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Book ; Online: Accessible Robot Control in Mixed Reality

Zhang, Ganlin / Zhang, Deheng / Duan, Longteng / Han, Guo

2023

Abstract: A novel method to control the Spot robot of Boston Dynamics by Hololens 2 is proposed. This method is mainly designed for people with physical disabilities, users can control the robot's movement and robot arm without using their hands. The eye gaze ... ...

Abstract	A novel method to control the Spot robot of Boston Dynamics by Hololens 2 is proposed. This method is mainly designed for people with physical disabilities, users can control the robot's movement and robot arm without using their hands. The eye gaze tracking and head motion tracking technologies of Hololens 2 are utilized for sending control commands. The movement of the robot would follow the eye gaze and the robot arm would mimic the pose of the user's head. Through our experiment, our method is comparable with the traditional control method by joystick in both time efficiency and user experience. Demo can be found on our project webpage: https://zhangganlin.github.io/Holo-Spot-Page/index.html Comment: Course Project of Mixed Reality at ETH Zurich
Keywords	Computer Science - Robotics ; Computer Science - Computer Vision and Pattern Recognition
Publishing date	2023-06-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Lossy Computing with Side Information via Multi-Hypergraphs

Yuan, Deheng / Guo, Tao / Bai, Bo / Han, Wei

2022

Abstract: We consider a problem of coding for computing, where the decoder wishes to estimate a function of its local message and the source message at the encoder within a given distortion. We show that the rate-distortion function can be characterized through a ... ...

Abstract	We consider a problem of coding for computing, where the decoder wishes to estimate a function of its local message and the source message at the encoder within a given distortion. We show that the rate-distortion function can be characterized through a characteristic multi-hypergraph, which simplifies the evaluation of the rate-distortion function.
Keywords	Computer Science - Information Theory
Publishing date	2022-05-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 was found in the bile juice from a patient with severe COVID-19.

Han, Deheng / Fang, Qiang / Wang, Xingxiang

Journal of medical virology

2020 Volume 93, Issue 1, Page(s) 102–104

MeSH term(s)	Bile/virology ; COVID-19/pathology ; COVID-19/virology ; Cholangiopancreatography, Endoscopic Retrograde ; Cholestasis/pathology ; Cholestasis/surgery ; Humans ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification
Keywords	covid19
Language	English
Publishing date	2020-06-29
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26169
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Zs.A 1320: Show issues

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Article ; Online: Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway.

Chen, Lu / Sun, Xingang / Wang, Zhen / Chen, Miao / He, Yuxian / Zhang, Han / Han, Deheng / Zheng, Liangrong

Toxicology and applied pharmacology

2023 Volume 482, Page(s) 116794

Abstract: Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative cardiotoxic effects. Resveratrol (Res) is a natural non-flavonoid polyphenol that can potentially provide cardiovascular benefits. We aimed to estimate the protective ... ...

Abstract	Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative cardiotoxic effects. Resveratrol (Res) is a natural non-flavonoid polyphenol that can potentially provide cardiovascular benefits. We aimed to estimate the protective effect of Res on Dox-induced cardiotoxicity (DIC) and explore whether it was related to attenuating ferroptosis. We established DIC models in C57BL/6 J mice, H9C2 cardiomyoblasts, and neonatal rat cardiomyocytes (NRCMs). We further treated H9C2 cells with RSL3, a ferroptosis agonist, to investigate whether Res exerted protective effects through inhibiting ferroptosis. Ferrostatin-1 (Fer-1) was applied to suppress ferroptosis. Dox treatment caused cardiac dysfunction and resulted in apparent ferroptotic damage in cardiac tissue, involving increased iron accumulation, glutathione depletion, increased expression of ferroptosis-related proteins, and decreased expression of glutathione peroxidase 4, which were alleviated by Fer-1 and Res administration. These findings were also confirmed in Dox-treated H9C2 cells and NRCMs, with Fer-1 and Res effectively attenuating Dox-induced cytotoxicity and ferroptosis. Furthermore, Res protected H9C2 cells from RSL3-induced ferroptotic cell death, and the protective effect was similar to that of Fer-1. Both Dox and RSL3 treatment increased the phosphorylation levels of mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinases; however, these changes were hindered by Res. This study demonstrates that Res effectively alleviates DIC by suppressing ferroptosis possibly through modulating the MAPK signaling pathway. Our results highlight that targeting ferroptosis can be a potential cardioprotective strategy for DIC.
MeSH term(s)	Mice ; Rats ; Animals ; Resveratrol/pharmacology ; Cardiotoxicity/pathology ; Ferroptosis ; Apoptosis ; Cell Line ; Mice, Inbred C57BL ; Signal Transduction ; Doxorubicin/pharmacology ; Myocytes, Cardiac ; Oxidative Stress
Chemical Substances	Resveratrol (Q369O8926L) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2023.116794
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Zs.B 14: Show issues

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Article ; Online: Determinants of left atrial thrombus or spontaneous echo contrast in nonvalvular atrial fibrillation.

Han, Deheng / Chu, Yanan / Wu, Yakui / Wang, Xingxiang

Thrombosis research

2020 Volume 195, Page(s) 233–237

Abstract: Background: The CHADS: Methods: We identified 1102 consecutive AF patients who underwent transesophageal echocardiography (TEE) for the purpose of the exclusion of LAT before catheter ablation, cardioversion or left atrial appendage occlusion. The ... ...

Abstract	Background: The CHADS Methods: We identified 1102 consecutive AF patients who underwent transesophageal echocardiography (TEE) for the purpose of the exclusion of LAT before catheter ablation, cardioversion or left atrial appendage occlusion. The clinical, echocardiographic and laboratory characteristics of patients were collected from the electronic medical record system. Results: In the study, the prevalence of LAT/SEC was only 4.36%. In the multivariate logistic analysis, hypertension, left atrial enlargement, prior stroke/TIA, left ventricular dysfunction, and renal dysfunction were predictors of LAT/SEC. Receiver operating characteristic curve analysis showed that c-statistics of the CHADS Conclusion: In our cohort, we found two variables not included in the CHA
MeSH term(s)	Atrial Fibrillation/complications ; Humans ; Predictive Value of Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; Thrombosis
Language	English
Publishing date	2020-08-07
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2020.07.055
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Zs.A 863: Show issues

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Article ; Online: Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study.

Chen, Lu / Sun, Xingang / Han, Deheng / Zhong, Jiawei / Zhang, Han / Zheng, Liangrong

Frontiers in public health

2022 Volume 10, Page(s) 1023935

Abstract: Background: Coronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is ... ...

Abstract	Background: Coronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is causally associated with the susceptibility, hospitalization, or severity of COVID-19 remains unconfirmed. We aimed to investigate the causal associations between VAT and susceptibility, hospitalization, and severity of COVID-19. Methods: We applied a two-sample Mendelian randomization (MR) study to infer causal associations between VAT and COVID-19 outcomes. Single-nucleotide polymorphisms significantly associated with VAT were derived from a large-scale genome-wide association study. The random-effects inverse-variance weighted method was used as the main MR approach, complemented by three other MR methods. Additional sensitivity analyses were also performed. Results: Genetically predicted higher VAT mass was causally associated with higher risks of COVID-19 susceptibility [odds ratios (ORs) = 1.13; 95% confidence interval (CI), 1.09-1.17; Conclusion: This study provided genetic evidence that higher VAT mass was causally associated with higher risks of susceptibility, hospitalization, and severity of COVID-19. VAT can be a useful tool for risk assessment in the general population and COVID-19 patients, as well as an important prevention target.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Intra-Abdominal Fat ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Hospitalization
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.1023935
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Article ; Online: A randomized clinical trial for meal bolus decision using learning-based control in adults with type 2 diabetes.

Liu, Wei / Cai, Deheng / Zhang, Rui / Zhang, Xiuying / Cai, Xiaoling / Tao, Liyuan / Han, Xueyao / Luo, Yingying / Li, Meng / Wu, Wenjing / Ma, Yumin / Shi, Dawei / Ji, Linong

The Journal of clinical endocrinology and metabolism

2024

Abstract: Background: We proposed an artificial-pancreas-like algorithm (AP-A) which could automatically determine the pre-prandial insulin dose based on intermittently scanned continuous glucose monitoring (isCGM) data trajectories in multiple dose injection ( ... ...

Abstract	Background: We proposed an artificial-pancreas-like algorithm (AP-A) which could automatically determine the pre-prandial insulin dose based on intermittently scanned continuous glucose monitoring (isCGM) data trajectories in multiple dose injection (MDI) therapy. We aim to determine whether pre-prandial insulin dose adjustments guided by the AP-A is as effective and safe as physician decisions. Methods: We performed a randomized, single-blind, clinical trial at a tertiary, referral hospital in Beijing, China. Type 2 diabetes participants were eligible if they were aged 18 years, with a glycated hemoglobin of 8.0% or higher. Eligible participants were randomly assigned (1:1) to the AP-A arm supervised by physician and the conventional physician treatment arm. The primary objective was to compare percentage time spent with sensor glucose level in 3.9-10.0 mmol/L (TIR) between the two study arms. Safety was assessed by the percentage time spent with sensor glucose level below 3.0 mmol/L (TBR). Results: 140 participants were screened, of whom 119 were randomly assigned to AP-A arm (n = 59) or physician arm (n = 60). The TIR achieved by the AP-A arm was statistically non-inferior compared with the control arm (72.4% (63.3-82.1) vs. 71.2% (54.9-81.4)), with a median difference of 1.33% (95% CI, -6.00 to 10.94, non-inferiority margin -7.5%). TBR was also statistically non-inferior between the AP-A and control arms (0.0% (0.0-0.0) vs. 0.0% (0.0-0.0), respectively; median difference (95% CI, 0.00% (0.00 to 0.00), non-inferiority margin 2.0%). Conclusions: The AP-A supported physician titration of pre-prandial insulin dosage offers non-inferior glycemic control compared with optimal physician care in type 2 diabetes.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae143
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Uh III Zs.134: Show issues

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Article: Preserved C-peptide is common and associated with higher time in range in Chinese type 1 diabetes.

Liu, Wei / Fang, Yayu / Cai, Xiaoling / Zhu, Yu / Zhang, Mingxia / Han, Xueyao / Li, Juan / Yin, Sai / Cai, Deheng / Chen, Jing / Wang, Lei / Shi, Dawei / Ji, Linong

Frontiers in endocrinology

2024 Volume 15, Page(s) 1335913

Abstract: Objective: The aim of this study is to determine the residual C-peptide level and to explore the clinical significance of preserved C-peptide secretion in glycemic control in Chinese individuals with type 1 diabetes (T1D).: Research design and methods! ...

Abstract	Objective: The aim of this study is to determine the residual C-peptide level and to explore the clinical significance of preserved C-peptide secretion in glycemic control in Chinese individuals with type 1 diabetes (T1D). Research design and methods: A total of 534 participants with T1D were enrolled and divided into two groups, low-C-peptide group (fasting C-peptide ≤10 pmol/L) and preserved-C-peptide group (fasting C-peptide >10 pmol/L), and clinical factors were compared between the two groups. In 174 participants who were followed, factors associated with C-peptide loss were also identified by Cox regression. In addition, glucose metrics derived from intermittently scanned continuous glucose monitoring were compared between individuals with low C-peptide and those with preserved C-peptide in 178 participants. Results: The lack of preserved C-peptide was associated with longer diabetes duration, glutamic acid decarboxylase autoantibody, and higher daily insulin doses, after adjustment {OR, 1.10 [interquartile range (IQR), 1.06-1.14]; OR, 0.46 (IQR, 0.27-0.77); OR, 1.04 (IQR, 1.02-1.06)}. In the longitudinal analysis, the percentages of individuals with preserved C-peptide were 71.4%, 56.8%, 71.7%, 62.5%, and 22.2% over 5 years of follow-up. Preserved C-peptide was also associated with higher time in range after adjustment of diabetes duration [62.4 (IQR, 47.3-76.6) vs. 50.3 (IQR, 36.2-63.0) %, adjusted Conclusions: Our results indicate that a high proportion of Chinese patients with T1D had preserved C-peptide secretion. Meanwhile, residual C-peptide was associated with favorable glycemic control, suggesting the importance of research on adjunctive therapy to maintain β-cell function in T1D.
MeSH term(s)	Humans ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring/methods ; C-Peptide ; Diabetes Mellitus, Type 1/drug therapy ; Hyperinsulinism/drug therapy ; Hypoglycemic Agents/therapeutic use
Chemical Substances	Blood Glucose ; C-Peptide ; Hypoglycemic Agents
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1335913
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Book ; Online: RLTF

Liu, Jiate / Zhu, Yiqin / Xiao, Kaiwen / Fu, Qiang / Han, Xiao / Yang, Wei / Ye, Deheng

Reinforcement Learning from Unit Test Feedback

2023

Abstract: The goal of program synthesis, or code generation, is to generate executable code based on given descriptions. Recently, there has been an increasing number of studies employing reinforcement learning (RL) to improve the performance of large language ... ...

Abstract	The goal of program synthesis, or code generation, is to generate executable code based on given descriptions. Recently, there has been an increasing number of studies employing reinforcement learning (RL) to improve the performance of large language models (LLMs) for code. However, current representative works either rely solely on offline frameworks, limiting the exploration of new sample spaces, or fall short in the utilization of unit test signals, not accounting for specific error locations within the code. To address these issues, we propose RLTF, i.e., Reinforcement Learning from Unit Test Feedback, a novel online RL framework with unit test feedback of multi-granularity for refining code LLMs. Our approach generates data in real-time during training and simultaneously utilizes fine-grained feedback signals to guide the model towards producing higher-quality code. Extensive experiments show that RLTF achieves state-of-the-art performance on the APPS and the MBPP benchmarks. Our code is available at: https://github.com/Zyq-scut/RLTF. Comment: Accepted by TMLR
Keywords	Computer Science - Artificial Intelligence ; Computer Science - Computation and Language ; Computer Science - Machine Learning
Subject code	004
Publishing date	2023-07-10
Publishing country	us
Document type	Book ; Online
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Article ; Online: SARS‐CoV‐2 was found in the bile juice from a patient with severe COVID‐19

Han, Deheng / Fang, Qiang / Wang, Xingxiang

Journal of Medical Virology ; ISSN 0146-6615 1096-9071

2020

Keywords	Virology ; Infectious Diseases ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1002/jmv.26169
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