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Article ; Online: Anti-nucleocapsid IgG antibodies in SARS-CoV-2 recovered health care workers: One year follow-up study.

Ahmad, Ashfaq / Haq, Mohsina / Rehman, Asif / Haq, Najib Ul

International journal of immunopathology and pharmacology

2023 Volume 37, Page(s) 3946320231187744

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Infant ; Follow-Up Studies ; SARS-CoV-2 ; COVID-19 ; Immunoglobulin G ; Antibodies, Viral ; Health Personnel
Chemical Substances	Immunoglobulin G ; Antibodies, Viral
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/03946320231187744
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Zs.A 2537: Show issues

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Article ; Online: Predictive Potential Of Il28b Gene In Hcv Patients, Resistant To Daclatasvir And Sofosbuvir In KPK Population.

Sardar, Sunya / Muhammad, Sardar / Haq, Mohsina / Haq, Najib Ul / Kashif Khan, Arbab Muhammad

Journal of Ayub Medical College, Abbottabad : JAMC

2024 Volume 35, Issue 4, Page(s) 523–529

Abstract: Background: Recently various combinations of direct acting antivirals (DAAs) have been tried successfully. The Sofosbuvir + Daclatasvir combination has been used with promising results. Recently, resistance has been noticed against DAAs. Therefore, ... ...

Abstract	Background: Recently various combinations of direct acting antivirals (DAAs) have been tried successfully. The Sofosbuvir + Daclatasvir combination has been used with promising results. Recently, resistance has been noticed against DAAs. Therefore, polymorphism at particular sites in the interleukin 28B gene are under study to find possible association with resistance. This study was aimed at finding out any association of SNPs rs8099917 and rs12979860 (IL28B gene) with response and resistance to treatment in HCV genotype 3 patients in Khyber Pakhtunkhwa. Methods: This cross sectional, Analytical study was conducted at Gastroenterology/hepatology OPD of Prime Teaching Hospital, Peshawar Medical College. Collected Samples were stored at -20o C in PCR Lab of the College. DNA extraction and genotyping was carried out at BJ Molecular Biology Lab in Rawalpindi. Data was analyzed by using SPSS version 21. Chi-Square Test was used to see the statistically significant differences between rs8099917 T/G and rs12979860 T/C model. Results: In the IL28-B gene, single nucleotide polymorphism at rs12979860 T/C model, we observed that there are 37.5% CC homozygous, 12.5% TT homozygous and 50% CT heterozygous genotypes in resistant patients and 42.85% CC homozygous, 28.57% TT and 28.57% CT genotype in responder group. In rs12979860 T/C model, genotype of IL28-B in the responder and resistant group significantly varies at p-value =0.00572. Conclusion: We conclude that in SNP at rs12979860, CC genotype is associated with clearance of HCV, while CT genotype was more prevalent in the resistant group and associated with chronicity.
MeSH term(s)	Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Carbamates ; Cross-Sectional Studies ; Genotype ; Hepacivirus/genetics ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/genetics ; Imidazoles ; Interferons/genetics ; Interleukins/genetics ; Pyrrolidines ; Ribavirin ; Sofosbuvir/therapeutic use ; Treatment Outcome ; Valine/analogs & derivatives
Chemical Substances	Antiviral Agents ; Carbamates ; daclatasvir (LI2427F9CI) ; Imidazoles ; Interferons (9008-11-1) ; Interleukins ; Pyrrolidines ; Ribavirin (49717AWG6K) ; Sofosbuvir (WJ6CA3ZU8B) ; Valine (HG18B9YRS7) ; interferon-lambda, human
Language	English
Publishing date	2024-02-24
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
DOI	10.55519/JAMC-04-11760
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Zs.A 6109: Show issues

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Article ; Online: Wild poliovirus outbreak in Afghanistan: A wake-up call for global health experts.

Awan, Usman Ayub / Malik, Muhammad Wasif / Kamran, Shehrish / Ahmed, Haroon / Haq, Mohsina / Afzal, Muhammad Sohail

The Journal of infection

2022 Volume 84, Issue 6, Page(s) 834–872

MeSH term(s)	Afghanistan/epidemiology ; Disease Outbreaks ; Global Health ; Humans ; Immunization Programs ; Poliomyelitis/epidemiology ; Poliovirus ; Population Surveillance
Language	English
Publishing date	2022-03-06
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.03.002
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Serum p53 antibodies detection in oral squamous cell carcinoma, oral potentially malignant disorders and healthy individuals: A multicentre study.

Khan, Abbas Saleem / Ahmad, Sajjad / Ullah, Zahoor / Haq, Mohsina / Farooq, Muhammad Umar / Khan, Muslim

JPMA. The Journal of the Pakistan Medical Association

2022 Volume 71, Issue 10, Page(s) 2364–2368

Abstract: Objective: To detect antibodies against p53 in serum of patients of oral squamous cell carcinoma and oral potentially malignant disorders compared to healthy individuals.: Methods: The descriptive cross-sectional study was conducted at the ... ...

Abstract	Objective: To detect antibodies against p53 in serum of patients of oral squamous cell carcinoma and oral potentially malignant disorders compared to healthy individuals. Methods: The descriptive cross-sectional study was conducted at the departments of Oral and Maxillofacial Surgery, Peshawar Dental College, Peshawar, Khyber College of Dentistry, Peshawar, and the Pakistan Institute of Medical Sciences, Islamabad, Pakistan, from April, 2016 to March, 2017, and comprised serum of oral squamous cell carcinoma patients in group A, oral potentially malignant disorder patients in group B and healthy individuals in group C. Serum concentrations of anti-p53 antibodies were determined by enzyme-linked immunosorbent assay. Data was analysed using SPSS 20. Results: Of the180 subjects, there were 60(33.3%) in each of the three groups. Circulating serum p53 antibodies were detected in 59(98.3%) cases in group A, 58(96.6%) in group B and in 20(33.3%) individuals in group C (p=0.001). Conclusions: The expression of circulating p53 antibodies in serum samples of squamous cell carcinoma and oral potentially malignant disorders patients indicates the potential to be a probable candidate for being taken as a diagnostic or prognostic biomarker.
MeSH term(s)	Biomarkers, Tumor ; Carcinoma, Squamous Cell/diagnosis ; Cross-Sectional Studies ; Head and Neck Neoplasms ; Humans ; Mouth Neoplasms ; Squamous Cell Carcinoma of Head and Neck ; Tumor Suppressor Protein p53
Chemical Substances	Biomarkers, Tumor ; Tumor Suppressor Protein p53
Language	English
Publishing date	2022-01-01
Publishing country	Pakistan
Document type	Journal Article ; Multicenter Study
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.1133
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Zs.B 845: Show issues

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Article ; Online: Incidence of Dengue fever, serotypes, clinical features, and laboratory markers: a case study of 2019 outbreak at district Shangla, KP, Pakistan.

Rehman, Abid Ur / Anwar, Faheem / Tayyab, Muhammad / Haq, Ihteshamul / Haq, Mohsina / Ahmed, Ashfaq / Haq, Hala / Khan, Abbas Saleem

African health sciences

2022 Volume 22, Issue 1, Page(s) 521–531

Abstract: Background: Dengue is a widely spread mosquito-borne infection in humans, which in recent decades declared is public health problem globally. The dengue virus contains 4 different serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) which belong to the genus ... ...

Abstract	Background: Dengue is a widely spread mosquito-borne infection in humans, which in recent decades declared is public health problem globally. The dengue virus contains 4 different serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) which belong to the genus Flavivirus. Aims: A descriptive experimental study was conducted to determine the epidemiology, types of Dengue serotypes, clinical features, laboratory probe, and markers for primary diagnosis of dengue virus infection in hospitalized patients. Methodology: A total of 691 suspects were diagnosed from August to October 2019 in district Shangla KP, Pakistan. Serological tests were used for nonstructural protein-1 antigen (NS1), and antibodies (immunoglobulin-M (IgM) & Immunoglobulin-G (IgG)) while real-time PCR was used to confirm the cases. The data was statistically analyzed using IBM-SPSS Statistics 20 version. Results: The dengue virus infection was more prevalent in the male group (68.09%) than the female group (31.1%). A large number of patients were from rural areas (63.5%) while from urban areas were (36.4%), whereas Besham tehsil was found the most affected compared to other regions. The most prevalent serotype observed in our study was DENV-3 (56.60%) while DENV-4 was the least prevalent serotype (1.88%). Among the age-wise analysis of dengue-virus-infected individuals, the age group of 19-37 years (64.07%) was found the most affected group. The month-wise analysis revealed that the highest number of infections (49.8%) were recorded in September. Significant differences were noticed among blood parameters. Conclusion: The possible reasons for the dengue overwhelming in the study area could be less or lack of awareness particularly regarding the transmission of viral infections, improper sewage management, and no effective vector control strategies that lead the dengue outbreaks in the study population.
MeSH term(s)	Adult ; Animals ; Antibodies, Viral ; Biomarkers ; Dengue ; Dengue Virus ; Disease Outbreaks ; Female ; Humans ; Immunoglobulin G ; Incidence ; Male ; Mosquito Vectors ; Pakistan ; Serogroup ; Viral Nonstructural Proteins ; Young Adult
Chemical Substances	Antibodies, Viral ; Biomarkers ; Immunoglobulin G ; Viral Nonstructural Proteins
Language	English
Publishing date	2022-08-13
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v22i1.61
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Zs.A 3851: Show issues

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Article ; Online: Description of clinicopathological characteristics of oral potentially malignant disorders with special focus on two histopathologic grading systems and subepithelial inflammatory infiltrate.

Khan, Abbas Saleem / Khan, Zafar Ali / Nisar, Muhammad / Saeed, Saleha / Maryam, Hoor / Haq, Mohsina / Naushin, Tehmina / Issrani, Rakhi

Journal of cancer research and therapeutics

2023 Volume 19, Issue Suppl 2, Page(s) S724–S730

Abstract: Objective: This study was conducted to evaluate the clinicopathological features of oral potentially malignant disorders (OPMDs) with a focus on two histologic grading systems and subepithelial inflammatory infiltrates.: Materials and methods: This ... ...

Abstract	Objective: This study was conducted to evaluate the clinicopathological features of oral potentially malignant disorders (OPMDs) with a focus on two histologic grading systems and subepithelial inflammatory infiltrates. Materials and methods: This cross-sectional and multicenter study was conducted from April 2016 to September 2021 and comprised patients diagnosed with OPMDs. Hematoxylin and eosin-stained slides of 127 cases were assessed based on the World Health Organization (WHO) 2005 classification system, namely, epithelial precursor lesions and binary system of oral epithelial dysplasia (OED). Chi-square test and Fisher's exact test were used to compare different categorical variables related to OPMDs. Results: The mean age of OPMD cases at presentation was 54.72 13.30 (P < 0.01) with a male to female ratio of 1.6:1. Oral leukoplakia (52.8%) was the most commonly diagnosed form of OPMD. Most OPMDs were classified as oral epithelial hyperplasia (59.1%) and the remaining (40.9%) as OED (P < 0.01). Of the 52 OPMDs with OED, all cases of mild dysplasia (36.5%) and carcinoma in situ (9.6%) were categorized as low-risk and high-risk lesions, respectively. Chronic inflammatory infiltrate (79.5%) was the most common subepithelial inflammatory alteration observed among OPMDs. Conclusions: Early detection of OPMDs is vital due to increased risk of developing into oral cancer. Timely clinicopathological risk assessment of OPMD is desirable for improving the prognosis and preventing the malignant transformation in oral premalignancy. Besides the epithelial precursor lesions' classification by the WHO, binary system of grading OED use can be encouraged. Also, subepithelial inflammatory infiltrate can be of importance in future research regarding OPMDs.
MeSH term(s)	Humans ; Male ; Female ; Cross-Sectional Studies ; Precancerous Conditions/pathology ; Leukoplakia, Oral/pathology ; Mouth Diseases ; Mouth Neoplasms/pathology ; Hyperplasia
Language	English
Publishing date	2023-04-29
Publishing country	India
Document type	Multicenter Study ; Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_969_22
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Article: Evaluation of therapeutic potential and anti-hyperchlostrolemic effects of prunes in albino rats: An experimental study.

Haq, Ihteshamul / Haq, Mohsina / Ali, Owais / Jaseem Khan, Muhammad / Ullah, Noor / Ali Khan, Aamir / Usman, Faheem / Asif, Ayesha / S Ataya, Farid / Fouad, Dalia / Iftikhar, Anwaar / Mehmood, Ahad

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 4(Special), Page(s) 1305–1312

Abstract: Hyperlipidemia is a global epidemic that causes various cardiovascular diseases (CVDs). Prunes include fiber and numerous phenolic compounds that decrease cholesterol by decreasing LDL oxidation and supporting heart health. This study examined the ... ...

Abstract	Hyperlipidemia is a global epidemic that causes various cardiovascular diseases (CVDs). Prunes include fiber and numerous phenolic compounds that decrease cholesterol by decreasing LDL oxidation and supporting heart health. This study examined the therapeutic effects of Prunus domestica prunes on plasma fatty acids in albino rats after ingesting prune pulp. After chemical examination, prunes were proximately examined for nutritional content. Prunus domestica pulp was given to hyperlipidemic rats for two months in a clinical trial. 12 albino rates and divide into 3 groups. First group was controlled, others experimental. The study's 15
MeSH term(s)	Animals ; Rats ; Cardiovascular Diseases ; Epidemics ; Fatty Acids ; Fruit ; Heart ; Prunus domestica
Chemical Substances	Fatty Acids
Language	English
Publishing date	2023-08-21
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Zs.A 6588: Show issues

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Article: Predictors of Mortality in Patients With Dengue Fever: Insights From a Comparative Analysis.

Mahmood, Afsheen / Haq, Anwar Ul / Amin, Said / Rahim, Fawad / Noor, Mohammad / Gul, Huma / Zafar, Sheraz / Ahmed Qureshi, Sobia / Batul, Khaula / Haq, Mohsina

Cureus

2023 Volume 15, Issue 3, Page(s) e36040

Abstract: Objective To determine the clinical and biochemical predictors of mortality in patients with dengue fever. Methods This was an analytical, cross-sectional study conducted at Hayatabad Medical Complex, Peshawar, Pakistan. The study participants were ... ...

Abstract	Objective To determine the clinical and biochemical predictors of mortality in patients with dengue fever. Methods This was an analytical, cross-sectional study conducted at Hayatabad Medical Complex, Peshawar, Pakistan. The study participants were patients admitted to the hospital for the management of dengue fever. Clinical parameters (age, gender, duration of hospital stay, and the presence of complications) and biochemical parameters [white blood cells count (WBC), platelet count, serum c-reactive protein (CRP) level, serum alanine aminotransferase (ALT) level, and serum creatinine] were recorded. These parameters were compared between the survivors and non-survivors of dengue fever. Results Out of 115 patients, the majority (n=82, 71.3%) were up to 45 years and the mean age was 38.40 ± 18.1 years. Most of the patients (n=105, 91.3%) survived. On univariate logistic regression analysis, age more than 45 years [odds ratio (OR) 0.141, 95% confidence interval (CI) 0.034 - 0.585, p = 0.007), leukocytosis (> 11,000/mcL) (OR 0.187, 95% CI 0.049 - 0.719, p = 0.015), and acute kidney injury (creatinine > 1.5 mg/dL) (OR 0.124, 95% CI 0.029 - 0.531, p = 0.005)] at the time of admission reduced the likelihood to survive. Leukocytosis and acute kidney injury remained significant independent predictors of mortality on multivariate logistic regression analysis. [(OR 0.201, 95% CI 0.042 - 0.960, p = 0.044) and (OR 0.148, 95% CI 0.026 - 0.857, p = 0.033) for survival, respectively]. Gender, duration of inpatient stay, thrombocytopenia (platelets < 30,000/mcL), and acute liver injury (ALT > 200 IU/L) were not associated with mortality from dengue fever. Conclusion Age over 45 years, leukocytosis, and acute kidney injury at presentation increased the likelihood of mortality from dengue fever in this study. Gender, duration of hospital stay, thrombocytopenia, and acute liver injury did not affect the odds of mortality.
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36040
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Article ; Online: Predictive value of tissue p53 protein expression and serum p53 antibodies in oral potentially malignant disorders: Relative to oral squamous cell carcinoma.

Khan, Abbas S / Ahmad, Sajjad / Ullah, Zahoor / Sadiq, Naveed / Haq, Mohsina / Sheikh, Ahmareen K

Journal of Taibah University Medical Sciences

2021 Volume 17, Issue 3, Page(s) 415–423

Abstract: Objective: This study aims to assess and report the predictive value of tissue p53 protein expression and serum p53 antibodies as a screening tool for oral potentially malignant disorders (OPMDs) cases with risk of malignant transformation.: Methods: ...

Abstract	Objective: This study aims to assess and report the predictive value of tissue p53 protein expression and serum p53 antibodies as a screening tool for oral potentially malignant disorders (OPMDs) cases with risk of malignant transformation. Methods: A case-control study was jointly conducted at the Department of Pathology and Oral and Maxillofacial Surgery in several dental institutes in the country from April 2016 to March 2017. A total of 180 eligible subjects (60 cases of OPMDs, 60 cases of oral squamous cell carcinoma, and 60 controls) were included in the study. Tissue p53 immunoreactivity was determined by immunohistochemistry, and serum concentrations of p53 antibodies were determined by enzyme-linked immunosorbent assay. Specimens were collected for laboratory investigations after obtaining written consent from both patients and controls. Results: Among the study participants, the recorded male to female ratio was close to 2:1, and most participants fell in the age range of 41-60 years and above. Of the 60 cases of OPMDs, the observed tissue p53 immunopositivity was 73.3% (n = 44) while for the p53 antibody, the seropositivity was 96.7% (n = 58). The sensitivity for p53 immunoreactivity was 73%, and specificity was 98.3% between OPMDs and healthy individuals. Conclusion: The present study provides evidence (for OPMDs) that serum p53 antibodies and p53 immunoreactivity could be used as a sensitivity test and a specific test, respectively, and may contribute to determining the potential of OPMD for malignant transformation risk.
Language	English
Publishing date	2021-12-31
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2817396-X
ISSN	1658-3612 ; 1658-3612
ISSN (online)	1658-3612
ISSN	1658-3612
DOI	10.1016/j.jtumed.2021.11.008
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Article: Identifying higher risk subgroups of health care workers for priority vaccination against COVID-19.

Haq, Mohsina / Rehman, Asif / Haq, Momina / Haq, Hala / Rajab, Hala / Ahmad, Junaid / Ahmed, Jawad / Anwar, Saeed / Ahmad, Sajjad / Haq, Najib Ul

Therapeutic advances in vaccines and immunotherapy

2022 Volume 10, Page(s) 25151355221080724

Abstract: Background: Health care workers (HCWs) are exposed to high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection due to close contact with infected patients in hospital. The objective of this study was to estimate the ... ...

Abstract	Background: Health care workers (HCWs) are exposed to high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection due to close contact with infected patients in hospital. The objective of this study was to estimate the seroprevalence and to identify the exposure risk of various subgroups among HCWs to prioritize them for early vaccination. Methods: This was a multicentre cross-sectional study conducted between 15 and 29 June 2020. A total of 987 HCWs were recruited randomly from two major tertiary-care hospitals of Peshawar city, Pakistan. The HCWs included doctors, nurses, paramedics and hospital support staff. The US Food and Drug Administration (FDA)-approved kit was used for the detection of SARS-CoV-2 antibodies. Results: Overall, 310 (31.4%) HCWs were seropositive for SARS-CoV-2 antibodies (95% confidence interval, CI: 28.5-34.4). Seroprevalence was higher in males (33.5%) and in age group 51-60 years (40.9%). Seropositivity increased with increasing age from 8.3% in age group ⩽20 to 40.9% in 51-60 years of age group ( Conclusion: Overall, our results concluded that nursing and paramedical staff are at higher risk and should be vaccinated on priority.
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2970613-0
ISSN	2515-1363 ; 2515-1355
ISSN (online)	2515-1363
ISSN	2515-1355
DOI	10.1177/25151355221080724
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