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Article ; Online: Antibiotic resistance among clinical

Preval, Nadia María Rodríguez / Spiller, Owen B / Mondeja Rodríguez, Brian A / Morales, Ruxana Sardiñas / Cintra, Yenis Ramírez / Rivera-Tapia, José A

Journal of medical microbiology

2022 Volume 71, Issue 2

Abstract: Introduction. ...

Abstract	Introduction.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Cuba ; Drug Resistance, Bacterial ; Erythromycin/pharmacology ; Humans ; Microbial Sensitivity Tests ; Tetracycline/pharmacology ; Ureaplasma/drug effects ; Ureaplasma/genetics ; Ureaplasma Infections/epidemiology ; Ureaplasma Infections/microbiology
Chemical Substances	Anti-Bacterial Agents ; Erythromycin (63937KV33D) ; Tetracycline (F8VB5M810T)
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001477
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Article ; Online: First detection and characterization of macrolide-resistant Mycoplasma pneumoniae strains in Cuba.

Rodriguez, Nadia / Mondeja, Brian / Sardiñas, Ruxana / Vega, Dania / Dumke, Roger

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2019 Volume 80, Page(s) 115–117

Abstract: Objectives: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in humans. Treatment of infections can be complicated by the occurrence of macrolide resistant strains. The study was conducted to evaluate the presence of resistant ... ...

Abstract	Objectives: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in humans. Treatment of infections can be complicated by the occurrence of macrolide resistant strains. The study was conducted to evaluate the presence of resistant strains in Cuba and to determine the corresponding genotypes. Methods: DNA of M. pneumoniae isolates and positive respiratory tract specimens collected in the years 2012 and 2017 were tested for resistance-associated mutations of 23S rRNA. In addition, strain types (P1 and MLVA) were determined. Results: Macrolide resistance mutations were confirmed in 5 out of 27 strains (18.5%). Whereas both P1 subtypes 1 and 2 as well variants V2a and V2c were identified, only two MLVA types (4/5/7/2 and 3/5/6/2) could be found. Conclusions: During both sampling years, circulation of macrolide resistant strains was demonstrated. No association of resistance with a particular P1/MLVA type was found. Future longitudinal sampling to monitor prevalence of macrolide resistance of M. pneumoniae is recommended to verify the resistance pattern of this important pathogen of human respiratory tract infections.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Cuba ; DNA, Bacterial/isolation & purification ; Drug Resistance, Bacterial ; Genotyping Techniques ; Humans ; Macrolides/pharmacology ; Mycoplasma pneumoniae/drug effects ; Mycoplasma pneumoniae/isolation & purification ; Pneumonia, Mycoplasma ; RNA, Ribosomal, 23S/isolation & purification ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/microbiology ; Specimen Handling
Chemical Substances	Anti-Bacterial Agents ; DNA, Bacterial ; Macrolides ; RNA, Ribosomal, 23S
Language	English
Publishing date	2019-01-10
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2018.12.018
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Zs.A 4516: Show issues

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Article: Defining Fluoroquinolone Resistance-Mediating Mutations from Non-Resistance Polymorphisms in

Sharratt, Martin / Sands, Kirsty / Portal, Edward A R / Boostrom, Ian / Mondeja, Brian A / Rodríguez, Nadia M / Jones, Lucy C / Spiller, Owen B

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 11

Abstract: Often dismissed as a commensal, ...

Abstract	Often dismissed as a commensal,
Language	English
Publishing date	2021-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10111379
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Article ; Online: Chlamydia trachomatis

Soto Brito, Yudira / Fonseca Castro, Darien Alejandro / Guilarte Garcia, Elias / Kouri Cardellá, Vivian / Ramirez Cardentey, Celeste / Mondeja Rodriguez, Brian Arturo / Concepción López, Jesús José / Sánchez Alvarez, María de Lourdes / López Pérez, Maida / Gutierrez Coronado, Teresita / Torres Mosqueda, Karelia / Suárez Licor, Georgina

International journal of STD & AIDS

2023 Volume 34, Issue 14, Page(s) 1024–1033

Abstract: Background: In Cuba, little is known regarding the prevalence of : Methods: A total of 496 individuals aged 12 to 24 were recruited from November 2018 to November 2019. Of them, 302 were patients attending at sexually transmitted infections (STI) ... ...

Abstract	Background: In Cuba, little is known regarding the prevalence of Methods: A total of 496 individuals aged 12 to 24 were recruited from November 2018 to November 2019. Of them, 302 were patients attending at sexually transmitted infections (STI) services and 194 were young volunteers. CT detections were carried out by real-time PCR and IgG serology. Results: The prevalence of CT using PCR was 9.1% (45/496); 12.3% (37/302) for subjects attending STI service and 4.1% (8/194) for young volunteers, being significantly higher in the first group (OR=3.25; Conclusions: The results suggest that Cuban adolescents and young populations are at highest risk of acquiring CT infection and developing reproductive complications. The data obtained advise the needs of implementation of a routine CT screening strategy, for timely diagnosis, detection and treatment at the earliest ages.
MeSH term(s)	Humans ; Adolescent ; Child ; Chlamydia trachomatis/genetics ; Sexual Behavior ; Chlamydia Infections/diagnosis ; Chlamydia Infections/epidemiology ; Chlamydia Infections/prevention & control ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Prevalence ; Immunoglobulin G ; Risk Factors
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624231191568
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Zs.A 2829: Show issues

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Article: SARS-CoV-2: theoretical analysis of the proposed algorithms to the enhancement and segmentation of high-resolution microscopy images-Part II.

Rodríguez, Roberto / Mondeja, Brian A / Valdes, Odalys / Resik, Sonia / Vizcaino, Ananayla / Acosta, Emilio F / González, Yorexis / Kourí, Vivian / Díaz, Angelina / Guzmán, María G

Signal, image and video processing

2022 Volume 16, Issue 3, Page(s) 595–604

Abstract: Today is a reality that the novel coronavirus SARS-Cov-2 has become a global pandemic. For this reason, the study of real microscopic images of this coronavirus is of great importance, as it allows us to carry out a more precise research on it. However, ... ...

Abstract	Today is a reality that the novel coronavirus SARS-Cov-2 has become a global pandemic. For this reason, the study of real microscopic images of this coronavirus is of great importance, as it allows us to carry out a more precise research on it. However, as we pointed out in a former paper as reported by Roberto Rodríguez (SARS-CoV-2: Enhancement and Segmentation of High-Resolution Microscopy Images. Part I", Sent to Signal, Image and Video Processing Video Processing, Springer, New York, 2020), many times these microscopic images present some blurring problems, which are always susceptible to be improved. The aim of this work is to carry out a theoretical analysis of the proposed algorithms to enhancement and segmentation of these microscopic images, which is important for the design and development of future algorithms before new epidemics.
Language	English
Publishing date	2022-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2391619-9
ISSN	1863-1711 ; 1863-1703
ISSN (online)	1863-1711
ISSN	1863-1703
DOI	10.1007/s11760-021-02045-7
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Article ; Online: Mycoplasma genitalium infections in Cuba: surveillance of urogenital syndromes, 2014-2015.

Mondeja, Brian A / Rodríguez, Nadia M / Blanco, Orestes / Fernández, Carmen / Jensen, Jørgen S

International journal of STD & AIDS

2018 Volume 29, Issue 10, Page(s) 994–998

Abstract: Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in urethritis in men and several inflammatory reproductive tract syndromes in women. The prevalence of M. genitalium infections in Cuban patients with urogenital syndromes is ... ...

Abstract	Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in urethritis in men and several inflammatory reproductive tract syndromes in women. The prevalence of M. genitalium infections in Cuban patients with urogenital syndromes is unknown. The aim of this study was to analyse the prevalence of M. genitalium infection in sexually-active Cuban men and women with urogenital syndromes as a part of aetiological surveillance of urogenital syndromes in Cuba. Samples from men and women with urogenital syndromes submitted to the Mycoplasma Reference Laboratory for mycoplasma diagnosis from 1 January 2014 to 1 June 2015 were analysed by polymerase chain reaction (PCR) for detection of M. genitalium. A total of 971 samples were received and processed. Of the patients tested, 5.7% (47/824) of women and 27.9% (41/147) of men were positive for M. genitalium. This paper presents the largest study of M. genitalium infections among Cuban patients with urogenital syndromes and is Cuba's first M. genitalium survey. We suggest that M. genitalium should be considered in the Cuban sexually transmitted infection management protocols as an important pathogen, particularly in men.
MeSH term(s)	Adult ; Cuba/epidemiology ; Female ; Humans ; Male ; Mycoplasma Infections/diagnosis ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/microbiology ; Mycoplasma genitalium/genetics ; Mycoplasma genitalium/isolation & purification ; Mycoplasma genitalium/pathogenicity ; Pelvic Inflammatory Disease/epidemiology ; Pelvic Inflammatory Disease/microbiology ; Polymerase Chain Reaction ; Population Surveillance ; Prevalence ; Sexually Transmitted Diseases, Bacterial/epidemiology ; Sexually Transmitted Diseases, Bacterial/microbiology ; Urethritis/diagnosis ; Urethritis/microbiology
Language	English
Publishing date	2018-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/0956462418767186
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Zs.A 2829: Show issues

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Article ; Online: Macrolide-resistant Mycoplasma genitalium infections in Cuban patients: an underestimated health problem.

Mondeja, Brian Arturo / Couri, Javier / Rodríguez, Nadia Maria / Blanco, Orestes / Fernández, Carmen / Jensen, Jørgen Skov

BMC infectious diseases

2018 Volume 18, Issue 1, Page(s) 601

Abstract: Background: The increasing prevalence of macrolide resistant Mycoplasma genitalium is a major concern worldwide. In Cuba, several cases of clinical treatment failure with 1 g single dose and extended azithromycin regimen have been detected and the aim ... ...

Abstract	Background: The increasing prevalence of macrolide resistant Mycoplasma genitalium is a major concern worldwide. In Cuba, several cases of clinical treatment failure with 1 g single dose and extended azithromycin regimen have been detected and the aim of the present investigation was to retrospectively determine the prevalence of macrolide-resistance mediating mutations (MRMM) in M. genitalium-positive samples conserved at the Cuban National Reference Laboratory of Mycoplasma Research between 2009 and 2016. Methods: A total of 280 positive DNA extracts were analysed by a 5' nuclease assay for detection of M. genitalium MRMM. Ten urogenital specimens from patients with azithromycin treatment failure and MRMM were inoculated in Vero cell to obtain the isolates for subsequent determination of antimicrobial susceptibility. Results: The overall prevalence of MRMM was 32%. No MRMM was detected in samples collected between 2009 and 2013 but since 2014 a dramatic increase to 90% (95% CI, 76-96%) in 2016 was seen. Three new M. genitalium isolates were isolated in Vero cell cultures and confirmed phenotypic resistance to macrolides in a cell-culture assisted susceptibility test. Preliminary observations suggest that combination therapy with levofloxacin and doxycycline may represent an affordable option for treatment of macrolide resistant M. genitalium infections. Conclusions: This investigation showed the rapid emergence and high prevalence of MRMM in M. genitalium-infected patients in Cuba and confirmed the phenotypic resistance in isolates carrying MRMM. We suggest that Cuban guidelines for sexually transmitted infections are modified to include testing for M. genitalium and detection of MRMM in patients with failure of syndromic treatment, to ensure that in these cases, the treatment will be guided by etiologic diagnosis.
MeSH term(s)	Adult ; Animals ; Anti-Bacterial Agents/therapeutic use ; Cercopithecus aethiops ; Cuba/epidemiology ; Diagnostic Errors/statistics & numerical data ; Drug Resistance, Bacterial/drug effects ; Female ; Humans ; Macrolides/therapeutic use ; Male ; Microbial Sensitivity Tests ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/microbiology ; Mycoplasma genitalium/drug effects ; Mycoplasma genitalium/genetics ; Mycoplasma genitalium/isolation & purification ; Prevalence ; Retrospective Studies ; Sexually Transmitted Diseases, Bacterial/drug therapy ; Sexually Transmitted Diseases, Bacterial/epidemiology ; Vero Cells
Chemical Substances	Anti-Bacterial Agents ; Macrolides
Language	English
Publishing date	2018-11-29
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-018-3523-9
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Article: SARS-CoV-2: enhancement and segmentation of high-resolution microscopy images-Part I.

Rodríguez, Roberto / Mondeja, Brian A / Valdés, Odalys / Resik, Sonia / Vizcaino, Ananayla / Acosta, Emilio F / González, Yorexis / Kourí, Vivian / Díaz, Angelina / Guzmán, María G

Signal, image and video processing

2021 Volume 15, Issue 8, Page(s) 1713–1721

Abstract: Possibly, and due to poor eating habits and unhealthy lifestyle, many viruses are transmitted to human people. Such is the case, of the novel coronavirus SARS-Cov-2, which has expanded of exponential way, practically, to whole world population. For this ... ...

Abstract	Possibly, and due to poor eating habits and unhealthy lifestyle, many viruses are transmitted to human people. Such is the case, of the novel coronavirus SARS-Cov-2, which has expanded of exponential way, practically, to whole world population. For this reason, the enhancement of real microscopic images of this coronavirus is of great importance. Of this way, one can highlight the
Language	English
Publishing date	2021-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2391619-9
ISSN	1863-1711 ; 1863-1703
ISSN (online)	1863-1711
ISSN	1863-1703
DOI	10.1007/s11760-021-01912-7
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Article ; Online: Mycoplasma genitalium resistente a macrólidos

Brian Mondeja / Javier Curí / Nadia Rodríguez / Orestes Blanco / Carmen Fernández / Lilia Ortega / Ruxana Sardiñas / Elias Guilarte / Vivian Kourí / Jorgen Jensen

Anales de la Academia de Ciencias de Cuba, Vol 11, Iss

un problema de salud poco conocido en Cuba, y en aumento

2021 Volume 2

Abstract: Introducción: Mycoplasma genitalium constituye un patógeno de transmisión sexual emergente. En estudios preliminares realizados en Cuba, en el Laboratorio Nacional de Referencia de Micoplasma en el Instituto Pedro Kourí, se demuestra la circulación de ... ...

Abstract	Introducción: Mycoplasma genitalium constituye un patógeno de transmisión sexual emergente. En estudios preliminares realizados en Cuba, en el Laboratorio Nacional de Referencia de Micoplasma en el Instituto Pedro Kourí, se demuestra la circulación de genotipos resistentes a macrólidos y a tetraciclinas en aislados clínicos en células Vero. Sin embargo, esta metodología es laboriosa y larga, lo cual lo hace poco útil para el manejo clínico y tratamiento de los pacientes. Objetivos: implementar una herramienta de diagnóstico molecular rápido y sensible basada en PCR en tiempo real, para determinar la susceptibilidad antimicrobiana a los macrólidos de M. genitalium, directamente en las muestras clínicas. Métodos: Se implementó una PCR en tiempo real que permite determinar la presencia de M. genitalium y su susceptibilidad antimicrobiana a los macrólidos, directamente en las muestras clínicas, lo que disminuye el tiempo entre el diagnóstico y el tratamiento y erradicación de este microorganismo en los pacientes positivos. Este hecho contribuye a cortar las cadenas de trasmisión de las ITS causadas por esta bacteria, incidiendo de forma positiva en el programa de control de las ITS en Cuba. Los resultados del método molecular fueron corroborados mediante el aislamiento en cultivos celulares y ensayos fenotípicos de susceptibilidad antimicrobiana, logrando una total coincidencia entre el resultado de la qPCR en la muestra clínicas y los aislados correspondientes. Resultados: Se detectó un incremento sustancial de la resistencia a macrólidos en M. genitalium desde un 18 % en 2014 hasta un 98 % en 2019, lo que han permitido a las autoridades sanitarias implementar protocolos de tratamiento sindrómicos antimicrobiano para las ITS más exactos, contribuyendo a un mejor uso de los antibióticos en nuestro país, en consonancias a las políticas actuales de la OMS para el uso racional de los antimicrobianos.
Keywords	mycoplasma genitalium ; resistencia antimicrobiana ; cuba ; macrólidos ; infecciones de trasmisión sexual ; Science ; Q ; Science (General) ; Q1-390
Language	Spanish
Publishing date	2021-06-01T00:00:00Z
Publisher	Academia de Ciencias de Cuba
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: endophthalmitis in a Cuban pediatric patient

Brian Arturo Mondeja Rodríguez / Ernesto Alimañy / Yigani Vila de Armas / Nadia María Rodríguez Preval

SAGE Open Medical Case Reports, Vol

2019 Volume 7

Abstract: Bacterial endophthalmitis is the most severe form of vision-threatening ocular infection. Mycoplasma pneumoniae is a primary respiratory pathogen that has been associated with several extrapulmonary manifestation, including ocular infection. In this work, ...

Abstract	Bacterial endophthalmitis is the most severe form of vision-threatening ocular infection. Mycoplasma pneumoniae is a primary respiratory pathogen that has been associated with several extrapulmonary manifestation, including ocular infection. In this work, we presented the microbiology diagnosis of an endophalmitis by M. pneumoniae using a novel A.R.I. WELL D-ONE® (CPM Scientifica, Italy) commercial micromethod in a Cuban pediatric patient. After positive M. pneumoniae confirmation, treatment with levofloxacin was initiated and successfully eliminated the ocular infection.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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