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  1. Article ; Online: MiR-548 K regulatory effect on the ABCG2 gene expression in MDR breast cancer cells.

    Saberiyan, Mohammadreza / Ghasemi, Zahra / Yaghoobi, Hajar

    Cancer reports (Hoboken, N.J.)

    2023  Volume 6, Issue 6, Page(s) e1816

    Abstract: Background: multidrug resistance (MDR) is One of the foremost challenges in overcoming breast cancer. Various molecular processes are involved in the development of MDR in breast cancer cells, including over expression of ABC transporters such as ABCG2 ( ...

    Abstract Background: multidrug resistance (MDR) is One of the foremost challenges in overcoming breast cancer. Various molecular processes are involved in the development of MDR in breast cancer cells, including over expression of ABC transporters such as ABCG2 (BCRP), increase breast cancer stem cells drug resistance, and epithelial mesenchymal transition.
    Aims: In the present study, we used bioinformatics and experimental analysis to investigate the role of miR-548 K, in the modulating of ABCG2, in MDR breast cancer cells.
    Methods and results: In silico inspections introduce 14 microRNAs targeting 3'-UTR region of ABCG2 transcripts, which are probably involved in breast cancer drug resistance. An association was highlighted between miR-548 k with ABC transporter family. The expression level of ABCG2 gene in MCF7-MX cell lines was significantly more than MCF7 cell lines. On the other hand, we increased the expression of miR-548 K in MCF7-MX and MCF7 cell lines through its transfection, which dramatically coincided with decreasion in the ABCG2 transcripts level. Additional studies on patient samples revealed that the expression of ABCG2 showed an increase in ABCG2 level in neoadjuvant chemotherapy drugs resistance (NCDR) patients compared to primary pre-operative chemotherapy drugs response (PCDR) patients. Also, a reduction in the expression of miR-548 K in NCDR patients was revealed.
    Conclusion: The results of our study suggest that miR-548 K may be involved in modulating the expression of ABCG2 in MDR breast cancer cells.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Cell Line, Tumor ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Drug Resistance, Multiple/genetics ; MicroRNAs/genetics ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/pharmacology ; Gene Expression
    Chemical Substances ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Neoplasm Proteins ; MicroRNAs ; ATP-Binding Cassette Transporters ; ABCG2 protein, human ; MIRN548 microRNA, human
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1816
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  2. Article ; Online: Crosstalk of NLRP3 inflammasome and noncoding RNAs in cardiomyopathies.

    Jafari, Negar / Shahabi Rabori, Venus / Zolfi Gol, Ali / Saberiyan, Mohammadreza

    Cell biochemistry and function

    2023  Volume 41, Issue 8, Page(s) 1060–1075

    Abstract: Cardiovascular diseases (CVDs) identified as a serious public health problem. Although there is a lot of evidence that inflammatory processes play a significant role in the progression of CVDs, however, the precise mechanism is not fully understood. ... ...

    Abstract Cardiovascular diseases (CVDs) identified as a serious public health problem. Although there is a lot of evidence that inflammatory processes play a significant role in the progression of CVDs, however, the precise mechanism is not fully understood. Nevertheless, recent studies have focused on inflammation and its related agents. Nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) is a type of pattern recognition receptor (PRR) that can recognize pathogen-associated molecular patterns and trigger innate immune response. NLRP3 is a component of the NOD-like receptor (NLR) family and have a pivotal role in detecting damage to cardiovascular tissue. It is suggested that activation of NLRP3 inflammasome leads to initiating and propagating the inflammatory response in cardiomyopathy. So, late investigations have highlighted the NLRP3 inflammasome activation in various forms of cardiomyopathy. On the other side, it was shown that noncoding RNAs (ncRNAs), particularly, microRNAs, lncRNAs, and circRNAs possess a regulatory function in the immune system's inflammatory response, implicating their involvement in various inflammatory disorders. In addition, their role in different cardiomyopathies was indicated in recent studies. This review article provides a summary of recent advancements focusing on the function of the NLRP3 inflammasome in common CVDs, especially cardiomyopathy, while also discussing the therapeutic potential of inhibiting the NLRP3 inflammasome regulated by ncRNAs.
    MeSH term(s) Humans ; Cardiomyopathies/genetics ; Cardiomyopathies/metabolism ; Inflammasomes/metabolism ; Inflammation ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 283643-9
    ISSN 1099-0844 ; 0263-6484
    ISSN (online) 1099-0844
    ISSN 0263-6484
    DOI 10.1002/cbf.3882
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  3. Article ; Online: Reduced expression of CFAP44 and CFAP44-AS1 may affect sperm motility and morphology.

    Kamel, Ali / Saberiyan, Mohammadreza / Mirfakhraie, Reza / Teimori, Hossein

    Andrologia

    2022  Volume 54, Issue 7, Page(s) e14447

    Abstract: Motility and morphology are two important characteristics of a fertile spermatozoon. CFAP44 gene encodes flagellar protein 44 involved in the formation and function of the flagella and cilia. Long non-coding RNAs are regulatory elements involved in ... ...

    Abstract Motility and morphology are two important characteristics of a fertile spermatozoon. CFAP44 gene encodes flagellar protein 44 involved in the formation and function of the flagella and cilia. Long non-coding RNAs are regulatory elements involved in several processes, including reproduction. We aimed to study the alterations in the expressions of CFAP44 and CFAP44-AS1 genes in infertile men with asthenozoospermia and terato-asthenozoospermia. In this case-control study, a total of 105 subjects, including 35 TAZ patients, 34 AZ patients and 35 normozoospermic men, were enrolled. After RNA extraction from spermatozoa samples, quantitative real-time PCR was performed to compare the expression of CFAP44 and CFAP44-AS1 between the studied groups. A meaningful reduction in CFAP44 expression and a significant reduction in the expression of CFAP44-AS1 were observed. Moreover, a positive correlation between both genes' expressions and normal sperm morphology was detected in NZ, AZ and TAZ groups. Also, there was a positive relation between CFAP44 gene expression and sperm motility in AZ and TAZ groups. The expression of CFAP44-AS1 was positively correlated with sperm motility and morphology. Present results confirm the role of CFAP44 and CFAP44-AS1 in the motility and morphology of spermatozoon, and deregulation of these genes may contribute to male infertility.
    MeSH term(s) Asthenozoospermia/genetics ; Asthenozoospermia/metabolism ; Case-Control Studies ; Humans ; Male ; Semen/metabolism ; Sperm Motility/genetics ; Spermatozoa/metabolism
    Language English
    Publishing date 2022-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 7280-1
    ISSN 1439-0272 ; 0303-4569
    ISSN (online) 1439-0272
    ISSN 0303-4569
    DOI 10.1111/and.14447
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  4. Article ; Online: DNAH5 gene and its correlation with linc02220 expression and sperm characteristics.

    Kamel, Ali / Saberiyan, Mohammadreza / Adelian, Samaneh / Teimori, Hossein

    Molecular biology reports

    2022  Volume 49, Issue 10, Page(s) 9365–9372

    Abstract: Background: Numerous pieces of evidence show that many environmental and genetic factors can cause male infertility. Much research in recent years has investigated the function of long non-coding RNAs (lncRNAs) in fertility. The main objective of the ... ...

    Abstract Background: Numerous pieces of evidence show that many environmental and genetic factors can cause male infertility. Much research in recent years has investigated the function of long non-coding RNAs (lncRNAs) in fertility. The main objective of the current study was to investigate the expression of Dynein Axonemal Heavy Chain 5 (DNAH5) as a gene that plays an essential role in sperm motility in individuals with asthenozoospermia and terato-asthenozoospermia. Alterations in linc02220 expression (located close to the DNAH5 gene), its action potential in DNAH5 regulating, and the correlation between their expression and normal sperm morphology and motility were also examined.
    Method and material: This study examined the semen of 31 asthenozoospermia individuals (AZ), 33 terato-asthenozoospermia (TAZ) individuals, and 33 normospermia (NZ) individuals with normal sperm as a control group. The expression levels of DNAH5 and linc02220 in the sperm samples were analyzed by real-time PCR.
    Results: Gene expression analysis revealed a significant association between DNAH5 expression and sperm motility and morphology (p < 0.0001). The DNAH5 expression levels in the TAZ and AZ groups were also significantly reduced; however, linc02220 was significantly upregulated in both TAZ and AZ groups compared to the NZ group (p < 0.0001). DNAH5 expression in the TAZ and AZ groups was negatively correlated with linc02220 expression, thus, DNAH5 downregulation was associated with linc02220 overexpression (p < 0.05).
    Conclusions: The gene linc02220 could be a potential regulatory target for DNAH5, and both could affect sperm's normal motility and morphology.
    MeSH term(s) Asthenozoospermia/genetics ; Axonemal Dyneins/genetics ; Dyneins/genetics ; Dyneins/metabolism ; Humans ; Male ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Semen/metabolism ; Sperm Motility/genetics ; Spermatozoa/metabolism
    Chemical Substances RNA, Long Noncoding ; Axonemal Dyneins (EC 3.6.4.2) ; DNAH5 protein, human (EC 3.6.4.2) ; Dyneins (EC 3.6.4.2)
    Language English
    Publishing date 2022-08-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07787-2
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  5. Article ; Online: Crosstalk between hypoxia-induced pyroptosis and immune escape in cancer: From mechanisms to therapy.

    Meybodi, Seyed Mohammadmahdi / Ejlalidiz, Mahsa / Manshadi, Mohammadsadegh Rezaeian / Raeisi, Mohammad / Zarin, Maryam / Kalhor, Zahra / Saberiyan, Mohammadreza / Hamblin, Michael R

    Critical reviews in oncology/hematology

    2024  Volume 197, Page(s) 104340

    Abstract: Pyroptosis can be triggered through both canonical and non-canonical inflammasome pathways, involving the cleavage of gasdermin (GSDM) protein family members, like GSDMD and GSDME. The impact of pyroptosis on tumors is nuanced, because its role in ... ...

    Abstract Pyroptosis can be triggered through both canonical and non-canonical inflammasome pathways, involving the cleavage of gasdermin (GSDM) protein family members, like GSDMD and GSDME. The impact of pyroptosis on tumors is nuanced, because its role in regulating cancer progression and anti-tumor immunity may vary depending on the tumor type, stage, location, and immune status. However, pyroptosis cannot be simply categorized as promoting or inhibiting tumors based solely on whether it is acute or chronic in nature. The interplay between pyroptosis and cancer is intricate, with some evidence suggesting that chronic pyroptosis may facilitate tumor growth, while the acute induction of pyroptosis could stimulate anti-cancer immune responses. Tumor hypoxia activates hypoxia inducible factor (HIF) signaling to modulate pyroptosis and immune checkpoint expression. Targeting this hypoxia-pyroptosis-immune escape axis could be a promising therapeutic strategy. This review highlights the complex crosstalk between hypoxia, pyroptosis, and immune evasion in the TME.
    Language English
    Publishing date 2024-04-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2024.104340
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  6. Article ; Online: DNAH5 gene and its correlation with linc02220 expression and sperm characteristics

    Kamel, Ali / Saberiyan, Mohammadreza / Adelian, Samaneh / Teimori, Hossein

    Mol Biol Rep. 2022 Oct., v. 49, no. 10 p.9365-9372

    2022  

    Abstract: BACKGROUND: Numerous pieces of evidence show that many environmental and genetic factors can cause male infertility. Much research in recent years has investigated the function of long non-coding RNAs (lncRNAs) in fertility. The main objective of the ... ...

    Abstract BACKGROUND: Numerous pieces of evidence show that many environmental and genetic factors can cause male infertility. Much research in recent years has investigated the function of long non-coding RNAs (lncRNAs) in fertility. The main objective of the current study was to investigate the expression of Dynein Axonemal Heavy Chain 5 (DNAH5) as a gene that plays an essential role in sperm motility in individuals with asthenozoospermia and terato-asthenozoospermia. Alterations in linc02220 expression (located close to the DNAH5 gene), its action potential in DNAH5 regulating, and the correlation between their expression and normal sperm morphology and motility were also examined. METHOD AND MATERIAL: This study examined the semen of 31 asthenozoospermia individuals (AZ), 33 terato-asthenozoospermia (TAZ) individuals, and 33 normospermia (NZ) individuals with normal sperm as a control group. The expression levels of DNAH5 and linc02220 in the sperm samples were analyzed by real-time PCR. RESULTS: Gene expression analysis revealed a significant association between DNAH5 expression and sperm motility and morphology (p < 0.0001). The DNAH5 expression levels in the TAZ and AZ groups were also significantly reduced; however, linc02220 was significantly upregulated in both TAZ and AZ groups compared to the NZ group (p < 0.0001). DNAH5 expression in the TAZ and AZ groups was negatively correlated with linc02220 expression, thus, DNAH5 downregulation was associated with linc02220 overexpression (p < 0.05). CONCLUSIONS: The gene linc02220 could be a potential regulatory target for DNAH5, and both could affect sperm’s normal motility and morphology.
    Keywords action potentials ; dynein ATPase ; gene expression ; genes ; male sterility ; quantitative polymerase chain reaction ; semen ; sperm motility ; spermatozoa
    Language English
    Dates of publication 2022-10
    Size p. 9365-9372.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07787-2
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  7. Article ; Online: Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility.

    Saberiyan, Mohammadreza / Mirfakhraie, Reza / Moghni, Mandana / Teimori, Hossein

    Reproductive sciences (Thousand Oaks, Calif.)

    2020  Volume 28, Issue 1, Page(s) 159–165

    Abstract: We investigated the relationship of t-complex-associated-testis-expressed 3 (TCTE3) and linc00574 expression levels with sperm motility and morphology in patients with asthenozoospermia (AZ) and terato-asthenozoospermia (TAZ). The study population ... ...

    Abstract We investigated the relationship of t-complex-associated-testis-expressed 3 (TCTE3) and linc00574 expression levels with sperm motility and morphology in patients with asthenozoospermia (AZ) and terato-asthenozoospermia (TAZ). The study population consisted of 31 AZ patients, 31 TAZ patients, and 32 normozoospermia (NZ) as controls. Quantitative real-time PCR was conducted to evaluate the expression levels of TCTE3 and linc00574. Bioinformatics investigations were performed using databases to find molecular pathway. TCTE3 expression was reduced significantly in AZ and TAZ patients (P < 0.05). Linc00574 expression level increased only in the AZ patients (P < 0.05). The subsequent analyses showed a significantly positive correlation between TCTE3 and linc00574 expression levels (P < 0.05). In addition, a significantly positive relationship was observed between TCTE3 expression level and sperm motility and morphology (P < 0.05). The present study suggests that TCTE3 expression is regulated by linc00574 through a negative self-regulating mechanism and therefore may affect the flagella structure and function.
    MeSH term(s) Adult ; Asthenozoospermia/genetics ; Asthenozoospermia/metabolism ; Asthenozoospermia/pathology ; Case-Control Studies ; Cell Shape ; Computational Biology ; Databases, Genetic ; Dyneins/genetics ; Dyneins/metabolism ; Humans ; Male ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Signal Transduction ; Sperm Count ; Sperm Motility ; Spermatozoa/metabolism ; Spermatozoa/pathology
    Chemical Substances RNA, Long Noncoding ; TCTE3 protein, human ; Dyneins (EC 3.6.4.2)
    Language English
    Publishing date 2020-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-020-00275-7
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  8. Article ; Online: The role of noncoding RNAs in metabolic reprogramming of cancer cells.

    Safi, Amir / Saberiyan, Mohammadreza / Sanaei, Mohammad-Javad / Adelian, Samaneh / Davarani Asl, Fateme / Zeinaly, Mahsa / Shamsi, Mahdi / Ahmadi, Reza

    Cellular & molecular biology letters

    2023  Volume 28, Issue 1, Page(s) 37

    Abstract: Metabolic reprogramming is a well-known feature of cancer that allows malignant cells to alter metabolic reactions and nutrient uptake, thereby promoting tumor growth and spread. It has been discovered that noncoding RNAs (ncRNAs), including microRNA ( ... ...

    Abstract Metabolic reprogramming is a well-known feature of cancer that allows malignant cells to alter metabolic reactions and nutrient uptake, thereby promoting tumor growth and spread. It has been discovered that noncoding RNAs (ncRNAs), including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), have a role in a variety of biological functions, control physiologic and developmental processes, and even influence disease. They have been recognized in numerous cancer types as tumor suppressors and oncogenic agents. The role of ncRNAs in the metabolic reprogramming of cancer cells has recently been noticed. We examine this subject, with an emphasis on the metabolism of glucose, lipids, and amino acids, and highlight the therapeutic use of targeting ncRNAs in cancer treatment.
    MeSH term(s) RNA, Untranslated/genetics ; RNA, Long Noncoding/genetics ; Biological Transport ; MicroRNAs/genetics ; Glucose ; RNA, Circular ; Neoplasms/genetics
    Chemical Substances RNA, Untranslated ; RNA, Long Noncoding ; MicroRNAs ; Glucose (IY9XDZ35W2) ; RNA, Circular
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2108724-6
    ISSN 1689-1392 ; 1689-1392
    ISSN (online) 1689-1392
    ISSN 1689-1392
    DOI 10.1186/s11658-023-00447-8
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  9. Article ; Online: Circular RNAs: Novel Biomarkers in Spermatogenesis Defects and Male Infertility.

    Saberiyan, Mohammadreza / Karimi, Elham / Safi, Amir / Movahhed, Parvaneh / Dehdehi, Leila / Haririan, Nazanin / Mirfakhraie, Reza

    Reproductive sciences (Thousand Oaks, Calif.)

    2022  Volume 30, Issue 1, Page(s) 62–71

    Abstract: Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs involved in several cellular and biological processes, including gene expression regulation, microRNA function, transcription regulation, and translation modification. Therefore, ... ...

    Abstract Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs involved in several cellular and biological processes, including gene expression regulation, microRNA function, transcription regulation, and translation modification. Therefore, these non-coding RNAs have important roles in the pathogenesis of various diseases. Male infertility is mainly due to abnormal sperm parameters such as motility, morphology, and concentration. Recent studies have confirmed the role of circRNAs in spermatogenesis, and the expression of several circRNAs is confirmed in seminal plasma, spermatozoa, and testicular tissue. It is suggested that deregulation of circRNAs is involved in different types of male infertility, including azoospermia, oligozoospermia, and asthenozoospermia. In the present review, we aimed to discuss the potential roles of circRNAs in spermatogenesis failure, sperm defects, and male infertility. Due to their conserved and special structure and tissue-specific expression pattern, circRNAs can be applied as reliable noninvasive molecular biomarkers, therapeutic and pharmaceutical targets in male infertility.
    MeSH term(s) Humans ; Male ; RNA, Circular ; Semen/metabolism ; Infertility, Male/diagnosis ; Infertility, Male/genetics ; Spermatogenesis/genetics ; Biomarkers/metabolism
    Chemical Substances RNA, Circular ; Biomarkers
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-022-00885-3
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  10. Article ; Online: The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer.

    Movahhed, Parvaneh / Saberiyan, Mohammadreza / Safi, Amir / Arshadi, Zahra / Kazerouni, Faranak / Teimori, Hossein

    Molecular biology reports

    2022  Volume 49, Issue 6, Page(s) 4959–4964

    Abstract: Background: The autophagy pathway is used by eukaryotic cells to maintain metabolic homeostasis. Autophagy has two functions in cancerous cells which could inhibit tumorigenesis or lead to cancer progression by increasing cell survival and proliferation. ...

    Abstract Background: The autophagy pathway is used by eukaryotic cells to maintain metabolic homeostasis. Autophagy has two functions in cancerous cells which could inhibit tumorigenesis or lead to cancer progression by increasing cell survival and proliferation.
    Methods and results: In this review article, Web of Science, PubMed, Scopus,  and Google Scholar were searched and summarized published studies to explore the relationship between DAPK1 and mTORC1 signaling association on autophagy in cancer. Autophagy is managed through various proteins including the mTOR, which is two separated structural and functional complexes known as mTORC1 and mTORC2. MTORC1 is an important component of the regulatory pathway affecting numerous cellular functions including proliferation, migration, invasion, and survival. This protein plays a key role in human cancers. The activity level of mTORC1 is regulated by the death-associated protein kinases (DAPks) family, especially DAPK1. In many cancers, DAPK1 acts as a tumor suppressor which can be attributed to its ability to suppress cellular transformation and to inhibit metastasis.
    Conclusions: A deep investigation not only will reveal more about the function of DAPK1 but also might provide insights into novel therapies aimed to modulate the autophagy pathway in cancer and to achieve better cancer therapy.
    MeSH term(s) Autophagy ; Death-Associated Protein Kinases/genetics ; Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Signal Transduction
    Chemical Substances DAPK1 protein, human (EC 2.7.11.1) ; Death-Associated Protein Kinases (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1)
    Language English
    Publishing date 2022-01-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07154-1
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