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  1. Article ; Online: Extrinsic hydrophobicity-controlled silver nanoparticles as efficient and stable catalysts for CO

    Ko, Young-Jin / Lim, Chulwan / Jin, Junyoung / Kim, Min Gyu / Lee, Ji Yeong / Seong, Tae-Yeon / Lee, Kwan-Young / Min, Byoung Koun / Choi, Jae-Young / Noh, Taegeun / Hwang, Gyu Weon / Lee, Woong Hee / Oh, Hyung-Suk

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3356

    Abstract: To realize economically feasible electrochemical ... ...

    Abstract To realize economically feasible electrochemical CO
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47490-3
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  2. Article: An Aqueous Process for Preparing Flexible Transparent Electrodes Using Non-Oxidized Graphene/Single-Walled Carbon Nanotube Hybrid Solution.

    Oh, Min Jae / Son, Gi-Cheol / Kim, Minkook / Jeon, Junyoung / Kim, Yong Hyun / Son, Myungwoo

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 15

    Abstract: In this study, we prepared flexible and transparent hybrid electrodes based on an aqueous solution of non-oxidized graphene and single-walled carbon nanotubes. We used a simple halogen intercalation method to obtain high-quality graphene flakes without a ...

    Abstract In this study, we prepared flexible and transparent hybrid electrodes based on an aqueous solution of non-oxidized graphene and single-walled carbon nanotubes. We used a simple halogen intercalation method to obtain high-quality graphene flakes without a redox process and prepared hybrid films using aqueous solutions of graphene, single-walled carbon nanotubes, and sodium dodecyl sulfate surfactant. The hybrid films showed excellent electrode properties, such as an optical transmittance of ≥90%, a sheet resistance of ~3.5 kΩ/sq., a flexibility of up to
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13152249
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  3. Article ; Online: Postoperative Computed Tomographic Assessment of the Complete Resection of an Infiltrative Lipoma Compressing the Spinal Cord in a Dog.

    Kim, Junyoung / Kim, Kitae / Oh, Dayoung / Myung, Hyunwook / Choi, Jihye / Yoon, Junghee

    Veterinary sciences

    2023  Volume 10, Issue 10

    Abstract: Infiltrative lipomas, which are locally invasive tumors composed of well-differentiated adipocytes, are histologically identical to lipomas but have a tendency to infiltrate adjacent muscle and fibrous tissue without metastasis, such as muscle; ... ...

    Abstract Infiltrative lipomas, which are locally invasive tumors composed of well-differentiated adipocytes, are histologically identical to lipomas but have a tendency to infiltrate adjacent muscle and fibrous tissue without metastasis, such as muscle; connective tissue; bone; and, in rare cases, peripheral nerves and the spinal cord. They differ from liposarcomas yet also exhibit neoplastic cell infiltration and often recur despite surgical removal. A 10-year-old spayed Maltese female dog presented with hindlimb paresis and back pain for two months. Computed tomography and magnetic resonance imaging revealed an extensive fatty mass impinging on the vertebral canal, compressing the spinal cord, and extending into the surrounding muscle layers and thoracic cavity. The mass was surgically removed, and subsequent postoperative computed tomography confirmed complete removal of the mass using Vitrea
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10100593
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  4. Article: Evaluation of the pulmonary vein ostia during the cardiac cycle using electrocardiography-gated cardiac computed tomography in cats.

    Kim, Junyoung / Kim, Dae-Hyun / Kim, Kitae / Oh, Dayoung / Choi, Jihye / Yoon, Junghee

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 1013963

    Abstract: Several studies in humans have provided detailed descriptions of the anatomy of the pulmonary veins (PVs) and their ostia for the implementation of thoracic interventions, such as radiofrequency ablation, for patients with atrial fibrillation. These ... ...

    Abstract Several studies in humans have provided detailed descriptions of the anatomy of the pulmonary veins (PVs) and their ostia for the implementation of thoracic interventions, such as radiofrequency ablation, for patients with atrial fibrillation. These studies have shown that electrocardiography (ECG)-gated multidetector computed tomography (MDCT) can evaluate the dimensional variations in the PVs or ostium according to the cardiac cycle. However, few studies have examined the PVs or ostia using MDCT in veterinary medicine. Therefore, this study investigated the variation in the diameter of the PV ostium in cats during the cardiac cycle using ECG-gated MDCT and determined the correlation between the size of the heart or left atrium (LA) and diameter of the PV ostium. This study included six cats, including five normal animals and one cat with hypertrophic cardiomyopathy. The PVs were found to drain into the LA
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.1013963
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  5. Book ; Online: Discovering Hierarchical Achievements in Reinforcement Learning via Contrastive Learning

    Moon, Seungyong / Yeom, Junyoung / Park, Bumsoo / Song, Hyun Oh

    2023  

    Abstract: Discovering achievements with a hierarchical structure in procedurally generated environments presents a significant challenge. This requires an agent to possess a broad range of abilities, including generalization and long-term reasoning. Many prior ... ...

    Abstract Discovering achievements with a hierarchical structure in procedurally generated environments presents a significant challenge. This requires an agent to possess a broad range of abilities, including generalization and long-term reasoning. Many prior methods have been built upon model-based or hierarchical approaches, with the belief that an explicit module for long-term planning would be advantageous for learning hierarchical dependencies. However, these methods demand an excessive number of environment interactions or large model sizes, limiting their practicality. In this work, we demonstrate that proximal policy optimization (PPO), a simple yet versatile model-free algorithm, outperforms previous methods when optimized with recent implementation practices. Moreover, we find that the PPO agent can predict the next achievement to be unlocked to some extent, albeit with limited confidence. Based on this observation, we introduce a novel contrastive learning method, called achievement distillation, which strengthens the agent's ability to predict the next achievement. Our method exhibits a strong capacity for discovering hierarchical achievements and shows state-of-the-art performance on the challenging Crafter environment in a sample-efficient manner while utilizing fewer model parameters.

    Comment: Accepted at NeurIPS 2023
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2023-07-07
    Publishing country us
    Document type Book ; Online
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  6. Book ; Online: Compressed Context Memory For Online Language Model Interaction

    Kim, Jang-Hyun / Yeom, Junyoung / Yun, Sangdoo / Song, Hyun Oh

    2023  

    Abstract: This paper presents a novel context compression method for Transformer language models in online scenarios such as ChatGPT, where the context continually expands. As the context lengthens, the attention process requires more memory and computational ... ...

    Abstract This paper presents a novel context compression method for Transformer language models in online scenarios such as ChatGPT, where the context continually expands. As the context lengthens, the attention process requires more memory and computational resources, which in turn reduces the throughput of the language model. To this end, we propose a compressed context memory system that continually compresses the growing context into a compact memory space. The compression process simply involves integrating a lightweight conditional LoRA into the language model's forward pass during inference. Based on the compressed context memory, the language model can perform inference with reduced memory and attention operations. Through evaluations on conversation, personalization, and multi-task learning, we demonstrate that our approach achieves the performance level of a full context model with $5\times$ smaller context memory space. Codes are available at https://github.com/snu-mllab/context-memory.
    Keywords Computer Science - Machine Learning ; Computer Science - Computation and Language
    Subject code 005
    Publishing date 2023-12-06
    Publishing country us
    Document type Book ; Online
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  7. Article ; Online: SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death.

    Oh, Junyoung / Cho, Woo-Hyun / Barcelon, Ellane / Kim, Kwang Hwan / Hong, Jinpyo / Lee, Sung Joong

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5496

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied by chronic neurological sequelae such as cognitive decline and mood disorder, but the underlying mechanisms have not yet been elucidated. We explored the possibility ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied by chronic neurological sequelae such as cognitive decline and mood disorder, but the underlying mechanisms have not yet been elucidated. We explored the possibility that the brain-infiltrating SARS-CoV-2 spike protein contributes to the development of neurological symptoms observed in COVID-19 patients in this study. Our behavioral study showed that administration of SARS-CoV-2 spike protein S1 subunit (S1 protein) to mouse hippocampus induced cognitive deficit and anxiety-like behavior in vivo. These neurological symptoms were accompanied by neuronal cell death in the dorsal and ventral hippocampus as well as glial cell activation. Interestingly, the S1 protein did not directly induce hippocampal cell death in vitro. Rather, it exerted neurotoxicity via glial cell activation, partially through interleukin-1β induction. In conclusion, our data suggest a novel pathogenic mechanism for the COVID-19-associated neurological symptoms that involves glia activation and non-cell autonomous hippocampal neuronal death by the brain-infiltrating S1 protein.
    MeSH term(s) Animals ; Antibodies, Viral/metabolism ; Anxiety ; COVID-19 ; Cell Death ; Cognition ; Cognitive Dysfunction/etiology ; Hippocampus/metabolism ; Humans ; Membrane Glycoproteins/metabolism ; Mice ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Envelope Proteins/metabolism
    Chemical Substances Antibodies, Viral ; Membrane Glycoproteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-09410-7
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  8. Article: Non-electrocardiography- and electrocardiography-gated computed tomography angiography for the evaluation of feline coronary arteries.

    Kim, Junyoung / Kim, Dae-Hyun / Kim, Kitae / Oh, Dayoung / Yoon, Junghee

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 952412

    Abstract: Objectives: Few studies have directly compared the clinical feasibility of electrocardiography-gated and non-electrocardiography-gated multidetector computed tomography for evaluating coronary arteries in veterinary medicine. We aimed to characterize ... ...

    Abstract Objectives: Few studies have directly compared the clinical feasibility of electrocardiography-gated and non-electrocardiography-gated multidetector computed tomography for evaluating coronary arteries in veterinary medicine. We aimed to characterize and visualize feline coronary arteries using these two imaging modalities. We hypothesed that ECG-gated MDCT is superior to or advantageous to the non-ECG gated.
    Methods: This prospective, controlled, comparative pilot study examined six client-owned cats (five clinically normal and one with hypertrophic cardiomyopathy) using non-electrocardiography-gated and retrospective electrocardiography-gated scans. Optimal non-electrocardiography scan timing or electrocardiography-gated R-R reconstruction interval for coronary artery visualization was determined. The degree of opacification and sharpness of proximal coronary branches was subjectively graded; coronary dominance, left coronary artery branching types, and the diameter and length of coronary artery branches were also assessed.
    Results: Non-electrocardiography-gated images provided the least information on the bilateral coronary artery ostium and proximal segments, while electrocardiography-gated images clarified the detailed course of the main coronary branches at diastole in all cats. The degree of opacification and sharpness of the coronary arteries was subjectively evaluated as good/excellent in all cats. Coronary dominance (left: four; right: two) and left coronary artery branching types (three different patterns, two additional tortuous branches) varied. Body weight and sex were not significantly associated with coronary artery length or diameter. Vertebral heart score positively correlated with the right coronary artery and negatively correlated with the left main coronary artery.
    Clinical significance: Electrocardiography-gated multidetector computed tomography provides images with adequate resolution to identify the anatomy of feline coronary arteries. Detailed morphological knowledge of feline coronary vessels will enable novel diagnostic and therapeutic methods in veterinary medicine.
    Language English
    Publishing date 2022-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.952412
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  9. Article ; Online: Non-electrocardiography- and electrocardiography-gated computed tomography angiography for the evaluation of feline coronary arteries

    Junyoung Kim / Dae-Hyun Kim / Kitae Kim / Dayoung Oh / Junghee Yoon

    Frontiers in Veterinary Science, Vol

    2022  Volume 9

    Abstract: ObjectivesFew studies have directly compared the clinical feasibility of electrocardiography-gated and non-electrocardiography-gated multidetector computed tomography for evaluating coronary arteries in veterinary medicine. We aimed to characterize and ... ...

    Abstract ObjectivesFew studies have directly compared the clinical feasibility of electrocardiography-gated and non-electrocardiography-gated multidetector computed tomography for evaluating coronary arteries in veterinary medicine. We aimed to characterize and visualize feline coronary arteries using these two imaging modalities. We hypothesed that ECG-gated MDCT is superior to or advantageous to the non-ECG gated.MethodsThis prospective, controlled, comparative pilot study examined six client-owned cats (five clinically normal and one with hypertrophic cardiomyopathy) using non-electrocardiography-gated and retrospective electrocardiography-gated scans. Optimal non-electrocardiography scan timing or electrocardiography-gated R-R reconstruction interval for coronary artery visualization was determined. The degree of opacification and sharpness of proximal coronary branches was subjectively graded; coronary dominance, left coronary artery branching types, and the diameter and length of coronary artery branches were also assessed.ResultsNon-electrocardiography-gated images provided the least information on the bilateral coronary artery ostium and proximal segments, while electrocardiography-gated images clarified the detailed course of the main coronary branches at diastole in all cats. The degree of opacification and sharpness of the coronary arteries was subjectively evaluated as good/excellent in all cats. Coronary dominance (left: four; right: two) and left coronary artery branching types (three different patterns, two additional tortuous branches) varied. Body weight and sex were not significantly associated with coronary artery length or diameter. Vertebral heart score positively correlated with the right coronary artery and negatively correlated with the left main coronary artery.Clinical significanceElectrocardiography-gated multidetector computed tomography provides images with adequate resolution to identify the anatomy of feline coronary arteries. Detailed morphological knowledge of feline coronary vessels will ...
    Keywords cardiomyopathy ; circumflex ; paraconal branch ; septal branch ; vertebral heart score ; Veterinary medicine ; SF600-1100
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  10. Article ; Online: INHAT subunit SET/TAF-Iβ regulates PRC1-independent H2AK119 mono-ubiquitination via E3 ligase MIB1 in colon cancer.

    Park, Junyoung / Kim, Ji-Young / Park, Jin Woo / Kang, Joo Young / Oh, Hyein / Hahm, Ja Young / Chae, Yun-Cheol / Chakravarti, Debabrata / Seo, Sang Beom

    NAR cancer

    2023  Volume 5, Issue 3, Page(s) zcad050

    Abstract: SET/TAF-Iβ, a subunit of the inhibitor of acetyltransferases (INHAT) complex, exhibits transcriptional repression activity by inhibiting histone acetylation. We find that SET/TAF-Iβ regulates mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), ... ...

    Abstract SET/TAF-Iβ, a subunit of the inhibitor of acetyltransferases (INHAT) complex, exhibits transcriptional repression activity by inhibiting histone acetylation. We find that SET/TAF-Iβ regulates mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), which is involved in polycomb-mediated transcriptional repression, in HCT116 cells. In this report, we demonstrate that SET/TAF-Iβ acts as an E2 ubiquitin-conjugating enzyme for PRC1-independent H2AK119ub. Furthermore, we identify that MIB1 is the E3 ligase partner for SET/TAF-Iβ using LC-MS/MS and
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ISSN 2632-8674
    ISSN (online) 2632-8674
    DOI 10.1093/narcan/zcad050
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