LIVIVO - Search results -

Search results

Result 1 - 10 of total 18

Search options

Article: Chemical Composition, Antioxidant, Anticancer, and Antibacterial Activities of Roots and Seeds of

Aziz, Ibrahim M / Alshalan, Rawan M / Rizwana, Humaira / Alkhelaiwi, Fetoon / Almuqrin, Abdulaziz M / Aljowaie, Reem M / Alkubaisi, Noorah A

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 1

Abstract: For centuries, plants and their components have been harnessed for therapeutic purposes, ... ...

Abstract	For centuries, plants and their components have been harnessed for therapeutic purposes, with
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17010121
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Information System Success for Organizational Sustainability

Abdullah Almuqrin / Ibrahim Mutambik / Abdulaziz Alomran / Justin Zuopeng Zhang

Sustainability, Vol 15, Iss 9233, p

Exploring the Public Institutions in Saudi Arabia

2023 Volume 9233

Abstract: Organizational sustainability supports the financial, social, and cultural well-being of organizations and their surrounding communities. However, few studies have examined organizational sustainability in Saudi Arabia or its link to information ... ...

Abstract	Organizational sustainability supports the financial, social, and cultural well-being of organizations and their surrounding communities. However, few studies have examined organizational sustainability in Saudi Arabia or its link to information technology. This study used self-reported data from a large sample of employees at various Saudi government institutions to conclude that these institutions moderately implemented organizational sustainability. Correlation and regression analyses demonstrated weak associations between various types of organizational sustainability and dimensions of information system success, where user satisfaction with information systems is the strongest positive predictor of perceived organizational sustainability. Organizational sustainability is still emerging in the public sector, and further research is needed to identify predictors of its success.
Keywords	organizational sustainability ; information system success ; Saudi Arabia ; public sector ; regression analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prevalence and association of hyperuricemia with liver function in Saudi Arabia: a large cross-sectional study.

Almuqrin, Abdulaziz / Alshuweishi, Yazeed Abdullah / Alfaifi, Mohammed / Daghistani, Hussam / Al-Sheikh, Yazeed A / Alfhili, Mohammad A

Annals of Saudi medicine

2024 Volume 44, Issue 1, Page(s) 18–25

Abstract: Background: Hyperuricemia is linked to an increased risk of various chronic diseases, but data on the prevalence and association of hyperuricemia with liver function in Saudi Arabia are scarce.: Objectives: Evaluate the prevalence, association, and ... ...

Abstract	Background: Hyperuricemia is linked to an increased risk of various chronic diseases, but data on the prevalence and association of hyperuricemia with liver function in Saudi Arabia are scarce. Objectives: Evaluate the prevalence, association, and risk measures of hyperuricemia and liver function in the Saudi population. Design: Retrospective, cross-sectional analysis. Setting: Database on large portion of Saudi population. Patients and methods: Laboratory data, age, and gender of the studied subjects were collected from Al Borg Diagnostics. Subjects were stratified, based on their uric acid (UA) levels, into three groups: hypouricemic, normouricemic, and hyperuricemic. The association of UA with liver enzymes was examined in all three groups. Main outcome measures: Association of serum UA levels with alanine transaminase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), and total bilirubin (TB). Sample size: 13 314 subjects. Results: Our study showed that the prevalence of hyperuricemia in the Saudi population is 17.3% (20.3% in males and 15.1% in females). We also found a positive correlation between ALT, AST, and TB with UA levels. The risk of being hyperuricemic was significantly increased in individuals with elevated ALT, AST, and TB. Individuals with elevated ALT, AST, and total TB had a higher chance of having hyperuricemia than those with normal activity. Notably, ALT, AST, and TB had good discriminating capacity for hyperuricemia. Conclusions: Hyperuricemia is highly prevalent in the Saudi population and is associated with compromised liver function. However, further studies are needed to elucidate the mechanisms underlying these findings in large prospective cohort studies in different populations. Limitations: Lack of data on other potential confounding variables.
MeSH term(s)	Male ; Female ; Humans ; Cross-Sectional Studies ; Hyperuricemia/epidemiology ; Hyperuricemia/complications ; Saudi Arabia/epidemiology ; Prospective Studies ; Prevalence ; Retrospective Studies ; Alanine Transaminase ; Liver
Chemical Substances	Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2024-02-01
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	639014-6
ISSN	0975-4466 ; 0256-4947
ISSN (online)	0975-4466
ISSN	0256-4947
DOI	10.5144/0256-4947.2024.18
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 3022: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Factors Influencing Public Trust in Open Government Data

Abdullah Almuqrin / Ibrahim Mutambik / Abdulaziz Alomran / Jeffrey Gauthier / Majed Abusharhah

Sustainability, Vol 14, Iss 15, p

2022 Volume 9765

Abstract: Open government data (OGD) involves exposing government data to the public, guided by the values of clarity, accountability, honesty, and integrity. This study investigates the impact of the perceived quality of data, systems, and services on citizens’ ... ...

Abstract	Open government data (OGD) involves exposing government data to the public, guided by the values of clarity, accountability, honesty, and integrity. This study investigates the impact of the perceived quality of data, systems, and services on citizens’ trust in OGD, with the information systems success model as the theoretical framework. A questionnaire was delivered electronically to reach OGD users around the world. A total of 358 complete responses were obtained, representing 63.58% of all responses. Structural equation modeling was used to analyze the hypothesized relationships between constructs based on users’ responses. The findings confirm the impact of data, system, and service quality on citizens’ perceived trust in OGD. Moreover, perceived system and service quality had a positive impact on perceived data quality, and perceived service quality had a positive effect on perceived system quality. These findings indicate that OGD service quality affects data and system quality, making it the most fundamental motivator of citizens’ trust in OGD. This highlights the role of open government platforms in developing public services and providing users with complete and correct data, feedback tools, and data visualization.
Keywords	open government data ; trust ; data quality ; system quality ; service quality ; information systems success model ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	306
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Assessing the Impact of COVID-19 Vaccines on Sickle Cell Anaemia Patients: A Comparative Analysis of Biochemical and Haematological Parameters.

Aldali, Jehad A / Alotaibi, Badi A / Aldali, Hamzah J / Alasiri, Glowi A / Alaseem, Ali / Almuqrin, Abdulaziz M / Alshalani, Abdulrahman / Alotaibi, Fahad T

Biomedicines

2023 Volume 11, Issue 8

Abstract: The coronavirus disease 2019 (COVID-19) vaccines have been developed to help prevent the spread of the virus infections. The COVID-19 vaccines, including Pfizer, Moderna, and AstraZeneca, have undergone rigorous testing and have demonstrated both safety ... ...

Abstract	The coronavirus disease 2019 (COVID-19) vaccines have been developed to help prevent the spread of the virus infections. The COVID-19 vaccines, including Pfizer, Moderna, and AstraZeneca, have undergone rigorous testing and have demonstrated both safety and effectiveness. Extensive evidence supports their effectiveness in preventing severe illness, hospitalization, and mortality associated with COVID-19 infection. The administration of COVID-19 vaccines can directly affect hematological and biochemical parameters, with reported cases showing an association with thrombosis and thrombocytopenia. Therefore, it was hypothesized that COVID-19 vaccines may also influence hematological and biochemical markers in sickle cell patients. This study aimed to investigate the side effects of COVID-19 vaccines on sickle cell patients, providing a comprehensive evaluation of hematological and biochemical parameters. To our knowledge, this is the first study of its kind conducted in Saudi Arabia. The study included the evaluation of Pfizer and Oxford-AstraZeneca vaccines in sickle cell patients, measuring key parameters. Our findings revealed varying impacts of both vaccines on the ALT, AST, and CRP levels. Notably, CRP and ALT exhibited potential as indicators for renal disease, diabetes, and arthritis. However, further investigations are necessary to uncover the underlying mechanisms that drive these observed differences and comprehend their clinical implications for this vulnerable patient population. The unique nature of our study fills a crucial research gap and underscores the need for additional research in this area.
Language	English
Publishing date	2023-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082203
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Risk Factors for Glucose 6-Phosphate Dehydrogenase and COVID-19 Disease-A Retrospective Study at a Major Saudi Tertiary Center.

Alotaibi, Badi A / Aldali, Jehad A / Aldali, Hamzah J / Alasiri, Glowi A / Elsokkary, Emadeldin M / Al Mugairi, Areej / Almuqrin, Abdulaziz M

Viruses

2023 Volume 15, Issue 6

Abstract: Glucose-6-phosphate dehydrogenase (G6PD) insufficiency is a common enzymatic defect worldwide; it affects over 400 million people and is associated with various disorders. Recent research suggests that G6PD-deficient cells are susceptible to infection by ...

Abstract	Glucose-6-phosphate dehydrogenase (G6PD) insufficiency is a common enzymatic defect worldwide; it affects over 400 million people and is associated with various disorders. Recent research suggests that G6PD-deficient cells are susceptible to infection by human coronaviruses, as the G6PD enzyme is involved in the metabolism of oxidative stress, which may enhance COVID-19 mortality. This retrospective study aimed to examine the effect of COVID-19 on patients with G6PD deficiency by comparing the laboratory parameters of patients with G6PD enzyme deficiency alone, COVID-19 alone, and those with both COVID-19 and G6PD enzyme deficiency treated at a major Saudi tertiary center. The results indicated significant differences in hematological and biochemical parameters between the three patient groups, indicating that COVID-19 may influence these parameters, and that they could be used to measure the severity of COVID-19 disease. Moreover, this study suggests that patients with G6PD enzyme deficiency may be at higher risk for severe COVID-19 outcomes. Although the study is limited by the lack of a random selection method for group membership, the Kruskal-Wallis H-test was used to statistical assess the data. The study's findings can enhance the understanding of the relation between COVID-19 infected and G6PD-deficiency patients and inform clinical decision making for an improved patient outcome.
MeSH term(s)	Humans ; Glucosephosphate Dehydrogenase ; Retrospective Studies ; Saudi Arabia/epidemiology ; COVID-19/complications ; Glucosephosphate Dehydrogenase Deficiency/epidemiology ; Glucosephosphate Dehydrogenase Deficiency/complications ; Risk Factors ; Phosphates ; Glucose
Chemical Substances	Glucosephosphate Dehydrogenase (EC 1.1.1.49) ; Phosphates ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061224
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Paediatric COVID-19 Outcomes: Haematology Parameters, Mortality Rates, and Hospitalization Duration.

Alshalani, Abdulrahman / Alotaibi, Badi A / Aldali, Jehad A / AlSudais, Hamood / Almuqrin, Abdulaziz M / Alshehri, Nasser A / Alamar, Nasser B / Alhejji, Mogtba A

Children (Basel, Switzerland)

2023 Volume 10, Issue 10

Abstract: The global COVID-19 pandemic has strained healthcare systems around the globe, necessitating extensive research into the variables that affect patient outcomes. This study examines the relationships between key haematology parameters, duration of ... ...

Abstract	The global COVID-19 pandemic has strained healthcare systems around the globe, necessitating extensive research into the variables that affect patient outcomes. This study examines the relationships between key haematology parameters, duration of hospital stay (LOS), and mortality rates in COVID-19 cases in paediatric patients. Researchers analyse relationships between independent variables (COVID-19 status, age, sex) and dependent variables (mortality, LOS, coagulation parameters, WBC count, RBC parameters) using multivariate regression models. Although the R-square values (0.6-3.7%) indicate limited explanatory power, coefficients with statistical significance establish the impact of independent variables on outcomes. Age emerges as a crucial predictor of mortality; the mortality rate decreases by 1.768% per age group. Both COVID-19 status and age have an inverse relationship with length of stay, emphasising the milder hospitalisation of children. Platelet counts decline with age and male gender, potentially revealing the influence of COVID-19 on haematological markers. There are significant correlations between COVID-19 status, age, gender and coagulation measures. Lower prothrombin time and D-dimer concentrations in elder COVID-19 patients are indicative of distinct coagulation profiles. WBC and RBC parameters exhibit correlations with variables: COVID-19-positive patients have lower WBC counts, whereas male COVID-19-positive patients have higher RBC counts. In addition, correlations exist between independent variables and the red cell distribution width, mean corpuscular volume, and mean corpuscular haemoglobin. However, there is no correlation between mean corpuscular haemoglobin concentration and outcomes, indicating complex interactions between haematological markers and outcomes. In essence, this study underlines the importance of age in COVID-19 mortality, provides novel insights into platelet counts, and emphasises the complexity of the relationships between haematological parameters and disease outcomes.
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10101615
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Fetal Acrania (Exencephaly) in the Context of a Pregnant Female Taking Adalimumab for Psoriasis: A Case Report.

Daham, Nujud / AlMuqrin, Abdullah / Madani, Abdulaziz / AlSaif, Fahad

Biologics : targets & therapy

2020 Volume 14, Page(s) 127–129

Abstract: Adalimumab is a fully human, recombinant, IgG1 monoclonal antibody that targets tumor necrosis factor-alpha (TNF-alpha). It has been established that adalimumab can cross the placenta and can be detected in the fetal circulation for up to 6 months ... ...

Abstract	Adalimumab is a fully human, recombinant, IgG1 monoclonal antibody that targets tumor necrosis factor-alpha (TNF-alpha). It has been established that adalimumab can cross the placenta and can be detected in the fetal circulation for up to 6 months postpartum. However, clinical studies have failed to show any consistent or specific adverse fetal outcomes from maternal exposure to adalimumab during pregnancy. In our report, we present a case of fetal acrania (exencephaly) in the setting of a pregnant female taking adalimumab prior to and during pregnancy. Exencephaly is a neural tube defect (NTD) that results from failure of closure of the neural fold. It is true that there were other risk factors that might have contributed to our patient's unfortunate outcome. For example, she did not take folic acid supplementation prior to or during her pregnancy. Nonetheless, studies have shown that folic acid deficiency alone is not sufficient to lead to the development of NTDs. Our patient's exposure to adalimumab during her pregnancy might have added to the risk in her situation. Our report aims to inform clinicians of that possible risk and to stimulate them to report any similar outcomes.
Language	English
Publishing date	2020-11-11
Publishing country	New Zealand
Document type	Case Reports
ISSN	1177-5475
ISSN	1177-5475
DOI	10.2147/BTT.S273762
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Knowledge and Perception of Physicians of Different Specialties in Saudi Arabia Toward

Hakami, Osamah Ahmad / Alsubaie, Refah Asheer / Albaqami, Bayan Abdulhadi / Almutlaq, Haifa Matar / Alqahtani, Nourah Mushabab / Alkhonezan, Manal / Almuqrin, Farah Fahad / Alghamdi, Abdullah Hussien / Alaryni, Abdullah Abdulaziz / Qutob, Rayan Abubakker

Journal of multidisciplinary healthcare

2023 Volume 16, Page(s) 763–771

Abstract: Background: Helicobacter pylori (H. pylori): Objective: To assess the knowledge and awareness of physicians of different specialties who practice in Saudi Arabia about : Methods: This is a cross-sectional study conducted between May and September ... ...

Abstract	Background: Helicobacter pylori (H. pylori) Objective: To assess the knowledge and awareness of physicians of different specialties who practice in Saudi Arabia about Methods: This is a cross-sectional study conducted between May and September 2022 on physicians across all regions in Saudi Arabia using a validated online questionnaire covering their knowledge and awareness of Results: The results showed that the mean awareness score of 474 physicians was 76.99± 6.9, indicating that participants had sufficient knowledge about Conclusion: Physicians in Saudi Arabia have relatively sufficient awareness of
Language	English
Publishing date	2023-03-19
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2453343-9
ISSN	1178-2390
ISSN	1178-2390
DOI	10.2147/JMDH.S403999
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcription.

Almuqrin, Abdulaziz / Davidson, Andrew D / Williamson, Maia Kavanagh / Lewis, Philip A / Heesom, Kate J / Morris, Susan / Gilbert, Sarah C / Matthews, David A

Genome medicine

2021 Volume 13, Issue 1, Page(s) 43

Abstract: Background: ChAdOx1 nCoV-19 is a recombinant adenovirus vaccine against SARS-CoV-2 that has passed phase III clinical trials and is now in use across the globe. Although replication-defective in normal cells, 28 kbp of adenovirus genes is delivered to ... ...

Abstract	Background: ChAdOx1 nCoV-19 is a recombinant adenovirus vaccine against SARS-CoV-2 that has passed phase III clinical trials and is now in use across the globe. Although replication-defective in normal cells, 28 kbp of adenovirus genes is delivered to the cell nucleus alongside the SARS-CoV-2 S glycoprotein gene. Methods: We used direct RNA sequencing to analyse transcript expression from the ChAdOx1 nCoV-19 genome in human MRC-5 and A549 cell lines that are non-permissive for vector replication alongside the replication permissive cell line, HEK293. In addition, we used quantitative proteomics to study over time the proteome and phosphoproteome of A549 and MRC5 cells infected with the ChAdOx1 nCoV-19 vaccine. Results: The expected SARS-CoV-2 S coding transcript dominated in all cell lines. We also detected rare S transcripts with aberrant splice patterns or polyadenylation site usage. Adenovirus vector transcripts were almost absent in MRC-5 cells, but in A549 cells, there was a broader repertoire of adenoviral gene expression at very low levels. Proteomically, in addition to S glycoprotein, we detected multiple adenovirus proteins in A549 cells compared to just one in MRC5 cells. Conclusions: Overall, the ChAdOx1 nCoV-19 vaccine's transcriptomic and proteomic repertoire in cell culture is as expected. The combined transcriptomic and proteomics approaches provide a detailed insight into the behaviour of this important class of vaccine using state-of-the-art techniques and illustrate the potential of this technique to inform future viral vaccine vector design.
MeSH term(s)	COVID-19/immunology ; COVID-19/metabolism ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Cell Line ; Cells, Cultured ; Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Polyadenylation ; Proteomics/methods ; RNA, Messenger ; RNA, Viral ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Transcription, Genetic
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; RNA, Viral ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2484394-5
ISSN	1756-994X ; 1756-994X
ISSN (online)	1756-994X
ISSN	1756-994X
DOI	10.1186/s13073-021-00859-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito