LIVIVO - Search results -

Search results

Result 1 - 10 of total 28

Search options

Article ; Online: IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs.

Shemesh, Maya / Lochte, Sara / Piehler, Jacob / Schreiber, Gideon

2021 Volume 14, Issue 710, Page(s) eabe4627

Abstract: Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 and JAK1, respectively. Ligand binding results in the cross-phosphorylation of ... ...

Abstract	Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 and JAK1, respectively. Ligand binding results in the cross-phosphorylation of TYK2 and JAK1, which then phosphorylate tyrosine residues in the ICDs of the receptor subunits and members of the STAT family of transcription factors. The phosphorylated STATs migrate to the nucleus and drive transcription. We analyzed receptor mutants in knockout cells to study the functional importance of various regions of the receptor ICDs. For IFNAR1, only the TYK2 binding site in the ICD was required for signaling. In contrast, successive truncations of the ICD of IFNAR2 proportionally decreased constitutive STAT binding, STAT phosphorylation, and target gene activation. These findings fit a model in which nonsuccessive stretches along the ICD interact with STATs. Tyrosine residues in the IFNAR1 ICD were not required for signaling, and single tyrosine mutations in the IFNAR2 ICD did not affect signal activation. However, simultaneous mutation of all the tyrosine residues in IFNAR2-ICD reduced STAT phosphorylation, STAT-mediated transcriptional activation, and antiviral activity but not constitutive STAT2 binding. We suggest that tyrosine phosphorylation on IFNAR2-ICD drives the dissociation of phosphorylated STATs, thus maintaining high signaling flux.
MeSH term(s)	HeLa Cells ; Humans ; Immunity, Innate ; Interferon Type I ; Janus Kinases ; Receptor, Interferon alpha-beta/genetics ; STAT Transcription Factors ; Signal Transduction
Chemical Substances	IFNAR1 protein, human ; IFNAR2 protein, human ; Interferon Type I ; STAT Transcription Factors ; Receptor, Interferon alpha-beta (156986-95-7) ; Janus Kinases (EC 2.7.10.2)
Language	English
Publishing date	2021-11-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abe4627
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Tinea capitis in an immigrant pediatric community; a clinical signs-based treatment approach.

Kassem, Riad / Shemesh, Yahel / Nitzan, Orna / Azrad, Maya / Peretz, Avi

BMC pediatrics

2021 Volume 21, Issue 1, Page(s) 363

Abstract: Background: Tinea capitis is a common cutaneous infection of the scalp and hair follicles, typically diagnosed by direct examination and culture. Treatment with oral antifungals is usually withheld until mycology results are available. In Israel, ... ...

Abstract	Background: Tinea capitis is a common cutaneous infection of the scalp and hair follicles, typically diagnosed by direct examination and culture. Treatment with oral antifungals is usually withheld until mycology results are available. In Israel, African refugee children demonstrate higher susceptibility to Tinea capitis and generally fail to undergo follow-up evaluations. Methods: This study aimed to identify the clinical characteristics and treatment responses of refugee children in Israel with Tinea capitis, in order to formulate a treatment plan for primary care physicians. To this end, demographic, clinical and laboratory data were extracted from the electronic medical records of 76 refugee children presenting with Tinea capitis during 2016-2017. All measured variables and derived parameters are presented using descriptive statistics. The correlation between background clinical and demographic data and Tinea capitis diagnosis was assessed using the chi-squared and Wilcoxon tests. Correlations between demographic/clinical/laboratory characteristics and other types of fungi or other important findings were assessed using a T-test. Results: Scaling was the most common clinical finding. Cultures were positive in 64 (84%) and direct examination in 65 (85%) cases, with a positive correlation between the methods in 75% of cases. The most common fungal strain was T. violaceum. Fluconazole treatment failed in 27% of cases. Griseofulvin 50 mg/kg/day was administered to 74 (97%) children, and induced clinical responses. No side effects were reported. Conclusions: The key aim of this study was to emphasize the importance of diagnosis and treatment of these immigrant children by their primary pediatric doctor since it takes, an average of 4.3 months until they visit a dermatologist. During this critical time period, the scalp can become severely and permanently damaged, and the infection can become systemic or cause an outbreak within the entire community. In conclusion, we recommend to relate to scaly scalp in high-risk populations as Tinea capitis, and to treat with griseofulvin at a dosage of up to 50 mg/kg/day, starting from the first presentation to the pediatrician.
MeSH term(s)	Antifungal Agents/therapeutic use ; Child ; Emigrants and Immigrants ; Fluconazole ; Griseofulvin/therapeutic use ; Humans ; Tinea Capitis/diagnosis ; Tinea Capitis/drug therapy ; Tinea Capitis/epidemiology
Chemical Substances	Antifungal Agents ; Griseofulvin (32HRV3E3D5) ; Fluconazole (8VZV102JFY)
Language	English
Publishing date	2021-08-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-021-02813-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: CRISPR/Cas9-based Knockout Strategy Elucidates Components Essential for Type 1 Interferon Signaling in Human HeLa Cells.

Urin, Victoria / Shemesh, Maya / Schreiber, Gideon

Journal of molecular biology

2019 Volume 431, Issue 17, Page(s) 3324–3338

Abstract: Type I interferons (IFNs) have a central role in innate and adaptive immunities, proliferation, and cancer surveillance. How IFN binding to its specific receptor, the IFN α and β receptor (IFNAR), can drive such variety of processes is an open question. ... ...

Abstract	Type I interferons (IFNs) have a central role in innate and adaptive immunities, proliferation, and cancer surveillance. How IFN binding to its specific receptor, the IFN α and β receptor (IFNAR), can drive such variety of processes is an open question. Here, to systematically and thoroughly investigate the molecular mechanism of IFN signaling, we used a CRISPR/Cas9-based approach in a human cell line (HeLa) to generate knockouts (KOs) of the genes participating in the type 1 IFN signaling cascade. We show that both IFNAR chains (IFNAR1 and IFNAR2) are absolutely required for any IFN-induced signaling. Deletion of either signal transducer and activator of transcription 1 (STAT1) or STAT2 had only a partial effect on IFN-induced antiviral activity or gene induction. However, the deletion of both genes completely abrogated any IFN-induced activity. So did a double STAT2-IFN regulatory factor 1 (IRF1) KO and, to a large extent, a STAT1 KO together with IRF9 knockdown. KO of any of the STATs had no effect on the phosphorylation of other STATs, indicating that they bound IFNAR independently. STAT3 and STAT6 phosphorylations were fully induced by type 1 IFN in the STAT1-STAT2 KO, but did not promote gene induction. Moreover, STAT3 KO did not affect type 1 IFN-induced gene or protein expression. Type 1 IFN also did not activate p38, AKT, or ERK kinase. We conclude that type 1 IFN-induced activities in HeLa cells are mediated by STAT1/STAT2/IRF9, STAT1/STAT1, or STAT2/IRF9 complexes and do not require alternative pathways.
MeSH term(s)	Antiviral Agents/pharmacology ; CRISPR-Cas Systems ; Gene Expression Regulation ; Gene Knockout Techniques/methods ; HeLa Cells ; Humans ; Interferon Regulatory Factor-1/genetics ; Interferon Type I/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit ; Phosphorylation ; Receptor, Interferon alpha-beta/genetics ; STAT1 Transcription Factor/genetics ; STAT2 Transcription Factor ; STAT3 Transcription Factor/genetics ; STAT6 Transcription Factor ; Signal Transduction/genetics
Chemical Substances	Antiviral Agents ; IFNAR1 protein, human ; IFNAR2 protein, human ; IRF1 protein, human ; IRF9 protein, human ; Interferon Regulatory Factor-1 ; Interferon Type I ; Interferon-Stimulated Gene Factor 3, gamma Subunit ; STAT1 Transcription Factor ; STAT1 protein, human ; STAT2 Transcription Factor ; STAT3 Transcription Factor ; STAT3 protein, human ; STAT6 Transcription Factor ; STAT6 protein, human ; Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2019-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2019.06.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 867: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Gelatin Stabilizes Nebulized Proteins in Pulmonary Drug Delivery against COVID-19.

Li, Chunlin / Marton, Ira / Harari, Daniel / Shemesh, Maya / Kalchenko, Vyacheslav / Pardo, Michal / Schreiber, Gideon / Rudich, Yinon

ACS biomaterials science & engineering

2022 Volume 8, Issue 6, Page(s) 2553–2563

Abstract: Delivering medication to the lungs via nebulization of pharmaceuticals is a noninvasive and efficient therapy route, particularly for respiratory diseases. The recent worldwide severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic ... ...

Abstract	Delivering medication to the lungs via nebulization of pharmaceuticals is a noninvasive and efficient therapy route, particularly for respiratory diseases. The recent worldwide severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic urges the development of such therapies as an effective alternative to vaccines. The main difficulties in using inhalation therapy are the development of effective medicine and methods to stabilize the biological molecules and transfer them to the lungs efficiently following nebulization. We have developed a high-affinity angiotensin-converting enzyme 2 (ACE2) receptor-binding domain (RBD-62) that can be used as a medication to inhibit infection with SARS-CoV-2 and its variants. In this study, we established a nebulization protocol for drug delivery by inhalation using two commercial vibrating mesh (VM) nebulizers (Aerogen Solo and PARI eFlow) that generate similar mist size distribution in a size range that allows efficient deposition in the small respiratory airway. In a series of experiments, we show the high activity of RBD-62, interferon-α2 (IFN-α2), and other proteins following nebulization. The addition of gelatin significantly stabilizes the proteins and enhances the fractions of active proteins after nebulization, minimizing the medication dosage. Furthermore, hamster inhalation experiments verified the feasibility of the protocol in pulmonary drug delivery. In short, the gelatin-modified RBD-62 formulation in coordination with VM nebulizer can be used as a therapy to cure SARS-CoV-2.
MeSH term(s)	Aerosols/chemistry ; Gelatin ; Humans ; Lung ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Aerosols ; Gelatin (9000-70-8)
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.2c00419
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: [CHANGES IN THE WAY WE OBSERVE, ASSESS AND TREAT APHASIA: FROM THE TRADITIONAL APPROACH TO THE PSYCHOLINGUISTIC AND SOCIAL APPROACHES].

Gvion, Aviah / Faran, Maya / Shemesh, Frida

Harefuah

2018 Volume 157, Issue 9, Page(s) 585–589

Abstract: Introduction: Aphasia is an acquired language impairment, initially identified and described before the 19th century. According to traditional models (Wernicke-Lichtheim-Geschwind) the aphasic symptoms can be clustered into particular syndromes, such as ...

Abstract	Introduction: Aphasia is an acquired language impairment, initially identified and described before the 19th century. According to traditional models (Wernicke-Lichtheim-Geschwind) the aphasic symptoms can be clustered into particular syndromes, such as Broca's, Wernicke's, Conduction aphasias, and more. Each syndrome is allegedly associated with a specific anatomical site. The major motivation for this model was to use the behavioral symptoms to learn about language and brain relationships. However, current advanced imaging techniques identify more precisely the loci of the deficit. Moreover, the model frequently fails to adequately describe the clinical symptoms, a description that is crucial for understanding the language deficit and for choosing the relevant treatment. For more than three decades, two alternative models are being used in the clinical setting and in research. First, the psycholinguistic model, which describes the normal stages that are involved in language processing. On the basis of this model it is possible to detect, for each individual with aphasia, the specific impaired stage or stages underlying the language deficits. Second, the social model of aphasia based on the ICF definitions of the World Health Organization. According to this model, it is suggested that the speech therapy intervention should focus not only on the language deficits but also on communication per se in order to enable the individual with aphasia to communicate with others despite the language deficits. In the current paper we will review these two models and their clinical implications.
MeSH term(s)	Aphasia ; Humans ; Psycholinguistics ; Speech Therapy ; Terminology as Topic
Language	Hebrew
Publishing date	2018-05-10
Publishing country	Israel
Document type	Journal Article ; Review
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 291: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: De novo developed protein binders mimicking Interferon lambda signaling

Kolářová, Lucie / Zahradník, Jiří / Huličiak, Maroš / Mikulecký, Pavel / Peleg, Yoav / Shemesh, Maya / Schreiber, Gideon / Schneider, Bohdan

FEBS journal. 2022 May, v. 289, no. 9

2022

Abstract: We hereby describe the process of design and selection of nonantibody protein binders mimicking cytokine signaling. We chose to mimic signaling of IFN‐λ1, type 3 interferon (also known as IL‐29) for its novelty and the importance of its biological ... ...

Abstract	We hereby describe the process of design and selection of nonantibody protein binders mimicking cytokine signaling. We chose to mimic signaling of IFN‐λ1, type 3 interferon (also known as IL‐29) for its novelty and the importance of its biological functions. All four known interferons λ signal through binding to the extracellular domains of IL‐28 receptor 1 (IL‐28R1) and IL‐10 receptor 2 (IL‐10R2). Our binders were therefore trained to bind both receptors simultaneously. The bifunctional binder molecules were developed by yeast display, a method of directed evolution. The signaling capacity of the bivalent binders was tested by measuring phosphorylation of the JAK/STAT signaling pathway and production of mRNA of six selected genes naturally induced by IFN‐ λ1 in human cell lines. The newly developed bivalent binders offer opportunities to study cytokine‐related biological functions and modulation of the cell behavior by receptor activation on the cell surfaces alternative to the use of natural IFN‐λ.
Keywords	directed evolution ; humans ; interferons ; interleukin-10 ; phosphorylation ; yeasts
Language	English
Dates of publication	2022-05
Size	p. 2672-2684.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16300
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2006/704: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: CRISPR/Cas9-based Knockout Strategy Elucidates Components Essential for Type 1 Interferon Signaling in Human HeLa Cells

Urin, Victoria / Shemesh, Maya / Schreiber, Gideon

Journal of molecular biology. 2019 Aug. 09, v. 431, no. 17

2019

Abstract	Type I interferons (IFNs) have a central role in innate and adaptive immunities, proliferation, and cancer surveillance. How IFN binding to its specific receptor, the IFN α and β receptor (IFNAR), can drive such variety of processes is an open question. Here, to systematically and thoroughly investigate the molecular mechanism of IFN signaling, we used a CRISPR/Cas9-based approach in a human cell line (HeLa) to generate knockouts (KOs) of the genes participating in the type 1 IFN signaling cascade. We show that both IFNAR chains (IFNAR1 and IFNAR2) are absolutely required for any IFN-induced signaling. Deletion of either signal transducer and activator of transcription 1 (STAT1) or STAT2 had only a partial effect on IFN-induced antiviral activity or gene induction. However, the deletion of both genes completely abrogated any IFN-induced activity. So did a double STAT2–IFN regulatory factor 1 (IRF1) KO and, to a large extent, a STAT1 KO together with IRF9 knockdown. KO of any of the STATs had no effect on the phosphorylation of other STATs, indicating that they bound IFNAR independently. STAT3 and STAT6 phosphorylations were fully induced by type 1 IFN in the STAT1–STAT2 KO, but did not promote gene induction. Moreover, STAT3 KO did not affect type 1 IFN-induced gene or protein expression. Type 1 IFN also did not activate p38, AKT, or ERK kinase. We conclude that type 1 IFN-induced activities in HeLa cells are mediated by STAT1/STAT2/IRF9, STAT1/STAT1, or STAT2/IRF9 complexes and do not require alternative pathways.
Keywords	antiviral properties ; gene induction ; genes ; human cell lines ; humans ; interferons ; mitogen-activated protein kinase ; monitoring ; neoplasms ; phosphorylation ; protein synthesis ; signal transduction ; transactivators
Language	English
Dates of publication	2019-0809
Size	p. 3324-3338.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2019.06.007
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 63/108: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: De novo developed protein binders mimicking Interferon lambda signaling.

Kolářová, Lucie / Zahradník, Jiří / Huličiak, Maroš / Mikulecký, Pavel / Peleg, Yoav / Shemesh, Maya / Schreiber, Gideon / Schneider, Bohdan

The FEBS journal

2021 Volume 289, Issue 9, Page(s) 2672–2684

Abstract: We hereby describe the process of design and selection of nonantibody protein binders mimicking cytokine signaling. We chose to mimic signaling of IFN-λ1, type 3 interferon (also known as IL-29) for its novelty and the importance of its biological ... ...

Abstract	We hereby describe the process of design and selection of nonantibody protein binders mimicking cytokine signaling. We chose to mimic signaling of IFN-λ1, type 3 interferon (also known as IL-29) for its novelty and the importance of its biological functions. All four known interferons λ signal through binding to the extracellular domains of IL-28 receptor 1 (IL-28R1) and IL-10 receptor 2 (IL-10R2). Our binders were therefore trained to bind both receptors simultaneously. The bifunctional binder molecules were developed by yeast display, a method of directed evolution. The signaling capacity of the bivalent binders was tested by measuring phosphorylation of the JAK/STAT signaling pathway and production of mRNA of six selected genes naturally induced by IFN- λ1 in human cell lines. The newly developed bivalent binders offer opportunities to study cytokine-related biological functions and modulation of the cell behavior by receptor activation on the cell surfaces alternative to the use of natural IFN-λ.
MeSH term(s)	Antiviral Agents/metabolism ; Cytokines/metabolism ; Humans ; Interferons/metabolism ; Interleukins/metabolism ; Signal Transduction
Chemical Substances	Antiviral Agents ; Cytokines ; Interleukins ; Interferons (9008-11-1)
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16300
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 260: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effect of Different Derivatization Protocols on the Calculation of Trophic Position Using Amino Acids Compound-Specific Stable Isotopes

Stephane Martinez / Maya Lalzar / Eli Shemesh / Shai Einbinder / Beverly Goodman Tchernov / Dan Tchernov

Frontiers in Marine Science, Vol

2020 Volume 7

Abstract: Amino acids compound-specific nitrogen stable isotope analysis (AA-CSIA) is an emerging tool in ecology for understanding trophic system dynamics. While it has been successfully used for several independent studies across a range of environments and ... ...

Abstract	Amino acids compound-specific nitrogen stable isotope analysis (AA-CSIA) is an emerging tool in ecology for understanding trophic system dynamics. While it has been successfully used for several independent studies across a range of environments and study locations, researchers have encountered calculation issues for determining trophic position values. Most studies introduce modifications to the constants of trophic position equation calculations, but then fail to account for the equation variations when comparing across separate research studies. The broad acceptance of this approach is anchored in an underlying presumption that no addition of the exogenous nitrogen atom occurs in the different methods; and therefore, such variations should not affect the outcome. In this paper, we evaluate the use of the EZfaast amino acid derivatization kit (chloroformate) and compare it to the isotopic results of two other derivatization methods. We highlight new considerations for working with AA-CSIA that might account for some of the variations in the results and lead researchers to modify constants in the equation. This study concludes that developing unique constants per derivatization method is required to have more accurate cross-study comparisons of trophic positions.
Keywords	trophic discrimination factor ; AA-CSIA ; eastern Mediterranean Sea ; food web ; nitrogen isotopic composition ; calibration ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Urbanization comprehensively impairs biological rhythms in coral holobionts.

Rosenberg, Yaeli / Simon-Blecher, Noa / Lalzar, Maya / Yam, Ruth / Shemesh, Aldo / Alon, Shahar / Perna, Gabriela / Cárdenas, Anny / Voolstra, Christian R / Miller, David J / Levy, Oren

Global change biology

2022 Volume 28, Issue 10, Page(s) 3349–3364

Abstract: Coral reefs are in global decline due to climate change and anthropogenic influences (Hughes et al., Conservation Biology, 27: 261-269, 2013). Near coastal cities or other densely populated areas, coral reefs face a range of additional challenges. While ... ...

Abstract	Coral reefs are in global decline due to climate change and anthropogenic influences (Hughes et al., Conservation Biology, 27: 261-269, 2013). Near coastal cities or other densely populated areas, coral reefs face a range of additional challenges. While considerable progress has been made in understanding coral responses to acute individual stressors (Dominoni et al., Nature Ecology & Evolution, 4: 502-511, 2020), the impacts of chronic exposure to varying combinations of sensory pollutants are largely unknown. To investigate the impacts of urban proximity on corals, we conducted a year-long in-natura study-incorporating sampling at diel, monthly, and seasonal time points-in which we compared corals from an urban area to corals from a proximal non-urban area. Here we reveal that despite appearing relatively healthy, natural biorhythms and environmental sensory systems were extensively disturbed in corals from the urban environment. Transcriptomic data indicated poor symbiont performance, disturbance to gametogenic cycles, and loss or shifted seasonality of vital biological processes. Altered seasonality patterns were also observed in the microbiomes of the urban coral population, signifying the impact of urbanization on the holobiont, rather than the coral host alone. These results should raise alarm regarding the largely unknown long-term impacts of sensory pollution on the resilience and survival of coral reefs close to coastal communities.
MeSH term(s)	Animals ; Anthozoa/physiology ; Coral Reefs ; Microbiota ; Periodicity ; Urbanization
Language	English
Publishing date	2022-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.16144
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 6338: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED