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  1. Article ; Online: COVID-19 and the brain: understanding the pathogenesis and consequences of neurological damage.

    Maliha, Sumaiya Tasnim / Fatemi, Rabeya / Araf, Yusha

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 318

    Abstract: SARS-CoV-2 has been known remarkably since December 2019 as a strain of pathogenic coronavirus. Starting from the earlier stages of the COVID-19 pandemic until now, we have witnessed many cases of neurological damage caused by SARS-CoV-2. There are many ... ...

    Abstract SARS-CoV-2 has been known remarkably since December 2019 as a strain of pathogenic coronavirus. Starting from the earlier stages of the COVID-19 pandemic until now, we have witnessed many cases of neurological damage caused by SARS-CoV-2. There are many studies and research conducted on COVID-19-positive-patients that have found brain-related abnormalities with clear neurological symptoms, ranging from simple headaches to life-threatening strokes. For treating neurological damage, knowing the actual pathway or mechanism of causing brain damage via SARS-CoV-2 is very important. For this reason, we have tried to explain the possible pathways of brain damage due to SARS-CoV-2 with mechanisms and illustrations. The SARS-CoV-2 virus enters the human body by binding to specific ACE2 receptors in the targeted cells, which are present in the glial cells and CNS neurons of the human brain. It is found that direct and indirect infections with SARS-CoV-2 in the brain result in endothelial cell death, which alters the BBB tight junctions. These probable alterations can be the reason for the excessive transmission and pathogenicity of SARS-CoV-2 in the human brain. In this precise review, we have tried to demonstrate the neurological symptoms in the case of COVID-19-positive-patients and the possible mechanisms of neurological damage, along with the treatment options for brain-related abnormalities. Knowing the transmission mechanism of SARS-CoV-2 in the human brain can assist us in generating novel treatments associated with neuroinflammation in other brain diseases.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Pandemics ; Brain ; Brain Injuries
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09279-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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  2. Article ; Online: Emerging health implications of climate change: dengue outbreaks and beyond in Bangladesh.

    Araf, Yusha / Akter, Marjana / Zhai, Jingbo / Zheng, Chunfu / Hossain, Md Golzar

    The Lancet. Microbe

    2024  Volume 5, Issue 3, Page(s) e213

    MeSH term(s) Humans ; Bangladesh/epidemiology ; Climate Change ; Dengue/epidemiology ; Disease Outbreaks
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00366-X
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  3. Article ; Online: Marburg virus outbreak in 2022: a public health concern.

    Araf, Yusha / Maliha, Sumaiya Tasnim / Zhai, Jingbo / Zheng, Chunfu

    The Lancet. Microbe

    2022  Volume 4, Issue 1, Page(s) e9

    MeSH term(s) Animals ; Humans ; Public Health ; Marburgvirus/genetics ; Disease Outbreaks ; Marburg Virus Disease/epidemiology
    Language English
    Publishing date 2022-10-06
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00258-0
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  4. Article ; Online: Circulating tumor DNA in cancer diagnosis, monitoring, and prognosis.

    Saha, Sudeepto / Araf, Yusha / Promon, Salman Khan

    Journal of the Egyptian National Cancer Institute

    2022  Volume 34, Issue 1, Page(s) 8

    Abstract: Background: Circulating tumor DNA (ctDNA) has become one of the crucial components for cancer detection with the increase of precision medicine practice. ctDNA has great potential as a blood-based biomarker for the detection and treatment of cancer in ... ...

    Abstract Background: Circulating tumor DNA (ctDNA) has become one of the crucial components for cancer detection with the increase of precision medicine practice. ctDNA has great potential as a blood-based biomarker for the detection and treatment of cancer in its early stages. The purpose of this article was to discuss ctDNA and how it can be utilized to detect cancer. The benefits and drawbacks of this cancer detection technology, as well as the field's future possibilities in various cancer management scenarios, are discussed. MAIN TEXT: ctDNA has clinical applications in disease diagnosis and monitoring. It can be used to identify mutations of interest and genetic heterogeneity. Another use of ctDNA is to monitor the effects of therapy by detecting mutation-driven resistance. Different technologies are being used for the detection of ctDNA. Next-generation sequencing, digital PCR, real-time PCR, and mass spectrometry are used. Using dPCR makes it possible to partition and analyze individual target sequences from a complex mixture. Mass-spectrometry technology enables accurate detection and quantification of ctDNA mutations at low frequency. Surface-enhanced Raman spectroscopy (SERS) and UltraSEEK are two systems based on this technology. There is no unified standard for detecting ctDNA as it exists in a low concentration in blood. As there is no defined approach, false positives occur in several methods due to inadequate sensitivities. Techniques used in ctDNA are costly and there is a limitation in clinical settings.
    Short conclusion: A detailed investigation is urgently needed to increase the test's accuracy and sensitivity. To find a standard marker for all forms of cancer DNA, more study is needed. Low concentrations of ctDNA in a sample require improved technology to provide the precision that low concentrations of ctDNA in a sample afford.
    MeSH term(s) Biomarkers, Tumor/genetics ; Circulating Tumor DNA/genetics ; DNA, Neoplasm/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation ; Neoplasms/diagnosis ; Neoplasms/genetics ; Prognosis
    Chemical Substances Biomarkers, Tumor ; Circulating Tumor DNA ; DNA, Neoplasm
    Language English
    Publishing date 2022-02-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1176790-x
    ISSN 2589-0409 ; 1110-0362
    ISSN (online) 2589-0409
    ISSN 1110-0362
    DOI 10.1186/s43046-022-00109-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3918: Show issues Location:
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  5. Article ; Online: Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington's disease.

    Saha, Sudeepto / Dey, Manami Jayati / Promon, Salman Khan / Araf, Yusha

    Regenerative therapy

    2022  Volume 21, Page(s) 406–412

    Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder which is caused due to repetitive CAG or glutamine expression along the coding region of the Huntington gene. This disease results in certain movement abnormalities, affective ... ...

    Abstract Huntington's disease (HD) is a progressive neurodegenerative disorder which is caused due to repetitive CAG or glutamine expression along the coding region of the Huntington gene. This disease results in certain movement abnormalities, affective disturbances, dementia and cognitive impairments. To this date, there is no proper cure for this rare and fatal neurological condition but there have been certain advancements in the field of genetic animal model research studies to elucidate the understanding of the pathogenesis of this condition. Currently, HD follows a certain therapeutic approach which just relieves the symptoms but doesn't cure the underlying cause of the disease. Stem cell therapy can be a breakthrough in developing a potential cure for this condition. In this review, we have discussed the pathogenesis and the efficacy and clinical practicality of the therapeutic application of stem cell transplantation in Huntington's disease. The application of this groundbreaking therapy on genetically altered animal models has been listed and analyzed in brief.
    Language English
    Publishing date 2022-09-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2835333-X
    ISSN 2352-3204 ; 2352-3204
    ISSN (online) 2352-3204
    ISSN 2352-3204
    DOI 10.1016/j.reth.2022.09.001
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  6. Article ; Online: The Deltacron conundrum: Its origin and potential health risks.

    Farheen, Saria / Araf, Yusha / Tang, Yan-Dong / Zheng, Chunfu

    Journal of medical virology

    2022  Volume 94, Issue 11, Page(s) 5096–5102

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since its outbreak in December 2019, has been capable of continuing the pandemic by mutating itself into different variants. Mass vaccinations, antibiotic treatment therapy, herd immunity, and ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since its outbreak in December 2019, has been capable of continuing the pandemic by mutating itself into different variants. Mass vaccinations, antibiotic treatment therapy, herd immunity, and preventive measures have reduced the disease's severity from the emerging variants. However, the virus is undergoing recombination among the current two variants: Delta and Omicron, resulting in a new variant, informally known as "Deltacron," which was controversial as it might be a product of lab contamination between Omicron and Delta samples. However, the proclamation was proved wrong, and the experts are putting more effort into better understanding the variant's epidemiological characteristics to control potential outbreaks. This review has discussed the potential mutations in the novel variant and prospective risk factors and therapeutic options in the context of this new variant. This study could be used as a guide for implementing appropriate controls in a sudden outbreak of this new variant.
    MeSH term(s) COVID-19/epidemiology ; Disease Outbreaks/prevention & control ; Humans ; Pandemics ; Prospective Studies ; SARS-CoV-2/genetics
    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27990
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Corticosteroids for COVID-19: worth it or not?

    Akter, Fariya / Araf, Yusha / Hosen, Mohammad Jakir

    Molecular biology reports

    2021  Volume 49, Issue 1, Page(s) 567–576

    Abstract: Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced COVID-19 implied the presence of excessive proinflammatory cytokines and chemokines in patients causing significant morbidity and mortality. To diminish systemic hyper ... ...

    Abstract Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced COVID-19 implied the presence of excessive proinflammatory cytokines and chemokines in patients causing significant morbidity and mortality. To diminish systemic hyper inflammation, a few physicians and researchers have utilized corticosteroids. Corticosteroid implementation has increased after the publication of interim guidelines regarding corticosteroid use in COVID-19 patients by WHO, despite the remaining controversies regarding long-term side effects and disease progression capability of corticosteroids. In different studies, the implementation of corticosteroids on COVID-19 patients revealed controversial results, which require further intensive research. This review will present the current outcomes and possibilities of using corticosteroids to treat COVID-19 patients.
    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; COVID-19/drug therapy ; Chemokines ; Cytokine Release Syndrome/drug therapy ; Cytokines ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Inflammation/drug therapy ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity
    Chemical Substances Adrenal Cortex Hormones ; Chemokines ; Cytokines ; Immunosuppressive Agents
    Language English
    Publishing date 2021-10-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06793-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Corticosteroids for COVID-19: worth it or not?

    Akter, Fariya / Araf, Yusha / Hosen, Mohammad Jakir

    Molecular biology reports. 2022 Jan., v. 49, no. 1

    2022  

    Abstract: Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced COVID-19 implied the presence of excessive proinflammatory cytokines and chemokines in patients causing significant morbidity and mortality. To diminish systemic hyper ... ...

    Abstract Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced COVID-19 implied the presence of excessive proinflammatory cytokines and chemokines in patients causing significant morbidity and mortality. To diminish systemic hyper inflammation, a few physicians and researchers have utilized corticosteroids. Corticosteroid implementation has increased after the publication of interim guidelines regarding corticosteroid use in COVID-19 patients by WHO, despite the remaining controversies regarding long-term side effects and disease progression capability of corticosteroids. In different studies, the implementation of corticosteroids on COVID-19 patients revealed controversial results, which require further intensive research. This review will present the current outcomes and possibilities of using corticosteroids to treat COVID-19 patients.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; adrenal cortex hormones ; chemokines ; disease progression ; inflammation ; molecular biology ; morbidity ; mortality ; pathogenesis
    Language English
    Dates of publication 2022-01
    Size p. 567-576.
    Publishing place Springer Netherlands
    Document type Article
    Note Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06793-0
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington’s disease

    Sudeepto Saha / Manami Jayati Dey / Salman Khan Promon / Yusha Araf

    Regenerative Therapy, Vol 21, Iss , Pp 406-

    2022  Volume 412

    Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder which is caused due to repetitive CAG or glutamine expression along the coding region of the Huntington gene. This disease results in certain movement abnormalities, affective ... ...

    Abstract Huntington's disease (HD) is a progressive neurodegenerative disorder which is caused due to repetitive CAG or glutamine expression along the coding region of the Huntington gene. This disease results in certain movement abnormalities, affective disturbances, dementia and cognitive impairments. To this date, there is no proper cure for this rare and fatal neurological condition but there have been certain advancements in the field of genetic animal model research studies to elucidate the understanding of the pathogenesis of this condition. Currently, HD follows a certain therapeutic approach which just relieves the symptoms but doesn't cure the underlying cause of the disease. Stem cell therapy can be a breakthrough in developing a potential cure for this condition. In this review, we have discussed the pathogenesis and the efficacy and clinical practicality of the therapeutic application of stem cell transplantation in Huntington's disease. The application of this groundbreaking therapy on genetically altered animal models has been listed and analyzed in brief.
    Keywords Huntington's disease ; Stem cells transplantation ; Pathogenesis ; Therapeutics ; Medicine (General) ; R5-920 ; Cytology ; QH573-671
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: 3D Bioprinting for Regenerating COVID-19-Mediated Irreversibly Damaged Lung Tissue.

    Akter, Fariya / Araf, Yusha / Promon, Salman Khan / Zhai, Jingbo / Zheng, Chunfu

    International journal of bioprinting

    2022  Volume 8, Issue 4, Page(s) 616

    Abstract: While the tension of COVID-19 is still increasing, patients who recovered from the infection are facing life-threatening consequences such as multiple organ failure due to the presence of angiotensin-converting enzyme 2 receptor in different organs. ... ...

    Abstract While the tension of COVID-19 is still increasing, patients who recovered from the infection are facing life-threatening consequences such as multiple organ failure due to the presence of angiotensin-converting enzyme 2 receptor in different organs. Among all the complications, death caused by respiratory failure is the most common because severe acute respiratory syndrome coronavirus 2 infects lung's type II epithelial, mucociliary, and goblet cells that eventually cause pneumonia and acute respiratory distress syndrome, which are responsible for the irreversible lung damage. Risk factors, such as age, comorbidities, diet, and lifestyle, are associated with disease severity. This paper reviews the potential of three-dimensional bioprinting in printing an efficient organ for replacement by evaluating the patient's condition.
    Language English
    Publishing date 2022-09-13
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2834694-4
    ISSN 2424-8002 ; 2424-8002
    ISSN (online) 2424-8002
    ISSN 2424-8002
    DOI 10.18063/ijb.v8i4.616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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