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Article ; Online: Rediscovery of Liara (Unalianus) heteracanthus (Redtenbacher, 1891) (Orthoptera: Tettigoniidae: Conocephalinae: Agraeciini) from India with notes on its distribution.

Kumar, Hirdesh / Kushwaha, Sandeep / Chand, D Suresh

Zootaxa

2021 Volume 5020, Issue 1, Page(s) 166–170

Abstract: More than one hundred years after its description, a male specimen of Liara(Unalianus)heteracanthus(Redtenbacher, 1891) was collected at a new locality in the Mizoram State, India. Opportunity is taken to redescribe and illustrate this specimen. ...

Abstract	More than one hundred years after its description, a male specimen of Liara(Unalianus)heteracanthus(Redtenbacher, 1891) was collected at a new locality in the Mizoram State, India. Opportunity is taken to redescribe and illustrate this specimen.
MeSH term(s)	Animal Distribution ; Animals ; India ; Male ; Orthoptera
Language	English
Publishing date	2021-08-11
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5020.1.8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A New Species of Gerenia Stål, 1878 (Orthoptera: Acrididae: Catantopinae) from India

Kumar, Hirdesh / Chandra, Kailash / Kushwaha, Sandeep

Transactions of the American Entomological Society. 2022 Jan. 26, v. 148, no. 1

2022

Abstract: A new species of the genus GereniaStål, 1878, Gerenia mizoramia Kumar & Chandra sp. nov ...

Abstract	A new species of the genus GereniaStål, 1878, Gerenia mizoramia Kumar & Chandra sp. nov., from Dampa Tiger Reserve, Mizoram, India is described here. The new species is similar to the Indian species, G. bengalensisBhowmik & Halder, 1983, but differs from it in the presence of a dark black oval spot in the middle of tegmen, apex of tegmen comparatively broad and hind wing slightly shorter than tegmen.
Keywords	Acrididae ; new species ; wings ; India
Language	English
Dates of publication	2022-0126
Size	p. 1-6.
Publishing place	American Entomological Society
Document type	Article
ZDB-ID	2483704-0
ISSN	2162-3139 ; 0002-8320
ISSN (online)	2162-3139
ISSN	0002-8320
DOI	10.3157/061.148.0101
Database	NAL-Catalogue (AGRICOLA)

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Article: Non-Synonymous Variants in Fat QTL Genes among High- and Low-Milk-Yielding Indigenous Breeds.

Topno, Neelam A / Kesarwani, Veerbhan / Kushwaha, Sandeep Kumar / Azam, Sarwar / Kadivella, Mohammad / Gandham, Ravi Kumar / Majumdar, Subeer S

Animals : an open access journal from MDPI

2023 Volume 13, Issue 5

Abstract: The effect of breed on milk components-fat, protein, lactose, and water-has been observed to be significant. As fat is one of the major price-determining factors for milk, exploring the variations in fat QTLs across breeds would shed light on the ... ...

Abstract	The effect of breed on milk components-fat, protein, lactose, and water-has been observed to be significant. As fat is one of the major price-determining factors for milk, exploring the variations in fat QTLs across breeds would shed light on the variable fat content in their milk. Here, on whole-genome sequencing, 25 differentially expressed hub or bottleneck fat QTLs were explored for variations across indigenous breeds. Out of these, 20 genes were identified as having nonsynonymous substitutions. A fixed SNP pattern in high-milk-yielding breeds in comparison to low-milk-yielding breeds was identified in the genes
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13050884
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tailoring crops with superior product quality through genome editing: an update.

Ravikiran, K T / Thribhuvan, R / Sheoran, Seema / Kumar, Sandeep / Kushwaha, Amar Kant / Vineeth, T V / Saini, Manisha

Planta

2023 Volume 257, Issue 5, Page(s) 86

Abstract: Main conclusion: In this review, using genome editing, the quality trait alterations in important crops have been discussed, along with the challenges encountered to maintain the crop products' quality. The delivery of economic produce with superior ... ...

Abstract	Main conclusion: In this review, using genome editing, the quality trait alterations in important crops have been discussed, along with the challenges encountered to maintain the crop products' quality. The delivery of economic produce with superior quality is as important as high yield since it dictates consumer's acceptance and end use. Improving product quality of various agricultural and horticultural crops is one of the important targets of plant breeders across the globe. Significant achievements have been made in various crops using conventional plant breeding approaches, albeit, at a slower rate. To keep pace with ever-changing consumer tastes and preferences and industry demands, such efforts must be supplemented with biotechnological tools. Fortunately, many of the quality attributes are resultant of well-understood biochemical pathways with characterized genes encoding enzymes at each step. Targeted mutagenesis and transgene transfer have been instrumental in bringing out desired qualitative changes in crops but have suffered from various pitfalls. Genome editing, a technique for methodical and site-specific modification of genes, has revolutionized trait manipulation. With the evolution of versatile and cost effective CRISPR/Cas9 system, genome editing has gained significant traction and is being applied in several crops. The availability of whole genome sequences with the advent of next generation sequencing (NGS) technologies further enhanced the precision of these techniques. CRISPR/Cas9 system has also been utilized for desirable modifications in quality attributes of various crops such as rice, wheat, maize, barley, potato, tomato, etc. The present review summarizes salient findings and achievements of application of genome editing for improving product quality in various crops coupled with pointers for future research endeavors.
MeSH term(s)	Gene Editing/methods ; CRISPR-Cas Systems/genetics ; Plants, Genetically Modified/genetics ; Genome, Plant/genetics ; Plant Breeding/methods ; Crops, Agricultural/genetics
Language	English
Publishing date	2023-03-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/s00425-023-04112-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Non-Synonymous Variants in Fat QTL Genes among High- and Low-Milk-Yielding Indigenous Breeds

Neelam A. Topno / Veerbhan Kesarwani / Sandeep Kumar Kushwaha / Sarwar Azam / Mohammad Kadivella / Ravi Kumar Gandham / Subeer S. Majumdar

Animals, Vol 13, Iss 884, p

2023 Volume 884

Abstract: The effect of breed on milk components—fat, protein, lactose, and water—has been observed to be significant. As fat is one of the major price-determining factors for milk, exploring the variations in fat QTLs across breeds would shed light on the ... ...

Abstract	The effect of breed on milk components—fat, protein, lactose, and water—has been observed to be significant. As fat is one of the major price-determining factors for milk, exploring the variations in fat QTLs across breeds would shed light on the variable fat content in their milk. Here, on whole-genome sequencing, 25 differentially expressed hub or bottleneck fat QTLs were explored for variations across indigenous breeds. Out of these, 20 genes were identified as having nonsynonymous substitutions. A fixed SNP pattern in high-milk-yielding breeds in comparison to low-milk-yielding breeds was identified in the genes GHR, TLR4, LPIN1, CACNA1C, ZBTB16, ITGA1, ANK1, and NTG5E and, vice versa, in the genes MFGE8, FGF2, TLR4, LPIN1, NUP98, PTK2, ZTB16, DDIT3 , and NT5E . The identified SNPs were ratified by pyrosequencing to prove that key differences exist in fat QTLs between the high- and low-milk-yielding breeds.
Keywords	milk fat ; whole-genome sequencing ; SNPs ; genomic variation ; variant calling ; indigenous breeds ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Non-Synonymous Variants in Fat QTL Genes among High- and Low-Milk-Yielding Indigenous Breeds

Topno, Neelam A. / Kesarwani, Veerbhan / Kushwaha, Sandeep Kumar / Azam, Sarwar / Kadivella, Mohammad / Gandham, Ravi Kumar / Majumdar, Subeer S.

Animals. 2023 Feb. 28, v. 13, no. 5

2023

Abstract	The effect of breed on milk components—fat, protein, lactose, and water—has been observed to be significant. As fat is one of the major price-determining factors for milk, exploring the variations in fat QTLs across breeds would shed light on the variable fat content in their milk. Here, on whole-genome sequencing, 25 differentially expressed hub or bottleneck fat QTLs were explored for variations across indigenous breeds. Out of these, 20 genes were identified as having nonsynonymous substitutions. A fixed SNP pattern in high-milk-yielding breeds in comparison to low-milk-yielding breeds was identified in the genes GHR, TLR4, LPIN1, CACNA1C, ZBTB16, ITGA1, ANK1, and NTG5E and, vice versa, in the genes MFGE8, FGF2, TLR4, LPIN1, NUP98, PTK2, ZTB16, DDIT3, and NT5E. The identified SNPs were ratified by pyrosequencing to prove that key differences exist in fat QTLs between the high- and low-milk-yielding breeds.
Keywords	gene expression regulation ; high-throughput nucleotide sequencing ; lactose ; lipid content ; milk
Language	English
Dates of publication	2023-0228
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13050884
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correlating multi-functional role of cold shock domain proteins with intrinsically disordered regions.

Chaudhary, Amit / Chaurasia, Pankaj Kumar / Kushwaha, Sandeep / Chauhan, Pallavi / Chawade, Aakash / Mani, Ashutosh

International journal of biological macromolecules

2022 Volume 220, Page(s) 743–753

Abstract: Cold shock proteins (CSPs) are an ancient and conserved family of proteins. They are renowned for their role in response to low-temperature stress in bacteria and nucleic acid binding activities. In prokaryotes, cold and non-cold inducible CSPs are ... ...

Abstract	Cold shock proteins (CSPs) are an ancient and conserved family of proteins. They are renowned for their role in response to low-temperature stress in bacteria and nucleic acid binding activities. In prokaryotes, cold and non-cold inducible CSPs are involved in various cellular and metabolic processes such as growth and development, osmotic oxidation, starvation, stress tolerance, and host cell invasion. In prokaryotes, cold shock condition reduces cell transcription and translation efficiency. Eukaryotic cold shock domain (CSD) proteins are evolved form of prokaryotic CSPs where CSD is flanked by N- and C-terminal domains. Eukaryotic CSPs are multi-functional proteins. CSPs also act as nucleic acid chaperons by preventing the formation of secondary structures in mRNA at low temperatures. In human, CSD proteins play a crucial role in the progression of breast cancer, colon cancer, lung cancer, and Alzheimer's disease. A well-defined three-dimensional structure of intrinsically disordered regions of CSPs family members is still undetermined. In this article, intrinsic disorder regions of CSPs have been explored systematically to understand the pleiotropic role of the cold shock family of proteins.
MeSH term(s)	Bacterial Proteins/chemistry ; Cold Shock Proteins and Peptides/chemistry ; Cold Temperature ; Cold-Shock Response ; Humans ; Intrinsically Disordered Proteins/chemistry ; Protein Structure, Secondary ; RNA, Messenger/genetics
Chemical Substances	Bacterial Proteins ; Cold Shock Proteins and Peptides ; Intrinsically Disordered Proteins ; RNA, Messenger
Language	English
Publishing date	2022-08-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.08.100
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Article: Spinal Segmental Myoclonus Presented as Unilateral Rotating Scapula.

Kushwaha, Suman / Panda, Akhila Kumar / Anthony, Aldrin / Singh, Sandeep / Madan, Dyutima / Maheshwari, Siddharth

Annals of Indian Academy of Neurology

2020 Volume 23, Issue 3, Page(s) 356

Language	English
Publishing date	2020-06-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2240174-X
ISSN	1998-3549 ; 0972-2327
ISSN (online)	1998-3549
ISSN	0972-2327
DOI	10.4103/aian.AIAN_208_19
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Article ; Online: Anti-biofilm activity of caffeine against uropathogenic E. coli is mediated by curli biogenesis.

Rathi, Bhawna / Gupta, Surbhi / Kumar, Parveen / Kesarwani, Veerbhan / Dhanda, Rakesh Singh / Kushwaha, Sandeep Kumar / Yadav, Manisha

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18903

Abstract: Biofilms are assemblages of sessile microorganisms that form an extracellular matrix around themselves and mediate attachment to surfaces. The major component of the extracellular matrix of Uropathogenic E. coli and other Enterobacteriaceae are curli ... ...

Abstract	Biofilms are assemblages of sessile microorganisms that form an extracellular matrix around themselves and mediate attachment to surfaces. The major component of the extracellular matrix of Uropathogenic E. coli and other Enterobacteriaceae are curli fibers, making biofilms robust and resistant to antimicrobials. It is therefore imperative to screen antibiofilm compounds that can impair biofilm formation. In the present study, we investigated the curli-dependent antibiofilm activity of caffeine against UPEC strain CFT073 and commensal strain E. coli K-12MG1655.Caffeine significantly reduced the biofilm formation of both UPEC and E. coli K-12 by 86.58% and 91.80% respectively at 48 mM caffeine as determined by Crystal Violet assay. These results were further confirmed by fluorescence microscopy and Scanning Electron Microscope (SEM). Caffeine significantly reduced the cytotoxicity and survivability of UPEC. Molecular docking analysis revealed a strong interaction between caffeine and curli regulator protein (Csg D) of E. coli. The qRT-PCR data also showed significant downregulation in the expression of CsgBA and the CsgDEFG operon at both 24 mM and 48 mM caffeine. The findings revealed that caffeine could inhibit E. coli biofilm formation by regulating curli assembly and thus may be used as an alternative therapeutic strategy for the treatment of chronic E. coli biofilm-related infections.
MeSH term(s)	Biofilms/drug effects ; Caffeine/pharmacology ; Fimbriae, Bacterial/metabolism ; Molecular Docking Simulation ; Uropathogenic Escherichia coli/drug effects
Chemical Substances	Caffeine (3G6A5W338E)
Language	English
Publishing date	2022-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-23647-2
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Article ; Online: Tailoring crops with superior product quality through genome editing: an update

Ravikiran, K. T. / Thribhuvan, R. / Sheoran, Seema / Kumar, Sandeep / Kushwaha, Amar Kant / Vineeth, T. V. / Saini, Manisha

Planta. 2023 May, v. 257, no. 5 p.86-86

2023

Abstract: MAIN CONCLUSION: In this review, using genome editing, the quality trait alterations in important crops have been discussed, along with the challenges encountered to maintain the crop products’ quality. The delivery of economic produce with superior ... ...

Abstract	MAIN CONCLUSION: In this review, using genome editing, the quality trait alterations in important crops have been discussed, along with the challenges encountered to maintain the crop products’ quality. The delivery of economic produce with superior quality is as important as high yield since it dictates consumer’s acceptance and end use. Improving product quality of various agricultural and horticultural crops is one of the important targets of plant breeders across the globe. Significant achievements have been made in various crops using conventional plant breeding approaches, albeit, at a slower rate. To keep pace with ever-changing consumer tastes and preferences and industry demands, such efforts must be supplemented with biotechnological tools. Fortunately, many of the quality attributes are resultant of well-understood biochemical pathways with characterized genes encoding enzymes at each step. Targeted mutagenesis and transgene transfer have been instrumental in bringing out desired qualitative changes in crops but have suffered from various pitfalls. Genome editing, a technique for methodical and site-specific modification of genes, has revolutionized trait manipulation. With the evolution of versatile and cost effective CRISPR/Cas9 system, genome editing has gained significant traction and is being applied in several crops. The availability of whole genome sequences with the advent of next generation sequencing (NGS) technologies further enhanced the precision of these techniques. CRISPR/Cas9 system has also been utilized for desirable modifications in quality attributes of various crops such as rice, wheat, maize, barley, potato, tomato, etc. The present review summarizes salient findings and achievements of application of genome editing for improving product quality in various crops coupled with pointers for future research endeavors.
Keywords	CRISPR-Cas systems ; barley ; corn ; cost effectiveness ; evolution ; horticulture ; industry ; potatoes ; product quality ; rice ; site-directed mutagenesis ; tomatoes ; transgenes ; wheat
Language	English
Dates of publication	2023-05
Size	p. 86.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/s00425-023-04112-4
Database	NAL-Catalogue (AGRICOLA)

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