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  1. Article ; Online: Alteplase and Thrombectomy - Not a Bridge to Dismantle.

    Ciccone, Alfonso

    The New England journal of medicine

    2021  Volume 385, Issue 20, Page(s) 1904–1905

    MeSH term(s) Fibrinolytic Agents/therapeutic use ; Humans ; Thrombectomy ; Tissue Plasminogen Activator
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2112663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  2. Article ; Online: SARS-CoV-2 vaccine-induced cerebral venous thrombosis.

    Ciccone, Alfonso

    European journal of internal medicine

    2021  Volume 89, Page(s) 19–21

    Abstract: The nosological entity of the cerebral venous thrombosis caused by the SARS-CoV-2 vaccination differs from the common cerebral venous thrombosis in that it is due to immune thrombocytopenia triggered by vaccination. Cerebral venous thrombosis is one of ... ...

    Abstract The nosological entity of the cerebral venous thrombosis caused by the SARS-CoV-2 vaccination differs from the common cerebral venous thrombosis in that it is due to immune thrombocytopenia triggered by vaccination. Cerebral venous thrombosis is one of several manifestations of this type of immune thrombocytopenia. Albeit many general aspects of management of cerebral venous thrombosis are similar, immune thrombocytopenia requires a specific therapeutic approach, which is not normally adopted for cerebral venous thrombosis due to other causes, therefore its early recognition is essential.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Thrombocytopenia/chemically induced ; Venous Thrombosis
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.05.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The importance of recognizing cerebral venous thrombosis following anti-COVID-19 vaccination.

    Ciccone, Alfonso / Zanotti, Bruno

    European journal of internal medicine

    2021  Volume 89, Page(s) 115–117

    MeSH term(s) Humans ; Intracranial Thrombosis/etiology ; Sinus Thrombosis, Intracranial ; Vaccination/adverse effects ; Venous Thrombosis/etiology
    Language English
    Publishing date 2021-05-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
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  4. Article ; Online: Complexity of the endovascular intervention and clinical outcomes in acute ischaemic stroke.

    Ciccone, Alfonso

    The Lancet. Neurology

    2014  Volume 13, Issue 9, Page(s) 865

    MeSH term(s) Brain Ischemia ; Endovascular Procedures/methods ; Female ; Humans ; Male ; Reperfusion/methods ; Stroke
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(14)70174-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: STAT3 silencing by an aptamer-based strategy hampers the crosstalk between NSCLC cells and cancer-associated fibroblasts.

    Ibba, Maria L / Ciccone, Giuseppe / Rotoli, Deborah / Coppola, Gabriele / Fiorelli, Alfonso / Catuogno, Silvia / Esposito, Carla L

    Molecular therapy. Nucleic acids

    2023  Volume 32, Page(s) 111–126

    Abstract: The identification of new effective therapeutic options for non-small-cell lung cancer (NSCLC) represents a crucial challenge in oncology. Recent studies indicate that cancer-associated fibroblasts (CAFs) participate in tumor progression by establishing ... ...

    Abstract The identification of new effective therapeutic options for non-small-cell lung cancer (NSCLC) represents a crucial challenge in oncology. Recent studies indicate that cancer-associated fibroblasts (CAFs) participate in tumor progression by establishing a favorable microenvironment that promotes cancer progression. Therefore, the development of strategies inhibiting the interplay between CAFs and cancer cells is considered a winning approach for the development of effective anti-cancer drugs. Among other factors, the signal transducer and activator of transcription-3 (STAT3) has been reported as a key mediator of CAF oncogenic actions, representing a promising therapeutic target. Here, we applied an aptamer-based conjugate (named Gint4.T-STAT3), containing a STAT3 siRNA linked to an aptamer binding and inhibiting the platelet-derived growth factor receptor (PDGFR)β, to obtain STAT3-specific silencing and interfere with CAF pro-tumorigenic functions. We demonstrated that this molecule effectively delivers the STAT3 siRNA in NSCLC cells, and blocks CAF-induced cancer cell growth and migration and reduced spheroid dimension. In addition, we found that Gint4.T-STAT3 alters CAF phenotype, thus functioning as a double-acting molecule able to inhibit the entire tumor bulk. Our data provide a proof of principle for the targeting of CAF pro-tumor functions through an aptamer-based drug, and can open innovative horizons in NSCLC therapy.
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.03.003
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  6. Article ; Online: Predictors of Nursing Home Placement in a Cohort of European People with Alzheimer's Disease and Other Dementia Cases Enrolled in SCU-B or Non SCU-B Centers: The RECage Study.

    Cesana, Bruno Mario / Bergh, Sverre / Ciccone, Alfonso / Cognat, Emmanuel / Fabbo, Andrea / Fascendini, Sara / Frisoni, Giovanni B / Froelich, Lutz / Handels, Ron / Jori, Maria Cristina / Mecocci, Patrizia / Merlo, Paola / Peters, Oliver / Tsolaki, Magda / Defanti, Carlo Alberto

    Journal of Alzheimer's disease : JAD

    2024  Volume 98, Issue 3, Page(s) 1043–1052

    Abstract: Background: Nursing home placement (NHP) can be the final step of patients with Alzheimer's disease.: Objective: We aimed to identify NHP predictors among 508 people with dementia with a 3-year follow-up.: Methods: We analyzed data from the ... ...

    Abstract Background: Nursing home placement (NHP) can be the final step of patients with Alzheimer's disease.
    Objective: We aimed to identify NHP predictors among 508 people with dementia with a 3-year follow-up.
    Methods: We analyzed data from the international observational RECage study, involving 508 people with especially Alzheimer's disease and comparing a cohort enrolled by five centers with a Special Care Unit for BPSD (behavioral and psychological symptoms of dementia) and another one enrolled by six centers lacking this facility. The tertiary objective of the study was to assess the possible role of the SCU-B in delaying NHP. We assessed the relationship of the baseline characteristics with NHP by means of univariate analysis followed by Cox's multivariate model.
    Results: Patients' mean age was 78.1 years, 54.9% were women. Diagnosis mean age was 75.4 (±8.32) years; the main diagnosis was Alzheimer's disease (296; 58.4%). During follow-up, 96 (18.9%) patients died and 153 (30.1%) were institutionalized without a statistically significant difference between the two cohorts (p = 0.9626). The mean NHP time was 902 (95% CI: 870-934). The multivariable analysis without death as a competing risk retained four independent predictors of NHP: age increase (hazard ratio (HR) = 1.023, 95% CI: 1.000-1.046), patient education level increase (HR = 1.062, 95% CI: 1.024-1.101), Neuropsychiatric Inventory total increase (HR = 1.018; 95% CI: 1.011-1.026), and total Mini-Mental State Examination as a favorable factor (HR = 0.948, 95% CI: 0.925-0.971). Gender (females versus males: HR = 1.265, 95% CI: 0.899-1.781) was included in the final Cox's model for adjusting the estimates for.
    Conclusions: Our data partially agree with the predictors of NHP in literature including the effect of high education level. No caregivers' factors were statistically significant.
    Clinical trial registration: NCT03507504.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Caregivers/psychology ; European People ; Nursing Homes ; Proportional Hazards Models ; Aged, 80 and over
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Observational Study ; Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6084: Show issues Location:
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  7. Article ; Online: Is polysomnography screening effective for stroke prevention?

    Proserpio, Paola / Ciccone, Alfonso / Nobili, Lino

    Expert review of neurotherapeutics

    2017  Volume 17, Issue 10, Page(s) 951–953

    Language English
    Publishing date 2017-07-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2017.1360765
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 6155: Show issues Location:
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  8. Article ; Online: Systematic review of organizational models for intra-arterial treatment of acute ischemic stroke.

    Ciccone, Alfonso / Berge, Eivind / Fischer, Urs

    International journal of stroke : official journal of the International Stroke Society

    2018  Volume 14, Issue 1, Page(s) 12–22

    Abstract: Background: Intra-arterial treatment of acute ischemic stroke requires changes to acute stroke services since most hospitals do not have on-site intra-arterial treatment facilities.: Aim: To identify models for delivery of intra-arterial treatment ... ...

    Abstract Background: Intra-arterial treatment of acute ischemic stroke requires changes to acute stroke services since most hospitals do not have on-site intra-arterial treatment facilities.
    Aim: To identify models for delivery of intra-arterial treatment and to compare process performance and clinical and radiological outcomes of the different models.
    Methods: We systematically searched the literature and contacted experts in the field. We performed a qualitative synthesis to identify models, and a quantitative review and meta-analysis of clinical and radiological outcomes under different organizational models.
    Summary of review: The searches retrieved 148 publications, of which 27 were used for the identification and description of models, and 9 for the comparison of the different models. We identified four main models: the mother-ship, drip-and ship, mobile interventionist, and mobile stroke unit models. There were no randomized-controlled trials of the different models, but non-randomized comparisons were possible using data from 8 observational studies and 1 randomized-controlled trial of intra-arterial therapy, of a total of 4127 patients. Comparison between the mother-ship and drip-and-ship models showed no difference in survival (OR 0.81; 95% CI 0.63-1.03), favorable functional outcome (OR 0.96; 95% CI 0.73-1.25), or arterial patency (OR 0.89; 95% CI 0.73-1.08).
    Conclusions: Different organizational models exist for intra-arterial treatment of acute ischemic stroke, but there is insufficient evidence to recommend a particular, universal model. Until one model can be shown to be superior, the choice of model should depend on local factors and patient characteristics.
    MeSH term(s) Brain Ischemia/drug therapy ; Endovascular Procedures ; Fibrinolytic Agents/therapeutic use ; Humans ; Infusions, Intra-Arterial ; Models, Organizational ; Stroke/drug therapy ; Thrombolytic Therapy
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2018-10-10
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1177/1747493018806157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6582: Show issues Location:
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  9. Article: A Confirmatory and an Exploratory Factor Analysis of the Cohen-Mansfield Agitation Inventory (CMAI) in a European Case Series of Patients with Dementia: Results from the RECage Study.

    Cesana, Bruno Mario / Poptsi, Eleni / Tsolaki, Magda / Bergh, Sverre / Ciccone, Alfonso / Cognat, Emmanuel / Fabbo, Andrea / Fascendini, Sara / Frisoni, Giovanni B / Frölich, Lutz / Jori, Maria Cristina / Mecocci, Patrizia / Merlo, Paola / Peters, Oliver / Defanti, Carlo Alberto

    Brain sciences

    2023  Volume 13, Issue 7

    Abstract: Background: One of the most widely used instruments for assessing agitation in dementia patients is the Cohen-Mansfield Agitation Inventory (CMAI), nevertheless no global score has been proposed. The aim of this study is: (a) to conduct a confirmatory ( ... ...

    Abstract Background: One of the most widely used instruments for assessing agitation in dementia patients is the Cohen-Mansfield Agitation Inventory (CMAI), nevertheless no global score has been proposed. The aim of this study is: (a) to conduct a confirmatory (CFA) and exploratory factor analysis (EFA) of CMAI on people with dementia and Psychological and Behavioral Symptoms (BPSD), and (b) to propose an alternative structure, based on clinical criteria including all CMAI items.
    Methods: Confirmatory and exploratory factor analyses were carried out on the CMAI 29 items administered at baseline to 505 patients with dementia (PwD) and BPSD enrolled in the international observational RECage study.
    Results: The three-factor structure has not been confirmed by the CFA, whilst the EFA was carried out respectively on 25 items disregarding 4 items with a prevalence ≤5% and then on 20 items disregarding 9 items with a prevalence ≤10%. The four-factor structure explaining 56% of the variance comprised Physically Aggressive behavior, Verbally Aggressive behavior, Physically non-aggressive behavior, and Physically and verbally aggressive behavior.
    Conclusions: A new grouping of all items according to a clinical criterion is proposed, allowing for a more sensible evaluation of the symptoms leading to better differentiation.
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13071025
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  10. Article: Prognostic Factors of Non-Predominant-Lepidic Lung Adenocarcinoma Presenting as Ground Glass Opacity: Results of a Multicenter Study.

    Messa, Fabiana / Siciliani, Alessandra / Piccioni, Giorgia / Leonardi, Beatrice / Ciccone, Anna Maria / D'Andrilli, Antonio / Andreetti, Claudio / Menna, Cecilia / Vanni, Camilla / Baccarini, Alberto Emiliano / Tiracorrendo, Matteo / Mancini, Massimiliano / Vecchione, Andrea / Nocera, Adriana / Calabrese, Giuseppe / Meacci, Elisa / Margaritora, Stefano / Natale, Giovanni / Fiorelli, Alfonso /
    Venuta, Federico / Rendina, Erino Angelo / Maurizi, Giulio / Ibrahim, Mohsen

    Journal of personalized medicine

    2024  Volume 14, Issue 2

    Abstract: This study aims to define the clinicopathological characteristics and prognosis of non-predominant lepidic invasive adenocarcinoma presenting as Ground Glass Opacity (GGO) nodules. The goal is to assess statistical relationships between histology, tumor ... ...

    Abstract This study aims to define the clinicopathological characteristics and prognosis of non-predominant lepidic invasive adenocarcinoma presenting as Ground Glass Opacity (GGO) nodules. The goal is to assess statistical relationships between histology, tumor size, location, and the incidence of relapse and lymph node dissemination. A retrospective multicenter study was conducted, including patients with GGO observed on CT scans between 2003 and 2021. Anamnestic, radiological, and histological data, as well as SUV values, lymphatic and vascular invasion, pathological stage, resection type, and adjuvant treatment, were analyzed. The primary endpoints were to evaluate prognostic factors for death and recurrence using Cox regression analysis. All 388 patients, including 277 with non-predominant lepidic invasive adenocarcinoma and 161 with lepidic adenocarcinoma, underwent curative anatomical resection. Non-predominant lepidic invasive adenocarcinoma demonstrated a worse prognosis than lepidic adenocarcinoma (
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14020153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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