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Article: Effective evaluation of HGcnMLP method for markerless 3D pose estimation of musculoskeletal diseases patients based on smartphone monocular video.

Hu, Rui / Diao, Yanan / Wang, Yingchi / Li, Gaoqiang / He, Rong / Ning, Yunkun / Lou, Nan / Li, Guanglin / Zhao, Guoru

Frontiers in bioengineering and biotechnology

2024 Volume 11, Page(s) 1335251

Abstract: Markerless pose estimation based on computer vision provides a simpler and cheaper alternative to human motion capture, with great potential for clinical diagnosis and remote rehabilitation assessment. Currently, the markerless 3D pose estimation is ... ...

Abstract	Markerless pose estimation based on computer vision provides a simpler and cheaper alternative to human motion capture, with great potential for clinical diagnosis and remote rehabilitation assessment. Currently, the markerless 3D pose estimation is mainly based on multi-view technology, while the more promising single-view technology has defects such as low accuracy and reliability, which seriously limits clinical application. This study proposes a high-resolution graph convolutional multilayer perception (HGcnMLP) human 3D pose estimation framework for smartphone monocular videos and estimates 15 healthy adults and 12 patients with musculoskeletal disorders (sarcopenia and osteoarthritis) gait spatiotemporal, knee angle, and center-of-mass (COM) velocity parameters, etc., and compared with the VICON gold standard system. The results show that most of the calculated parameters have excellent reliability (VICON, ICC (2, k): 0.853-0.982; Phone, ICC (2, k): 0.839-0.975) and validity (Pearson r: 0.808-0.978, p
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1335251
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Article ; Online: Adding immune checkpoint blockade to neoadjuvant chemoradiation in locally advanced rectal cancer.

Pang, Kai / Yang, Yun / Zhao, Pengfei / Wu, Guocong / Li, Jun / Gao, Jiale / Yao, Hongwei / Yang, Yingchi / Zhang, Zhongtao

The British journal of surgery

2022 Volume 109, Issue 11, Page(s) 1178–1179

MeSH term(s)	Humans ; Immune Checkpoint Inhibitors ; Neoadjuvant Therapy ; Rectal Neoplasms/therapy ; Rectum
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znac298
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Article ; Online: Extraction and Purification, Structural Characterization and Biological Activity of a Polysaccharide, PRP-1, from Plumeria rubra.

Yu, Yongshi / Xia, Yingchi / Sun, Ningyun / Tian, Yamei / Chen, Xin / Fan, Lixia / Zhao, Chaochao / Xia, Chenglai / Yang, Anping / Liu, Hui

Chemistry & biodiversity

2023 Volume 20, Issue 8, Page(s) e202300866

Abstract: Polysaccharides derived from the flowers of Plumeria rubra (PRP) have shown a variety of beneficial effects on improving human health. However, the structural features and bioactivities of PRP remain unclear. A novel neutral polysaccharide (named PRP-1) ... ...

Abstract	Polysaccharides derived from the flowers of Plumeria rubra (PRP) have shown a variety of beneficial effects on improving human health. However, the structural features and bioactivities of PRP remain unclear. A novel neutral polysaccharide (named PRP-1) with a molecular weight of 23 kDa was extracted and purified from the flowers of P. rubra. PRP-1 was consisted of arabinose, galactose, glucose, xylose and mannose, with a molar ratio of 1.49: 27.89: 50.24: 13.02: 7.36. The structural characterization based on the methylation and 1D/2D nuclear magnetic resonance analyses indicated that PRP-1 was composed of →4)-Glcp-(1→, →4,6)-Glcp-(1→, →4)-Galp-(1→, →2)-Galp-(1→, t-Gal(p), →4)-Manp-(1→, →4,6)-Manp-(1→, t-Man(p), →2)-Xylp-(1→, and t-Xyl(p). Scanning electron microscopy revealed that PRP-1 possess a compact three-dimensional curling network structure in the terms of morphology. PRP-1 exhibited anti-inflammatory activity, which have moderate inhibitory effects on TNF-α and IL-6 production in lipopolysaccharide (LPS)-induced RAW 264.7 cells. In addition, PRP-1 showed ABTS, OH radicals scavenging and the Fe
MeSH term(s)	Humans ; Polysaccharides/chemistry ; Glucose ; Galactose ; Molecular Weight ; Apocynaceae ; Platelet-Rich Plasma
Chemical Substances	Polysaccharides ; Glucose (IY9XDZ35W2) ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300866
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Article ; Online: Publisher Correction: SARS-CoV-2 spike protein interacts with and activates TLR4.

Zhao, Yingchi / Kuang, Ming / Li, Junhong / Zhu, Ling / Jia, Zijing / Guo, Xuefei / Hu, Yaling / Kong, Jun / Yin, Hang / Wang, Xiangxi / You, Fuping

Cell research

2021 Volume 31, Issue 7, Page(s) 825

Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Published Erratum
ZDB-ID	1319303-x
ISSN	1748-7838 ; 1001-0602
ISSN (online)	1748-7838
ISSN	1001-0602
DOI	10.1038/s41422-021-00501-0
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Article ; Online: OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.

Zhang, Zeming / Wang, Dandan / Wang, Peiyan / Zhao, Yingchi / You, Fuping

Journal of immunology (Baltimore, Md. : 1950)

2020 Volume 204, Issue 7, Page(s) 1904–1918

Abstract: IFN regulatory factor 3 (IRF3) is critical for the transcription of type I IFNs in defensing virus and promoting inflammatory responses. Although several kinds of posttranslational modifications have been identified to modulate the activity of IRF3, ... ...

Abstract	IFN regulatory factor 3 (IRF3) is critical for the transcription of type I IFNs in defensing virus and promoting inflammatory responses. Although several kinds of posttranslational modifications have been identified to modulate the activity of IRF3, whether atypical ubiquitination participates in the function regulation, especially the DNA binding capacity of IRF3, is unknown. In this study, we found that the ovarian tumor domain containing deubiquitinase OTUD1 deubiquitinated IRF3 and attenuated its function. An atypical ubiquitination, K6-linked ubiquitination, was essential for the DNA binding capacity of IRF3 and subsequent induction of target genes. Mechanistically, OTUD1 cleaves the viral infection-induced K6-linked ubiquitination of IRF3, resulting in the disassociation of IRF3 from the promoter region of target genes, without affecting the protein stability, dimerization, and nuclear translocation of IRF3 after a viral infection.
MeSH term(s)	Animals ; Cell Line ; HEK293 Cells ; Herpes Simplex/metabolism ; Herpesvirus 1, Human/pathogenicity ; Humans ; Immunity, Innate/physiology ; Interferon Regulatory Factor-3/metabolism ; Interferon Type I/metabolism ; Mice ; Mice, Inbred C57BL ; Promoter Regions, Genetic/physiology ; Protein Stability ; Signal Transduction/physiology ; Ubiquitin-Specific Proteases/metabolism ; Ubiquitination/physiology
Chemical Substances	IRF3 protein, human ; Interferon Regulatory Factor-3 ; Interferon Type I ; OTUD1 protein, human (EC 3.4.19.12) ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2020-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1900305
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Article ; Online: XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.

Kuang, Ming / Zhao, Yingchi / Yu, Haitao / Li, Siji / Liu, Tianyi / Chen, Luoying / Chen, Jingxuan / Luo, Yujie / Guo, Xuefei / Wei, Xuemei / Li, Yunfei / Zhang, Zeming / Wang, Dandan / You, Fuping

Science advances

2023 Volume 9, Issue 33, Page(s) eadg5211

Abstract: A rapid induction of antiviral genes is critical for eliminating viruses, which requires activated transcription factors and opened chromatins to initiate transcription. However, it remains elusive how the accessibility of specific chromatin is regulated ...

Abstract	A rapid induction of antiviral genes is critical for eliminating viruses, which requires activated transcription factors and opened chromatins to initiate transcription. However, it remains elusive how the accessibility of specific chromatin is regulated during infection. Here, we found that XAF1 functioned as an epigenetic regulator that liberated repressed chromatin after infection. Upon RNA virus infection, MAVS recruited XAF1 and TBK1. TBK1 phosphorylated XAF1 at serine-252 and promoted its nuclear translocation. XAF1 then interacted with TRIM28 with the guidance of IRF1 to the specific locus of antiviral genes. XAF1 de-SUMOylated TRIM28 through its PHD domain, which led to increased accessibility of the chromatin and robust induction of antiviral genes. XAF1-deficient mice were susceptible to RNA virus due to impaired induction of antiviral genes. Together, XAF1 acts as an epigenetic regulator that promotes the opening of chromatin and activation of antiviral immunity by targeting TRIM28 during infection.
MeSH term(s)	Animals ; Mice ; Adaptor Proteins, Signal Transducing/genetics ; Apoptosis Regulatory Proteins ; Chromatin/genetics ; Epigenomics ; Immunity ; RNA ; RNA Virus Infections/immunology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Apoptosis Regulatory Proteins ; Chromatin ; RNA (63231-63-0) ; XAF1 protein, mouse
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adg5211
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Article ; Online: Cytosolic and nuclear recognition of virus and viral evasion.

Li, Siji / Cao, Lili / Zhang, Zeming / Kuang, Ming / Chen, Luoying / Zhao, Yingchi / Luo, Yujie / Yin, Zhinan / You, Fuping

Molecular biomedicine

2021 Volume 2, Issue 1, Page(s) 30

Abstract: The innate immune system is the first line of host defense, which responds rapidly to viral infection. Innate recognition of viruses is mediated by a set of pattern recognition receptors (PRRs) that sense viral genomic nucleic acids and/or replication ... ...

Abstract	The innate immune system is the first line of host defense, which responds rapidly to viral infection. Innate recognition of viruses is mediated by a set of pattern recognition receptors (PRRs) that sense viral genomic nucleic acids and/or replication intermediates. PRRs are mainly localized either to the endosomes, the plasma membrane or the cytoplasm. Recent evidence suggested that several proteins located in the nucleus could also act as viral sensors. In turn, these important elements are becoming the target for most viruses to evade host immune surveillance. In this review, we focus on the recent progress in the study of viral recognition and evasion.
Language	English
Publishing date	2021-10-10
Publishing country	Singapore
Document type	Journal Article ; Review
ISSN	2662-8651
ISSN (online)	2662-8651
DOI	10.1186/s43556-021-00046-z
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Article ; Online: Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia.

Huang, Xin / Li, Yizhen / Zhang, Jingliao / Yan, Lei / Zhao, Huanbin / Ding, Liang / Bhatara, Sheetal / Yang, Xu / Yoshimura, Satoshi / Yang, Wenjian / Karol, Seth E / Inaba, Hiroto / Mullighan, Charles / Litzow, Mark / Zhu, Xiaofan / Zhang, Yingchi / Stock, Wendy / Jain, Nitin / Jabbour, Elias /

Kornblau, Steven M / Konopleva, Marina / Pui, Ching-Hon / Paietta, Elisabeth / Evans, William / Yu, Jiyang / Yang, Jun J

Cancer cell

2024 Volume 42, Issue 4, Page(s) 552–567.e6

Abstract: Leukemia can arise at various stages of the hematopoietic differentiation hierarchy, but the impact of developmental arrest on drug sensitivity is unclear. Applying network-based analyses to single-cell transcriptomes of human B cells, we define genome- ... ...

Abstract	Leukemia can arise at various stages of the hematopoietic differentiation hierarchy, but the impact of developmental arrest on drug sensitivity is unclear. Applying network-based analyses to single-cell transcriptomes of human B cells, we define genome-wide signaling circuitry for each B cell differentiation stage. Using this reference, we comprehensively map the developmental states of B cell acute lymphoblastic leukemia (B-ALL), revealing its strong correlation with sensitivity to asparaginase, a commonly used chemotherapeutic agent. Single-cell multi-omics analyses of primary B-ALL blasts reveal marked intra-leukemia heterogeneity in asparaginase response: resistance is linked to pre-pro-B-like cells, with sensitivity associated with the pro-B-like population. By targeting BCL2, a driver within the pre-pro-B-like cell signaling network, we find that venetoclax significantly potentiates asparaginase efficacy in vitro and in vivo. These findings demonstrate a single-cell systems pharmacology framework to predict effective combination therapies based on intra-leukemia heterogeneity in developmental state, with potentially broad applications beyond B-ALL.
MeSH term(s)	Humans ; Asparaginase/pharmacology ; Network Pharmacology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Signal Transduction ; Leukemia/drug therapy
Chemical Substances	Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2024.03.003
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Article ; Online: Short- and long-term outcomes of laparoscopic versus open selective lateral pelvic lymph node dissection for locally advanced middle-low rectal cancer: Results of a multicentre lateral node study in China.

Tang, Jianqiang / Zhou, Sicheng / Zhao, Wei / Lou, Zheng / Liang, Jianwei / Feng, Bo / Yang, Yingchi / Wang, Xin / Liu, Qian

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2022 Volume 24, Issue 11, Page(s) 1325–1334

Abstract: Aim: Lateral pelvic lymph node dissection (LPND) is a technically challenging procedure, and the safety and feasibility of laparoscopic LPND remains undetermined. Here, we compared the short- and long-term survival outcomes of laparoscopic LPND with ... ...

Abstract	Aim: Lateral pelvic lymph node dissection (LPND) is a technically challenging procedure, and the safety and feasibility of laparoscopic LPND remains undetermined. Here, we compared the short- and long-term survival outcomes of laparoscopic LPND with those of open LPND. Methods: From January 2012 to December 2019, locally advanced middle-low rectal cancer patients with clinical evidence of lateral pelvic lymph node metastasis (LPNM) who underwent total mesorectal excision with LPND at three institutions were included. Propensity score matching was used to minimize selection bias. The short-term and oncological outcomes of open and laparoscopic LPND were compared. Results: Overall, 384 patients were enrolled into the study including 277 and 107 patients who underwent laparoscopic and open LPND, respectively. After matching, patients were stratified into laparoscopic (n = 100) and open (n = 100) LPND groups. Patients in the laparoscopic LPND group had a shorter operation time (255 vs. 300 min, p = 0.001), less intraoperative blood loss (50 vs. 300 ml, p < 0.001), lower incidence of postoperative complications (32.0% vs. 15.0%, p = 0.005), shorter postoperative hospital stay (8 vs. 14 days, p < 0.001), and excision of more lateral pelvic lymph nodes (9 vs. 7, p = 0.025) than those in the open LPND group. The 3-year overall survival (p = 0.581) and 3-year disease-free survival (p = 0.745) rates were similar between the groups, and LPNM was an independent predictor of survival. Conclusion: Laparoscopic LPND is technically safe and feasible with favourable short-term results and similar oncological outcomes as open surgery in selected patients.
MeSH term(s)	Humans ; Retrospective Studies ; Lymph Node Excision/methods ; Rectal Neoplasms/pathology ; Laparoscopy/methods ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Neoplasms, Second Primary/pathology ; Treatment Outcome
Language	English
Publishing date	2022-07-01
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16223
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Article ; Online: BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis.

Feng, Zhewen / Yang, Xiaobao / Tian, Mingwei / Zeng, Na / Bai, Zhigang / Deng, Wei / Zhao, Yanyan / Guo, Jianru / Yang, Yingchi / Zhang, Zhongtao / Yang, Yun

BMC cancer

2023 Volume 23, Issue 1, Page(s) 807

Abstract: Background: Breast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers. However, the role of BRCA is unclear in colorectal cancer; the results regarding the association ... ...

Abstract	Background: Breast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers. However, the role of BRCA is unclear in colorectal cancer; the results regarding the association between BRCA gene mutations and colorectal cancer risk are inconsistent and even controversial. This study aimed to investigate whether BRCA1 and BRCA2 gene mutations are associated with colorectal cancer risk. Methods: In this systematic review, we searched PubMed/MEDLINE, Embase and Cochrane Library databases, adhering to PRISMA guidelines. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Unadjusted odds ratios (ORs) were used to estimate the probability of Breast Cancer Type 1 Susceptibility gene (BRCA1) and Breast Cancer Type 2 Susceptibility gene (BRCA2) mutations in colorectal cancer patients. The associations were evaluated using fixed effect models. Results: Fourteen studies were included in the systematic review. Twelve studies, including seven case-control and five cohort studies, were included in the meta-analysis. A significant increase in the frequency of BRCA1 and BRCA2 mutations was observed in patients with colorectal cancer [OR = 1.34, 95% confidence interval (CI) = 1.02-1.76, P = 0.04]. In subgroup analysis, colorectal cancer patients had an increased odds of BRCA1 (OR = 1.48, 95% CI = 1.10-2.01, P = 0.01) and BRCA2 (OR = 1.56, 95% CI = 1.06-2.30, P = 0.02) mutations. Conclusions: BRCA genes are one of the genes that may increase the risk of developing colorectal cancer. Thus, BRCA genes could be potential candidates that may be included in the colorectal cancer genetic testing panel.
MeSH term(s)	Male ; Humans ; Genes, Tumor Suppressor ; Genetic Testing ; Mutation ; Colorectal Neoplasms/genetics ; Breast Neoplasms
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11328-w
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