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  1. Article ; Online: The authors reply.

    Chotalia, Minesh / Patel, Jaimin M / Parekh, Dhruv / Bangash, Mansoor N

    Critical care medicine

    2023  Volume 51, Issue 2, Page(s) e66–e67

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Editorial: intended victim or innocent bystander? The liver in COVID-19.

    Packer, Greg / Bangash, Mansoor N

    Alimentary pharmacology & therapeutics

    2020  Volume 52, Issue 7, Page(s) 1218–1219

    Keywords covid19
    Language English
    Publishing date 2020-10-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Cardiovascular Subphenotypes in ARDS: Diagnostic and Therapeutic Implications and Overlap with Other ARDS Subphenotypes.

    Chotalia, Minesh / Patel, Jaimin M / Bangash, Mansoor N / Parekh, Dhruv

    Journal of clinical medicine

    2023  Volume 12, Issue 11

    Abstract: Acute respiratory distress syndrome (ARDS) is a highly heterogeneous clinical condition. Shock is a poor prognostic sign in ARDS, and heterogeneity in its pathophysiology may be a barrier to its effective treatment. Although right ventricular dysfunction ...

    Abstract Acute respiratory distress syndrome (ARDS) is a highly heterogeneous clinical condition. Shock is a poor prognostic sign in ARDS, and heterogeneity in its pathophysiology may be a barrier to its effective treatment. Although right ventricular dysfunction is commonly implicated, there is no consensus definition for its diagnosis, and left ventricular function is neglected. There is a need to identify the homogenous subgroups within ARDS, that have a similar pathobiology, which can then be treated with targeted therapies. Haemodynamic clustering analyses in patients with ARDS have identified two subphenotypes of increasingly severe right ventricular injury, and a further subphenotype of hyperdynamic left ventricular function. In this review, we discuss how phenotyping the cardiovascular system in ARDS may align with haemodynamic pathophysiology, can aid in optimally defining right ventricular dysfunction and can identify tailored therapeutic targets for shock in ARDS. Additionally, clustering analyses of inflammatory, clinical and radiographic data describe other subphenotypes in ARDS. We detail the potential overlap between these and the cardiovascular phenotypes.
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12113695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Definition and evolution of right ventricular dysfunction in critically ill COVID-19 patients.

    Chotalia, Minesh / Bangash, Mansoor N / Patel, Jaimin M / Parekh, Dhruv

    Annals of intensive care

    2022  Volume 12, Issue 1, Page(s) 82

    Language English
    Publishing date 2022-08-30
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-022-01055-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardiovascular Subphenotypes in ARDS

    Minesh Chotalia / Jaimin M. Patel / Mansoor N. Bangash / Dhruv Parekh

    Journal of Clinical Medicine, Vol 12, Iss 3695, p

    Diagnostic and Therapeutic Implications and Overlap with Other ARDS Subphenotypes

    2023  Volume 3695

    Abstract: Acute respiratory distress syndrome (ARDS) is a highly heterogeneous clinical condition. Shock is a poor prognostic sign in ARDS, and heterogeneity in its pathophysiology may be a barrier to its effective treatment. Although right ventricular dysfunction ...

    Abstract Acute respiratory distress syndrome (ARDS) is a highly heterogeneous clinical condition. Shock is a poor prognostic sign in ARDS, and heterogeneity in its pathophysiology may be a barrier to its effective treatment. Although right ventricular dysfunction is commonly implicated, there is no consensus definition for its diagnosis, and left ventricular function is neglected. There is a need to identify the homogenous subgroups within ARDS, that have a similar pathobiology, which can then be treated with targeted therapies. Haemodynamic clustering analyses in patients with ARDS have identified two subphenotypes of increasingly severe right ventricular injury, and a further subphenotype of hyperdynamic left ventricular function. In this review, we discuss how phenotyping the cardiovascular system in ARDS may align with haemodynamic pathophysiology, can aid in optimally defining right ventricular dysfunction and can identify tailored therapeutic targets for shock in ARDS. Additionally, clustering analyses of inflammatory, clinical and radiographic data describe other subphenotypes in ARDS. We detail the potential overlap between these and the cardiovascular phenotypes.
    Keywords acute respiratory distress syndrome ; latent class analysis ; right ventricular dysfunction ; right ventricular failure ; subphenotypes ; transthoracic echocardiography ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Mechanisms of Post-critical Illness Cardiovascular Disease.

    Owen, Andrew / Patel, Jaimin M / Parekh, Dhruv / Bangash, Mansoor N

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 854421

    Abstract: Prolonged critical care stays commonly follow trauma, severe burn injury, sepsis, ARDS, and complications of major surgery. Although patients leave critical care following homeostatic recovery, significant additional diseases affect these patients during ...

    Abstract Prolonged critical care stays commonly follow trauma, severe burn injury, sepsis, ARDS, and complications of major surgery. Although patients leave critical care following homeostatic recovery, significant additional diseases affect these patients during and beyond the convalescent phase. New cardiovascular and renal disease is commonly seen and roughly one third of all deaths in the year following discharge from critical care may come from this cluster of diseases. During prolonged critical care stays, the immunometabolic, inflammatory and neurohumoral response to severe illness in conjunction with resuscitative treatments primes the immune system and parenchymal tissues to develop a long-lived pro-inflammatory and immunosenescent state. This state is perpetuated by persistent Toll-like receptor signaling, free radical mediated isolevuglandin protein adduct formation and presentation by antigen presenting cells, abnormal circulating HDL and LDL isoforms, redox and metabolite mediated epigenetic reprogramming of the innate immune arm (trained immunity), and the development of immunosenescence through T-cell exhaustion/anergy through epigenetic modification of the T-cell genome. Under this state, tissue remodeling in the vascular, cardiac, and renal parenchymal beds occurs through the activation of pro-fibrotic cellular signaling pathways, causing vascular dysfunction and atherosclerosis, adverse cardiac remodeling and dysfunction, and proteinuria and accelerated chronic kidney disease.
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.854421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 and the liver: little cause for concern.

    Bangash, Mansoor N / Patel, Jaimin / Parekh, Dhruv

    The lancet. Gastroenterology & hepatology

    2020  Volume 5, Issue 6, Page(s) 529–530

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Liver Diseases/virology ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-20
    Publishing country Netherlands
    Document type Letter
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(20)30084-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial

    Packer, Greg / Bangash, Mansoor N

    intended victim or innocent bystander? The liver in COVID-19.

    2020  

    Keywords WI Digestive system. Gastroenterology ; covid19
    Language English
    Publisher Wiley-Blackwell
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Acute liver failure.

    Arshad, Mohammed A / Murphy, Nicholas / Bangash, Mansoor N

    Clinical medicine (London, England)

    2020  Volume 20, Issue 5, Page(s) 505–508

    Abstract: Acute liver failure is a rare syndrome and is primarily caused by paracetamol toxicity in developed nations. Survival for patients with acute liver failure has steadily improved over the last few decades from approximately 20% to greater than 60%. This ... ...

    Abstract Acute liver failure is a rare syndrome and is primarily caused by paracetamol toxicity in developed nations. Survival for patients with acute liver failure has steadily improved over the last few decades from approximately 20% to greater than 60%. This marked improvement in survival has been due to a combination of improvements in medical practice and the use of emergency liver transplantation in selected patients. Early recognition and timely initial management in the non-specialist centre can significantly improve outcomes. Patients should be simultaneously discussed with a transplant centre and referred to critical care. Close liaison with transplant centres to ensure timely transfer in deteriorating patients is important.
    MeSH term(s) Acetaminophen ; Analgesics, Non-Narcotic ; Critical Care ; Drug Overdose ; Emergencies ; Humans ; Liver Failure, Acute/diagnosis ; Liver Failure, Acute/therapy ; Liver Transplantation
    Chemical Substances Analgesics, Non-Narcotic ; Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2020-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2020-0612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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