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Article ; Online: التغيرات الدينية في مصر القديمة وظهور عبادة التفريد للإمبراطورية المصرية ‏ في عهد امنوفس الرابع (اخناتون)‏

الأستاذ, Vol 61, Iss

2022 Volume 2

Abstract: كان للدين دوراً هاماً في حياة الإنسان بوادي النيل، لم توجد تأثيرات تؤثر علية مثل الدين بشكل مباشر، وكان المصريون القدماء يستخدمون كل شيء محيط بهم من الظواهر يجدون له تفسراً دينياً. فحياة الإنسان المصري مرتبطة ارتباط وثيق بالدين، وكانت الظواهر الكونية ... ...

Abstract	كان للدين دوراً هاماً في حياة الإنسان بوادي النيل، لم توجد تأثيرات تؤثر علية مثل الدين بشكل مباشر، وكان المصريون القدماء يستخدمون كل شيء محيط بهم من الظواهر يجدون له تفسراً دينياً. فحياة الإنسان المصري مرتبطة ارتباط وثيق بالدين، وكانت الظواهر الكونية والفلكية هي المبشر الأول للدين وفسر الانسان الاشياء التي يعجز عن فهمها انها تعود الى قوه خارقة للعاده، والخوف منها دعاه لاحترامها والخضوع لها، ومن هنا نشأت الديانة. على الرغم أن الانسان لم يشاهد هذه القوي لكنه مؤمن بوجودها، وعمل لها صور في مخيلته، بل اعتقد انها كالبشر يمكن إرضائها بالقرابين، حتى استقر في وعيه الصلة الروحية بينه وبين الآلهة فأحبها واعتمد عليها. لم يؤمن المصري القديم بدين واحد، فوجد دين الدولة الرسمي وهناك المقدسات الشعبية والعقيدة لكل قرية أو مدينة تسير جنبا إلى جنب دون تعصب أو تناحر.
Keywords	التغيرات الدينية ; مصر القديمة ; عبادة التوحيد ; للامبراطورية المصرية ; اخناتون ; Social sciences (General) ; H1-99
Language	Arabic
Publishing date	2022-06-01T00:00:00Z
Publisher	Collage of Education Ibn Rushd / University of Baghdad
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anthropogenic-induced environmental and ecological changes in the Nile Delta over the past half-century.

Abdel-Raheem, Khalaf H M / Khalil, Mahmoud M / Abdelhady, Ahmed A / Tan, Liangcheng

The Science of the total environment

2024 Volume 926, Page(s) 171941

Abstract: Anthropogenic activities over the past half-century have had a negative impact on the wetland ecosystem in the Nile Delta, which provides essential provisioning and regulating services. Therefore, it is crucial to systematically investigate pollution ... ...

Abstract	Anthropogenic activities over the past half-century have had a negative impact on the wetland ecosystem in the Nile Delta, which provides essential provisioning and regulating services. Therefore, it is crucial to systematically investigate pollution levels and their ecological consequences at both spatial and temporal scales in order to promote sustainable development. In this study, data on metal pollution in the Manzala Lake were compiled through a systematic review of all published literature from 1968 to 2020. Additionally, agricultural data (including land use, pesticide and fertilizer usage, and discharge) and economic data for the same time period were collected to identify the main drivers of pollution. The results indicated an overall increasing trend in heavy metal concentrations during the study period. The average concentrations of metals, arranged in descending order, were as follows: Fe (15,115.5 μg/g) > Mn (722 μg/g) > Zn (115.4 μg/g) > Cu (65.9 μg/g) > Ni (62.5 μg/g) > Cr (58.1 μg/g) > Pb (54.1 μg/g) > Cd (4.7 μg/g) > Hg (0.1 μg/g). A linear regression model revealed that wastewater discharge, water reuse, and the use of pesticides and fertilizers are the main sources of heavy metal pollution in the Manzala Lake. Consequently, there has been a dramatic decrease in the biodiversity of fish and molluscan communities. The study also found a correlation between heavy metal pollution and socio-economic development, highlighting the urgent need for attention to the conservation, management, and sustainable development of the lake.
MeSH term(s)	Ecosystem ; Water Pollutants, Chemical/analysis ; Environmental Monitoring/methods ; Geologic Sediments ; Risk Assessment ; Metals, Heavy/analysis ; Pesticides ; Lakes ; China
Chemical Substances	Water Pollutants, Chemical ; Metals, Heavy ; Pesticides
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171941
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Article ; Online: Historical changes in fish landings indicate a significant shift in fish catch composition and biodiversity loss in the Nile-Delta lakes.

Abdelhady, Ahmed A / Samy-Kamal, Mohamed / Abdel-Raheem, Khalaf H M / Ahmed, Mohamed S / Khalil, Mahmoud M

Marine pollution bulletin

2023 Volume 194, Issue Pt B, Page(s) 115368

Abstract: To monitor the changes in fish biodiversity and to elucidate the factors responsible for these changes, the landings composition (LC) over the past 30 years in the Nile-Delta lakes was quantitatively analyzed. The LC data indicates a shift in target ... ...

Abstract	To monitor the changes in fish biodiversity and to elucidate the factors responsible for these changes, the landings composition (LC) over the past 30 years in the Nile-Delta lakes was quantitatively analyzed. The LC data indicates a shift in target species towards demersal opportunistic species. A significant difference (P < 0.001) between two main intervals highlighted in both PERMANOVA and PCA plot; the first interval (1991-2002) is dominated by Tilapia and rare species, while the second interval (2003-2020) is dominated by the opportunistic catfish and mullet species. Noticeable declines in species richness and landings of rare species were observed, where rare taxa either have been overexploited or they may be positively affected by increasing pollution levels than do other dominated species such as Tilapia. In contrast, opportunistic fish species such as catfish and mullet, have flourished in such polluted water due to their ability to tolerate seasonal pollution-related hypoxia.
MeSH term(s)	Animals ; Lakes ; Fishes ; Biodiversity ; Smegmamorpha ; Tilapia ; Catfishes ; Water Pollution
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115368
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Article ; Online: Mixed agricultural, industrial, and domestic drainage water discharge poses a massive strain on freshwater ecosystems: a case from the Nile River in Upper Egypt.

Khalil, Mahmoud M / Aboueldahab, Sherif M / Abdel-Raheem, Khalaf H M / Ahmed, Mohamed / Ahmed, Mohamed S / Abdelhady, Ahmed A

Environmental science and pollution research international

2023 Volume 30, Issue 58, Page(s) 122642–122662

Abstract: Heavy metal and pesticide pollution of freshwater ecosystems, i.e., rivers, raises significant concerns worldwide, where practical solutions to reduce the threats become urgent need. Heavy metals and pesticides are top of the list of environmental ... ...

Abstract	Heavy metal and pesticide pollution of freshwater ecosystems, i.e., rivers, raises significant concerns worldwide, where practical solutions to reduce the threats become urgent need. Heavy metals and pesticides are top of the list of environmental toxicants endangering nature; therefore, pesticides and heavy metals were measured at 10 stations along the Al-Zennar agricultural drain and the Nile River at Assiut city in Upper Egypt, to assess potential negative impact on the water/sediment's quality. The sediment of the streambed is a sink for pesticides and heavy metals, where both water and sediments have higher contamination factor (CF) for Cd, Pb, Cr, Cu, and Zn. In addition, the Nile water is highly contaminated by PCBs. The distance to the point source and hydrodynamics (flow rate and stream gradient) has major influences in pollutant concentrations as indicated by regression models. Dilution effect and rapid sedimentation may comment on the lower concentrations of the pollutants in the Nile comparatively to the drain and on the water comparatively to the sediments. The physiochemistry of the stations has minor effect on the metal/pesticide concentration, where the variable importance of projection (VIP) of the partial least square model indicated that total dissolved solids (TDS), total suspended solids (TSS), SO
MeSH term(s)	Rivers ; Water ; Water Pollutants, Chemical/analysis ; Egypt ; Ecosystem ; Environmental Monitoring ; Geologic Sediments ; Fresh Water ; Metals, Heavy/analysis ; Water Quality ; Pesticides ; Environmental Pollutants
Chemical Substances	Water (059QF0KO0R) ; Water Pollutants, Chemical ; Metals, Heavy ; Pesticides ; Environmental Pollutants
Language	English
Publishing date	2023-11-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-30994-8
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Article ; Online: Coping with depression and anxiety in Egyptian physicians during COVID-19 pandemic

Khalaf, Ola Osama / Khalil, Mohamed A. / Abdelmaksoud, Reham

Middle East Curr Psychiatry

Abstract: BACKGROUND: The COVID-19 pandemic is a public health emergency with a negative impact on mental health. Healthcare workers are one of the most vulnerable groups to psychological stress in pandemics especially COVID-19. In this cross-sectional study, we ... ...

Abstract	BACKGROUND: The COVID-19 pandemic is a public health emergency with a negative impact on mental health. Healthcare workers are one of the most vulnerable groups to psychological stress in pandemics especially COVID-19. In this cross-sectional study, we assessed depression, stress, and coping among a sample of Egyptian physicians using an electronic survey. It included demographic data; Depression, Anxiety and Stress Scale-21 Items (DASS-21); and Brief Resilient Coping Scale (BRCS). RESULTS: We found that the majority of the sample were females (61.2%), in medical specialties (51.2%), and living with vulnerable family members (92.4 %). The majority (63%) suffered from severe or extremely severe depression, 77.6% had extremely severe anxiety, and 72% suffered from stress. BRCS showed that only 17.1% had high resilient coping. Female physicians had significantly higher depression, anxiety, and stress scores of DASS than male physicians (p = 0.001, < 0.001, and < 0.001, respectively). The anxiety scale was significantly higher in those with chronic diseases (p = 0.040) while the stress scale was lower significantly in those with higher academic degree (p = 0.034). Age had a significantly negative correlation with DASS anxiety (p = 0.031) and stress scores (p = 0.037). The BRCS score had a significantly negative correlation with the depression, anxiety, and stress scales of DASS (p = 0.018, 0.014, and 0.007 respectively). CONCLUSION: The COVID-19 pandemic has a negative impact on the psychological well-being of the studied Egyptian physicians. Prophylactic measures should be implemented to avoid development of psychiatric symptoms in physicians.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1186/s43045-020-00070-9
Database	COVID19

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Article ; Online: Patterns and grades of presentation of colon cancer in Northern Saudi Arabia

Saleh H Alharbi / Khalil I Alshammari / Khulaif Khalaf Alanazi / Hussain Gadelkarim Ahmed

Gastroenterology Review, Vol 16, Iss 3, Pp 235-

2021 Volume 239

Keywords	colon cancer ; colorectal adenocarcinoma ; mucinous adenocarcinoma ; saudi arabia ; Medicine ; R
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Patterns and grades of presentation of colon cancer in Northern Saudi Arabia.

Alharbi, Saleh H / Alshammari, Khalil I / Alanazi, Khulaif Khalaf / Ahmed, Hussain Gadelkarim

Przeglad gastroenterologiczny

2021 Volume 16, Issue 3, Page(s) 235–239

Abstract: Introduction: The primary concern related to colon cancer in Saudi Arabia is the presentation of many patients with advanced disease stages.: Aim: To determine the patterns and grades of colon cancer presentation in Northern Saudi Arabia.: Material ...

Abstract	Introduction: The primary concern related to colon cancer in Saudi Arabia is the presentation of many patients with advanced disease stages. Aim: To determine the patterns and grades of colon cancer presentation in Northern Saudi Arabia. Material and methods: Retrieved data and tissue blocks related to 50 colorectal patients from King Khalid Hospital, Hai'l province, Northern Saudi Arabia were used. The sample represented all available colorectal specimens (full coverage of cancer cases within 10 years). The retrieved data included a full histopathology report, gender, and age. All tissues were retrieved in the form of formalin-fixed paraffin wax processed blocks. The tissues were found to be obtained in the form of colonoscopy or/and biopsy. Results: The diagnosed colon cancers included conventional adenocarcinoma 36 (72%), mucinous adenocarcinoma 4 (8%), carcinoma- Conclusions: Conventional adenocarcinoma is the most common presenting colon cancer at and relatively younger age. Mucinous adenocarcinoma is frequently presented in female patients of a somewhat more youthful generation. Most patients are diagnosed with moderately differentiated adenocarcinoma, followed by poorly differentiated adenocarcinoma. The findings necessitate the urgent intervention of national policies for early detection by implementing sustainable screening programs.
Language	English
Publishing date	2021-03-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596134-2
ISSN	1897-4317 ; 1895-5770
ISSN (online)	1897-4317
ISSN	1895-5770
DOI	10.5114/pg.2021.104168
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Article ; Online: Psychophysiological responses to manual lifting of unknown loads.

Khalaf, Tamer M / Ramadan, Mohamed Z / Ragab, Adham E / Alhaag, Mohammed H / AlSharabi, Khalil A

PloS one

2021 Volume 16, Issue 2, Page(s) e0247442

Abstract: Background: The handling of unknown weights, which is common in daily routines either at work or during leisure time, is suspected to be highly associated with the incidence of low back pain (LBP).: Objectives: To investigate the effects of knowledge ...

Abstract	Background: The handling of unknown weights, which is common in daily routines either at work or during leisure time, is suspected to be highly associated with the incidence of low back pain (LBP). Objectives: To investigate the effects of knowledge and magnitude of a load (to be lifted) on brain responses, autonomic nervous activity, and trapezius and erector spinae muscle activity. Methods: A randomized, within-subjects experiment involving manual lifting was conducted, wherein 10 participants lifted three different weights (1.1, 5, and 15 kg) under two conditions: either having or not having prior knowledge of the weight to be lifted. Results: The results revealed that the lifting of unknown weights caused increased average heart rate and percentage of maximum voluntary contraction (%MVC) but decreased average inter-beat interval, very-low-frequency power, low-frequency power, and low-frequency/high-frequency ratio. Regardless of the weight magnitude, lifting of unknown weights was associated with smaller theta activities in the power spectrum density (PSD) of the central region, smaller alpha activities in the PSD of the frontal region, and smaller beta activities in the PSDs of both the frontal and central regions. Moreover, smaller alpha and beta activities in the PSD of the parietal region were associated only with lifting of unknown lightweights. Conclusions: Uncertainty regarding the weight to be lifted could be considered as a stress-adding variable that may increase the required physical demand to be sustained during manual lifting tasks. The findings of this study stress the importance of eliminating uncertainty associated with handling unknown weights, such as in the cases of handling patients and dispatching luggage. This can be achieved through preliminary self-sensing of the load to be lifted, or the cautious disclosure of the actual weight of manually lifted objects, for example, through clear labeling and/or a coding system.
MeSH term(s)	Adult ; Autonomic Nervous System/physiology ; Brain/physiology ; Electrocardiography ; Electroencephalography ; Electromyography ; Healthy Volunteers ; Heart Rate ; Humans ; Lifting/adverse effects ; Male ; Superficial Back Muscles/physiology ; Uncertainty
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0247442
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Article ; Online: Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance.

Khalaf, Khalil / Hana, Doris / Chou, Jadzia Tin-Tsen / Singh, Chandpreet / Mackiewicz, Andrzej / Kaczmarek, Mariusz

Frontiers in immunology

2021 Volume 12, Page(s) 656364

Abstract: The tumor microenvironment (TME) is a complex and ever-changing "rogue organ" composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM). These complex components, utilizing both benign and ... ...

Abstract	The tumor microenvironment (TME) is a complex and ever-changing "rogue organ" composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM). These complex components, utilizing both benign and malignant cells, nurture the harsh, immunosuppressive and nutrient-deficient environment necessary for tumor cell growth, proliferation and phenotypic flexibility and variation. An important aspect of the TME is cellular crosstalk and cell-to-ECM communication. This interaction induces the release of soluble factors responsible for immune evasion and ECM remodeling, which further contribute to therapy resistance. Other aspects are the presence of exosomes contributed by both malignant and benign cells, circulating deregulated microRNAs and TME-specific metabolic patterns which further potentiate the progression and/or resistance to therapy. In addition to biochemical signaling, specific TME characteristics such as the hypoxic environment, metabolic derangements, and abnormal mechanical forces have been implicated in the development of treatment resistance. In this review, we will provide an overview of tumor microenvironmental composition, structure, and features that influence immune suppression and contribute to treatment resistance.
MeSH term(s)	Animals ; Biomarkers ; Cancer-Associated Fibroblasts/immunology ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Drug Resistance, Neoplasm/immunology ; Energy Metabolism ; Extracellular Matrix/immunology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Immunologic Surveillance ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; MicroRNAs/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Tumor Escape/immunology ; Tumor Microenvironment/immunology ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/pathology
Chemical Substances	Biomarkers ; MicroRNAs ; Reactive Oxygen Species
Language	English
Publishing date	2021-05-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.656364
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Article ; Online: SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment.

Khalaf, Khalil / Papp, Natalia / Chou, Jadzia Tin-Tsen / Hana, Doris / Mackiewicz, Andrzej / Kaczmarek, Mariusz

Frontiers in immunology

2020 Volume 11, Page(s) 570927

Abstract: The emergence and rapid spread of SARS-CoV-2 in December 2019 has brought the world to a standstill. While less pathogenic than the 2002-2003 SARS-CoV, this ... ...

Abstract	The emergence and rapid spread of SARS-CoV-2 in December 2019 has brought the world to a standstill. While less pathogenic than the 2002-2003 SARS-CoV, this novel
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Angiotensin-Converting Enzyme 2 ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/genetics ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/pathology ; Coronavirus Infections/therapy ; Disease Reservoirs/virology ; Drug Repositioning/methods ; Humans ; Immunoenzyme Techniques ; Immunotherapy ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/pathology ; Pneumonia, Viral/therapy ; Receptors, Virus/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Serologic Tests/methods ; Spike Glycoprotein, Coronavirus/metabolism
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Viral ; Antiviral Agents ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	English
Publishing date	2020-10-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.570927
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