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Article ; Online: Understanding the "Social" in "Social Media". An Analysis of Twitter Engagement of Pulmonary and Critical Care Fellowship Programs.

Gandotra, Sheetal / Stewart, Nancy H / Khateeb, Dina / Garcha, Puneet / Carlos, W Graham / Carroll, Christopher L / Kaul, Viren

ATS scholar

2021 Volume 2, Issue 2, Page(s) 202–211

Abstract: Background:: Objective:: Methods:: Results:: Conclusion: ...

Abstract	Background: Objective: Methods: Results: Conclusion:
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article
ISSN	2690-7097
ISSN (online)	2690-7097
DOI	10.34197/ats-scholar.2020-0100OC
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparing the Digital Footprint of Pulmonary and Critical Care Conferences on Twitter.

Carroll, Christopher L / Kaul, Viren / Dangayach, Neha S / Szakmany, Tamas / Winter, Gretchen / Khateeb, Dina / Carlos, W Graham / Kudchadkar, Sapna R

ATS scholar

2021 Volume 2, Issue 3, Page(s) 432–441

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-13
Publishing country	United States
Document type	Journal Article
ISSN	2690-7097
ISSN (online)	2690-7097
DOI	10.34197/ats-scholar.2021-0041OC
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Azygous lobe: a normal variant of pulmonary anatomy.

Melnick, Stephen / Loynd, Richard / Khateeb, Dina

Journal of community hospital internal medicine perspectives

2016 Volume 6, Issue 6, Page(s) 33776

Language	English
Publishing date	2016-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2616884-4
ISSN	2000-9666
ISSN	2000-9666
DOI	10.3402/jchimp.v6.33776
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction to

Ahmed M. Magdy / Mohammad A. Saad / Ahmed F. El Khateeb / Mona I. Ahmed / Dina H. Gamal El-Din

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

Comparative evaluation of semi-quantitative CT-severity scoring versus serum lactate dehydrogenase as prognostic biomarkers for disease severity and clinical outcome of COVID-19 patients

2021 Volume 1

Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rheumatoid arthritis patients treated with Janus kinase inhibitors show reduced humoral immune responses following BNT162b2 vaccination.

Iancovici, Liat / Khateeb, Dina / Harel, Ofer / Peri, Regina / Slobodin, Gleb / Hazan, Yoav / Melamed, Doron / Kessel, Aharon / Bar-On, Yotam

Rheumatology (Oxford, England)

2021 Volume 61, Issue 8, Page(s) 3439–3447

Abstract: Objectives: The mRNA-based COVID-19 vaccines are now employed globally and have shown high efficacy in preventing SARS-CoV-2 infection. However, less is known about the vaccine efficacy in immune-suppressed individuals. This study sought to explore ... ...

Abstract	Objectives: The mRNA-based COVID-19 vaccines are now employed globally and have shown high efficacy in preventing SARS-CoV-2 infection. However, less is known about the vaccine efficacy in immune-suppressed individuals. This study sought to explore whether humoral immunity to the COVID-19 vaccine BNT162b2 is altered in RA patients treated with Janus kinase inhibitors by analysing their antibodies titre, neutralization activity and B cell responses. Methods: We collected plasma samples from 12 RA patients who were treated with Janus kinase inhibitors and received two doses of the BNT162b2 vaccine, as well as 26 healthy individuals who were vaccinated with the same vaccine. We analysed the quantity of the anti-spike IgG and IgA antibodies that were elicited following the BNT162b2 vaccination, the plasma neutralization capacity and the responsiveness of the B-lymphocytes. We used ELISA to quantify the antibody titres, and a plasma neutralization assay was used to determine the virus neutralization capacity. Alteration in expression of the genes that are associated with B cell activation and the germinal centre response were analysed by quantitative PCR. Results: Reduced levels of anti-spike IgG antibodies and neutralization capacity were seen in the RA patients who were treated with JAK inhibitors in comparison with healthy individuals. Furthermore, B cell responsiveness to the SARS-CoV-2 spike protein was reduced in the RA patients. Conclusion: RA patients who are treated with JAK inhibitors show a suppressed humoral response following BNT162b2 vaccination, as revealed by the quantity and quality of the anti-spike antibodies.
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; Arthritis, Rheumatoid/drug therapy ; BNT162 Vaccine/immunology ; COVID-19/prevention & control ; Humans ; Immunity, Humoral ; Immunoglobulin G ; Janus Kinase Inhibitors/therapeutic use ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Vaccination
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Janus Kinase Inhibitors ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keab879
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Oral Tuberculosis: A Rare Manifestation of Disseminated Disease in a Patient with Dermatomyositis on Chronic Corticosteroids.

Khateeb, Dina / Kang, Mohleen / Capitle, Eugenio / Feurdean, Mirela

Case reports in medicine

2016 Volume 2016, Page(s) 8193178

Abstract: Tuberculosis remains one of the leading causes of death around the world despite advancements in diagnostic testing and medical therapies. It commonly affects the lungs, but isolated extra pulmonary clinical manifestations have been reported. ... ...

Abstract	Tuberculosis remains one of the leading causes of death around the world despite advancements in diagnostic testing and medical therapies. It commonly affects the lungs, but isolated extra pulmonary clinical manifestations have been reported. Tuberculosis of the oral cavity is exceedingly rare. We present a case of a patient with dermatomyositis on chronic steroid therapy, who presented with tuberculosis involving the tongue as the only clinical manifestation of disseminated disease. Physicians must be aware of extra pulmonary manifestations of tuberculosis in patients at risk, in order to avoid delays in diagnosis and treatment and to prevent further contagion.
Language	English
Publishing date	2016-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2502642-2
ISSN	1687-9635 ; 1687-9627
ISSN (online)	1687-9635
ISSN	1687-9627
DOI	10.1155/2016/8193178
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Azygous lobe

Stephen Melnick / Richard Loynd / Dina Khateeb

Journal of Community Hospital Internal Medicine Perspectives, Vol 6, Iss 6, Pp 1-

a normal variant of pulmonary anatomy

2016 Volume 1

Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection.

Khateeb, Dina / Gabrieli, Tslil / Sofer, Bar / Hattar, Adi / Cordela, Sapir / Chaouat, Abigael / Spivak, Ilia / Lejbkowicz, Izabella / Almog, Ronit / Mandelboim, Michal / Bar-On, Yotam

PLoS pathogens

2022 Volume 18, Issue 1, Page(s) e1010242

Abstract: In-depth analysis of SARS-CoV-2 quasispecies is pivotal for a thorough understating of its evolution during infection. The recent deployment of COVID-19 vaccines, which elicit protective anti-spike neutralizing antibodies, has stressed the importance of ... ...

Abstract	In-depth analysis of SARS-CoV-2 quasispecies is pivotal for a thorough understating of its evolution during infection. The recent deployment of COVID-19 vaccines, which elicit protective anti-spike neutralizing antibodies, has stressed the importance of uncovering and characterizing SARS-CoV-2 variants with mutated spike proteins. Sequencing databases have allowed to follow the spread of SARS-CoV-2 variants that are circulating in the human population, and several experimental platforms were developed to study these variants. However, less is known about the SARS-CoV-2 variants that are developed in the respiratory system of the infected individual. To gain further insight on SARS-CoV-2 mutagenesis during natural infection, we preformed single-genome sequencing of SARS-CoV-2 isolated from nose-throat swabs of infected individuals. Interestingly, intra-host SARS-CoV-2 variants with mutated S genes or N genes were detected in all individuals who were analyzed. These intra-host variants were present in low frequencies in the swab samples and were rarely documented in current sequencing databases. Further examination of representative spike variants identified by our analysis showed that these variants have impaired infectivity capacity and that the mutated variants showed varied sensitivity to neutralization by convalescent plasma and to plasma from vaccinated individuals. Notably, analysis of the plasma neutralization activity against these variants showed that the L1197I mutation at the S2 subunit of the spike can affect the plasma neutralization activity. Together, these results suggest that SARS-CoV-2 intra-host variants should be further analyzed for a more thorough characterization of potential circulating variants.
MeSH term(s)	Adult ; Aged ; BNT162 Vaccine/administration & dosage ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/prevention & control ; Child ; Coronavirus Nucleocapsid Proteins/genetics ; Coronavirus Nucleocapsid Proteins/immunology ; Databases, Nucleic Acid ; Female ; Genome, Viral ; HEK293 Cells ; Humans ; Male ; Middle Aged ; Mutation ; Phosphoproteins/genetics ; Phosphoproteins/immunology ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Sequence Analysis, RNA ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
Chemical Substances	Coronavirus Nucleocapsid Proteins ; Phosphoproteins ; Spike Glycoprotein, Coronavirus ; nucleocapsid phosphoprotein, SARS-CoV-2 ; spike protein, SARS-CoV-2 ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1010242
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative evaluation of semi-quantitative CT-severity scoring versus serum lactate dehydrogenase as prognostic biomarkers for disease severity and clinical outcome of COVID-19 patients

Ahmed M. Magdy / Mohammad A. Saad / Ahmed F. El Khateeb / Mona I. Ahmed / Dina H. Gamal El-Din

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

2021 Volume 11

Abstract: Abstract Background Coronavirus disease 2019 pandemic causes significant strain on healthcare infrastructure and medical resources. So, it becomes crucial to identify reliable predictor biomarkers for COVID-19 disease severity and short term mortality. ... ...

Abstract	Abstract Background Coronavirus disease 2019 pandemic causes significant strain on healthcare infrastructure and medical resources. So, it becomes crucial to identify reliable predictor biomarkers for COVID-19 disease severity and short term mortality. Many biomarkers are currently investigated for their prognostic role in COVID-19 patients. Our study is retrospective and aims to evaluate role of semi-quantitative CT-severity scoring versus LDH as prognostic biomarkers for COVID-19 disease severity and short-term clinical outcome. Results Two hundred sixty-six patients between April 2020 and November 2020 with positive RT-PCR results underwent non-enhanced CT scan chest in our hospital and were retrospectively evaluated for CT severity scoring and serum LDH level measurement. Data were correlated with clinical disease severity. CT severity score and LDH were significantly higher in severe and critical cases compared to mild cases (P value < 0.001). High predictive significance of CT severity score for COVID-19 disease course noted, with cut-off value ≥ 13 highly predictive of severe disease (96.96% accuracy); cut-off value ≥ 16 highly predictive of critical disease (94.21% accuracy); and cut-off value ≥ 19 highly predictive of short-term mortality (92.56% accuracy). CT severity score has higher sensitivity, specificity, positive, and negative predictive values as well as overall accuracy compared to LDH level in predicting severe, critical cases, and short-term mortality. Conclusion Semi-quantitative CT severity scoring has high predictive significance for COVID-19 disease severity and short-term mortality with higher sensitivity, specificity, and overall accuracy compared to LDH. Our study strongly supports the use of CT severity scoring as a powerful prognostic biomarker for COVID-19 disease severity and short-term clinical outcome to allow triage of need for hospital admission, earlier medical interference, and to effectively prioritize medical resources for cases with high mortality risk for better ...
Keywords	Coronavirus disease 2019 (COVID-19) ; Prognostic biomarker ; CT severity scoring ; LDH ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	006
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Oral Tuberculosis

Dina Khateeb / Mohleen Kang / Eugenio Capitle / Mirela Feurdean

Case Reports in Medicine, Vol

A Rare Manifestation of Disseminated Disease in a Patient with Dermatomyositis on Chronic Corticosteroids

2016 Volume 2016

Abstract	Tuberculosis remains one of the leading causes of death around the world despite advancements in diagnostic testing and medical therapies. It commonly affects the lungs, but isolated extra pulmonary clinical manifestations have been reported. Tuberculosis of the oral cavity is exceedingly rare. We present a case of a patient with dermatomyositis on chronic steroid therapy, who presented with tuberculosis involving the tongue as the only clinical manifestation of disseminated disease. Physicians must be aware of extra pulmonary manifestations of tuberculosis in patients at risk, in order to avoid delays in diagnosis and treatment and to prevent further contagion.
Keywords	Medicine ; R
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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