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  1. Book: Basic immunology

    Abbas, Abul K. / Lichtman, Andrew H. / Pillai, Shiv / Baker, David L.

    functions and disorders of the immune system

    2024  

    Author's details Abul K. Abbas, MBBS, Professor Emeritus, Pathology, University of California San Francisco, (San Francisco, California), Andrew H. Lichtman, MD, PhD, Professor of Pathology, Harvard Medical School, Brigham and Women's Hospital, (Boston, Massachusetts), Shiv Pillai, MBBS, PhD, Professor of Medicine and Health Sciences and Technology, Harvard Medical School, Massachusetts General Hospital, (Boston, Massachusetts) ; Illustrations by David L. Baker, MA
    MeSH term(s) Immunity ; Hypersensivity ; Immune Sysmtem/physiology ; Immunologic Deficiency Syndromes
    Language English
    Size v, 345 Seiten, Illustrationen, Diagramme
    Edition 7th edition
    Publisher Elsevier
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Note Auf dem Einband: Enhanced Digital Version
    Accompanying material Zugang zur Online-Ausgabe über Code
    HBZ-ID HT030130010
    ISBN 978-0-443-10519-7 ; 0-443-10519-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 997 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: A twist in the tail: Of T cell subsets and disease.

    Pillai, Shiv

    The Journal of experimental medicine

    2023  Volume 220, Issue 11

    Abstract: In this issue of JEM, the work of Joachim et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20231028) on knockin mice with a specific tail mutation in LAT provides valuable insights about cytotoxic CD4+ T cells and human inflammatory diseases. ...

    Abstract In this issue of JEM, the work of Joachim et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20231028) on knockin mice with a specific tail mutation in LAT provides valuable insights about cytotoxic CD4+ T cells and human inflammatory diseases.
    MeSH term(s) Humans ; Animals ; Mice ; Tail ; T-Lymphocyte Subsets ; T-Lymphocytes, Cytotoxic ; Mutation/genetics
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20231423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is it bad, is it good, or is IgG4 just misunderstood?

    Pillai, Shiv

    Science immunology

    2023  Volume 8, Issue 81, Page(s) eadg7327

    Abstract: Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than ... ...

    Abstract Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell-dependent elimination of infected cells (see related Research Article by Irrgang
    MeSH term(s) Humans ; Immunoglobulin G ; COVID-19 Vaccines ; COVID-19
    Chemical Substances Immunoglobulin G ; COVID-19 Vaccines
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adg7327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Does the SARS-CoV-2 spike really have an Achilles heel?

    Pillai, Shiv

    The Journal of clinical investigation

    2023  Volume 133, Issue 8

    Abstract: The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an ... ...

    Abstract The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an anti-SARS-CoV-2 spike antibody, isolated from a patient, that targets a vulnerable site on the spike protein receptor binding domain when it adopts a configuration called the "up" conformation. This antibody cross-neutralized all variants studied, including recent Omicron subvariants, and was protective against multiple variants in a hamster model. These results are of interest when considering the next generation of prophylactic and therapeutic antibodies for COVID-19, but they may also shape future approaches to vaccination against SARS-CoV-2.
    MeSH term(s) Animals ; Cricetinae ; Humans ; SARS-CoV-2 ; COVID-19 ; Antibodies, Viral ; Vaccination ; Antibodies, Neutralizing
    Chemical Substances Antibodies, Viral ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI168080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Does the SARS-CoV-2 spike really have an Achilles heel?

    Shiv Pillai

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 8

    Abstract: The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an ... ...

    Abstract The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an anti-SARS-CoV-2 spike antibody, isolated from a patient, that targets a vulnerable site on the spike protein receptor binding domain when it adopts a configuration called the “up” conformation. This antibody cross-neutralized all variants studied, including recent Omicron subvariants, and was protective against multiple variants in a hamster model. These results are of interest when considering the next generation of prophylactic and therapeutic antibodies for COVID-19, but they may also shape future approaches to vaccination against SARS-CoV-2.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: T

    Pillai, Shiv

    Science immunology

    2022  Volume 7, Issue 68, Page(s) eabo2989

    Abstract: Figure: see text]. ...

    Abstract [Figure: see text].
    MeSH term(s) Humans ; Multiple Sclerosis ; Th17 Cells
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abo2989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Only pregnant moms can do it….

    Pillai, Shiv

    Science immunology

    2022  Volume 7, Issue 73, Page(s) eadd6618

    Abstract: During pregnancy, sialic acid ... ...

    Abstract During pregnancy, sialic acid on
    MeSH term(s) Antibodies, Bacterial ; Female ; Humans ; Infant, Newborn ; Listeria monocytogenes ; Listeriosis ; Pregnancy
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.add6618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An e-Xist-ential two-edged sword for women.

    Zhang, Zhenrui / Pillai, Shiv

    Science immunology

    2024  Volume 9, Issue 93, Page(s) eado6826

    Abstract: Xist-containing ribonucleoproteins drive autoimmunity in women. ...

    Abstract Xist-containing ribonucleoproteins drive autoimmunity in women.
    MeSH term(s) Humans ; Female ; Ribonucleoproteins ; Autoimmunity
    Chemical Substances Ribonucleoproteins
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.ado6826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 vaccination washes away original antigenic sin.

    Pillai, Shiv

    Trends in immunology

    2022  Volume 43, Issue 4, Page(s) 271–273

    Abstract: According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. ... ...

    Abstract According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also known as 'original antigenic sin', and this results in limited immunological breadth.
    MeSH term(s) Antigens ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antigens ; COVID-19 Vaccines
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2022.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Suboptimal Humoral Immunity in Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Viral Variant Generation.

    Pillai, Shiv

    Clinics in laboratory medicine

    2021  Volume 42, Issue 1, Page(s) 75–84

    Abstract: This review describes the underlying basis for the sup-optimal humoral immune response in coronavirus disease (COVID)-19 including the absence of evidence for affinity maturation in the vast majority of patients and the absence of germinal centers even ... ...

    Abstract This review describes the underlying basis for the sup-optimal humoral immune response in coronavirus disease (COVID)-19 including the absence of evidence for affinity maturation in the vast majority of patients and the absence of germinal centers even in severe disease. Suboptimal humoral and cellular immunity may provide the optimal conditions for the generation and selection of viral variants.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunity, Cellular ; Immunity, Humoral ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2021.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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