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Article ; Online: SARS-CoV-2: the many pros of targeting PLpro.

McClain, Christopher B / Vabret, Nicolas

Signal transduction and targeted therapy

2020 Volume 5, Issue 1, Page(s) 223

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Immunity, Innate ; Pandemics ; Papain ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
Chemical Substances	Papain (EC 3.4.22.2)
Keywords	covid19
Language	English
Publishing date	2020-10-06
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-020-00335-z
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Article ; Online: SARS-CoV-2

Christopher B. McClain / Nicolas Vabret

Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-

the many pros of targeting PLpro

2020 Volume 2

Keywords	Medicine ; R ; Biology (General) ; QH301-705.5 ; covid19
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regional anesthesia in patients with Charcot-Marie-Tooth disease: a historical cohort study of 53 patients.

McClain, Robert L / Rubin, Devon I / Bais, Kimmy S / Navarro, Antonio M / Robards, Christopher B / Porter, Steven B

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2022 Volume 69, Issue 7, Page(s) 880–884

Abstract: Purpose: Anesthetic management for patients with Charcot-Marie-Tooth disease (CMT) is controversial. Description of the use of regional anesthesia (RA) in patients with CMT is limited. Regional anesthesia has traditionally been avoided because of risk ... ...

Title translation	Anesthésie régionale chez les patients atteints de la maladie de Charcot-Marie-Tooth : une étude de cohorte historique de 53 patients.
Abstract	Purpose: Anesthetic management for patients with Charcot-Marie-Tooth disease (CMT) is controversial. Description of the use of regional anesthesia (RA) in patients with CMT is limited. Regional anesthesia has traditionally been avoided because of risk of nerve injury. We retrospectively reviewed patients with CMT who received RA at our institution. Methods: We performed a historical cohort study of all patients with CMT who received RA from 30 April 2010 to 30 April 2020 within our institution. Charts were reviewed for information on demographics, RA procedures, perioperative variables, evidence of neurologic complications, post-RA neurology consults, and perioperative electromyography (EMG) results. Electromyographs were reviewed by a neurologist who was blinded to the surgical and RA details. Results: Fifty-three patients received a total of 132 regional anesthetics during the study period. Twenty-five patients received RA on more than one occasion. Fifty-five EMGs and 14 postoperative neurology consults were performed. Two patients had neurology consults with peripheral nerve block (PNB) distribution complaints years later. Neither attributed the complaints to the PNB. The other neurology consults were for unrelated complaints. No EMG results suggested injury related to PNB. Conclusion: This study found no evidence of documented neurologic complications or an increased risk of nerve injury related to RA in CMT patients.
MeSH term(s)	Anesthesia, Conduction ; Charcot-Marie-Tooth Disease/complications ; Charcot-Marie-Tooth Disease/surgery ; Cohort Studies ; Female ; Humans ; Peripheral Nerves ; Pregnancy Complications ; Retrospective Studies
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-022-02258-5
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Article ; Online: Evaluation of total inward leakage for NIOSH-approved elastomeric half-facepiece, full-facepiece, and powered air-purifying respirators using sodium chloride and corn oil aerosols.

Rengasamy, Samy / Zhuang, Ziqing / Lawrence, Robert B / Boutin, Brenda / Yorio, Patrick / Horvatin, Matthew / McClain, Caitlin / Harris, James R / Coffey, Christopher

Journal of occupational and environmental hygiene

2021 Volume 18, Issue 7, Page(s) 305–313

Abstract: Recently, total inward leakage (TIL) for filtering facepiece and elastomeric half-mask respirators (EHRs) was measured according to the International Organization for Standardization (ISO) test method standard 16900-1:2014 that showed larger TIL for corn ...

Abstract	Recently, total inward leakage (TIL) for filtering facepiece and elastomeric half-mask respirators (EHRs) was measured according to the International Organization for Standardization (ISO) test method standard 16900-1:2014 that showed larger TIL for corn oil aerosol than for NaCl aerosol. Comparison of TIL measured for different aerosols for higher protection level respirators is lacking. The objective of this study was to determine TIL for EHRs, full-facepiece respirators, and loose-fitting and tight-fitting powered air-purifying respirators (PAPRs) using NaCl and corn oil aerosols to compare. TIL was measured for two models each of EHRs, full-facepiece respirators, and loose-fitting and tight-fitting PAPRs. After fit testing with a PortaCount (TSI, St. Paul, MN) using the Occupational Safety and Health Administration (OSHA) protocol, eight subjects were tested in the NaCl aerosol chamber first and then in the corn oil aerosol chamber, while another eight subjects tested in the reverse order. Subjects were randomly assigned to one of the two groups. TIL was measured as a ratio of mass-based aerosol concentrations inside the mask to the test chamber while the subjects performed ISO 16900-1-defined exercises using continuous sampling methods. The concentration of corn oil aerosol was measured with one light scattering photometer, alternately, and NaCl aerosol was measured using two flame photometers. Results showed the geometric mean TIL for EHR was significantly (
MeSH term(s)	Aerosols ; Corn Oil ; Filtration ; Humans ; National Institute for Occupational Safety and Health, U.S. ; Occupational Exposure/prevention & control ; Particle Size ; Respiratory Protective Devices ; Sodium Chloride/analysis ; United States
Chemical Substances	Aerosols ; Sodium Chloride (451W47IQ8X) ; Corn Oil (8001-30-7)
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2131820-7
ISSN	1545-9632 ; 1545-9624
ISSN (online)	1545-9632
ISSN	1545-9624
DOI	10.1080/15459624.2021.1919685
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Article ; Online: MMP2 and TLRs modulate immune responses in the tumor microenvironment.

Muniz-Bongers, Luciana R / McClain, Christopher B / Saxena, Mansi / Bongers, Gerold / Merad, Miriam / Bhardwaj, Nina

JCI insight

2021 Volume 6, Issue 12

Abstract: The presence of an immunosuppressive tumor microenvironment is a major obstacle in the success of cancer immunotherapies. Because extracellular matrix components can shape the microenvironment, we investigated the role of matrix metalloproteinase 2 (MMP2) ...

Abstract	The presence of an immunosuppressive tumor microenvironment is a major obstacle in the success of cancer immunotherapies. Because extracellular matrix components can shape the microenvironment, we investigated the role of matrix metalloproteinase 2 (MMP2) in melanoma tumorigenesis. We found that MMP2 signals proinflammatory pathways on antigen presenting cells, and this requires both TLR2 and TLR4. B16 melanoma cells that express MMP2 at baseline have slower kinetics in Tlr2-/- Tlr4-/- mice, implicating MMP2 in promoting tumor growth. Indeed, Mmp2 overexpression in B16 cells potentiated rapid tumor growth, which was accompanied by reduced intratumoral cytolytic cells and increased M2 macrophages. In contrast, knockdown of Mmp2 slowed tumor growth and enhanced T cell proliferation and NK cell recruitment. Finally, we found that these effects of MMP2 are mediated through dysfunctional DC-T cell cross-talk as they are lost in Batf3-/- and Rag2-/- mice. These findings provide insights into the detrimental role of endogenous alarmins like MMP2 in modulating immune responses in the tumor microenvironment.
MeSH term(s)	Animals ; Cells, Cultured ; Female ; HEK293 Cells ; Humans ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/immunology ; Matrix Metalloproteinase 2/metabolism ; Mice ; Mice, Inbred C57BL ; Toll-Like Receptors/genetics ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism ; Tumor Microenvironment/immunology
Chemical Substances	Toll-Like Receptors ; MMP2 protein, human (EC 3.4.24.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.144913
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Article ; Online: Peripheral Nerve Blocks and Immediate Postoperative Recovery: A Single-Institution Survey of Perianesthesia Nurses' Preferences and Opinions.

McClain, Robert L / Porter, Steven B / Scott, Courtney L / Mazer, Laura S / Robards, Christopher B

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2019 Volume 34, Issue 5, Page(s) 965–970.e6

Abstract: Purpose: To ascertain the preferences of perianesthesia nurses regarding peripheral nerve blocks (PNBs) and their impact on patient recovery after total joint replacement (TJR).: Design: Survey of perianesthesia nurses at a single medical center.: ... ...

Abstract	Purpose: To ascertain the preferences of perianesthesia nurses regarding peripheral nerve blocks (PNBs) and their impact on patient recovery after total joint replacement (TJR). Design: Survey of perianesthesia nurses at a single medical center. Methods: Fifty-nine perianesthesia nurses completed a 23-question survey on PNBs for TJR. Findings: Most agreed PNBs improved patients' pain after knee, hip, and shoulder TJR (35 [92.1%], 35 [92.1%], and 34 [91.9%], respectively). Most felt lower extremity PNBs increased risk of falling (26 [70.3%]), whereas 7 of 35 (20.0%) felt patients fell more after spinal anesthesia than after general anesthesia. Respondents preferred a block to opioid-based analgesia if they were to have lower extremity TJR or total shoulder replacement (100% [30/30 and 33/33]). Conclusions: The perianesthesia nurses surveyed felt PNBs improved pain control and patient recovery despite a perceived risk of falling for lower extremity TJR, and they preferred PNB when considering TJR surgery for themselves.
MeSH term(s)	Adult ; Arthroplasty, Replacement/methods ; Arthroplasty, Replacement/standards ; Female ; Humans ; Male ; Middle Aged ; Nerve Block/methods ; Nerve Block/standards ; Nurses/psychology ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Perioperative Nursing/methods ; Perioperative Nursing/standards ; Peripheral Nerves/drug effects ; Peripheral Nerves/physiopathology ; Postoperative Care/methods ; Postoperative Care/psychology ; Postoperative Period ; Surveys and Questionnaires
Language	English
Publishing date	2019-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2019.02.006
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Zs.A 2458: Show issues

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Article ; Online: A Multicenter, Controlled Human Infection Study of Influenza A(H1N1)pdm09 in Healthy Adults.

The Journal of infectious diseases

2023 Volume 228, Issue 3, Page(s) 287–298

Abstract: Background: We evaluated the associations between baseline influenza virus-specific hemagglutination inhibition (HAI) and microneutralization (MN) titers and subsequent symptomatic influenza virus infection in a controlled human infection study.: ... ...

Abstract	Background: We evaluated the associations between baseline influenza virus-specific hemagglutination inhibition (HAI) and microneutralization (MN) titers and subsequent symptomatic influenza virus infection in a controlled human infection study. Methods: We inoculated unvaccinated healthy adults aged 18-49 years with an influenza A/California/04/2009/H1N1pdm-like virus (NCT04044352). We collected serial safety labs, serum for HAI and MN, and nasopharyngeal swabs for reverse-transcription polymerase chain reaction (RT-PCR) testing. Analyses used the putative seroprotective titer of ≥40 for HAI and MN. The primary clinical outcome was mild-to-moderate influenza disease (MMID), defined as ≥1 postchallenge positive qualitative RT-PCR test with a qualifying symptom/clinical finding. Results: Of 76 participants given influenza virus challenge, 54 (71.1%) experienced MMID. Clinical illness was generally very mild. MMID attack rates among participants with baseline titers ≥40 by HAI and MN were 64.9% and 67.9%, respectively, while MMID attack rates among participants with baseline titers <40 by HAI and MN were 76.9% and 78.3%, respectively. The estimated odds of developing MMID decreased by 19% (odds ratio, 0.81 [95% confidence interval, .62-1.06]; P = .126) for every 2-fold increase in baseline HAI. There were no significant adverse events. Conclusions: We achieved a 71.1% attack rate of MMID. High baseline HAI and MN were associated with protection from illness. Clinical Trials Registration. NCT04044352.
MeSH term(s)	Humans ; Adult ; Influenza, Human/prevention & control ; Influenza A Virus, H1N1 Subtype ; Antibodies, Viral ; Research Design ; Hemagglutination Inhibition Tests ; Influenza Vaccines
Chemical Substances	Antibodies, Viral ; Influenza Vaccines
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad021
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Article ; Online: Multi-objective optimization identifies a specific and interpretable COVID-19 host response signature.

Cappuccio, Antonio / Chawla, Daniel G / Chen, Xi / Rubenstein, Aliza B / Cheng, Wan Sze / Mao, Weiguang / Burke, Thomas W / Tsalik, Ephraim L / Petzold, Elizabeth / Henao, Ricardo / McClain, Micah T / Woods, Christopher W / Chikina, Maria / Troyanskaya, Olga G / Sealfon, Stuart C / Kleinstein, Steven H / Zaslavsky, Elena

Cell systems

2022 Volume 13, Issue 12, Page(s) 989–1001.e8

Abstract: The identification of a COVID-19 host response signature in blood can increase the understanding of SARS-CoV-2 pathogenesis and improve diagnostic tools. Applying a multi-objective optimization framework to both massive public and new multi-omics data, ... ...

Abstract	The identification of a COVID-19 host response signature in blood can increase the understanding of SARS-CoV-2 pathogenesis and improve diagnostic tools. Applying a multi-objective optimization framework to both massive public and new multi-omics data, we identified a COVID-19 signature regulated at both transcriptional and epigenetic levels. We validated the signature's robustness in multiple independent COVID-19 cohorts. Using public data from 8,630 subjects and 53 conditions, we demonstrated no cross-reactivity with other viral and bacterial infections, COVID-19 comorbidities, or confounders. In contrast, previously reported COVID-19 signatures were associated with significant cross-reactivity. The signature's interpretation, based on cell-type deconvolution and single-cell data analysis, revealed prominent yet complementary roles for plasmablasts and memory T cells. Although the signal from plasmablasts mediated COVID-19 detection, the signal from memory T cells controlled against cross-reactivity with other viral infections. This framework identified a robust, interpretable COVID-19 signature and is broadly applicable in other disease contexts. A record of this paper's transparent peer review process is included in the supplemental information.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Virus Diseases
Language	English
Publishing date	2022-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2854138-8
ISSN	2405-4720 ; 2405-4712
ISSN (online)	2405-4720
ISSN	2405-4712
DOI	10.1016/j.cels.2022.11.008
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Article: Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys.

Kavanagh, Kylie / Day, Stephen M / Pait, Morgan C / Mortiz, William R / Newgard, Christopher B / Ilkayeva, Olga / Mcclain, Donald A / Macauley, Shannon L

Frontiers in neuroscience

2019 Volume 13, Page(s) 843

Abstract: Epidemiological studies suggest that individuals with type 2 diabetes (T2D) have a twofold to fourfold increased risk for developing Alzheimer's disease (AD), however, the exact mechanisms linking the two diseases are unknown. In both conditions, the ... ...

Abstract	Epidemiological studies suggest that individuals with type 2 diabetes (T2D) have a twofold to fourfold increased risk for developing Alzheimer's disease (AD), however, the exact mechanisms linking the two diseases are unknown. In both conditions, the majority of pathophysiological changes, including glucose and insulin dysregulation, insulin resistance, and AD-related changes in Aβ and tau, occur decades before the onset of clinical symptoms and diagnosis. In this study, we investigated the relationship between metabolic biomarkers associated with T2D and amyloid pathology including Aβ levels, from cerebrospinal fluid (CSF) and fasting plasma of healthy, pre-diabetic (PreD), and T2D vervet monkeys (
Language	English
Publishing date	2019-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2019.00843
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Article: Peripheral nerve blocks and postoperative physical therapy: a single-institution survey of physical therapists' preferences and opinions.

McClain, Robert L / Porter, Steven B / Arnold, Scott M / Robards, Christopher B

Romanian journal of anaesthesia and intensive care

2017 Volume 24, Issue 2, Page(s) 115–124

Abstract: Background and aims: Our aim was to ascertain the opinions and preferences of physical therapists with regard to use of peripheral nerve blocks and their impact on the recovery of patients undergoing total joint replacement.: Methods: We conducted an ...

Abstract	Background and aims: Our aim was to ascertain the opinions and preferences of physical therapists with regard to use of peripheral nerve blocks and their impact on the recovery of patients undergoing total joint replacement. Methods: We conducted an anonymous 24-question survey of 20 full-time inpatient physical therapists at a single tertiary care medical center. Results: One respondent indicated they never work with patients who have undergone total joint replacement surgery. Nineteen questionnaires were included in the final analysis. Questions omitted by respondents or with write-in answers were not included in the analysis. A majority of respondents (15 [78.9%]) agreed nerve blocks somewhat to greatly improve a patient's pain after total joint replacement surgery. Most respondents answered that nerve blocks somewhat to greatly impede a patient's ability to participate in physical therapy (14 [73.6%]) and make therapy somewhat to very difficult for them as physical therapists (16 [84.2%]). When asked about specific surgeries, (17/18 [94.4%]) and (14/18 [77.8%]) of respondents would prefer that their patients receive periarticular infiltration or no block at all after total knee arthroplasty or total hip arthroplasty, respectively. All respondents (19 [100%]) answered that they thought lower extremity nerve blocks increased a patient's risk of falling after surgery. Conclusions: According to the physical therapists we surveyed, nerve blocks impede patient recovery and increase the risk of falls, despite their positive impact on pain control. When considering surgery for themselves, therapists indicated they would not want a nerve block.
Language	English
Publishing date	2017-09-25
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2977912-1
ISSN	2502-0307 ; 2392-7518
ISSN (online)	2502-0307
ISSN	2392-7518
DOI	10.21454/rjaic.7518.242.prh
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