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  1. Article ; Online: Lessons in Level-loading: How Lean Manufacturing Principles can be Utilized for Fertility Clinic Optimization.

    Osmundsen, Elizabeth B / Pavlovic, Zoran J / Combs, Joshua C

    Fertility and sterility

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2024.04.029
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    Zs.A 73: Show issues Location:
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  2. Article ; Online: SARS CoV-2: a review of current treatment regimens.

    Combs, Joshua C

    Global reproductive health

    2020  Volume 5

    Abstract: SARS CoV-2, otherwise known as Corona virus 2019 (COVID-19) has left >300,000 dead without a definitive cure in sight. Significant research has been conducted regarding the use of currently available pharmacotherapies and multiple clinical trials are ... ...

    Abstract SARS CoV-2, otherwise known as Corona virus 2019 (COVID-19) has left >300,000 dead without a definitive cure in sight. Significant research has been conducted regarding the use of currently available pharmacotherapies and multiple clinical trials are underway to bring new treatments to market. While supportive treatment remains the standard of care, additional therapeutic regimens including antivirals, monoclonal antibodies, antibiotics, anti-inflammatories, immunoenhancers, vitamins, systemic steroids, inhalants, anticoagulants, and convalescent plasma are showing promise.
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article
    ISSN 2473-3709
    ISSN (online) 2473-3709
    DOI 10.1097/GRH.0000000000000041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Taking AIm at medical misinformation.

    Hamilton, Andrew K / Goldstein, Michael J / Combs, Joshua C

    Fertility and sterility

    2023  Volume 120, Issue 3 Pt 2, Page(s) 584–585

    MeSH term(s) Humans ; Communication ; Social Media
    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2023.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SARS CoV-2

    Combs, Joshua C.

    Global Reproductive Health

    a review of current treatment regimens

    2020  Volume 5, Issue 2, Page(s) e41–e41

    Keywords covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ISSN 2473-3709
    DOI 10.1097/grh.0000000000000041
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Just perhaps: much ado about nothing.

    Combs, Joshua C / Gay, Steven A / DeCherney, Alan H

    Fertility and sterility

    2021  Volume 116, Issue 2, Page(s) 367–368

    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2021.06.005
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  6. Article ; Online: Polycystic Ovarian Syndrome Genetics and Epigenetics.

    Combs, Joshua C / Hill, Micah J / Decherney, Alan H

    Clinical obstetrics and gynecology

    2020  Volume 64, Issue 1, Page(s) 20–25

    Abstract: Polycystic ovarian syndrome and its associated endocrine abnormalities comprise one of the most common metabolic spectrum disorders within the human race. Because of the variance in phenotypic expression among individuals and within family lineages, ... ...

    Abstract Polycystic ovarian syndrome and its associated endocrine abnormalities comprise one of the most common metabolic spectrum disorders within the human race. Because of the variance in phenotypic expression among individuals and within family lineages, attention has been turned to genetic and epigenetic changes in which the root cause of the disorder may lie. Further understanding of DNA/histone methylation and microRNA patterns may help to improve the accuracy of diagnosis and lead to future treatment options.
    MeSH term(s) DNA Methylation ; Epigenesis, Genetic ; Female ; Humans ; MicroRNAs/genetics ; Phenotype ; Polycystic Ovary Syndrome/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0000000000000581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Live birth after transfer of a single euploid vitrified-warmed blastocyst according to standard timing vs. timing as recommended by endometrial receptivity analysis.

    Doyle, Nicole / Combs, Joshua C / Jahandideh, Samad / Wilkinson, Victoria / Devine, Kate / O'Brien, Jeanne E

    Fertility and sterility

    2022  Volume 118, Issue 2, Page(s) 314–321

    Abstract: Objective: To determine whether endometrial receptivity analysis (ERA) improves live births in patients with and without a history of unsuccessful frozen embryo transfers (FETs).: Design: Retrospective cohort study.: Setting: Large reproductive ... ...

    Abstract Objective: To determine whether endometrial receptivity analysis (ERA) improves live births in patients with and without a history of unsuccessful frozen embryo transfers (FETs).
    Design: Retrospective cohort study.
    Setting: Large reproductive center.
    Patient(s): Patients with and without ERA before euploid single FET were included in the analysis.
    Intervention(s): Subjects in the exposed group underwent ERA and ERA-timed FETs. Subjects in the unexposed group followed a standard protocol FET without ERA. Outcomes were compared between nonreceptive and receptive subjects undergoing an ERA-timed FET and between ERA-timed vs. standard protocol FETs.
    Main outcome measure(s): The primary outcome was a live birth; secondary outcomes were biochemical and clinical pregnancy rates.
    Result(s): A total of 307 ERA-timed FETs and 2,284 standard protocol FETs were analyzed. One hundred twenty-five patients (40.7%) were ERA receptive, and 182 (59.3%) were ERA nonreceptive. After adjusting for the number of the previously failed FETs, there was no difference in the proportion of receptive and nonreceptive ERA results. There were no statistically significant differences in live births in patients with ERA-receptive vs. ERA-nonreceptive results (48.8% and 41.7%, respectively; adjusted odds ratio 1.17; 95% CI, 0.97-1.40). There were no statistically significant differences in live births in patients with or without ERA testing results before FET (44.6% and 51.3%, respectively; adjusted odds ratio 0.87; 95% CI, 0.73-1.04).
    Conclusion(s): Patients with an increasing number of previous failed euploid FET cycles are not at an increased risk of a displaced window of implantation. Patients categorized as receptive vs. nonreceptive and those without ERA testing results have comparable FET success rates.
    MeSH term(s) Blastocyst ; Cryopreservation/methods ; Embryo Transfer/methods ; Female ; Humans ; Live Birth ; Pregnancy ; Pregnancy Rate ; Retrospective Studies
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2022.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A female woolly mammoth's lifetime movements end in an ancient Alaskan hunter-gatherer camp.

    Rowe, Audrey G / Bataille, Clement P / Baleka, Sina / Combs, Evelynn A / Crass, Barbara A / Fisher, Daniel C / Ghosh, Sambit / Holmes, Charles E / Krasinski, Kathryn E / Lanoë, François / Murchie, Tyler J / Poinar, Hendrik / Potter, Ben / Rasic, Jeffrey T / Reuther, Joshua / Smith, Gerad M / Spaleta, Karen J / Wygal, Brian T / Wooller, Matthew J

    Science advances

    2024  Volume 10, Issue 3, Page(s) eadk0818

    Abstract: Woolly mammoths in mainland Alaska overlapped with the region's first people for at least a millennium. However, it is unclear how mammoths used the space shared with people. Here, we use detailed isotopic analyses of a female mammoth tusk found in a 14, ... ...

    Abstract Woolly mammoths in mainland Alaska overlapped with the region's first people for at least a millennium. However, it is unclear how mammoths used the space shared with people. Here, we use detailed isotopic analyses of a female mammoth tusk found in a 14,000-year-old archaeological site to show that she moved ~1000 kilometers from northwestern Canada to inhabit an area with the highest density of early archaeological sites in interior Alaska until her death. DNA from the tusk and other local contemporaneous archaeological mammoth remains revealed that multiple mammoth herds congregated in this region. Early Alaskans seem to have structured their settlements partly based on mammoth prevalence and made use of mammoths for raw materials and likely food.
    MeSH term(s) Humans ; Animals ; Female ; Infant, Newborn ; Mammoths/genetics ; DNA ; Canada ; Alaska ; Fossils
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adk0818
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  9. Article ; Online: Preimplantation genetic testing for sickle cell disease: a cost-effectiveness analysis.

    Combs, Joshua C / Dougherty, Maura / Yamasaki, Meghan U / DeCherney, Alan H / Devine, Kate M / Hill, Micah J / Rothwell, Erin / O'Brien, Jeanne E / Nelson, Richard E

    F&S reports

    2023  Volume 4, Issue 3, Page(s) 300–307

    Abstract: Objective: To evaluate the cost-effectiveness of in vitro fertilization with preimplantation genetic testing for monogenic disease (IVF + PGT-M) in the conception of a nonsickle cell disease (non-SCD) individual compared with standard of care treatment ... ...

    Abstract Objective: To evaluate the cost-effectiveness of in vitro fertilization with preimplantation genetic testing for monogenic disease (IVF + PGT-M) in the conception of a nonsickle cell disease (non-SCD) individual compared with standard of care treatment for a naturally conceived, sickle cell disease (SCD)-affected individual.
    Design: A Markov simulation model was constructed to evaluate a one-time IVF + PGT-M treatment compared with the lifetime standard of care costs of treatment for an individual potentially born with SCD. Using an annual discount rate of 3% for cost and outcome measures, quality-adjusted life years were constructed from utility weights and life expectancy values and then used as the effectiveness measurement. An incremental cost-effectiveness ratio was calculated for both treatment arms, and a willingness-to-pay threshold of $50,000 per quality-adjusted life year was assumed.
    Setting: Tertiary care or university medical center.
    Patients: A hypothetical cohort of 10,000 patients was analzyed over a lifetime horizon using yearly cycles.
    Interventions: In vitro fertilization with preimplantation genetic testing for monogenic disease use in conception of a non-SCD individual.
    Main outcome measures: The primary outcomes of interest were the incremental cost and effectiveness of an IVF+PGT-M conception compared with the SOC treatment of an SCD-affected individual.
    Results: In vitro fertilization with preimplantation genetic testing for monogenic disease was the optimal strategy in 93.17% of the iterations. An incremental savings of $137,594 was demonstrated with a gain of 1.96 QALYs and 3.69 life years over a lifetime. Sensitivity analysis demonstrated that SOC treatment never met equivalent cost-effectiveness.
    Conclusions: Our model demonstrates that IVF + PGT-M for selection against SCD, compared with lifetime SOC treatment for those affected, is the most cost-effective strategy within the United States healthcare sector.
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3341
    ISSN (online) 2666-3341
    DOI 10.1016/j.xfre.2023.06.001
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  10. Article ; Online: Postdeployment Fertility Challenges and Treatment in the Modern Era.

    Lentscher, Jessica A / Combs, Joshua C / Walker, Karrie / Young, Christopher M / Chason, Rebecca

    Seminars in reproductive medicine

    2020  Volume 37, Issue 5-06, Page(s) 239–245

    Abstract: Current war-fighting environments have shifted dramatically over the past decade, and with this change, new types of injuries are afflicting American soldiers. Operative Enduring Freedom and Operation Iraqi Freedom have noted an increased use of ... ...

    Abstract Current war-fighting environments have shifted dramatically over the past decade, and with this change, new types of injuries are afflicting American soldiers. Operative Enduring Freedom and Operation Iraqi Freedom have noted an increased use of sophisticated improvised explosive devices by adversaries. Injuries not frequently seen in previous conflict are dismounted complex blast injuries, which involve multiple proximal amputations, pelvic fractures, and extensive perineal wounds. Thus, an unforeseen consequence of the decreased mortality rate after these complex blast injuries is a new wave of U.S. service members facing the challenges of recovering from the catastrophic amputations and genitourinary injuries. New applications of sperm retrieval methods may be used in these specific populations, as they recover and wish to purse family-building goals. Spinal cord injuries, traumatic brain injuries, and considerations unique to the female soldier are explored in this review of urologic care in wounded veterans.
    MeSH term(s) Afghan Campaign 2001- ; Female ; Fertility ; Humans ; Iraq War, 2003-2011 ; Military Personnel ; United States/epidemiology ; Veterans
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2042479-6
    ISSN 1526-4564 ; 1526-8004
    ISSN (online) 1526-4564
    ISSN 1526-8004
    DOI 10.1055/s-0040-1713430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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