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Article ; Online: Lin

Xu, Haoyu / Tan, Shaojing / Zhao, Yu / Zhang, Lin / Cao, Weiyun / Li, Xing / Tian, Jiayi / Wang, Xiaojing / Li, Xiaoyan / Wang, Fengchao / Cao, Jiani / Zhao, Tongbiao

Cell proliferation

2023 Volume 56, Issue 11, Page(s) e13490

Abstract: ... myeloid repopulating activity are specifically enriched in a Lin ...

Abstract	Despite extensive characterization of the state and function of haematopoietic stem cells (HSCs), the use of transcription factors to define the HSC population is still limited. We show here that the HSC population in mouse bone marrow can be defined by the distinct expression levels of Spi1 and Gata1. By using a double fluorescence knock-in mouse model, PGdKI, in which the expression levels of PU.1 and GATA-1 are indicated by the expression of GFP and mCherry, respectively, we uncover that the HSCs with lymphoid and myeloid repopulating activity are specifically enriched in a Lin
MeSH term(s)	Mice ; Animals ; Cell Lineage ; Hematopoietic Stem Cells/metabolism ; Receptor Protein-Tyrosine Kinases ; Proto-Oncogene Proteins c-kit/metabolism ; Bone Marrow Cells/metabolism ; Mice, Inbred C57BL
Chemical Substances	Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.13490
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Article ; Online: Correction for Lin et al., "Clinical Diagnostic Performance of Droplet Digital PCR for Suspected Bloodstream Infections".

Lin, Ke / Zhao, Yuanhan / Xu, Bin / Yu, Shenglei / Fu, Zhangfan / Zhang, Yi / Wang, Hongyu / Song, Jieyu / Fan, Mingxiang / Zhou, Yang / Ai, Jingwen / Qiu, Chao / Zhang, Haocheng / Zhang, Wenhong

Microbiology spectrum

2023 Volume 12, Issue 1, Page(s) e0153423

Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01534-23
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Article ; Online: Caenorhabditis elegans LIN-24, a homolog of bacterial pore-forming toxin, protects the host from microbial infection.

Zhang, Huijie / Zeng, Weirong / Zhao, Ming-Ming / Wang, Jiali / Wang, Qiquan / Chen, Ting / Zhang, Yuyan / Lee, Wenhui / Chen, Shenghan / Zhang, Yun / Lan, Xinqiang / Xiang, Yang

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2023 Volume 37, Issue 10, Page(s) e23162

Abstract: ... bacteria species, it remains unclear whether their anti-bacterial function is conserved. LIN-24 is an af ... that LIN-24 knockdown reduced the maximum lifespan of worms. RNA-seq analysis identified 323 differentially ... expressed genes (DEGs) post-LIN-24 knockdown that were enriched in "immune response" and "lysosome pathway ...

Abstract	Aerolysin-like pore-forming protein (af-PFP) superfamily members are double-edge swords that assist the bacterial infection but shied bacteria from the host by various mechanisms in some species including the toad Bombina maxima and zebrafish. While members of this family are widely expressed in all kingdoms, especially non-bacteria species, it remains unclear whether their anti-bacterial function is conserved. LIN-24 is an af-PFP that is constitutively expressed throughout the Caenorhabditis elegans lifespan. Here, we observed that LIN-24 knockdown reduced the maximum lifespan of worms. RNA-seq analysis identified 323 differentially expressed genes (DEGs) post-LIN-24 knockdown that were enriched in "immune response" and "lysosome pathway," suggesting a possible role for LIN-24 in resisting microbial infection. In line with this, we found that Pseudomonas aeruginosa 14 (PA14) infection induced LIN-24 expression, and that survival after PA14 infection was significantly reduced by LIN-24 knockdown. In contrast, LIN-24 overexpression (LIN-24-OE) conferred protection against PA14 infection, with worms showing longer survival time and reduced bacterial load. Weighted gene co-expression network analysis of LIN-24-OE worms showed that the highest correlation module was enriched in factors related to immunity and the defense response. Finally, by predicting transcription factors from RNA-seq data and knocking down candidate transcription factors in LIN-24-OE worms, we revealed that LIN-24 may protect worms against bacterial infection by stimulating DAF-16-mediated immune responses. These findings agree with our previous studies showing an anti-microbial role for the amphibian-derived af-PFP complex βγ-CAT, suggesting that af-PFPs may play a conserved role in combatting microbial infections. Further research is needed to determine the roles this protein family plays in other physio-pathological processes, such as metabolism, longevity, and aging.
MeSH term(s)	Animals ; Aging ; Caenorhabditis elegans/genetics ; Longevity ; Caenorhabditis elegans Proteins/genetics
Chemical Substances	perflutren (CK0N3WH0SR) ; Caenorhabditis elegans Proteins
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202300063R
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Article ; Online: Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion.

Martinez, Michael A Q / Mullarkey, Angelina A / Yee, Callista / Zhao, Chris Z / Zhang, Wan / Shen, Kang / Matus, David Q

Biology open

2022 Volume 11, Issue 12

Abstract: ... that EGL-43 represses LIN-12 (Notch) expression to prevent AC proliferation, suggesting that Notch ... signaling has mitogenic effects in the invasive AC. To reexamine the relationship between EGL-43 and LIN-12 ... and lin-12. Auxin-induced degradation of either EGL-43 or LIN-12 resulted in the expected AC ...

Abstract	Development of the Caenorhabditis elegans reproductive tract is orchestrated by the anchor cell (AC). This occurs in part through a cell invasion event that connects the uterine and vulval tissues. Several key transcription factors regulate AC invasion, such as EGL-43, HLH-2, and NHR-67. Specifically, these transcription factors function together to maintain the post-mitotic state of the AC, a requirement for AC invasion. Recently, a mechanistic connection has been made between loss of EGL-43 and AC cell-cycle entry. The current model states that EGL-43 represses LIN-12 (Notch) expression to prevent AC proliferation, suggesting that Notch signaling has mitogenic effects in the invasive AC. To reexamine the relationship between EGL-43 and LIN-12, we first designed and implemented a heterologous co-expression system called AIDHB that combines the auxin-inducible degron (AID) system of plants with a live cell-cycle sensor based on human DNA helicase B (DHB). After validating AIDHB using AID-tagged GFP, we sought to test it by using AID-tagged alleles of egl-43 and lin-12. Auxin-induced degradation of either EGL-43 or LIN-12 resulted in the expected AC phenotypes. Lastly, we seized the opportunity to pair AIDHB with RNAi to co-deplete LIN-12 and EGL-43, respectively, which revealed that LIN-12 is not required for AC proliferation following loss of EGL-43.
MeSH term(s)	Animals ; Female ; Humans ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Indoleacetic Acids/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Vulva/metabolism
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Caenorhabditis elegans Proteins ; HLH-2 protein, C elegans ; Indoleacetic Acids ; Lin-12 protein, C elegans ; Nhr-67 protein, C elegans ; Receptors, Cytoplasmic and Nuclear ; Receptors, Notch ; Transcription Factors ; Egl-43 protein, C elegans
Language	English
Publishing date	2022-12-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.059668
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Article ; Online: Epidemiological characteristics of norovirus infection in Lin’an District of Hangzhou City from 2012 to 2020

SHI Shuiliang / LYU Lei / DUAN Tianxiao / ZHAO Ming / YE Yajun / YUAN Busheng / LI Xuan

Shanghai yufang yixue, Vol 34, Iss 7, Pp 650-

2022 Volume 654

Abstract: ObjectiveTo determine the epidemiological characteristics of norovirus infections in Lin ... reported in Lin’an District of Hangzhou from 2012 to 2020， including 8 outbreaks in kindergartens， 15 ones ... epidemic of norovirus infection in Lin’an District， Hangzhou City is characterized by certain population ...

Abstract	ObjectiveTo determine the epidemiological characteristics of norovirus infections in Lin’an District， Hangzhou City from 2012 to 2020， and provide scientific evidence for improving preventive and control measures.MethodsDescriptive epidemiological methods were used to characterize the epidemic and conduct statistical analysis to determine related factors.ResultsA total of 37 clustered outbreaks of norovirus infection were reported in Lin’an District of Hangzhou from 2012 to 2020， including 8 outbreaks in kindergartens， 15 ones in elementary schools， 8 ones in middle and high schools， 2 ones in universities， and 4 other ones. The total number of cases with norovirus infection was 1 194， with the average attack rate of 3.76%. The incidence of norovirus was higher in winter and spring. It was also higher in urban areas， followed by suburban and mountainous areas neighbored to traffic lines. Moreover， attack rates differed significantly by transmission routes， including mixed contact and aerosol transmission， contact transmission， food-borne transmission， and water-borne transmission （χ2=186.91，P<0.001）. There was significant difference in the incidence among kindergartens， schools， and universities （χ2=980.15，P<0.001）. In the 37 outbreaks， norovirus were mainly classified as GⅡ in the 34 ones （accounting for 91.89%）， and GⅠ in the remaining 3 ones.ConclusionThe epidemic of norovirus infection in Lin’an District， Hangzhou City is characterized by certain population， time， space， transmission routes， and strains. It warrants enhanced health education and promotion， preparedness and response plan， syndromic surveillance， early alerting， school closure， and environmental disinfection for further prevention and control of norovirus infection.
Keywords	norovirus ; epidemiology ; characteristics ; hangzhou ; Medicine ; R
Subject code	900
Language	Chinese
Publishing date	2022-07-01T00:00:00Z
Publisher	Shanghai Preventive Medicine Association
Document type	Article ; Online
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Article ; Online: Notice of Retraction: Lin HX et al. Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial. JAMA Intern Med. 2024;184(3):291-299.

Liu, Zhao

JAMA internal medicine

2024

Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article ; Comment ; Retraction of Publication
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2024.1125
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Article ; Online: Simultaneous determination of multiple constituents of Qi-Lin pill by UPLC-MS/MS: Applications to pharmacokinetics and testicular tissue distribution in rats.

Li, Rui-Xin / Fan, Cai-Lian / Xu, Wan-Yi / Wei, Wen / Wang, Xiao-Xing / Li, Zi-Ting / Zhao, Peng-Cheng / Su, Zhi-Jian / Tang, Xi-Yang / Yao, Zhi-Hong / Dai, Yi

Journal of pharmaceutical and biomedical analysis

2022 Volume 223, Page(s) 115157

Abstract: Qi-Lin pill (QLP) is an effective traditional Chinese medicine prescription (TCMP) that has been ...

Abstract	Qi-Lin pill (QLP) is an effective traditional Chinese medicine prescription (TCMP) that has been used for the treatment of the oligoasthenozoospermia in China. Recently, some articles described the pharmacological effects of QLP and multiple ingredients in QLP contribute to its effects. However, the pharmacokinetic and target tissue distribution data of QLP are still unknown. In the present study, according to the Bioanalytical Method Validation Guidance of FDA, a sensitive and selective UPLC-MS/MS method was developed and validated for simultaneous determination of multiple constituents in rat plasma and testicular tissue, including morusimic acid A, codonopyrridium B, magnoflorine, emodin, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG), ecliptasaponin A, paeoniflorin, albiflorin, gallic acid, danshensu, salvianolic acid A, catechin, isosinensetin, nobiletin, formononetin, calycosin, icariside II, icariin and epimedin C. For 19 analytes, the LLOQs reached 0.01-4 ng/mL. And all calibration curves showed favorable linearity (r ≥ 0.9903) in linear ranges. The intra-day and inter-day precision (relative standard deviation) for all analytes was less than 14.92 %, and the accuracies (as relative error) were in the range of - 6.44 % to 6.22 %. Extraction recoveries and matrix effects of analytes and IS were acceptable. All analytes were stable during the assay and storage in plasma samples. The method was successfully applied for the pharmacokinetics and testis distribution of multiple chemical constituents in QLP after a single oral dose. As a result, high exposure of danshensu, gallic acid, paeoniflorin and albiflorin were observed in rat plasma and testicular tissue. Among the flavonoids, isosinensetin and nobiletin had high exposure in testicular tissue. Moreover, alleviation of progesterone reduction was evaluated in H
MeSH term(s)	Animals ; Male ; Rats ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid ; Drugs, Chinese Herbal/pharmacokinetics ; Gallic Acid ; Hydrogen Peroxide ; Reproducibility of Results ; Tandem Mass Spectrometry/methods ; Testis ; Tissue Distribution
Chemical Substances	3,4-dihydroxyphenyllactic acid (4GF33A5PAJ) ; albiflorin (39011-90-0) ; Drugs, Chinese Herbal ; Gallic Acid (632XD903SP) ; Hydrogen Peroxide (BBX060AN9V) ; peoniflorin (21AIQ4EV64)
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2022.115157
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Article ; Online: Corrigendum for Li D, Lin Y, Huang Y, et al (2018) https://doi.org/10.1002/pd.5329.

Li, Duan / Lin, Yunting / Huang, Yonglan / Zhang, Wen / Jiang, Minyan / Li, Xiuzhen / Zhao, Xiaoyuan / Sheng, Huiying / Yin, Xi / Su, Xueying / Shao, Yongxian / Liu, Zongcai / Li, Dongzhi / Li, Fatao / Liao, Can / Liu, Li

Prenatal diagnosis

2019 Volume 39, Issue 1, Page(s) 57

Language	English
Publishing date	2019-01-10
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	82031-3
ISSN	1097-0223 ; 0197-3851
ISSN (online)	1097-0223
ISSN	0197-3851
DOI	10.1002/pd.5387
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Article ; Online: Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion

Michael A. Q. Martinez / Angelina A. Mullarkey / Callista Yee / Chris Z. Zhao / Wan Zhang / Kang Shen / David Q. Matus

Biology Open, Vol 11, Iss

2022 Volume 12

Keywords	c. elegans ; anchor cell invasion ; egl-43 ; lin-12 ; aid ; dhb ; Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	The Company of Biologists
Document type	Article ; Online
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Article ; Online: Investigation of Ramsey spectroscopy in a lin-par-lin Ramsey coherent population trapping clock with dispersion detection.

Sun, X L / Zhang, J W / Cheng, P F / Xu, C / Zhao, L / Wang, L J

Optics express

2016 Volume 24, Issue 5, Page(s) 4532–4541

Abstract: We demonstrate that the lin-par-lin Ramsey coherent population trapping ...

Abstract	We demonstrate that the lin-par-lin Ramsey coherent population trapping
Language	English
Publishing date	2016-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.24.004532
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