ...

    Abstract In this article, a decentralized adaptive neural network (NN) event-triggered sensor failure compensation control issue is investigated for nonlinear switched large-scale systems. Due to the presence of unknown control coefficients, output interactions, sensor faults, and arbitrary switchings, previous works cannot solve the investigated issue. First, to estimate unmeasured states, a novel observer is designed. Then, NNs are utilized for identifying both interconnected terms and unstructured uncertainties. A novel fault compensation mechanism is proposed to circumvent the obstacle caused by sensor faults, and a Nussbaum-type function is introduced to tackle unknown control coefficients. A novel switching threshold strategy is developed to balance communication constraints and system performance. Based on the common Lyapunov function (CLF) method, an event-triggered decentralized control scheme is proposed to guarantee that all closed-loop signals are bounded even if sensors undergo failures. It is shown that the Zeno behavior is avoided. Finally, simulation results are presented to show the validity of the proposed strategy.
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2021.3069817
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  7. Article: Effect of Lankford Coefficients on Springback Behavior during Deep Drawing of Stainless Steel Cylinders.

    Wu, Fei / Hong, Yihao / Zhang, Zhengrong / Huang, Chun / Huang, Zhenrong

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: Accurate prediction of springback is increasingly required during deep-drawing formation of anisotropic stainless steel sheets. The anisotropy of sheet thickness direction is very important for predicting the springback and final shape of a workpiece. ... ...

    Abstract Accurate prediction of springback is increasingly required during deep-drawing formation of anisotropic stainless steel sheets. The anisotropy of sheet thickness direction is very important for predicting the springback and final shape of a workpiece. The effect of Lankford coefficients (r
    Language English
    Publishing date 2023-06-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16124321
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  8. Article ; Online: STAT3 regulates 5-Fu resistance in human colorectal cancer cells by promoting Mcl-1-dependent cytoprotective autophagy.

    Yue, Yuanyi / Zhang, Qiang / Wang, Xueqing / Sun, Zhengrong

    Cancer science

    2023  Volume 114, Issue 6, Page(s) 2293–2305

    Abstract: Chemoresistance to 5-fluorouracil (5-Fu)-based chemotherapy is one of the primary reasons for the failure of colorectal cancer (CRC) management. STAT3 can mediate tumor drug resistance through a variety of diverse mechanisms. Nonetheless, the underlying ... ...

    Abstract Chemoresistance to 5-fluorouracil (5-Fu)-based chemotherapy is one of the primary reasons for the failure of colorectal cancer (CRC) management. STAT3 can mediate tumor drug resistance through a variety of diverse mechanisms. Nonetheless, the underlying mechanisms of STAT3-induced 5-Fu resistance in CRC are still poorly understood. Here, we aimed to investigate the potential mechanism(s) of STAT3-induced 5-Fu resistance in CRC. Quantitative RT-PCR and Western blot were used to test the expression of STAT3 and Mcl-1 in chemosensitive and chemoresistant CRC tissues and cell lines. After overexpression or knockdown of STAT3 or Mcl-1, and/or treatment with or without 5-Fu or chloroquine (CQ), we tested cell viability, inhibitory concentration 50% (IC
    MeSH term(s) Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Cell Line, Tumor ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Drug Resistance, Neoplasm ; Apoptosis ; Autophagy/genetics ; Cell Proliferation ; STAT3 Transcription Factor/metabolism
    Chemical Substances Fluorouracil (U3P01618RT) ; STAT3 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2023-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Finite-Time Adaptive Neural Control for a Class of Nonlinear Systems With Asymmetric Time-Varying Full-State Constraints.

    Zhang, Yan / Guo, Jian / Xiang, Zhengrong

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 12, Page(s) 10154–10163

    Abstract: In this article, an adaptive finite-time tracking control scheme is developed for a category of uncertain nonlinear systems with asymmetric time-varying full-state constraints and actuator failures. First, in the control design process, the original ... ...

    Abstract In this article, an adaptive finite-time tracking control scheme is developed for a category of uncertain nonlinear systems with asymmetric time-varying full-state constraints and actuator failures. First, in the control design process, the original constrained nonlinear system is transformed into an equivalent "unconstrained" one by using the uniform barrier function (UBF). Then, by introducing a new coordinate transformation and incorporating it into each recursive step of adaptive finite-time control design based on the backstepping technique, more general state constraints can be handled. In addition, since the nonlinear function in the system is unknown, neural network is employed to approximate it. Considering singularity, the virtual control signal is designed as a piecewise function to guarantee the performance of the system within a finite time. The developed finite-time control method ensures that all signals in the closed-loop system are bounded, and the output tracking error converges to a small neighborhood of the origin. At last, the simulation example illustrates the feasibility and superiority of the presented control method.
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3164948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Toroidal micelles formed in viscoelastic aqueous solutions of a double-tailed surfactant with two quaternary ammonium head groups.

    Lin, Zhengrong / Li, Hongye / Zhang, Jinpeng / Pei, Xiaomei / Chen, Zhao / Cui, Zhenggang / Song, Binglei

    Soft matter

    2024  Volume 20, Issue 4, Page(s) 804–812

    Abstract: Innovation in surfactant structures is an effective way to prepare new soft materials with novel applications. In this study, we synthesized a double-tailed surfactant containing two quaternary ammonium head groups (Di-C12-N2). The Di-C12-N2 solution ... ...

    Abstract Innovation in surfactant structures is an effective way to prepare new soft materials with novel applications. In this study, we synthesized a double-tailed surfactant containing two quaternary ammonium head groups (Di-C12-N2). The Di-C12-N2 solution behavior was investigated by surface tension, fluorescence, rheology, and cryo-TEM methods. Although Di-C12-N2 contained a large double-tailed hydrophobic group, the solubility of Di-C12-N2 was ∼90 mmol L
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d3sm01132a
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