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  1. Article ; Online: Immune landscape of female reproductive tract and HIV susceptibility.

    Byrareddy, Siddappa N

    EBioMedicine

    2021  Volume 70, Page(s) 103497

    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/metabolism ; Chemokines/metabolism ; Female ; Genitalia, Female/immunology ; HIV Infections/immunology ; Humans ; Menstrual Cycle/blood ; Menstrual Cycle/immunology ; Receptors, CCR7/metabolism
    Chemical Substances CCR7 protein, human ; Chemokines ; Receptors, CCR7
    Language English
    Publishing date 2021-07-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immune landscape of female reproductive tract and HIV susceptibility

    Siddappa N. Byrareddy

    EBioMedicine, Vol 70, Iss , Pp 103497- (2021)

    2021  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: HIV-associated dysbiosis and immune recovery during antiretroviral therapy.

    Johnson, Samuel D / Byrareddy, Siddappa N

    Clinical and translational discovery

    2022  Volume 2, Issue 2

    Abstract: The microbiomes of people living with HIV (PLWH) are significantly dysregulated with a loss of bacteria diversity and shifts in composition, including increases in pathogenic and decreases in beneficial species. Because of the microbiome's role in ... ...

    Abstract The microbiomes of people living with HIV (PLWH) are significantly dysregulated with a loss of bacteria diversity and shifts in composition, including increases in pathogenic and decreases in beneficial species. Because of the microbiome's role in modulating health, the effect of this dysbiosis on immune response in PLWH has been a significant concern, mainly because these shifts can persist even after viral suppression during combination antiretroviral therapy (cART). However, due to limitations on sample availability, few studies have been able to provide insights into these microbiome-immune interactions. Recently, Olivas-Martínez, et al. characterized ileum and caecum mucosa-associated microbiomes of PLWH based on their level of peripheral CD4+ T-cell reconstitution following long-term cART. Their analysis revealed distinct microbiome signatures predictive of recovery. Additionally, differences in markers of gut inflammation and damage between response groups were described, further implicating mucosal disruptions with immune reconstitution. These new data demonstrate an interdependence of microbiome and therapy response, and additional studies were urgently required to fully elucidate this crosstalk and microbiome dynamics from before/after infection and finally, long-term viral suppression with cART.
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2768-0622
    ISSN (online) 2768-0622
    DOI 10.1002/ctd2.58
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SARS-CoV-2 Omicron Spike shows strong binding affinity and favourable interaction landscape with the TLR4/MD2 compared to other variants.

    Chakraborty, Chiranjib / Mallick, Bidyut / Bhattacharya, Manojit / Byrareddy, Siddappa N

    Journal, genetic engineering & biotechnology

    2024  Volume 22, Issue 1, Page(s) 100347

    Abstract: Emergences of SARS-CoV-2 variants have made the pandemic more critical. Toll-like receptor 4 (TLR4) recognizes the molecular patterns of pathogens and activates the production of proinflammatory cytokines to restrain the infection. We have identified a ... ...

    Abstract Emergences of SARS-CoV-2 variants have made the pandemic more critical. Toll-like receptor 4 (TLR4) recognizes the molecular patterns of pathogens and activates the production of proinflammatory cytokines to restrain the infection. We have identified a molecular basis of interaction between the Spike and TLR4 of SARS-CoV-2 and its present and past VOCs (variant- of concern) through in silico analysis. The interaction of wild type Spike with TLR4 showed 15 number hydrogen bonds formation. Similarly, the Alpha variants' Spike with the TLR4 has illustrated that 14 hydrogen bonds participated in the interaction. However, the Delta Spike and TLR4 interaction interface showed that 17 hydrogen bonds were formed during the interaction. Furthermore, Omicron S-glycoprotein and TLR4 interaction interface was depicted (interaction score: -170.3), and 16 hydrogen bonds were found to have been formed in the interaction. Omicron S-glycoprotein shows stronger binding affinity with the TLR4 than wild type, Alpha, and Delta variants. Similarly, the Alpha Spike shows higher binding affinity with TLR4 than the wild type and Delta variant. Now, it is an open question of the molecular basis of the interaction of Spike and TLR4 and the activated downstream signaling events of TLR4 for SARS-CoV-2 and its variants.
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2637420-1
    ISSN 2090-5920 ; 1687-157X ; 2090-5920
    ISSN (online) 2090-5920
    ISSN 1687-157X ; 2090-5920
    DOI 10.1016/j.jgeb.2023.100347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Are we moving toward ending SARS-CoV-2?

    Mishra, Anurag R / Nayak, Debasis / Byrareddy, Siddappa N

    Journal of medical virology

    2022  Volume 94, Issue 7, Page(s) 2921–2924

    MeSH term(s) COVID-19/prevention & control ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27722
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  6. Article ; Online: Dual role for microbial short-chain fatty acids in modifying SIV disease trajectory following anti-α4β7 antibody administration.

    Johnson, Samuel D / Pilli, Nageswara / Yu, Jianshi / Knight, Lindsey A / Kane, Maureen A / Byrareddy, Siddappa N

    Annals of medicine

    2024  Volume 56, Issue 1, Page(s) 2315224

    Abstract: Background: Human Immunodeficiency Virus (HIV)/Simian Immunodeficiency Virus (SIV) infection is associated with significant gut damage, similar to that observed in patients with inflammatory bowel disease (IBD). This pathology includes loss of ... ...

    Abstract Background: Human Immunodeficiency Virus (HIV)/Simian Immunodeficiency Virus (SIV) infection is associated with significant gut damage, similar to that observed in patients with inflammatory bowel disease (IBD). This pathology includes loss of epithelial integrity, microbial translocation, dysbiosis, and resultant chronic immune activation. Additionally, the levels of all-
    Materials and methods: To determine whether the microbiome contributes to gut homeostasis after anti-α4β7 antibody administered to SIV-infected rhesus macaques, faecal SCFA concentrations were determined, 16S rRNA sequencing was performed, plasma viral loads were determined, plasma retinoids were measured longitudinally, and gut retinoid synthesis/response gene expression was quantified.
    Results: Our results suggest that anti-α4β7 antibody facilitates the return of retinoid metabolism to baseline levels after SIV infection. Furthermore, faecal SCFAs were shown to be associated with retinoid synthesis gene expression and rebound viral loads after therapy interruption.
    Conclusions: Taken together, these data demonstrate the therapeutic advantages of anti-α4β7 antibody administration during HIV/SIV infection and that the efficacy of anti-α4β7 antibody may depend on microbiome composition and SCFA generation.
    MeSH term(s) Animals ; Humans ; Simian Immunodeficiency Virus/genetics ; Macaca mulatta/genetics ; Macaca mulatta/metabolism ; RNA, Ribosomal, 16S/genetics ; Integrins/metabolism ; Integrins/therapeutic use ; HIV Infections ; Retinoids/therapeutic use
    Chemical Substances RNA, Ribosomal, 16S ; Integrins ; Retinoids
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2024.2315224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Missing subunits of Mpox replication complex: Possible impact on structural organization.

    Kannan, Saathvik R / Reddy, Athreya S / Burris, Dana M / Byrareddy, Siddappa N / Singh, Kamal

    The Journal of infection

    2023  Volume 87, Issue 5, Page(s) 445–447

    MeSH term(s) Monkeypox virus/physiology ; Virus Replication
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.08.008
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  8. Article ; Online: SARS-CoV2 induced respiratory distress: Can cannabinoids be added to anti-viral therapies to reduce lung inflammation?

    Byrareddy, Siddappa N / Mohan, Mahesh

    Brain, behavior, and immunity

    2020  Volume 87, Page(s) 120–121

    MeSH term(s) COVID-19 ; Cannabinoids/therapeutic use ; Humans ; Pneumonia/drug therapy ; RNA, Viral ; Respiratory Distress Syndrome/drug therapy ; SARS-CoV-2
    Chemical Substances Cannabinoids ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country Netherlands
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2020.04.079
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  9. Article ; Online: Combining antiviral drugs with BET inhibitors is beneficial in combatting SARS-CoV-2 infection.

    Acharya, Arpan / Kutateladze, Tatiana G / Byrareddy, Siddappa N

    Clinical and translational discovery

    2022  Volume 2, Issue 2

    Abstract: The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has resulted in more than 500 million cases and 6 million deaths. Several antiviral therapies and vaccines have been developed to mitigate the spread of this infection. However, new ... ...

    Abstract The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has resulted in more than 500 million cases and 6 million deaths. Several antiviral therapies and vaccines have been developed to mitigate the spread of this infection. However, new approaches are required to battle emerging SARS-CoV-2 variants containing mutations that can reduce the vaccines' efficacy. The use of a combination of viral drugs with inhibitors of the mTOR signaling pathways has emerged as one of the promising novel approaches. We recently showed that SF2523, a dual activity small molecule that inhibits PI3K and BRD4, acts synergistically with the antiviral drugs remdesivir and MU-UNMC-2. Our findings suggest that the mTOR pathways are necessary for SARS-CoV-2 pathogenesis in human cells and targeting PI3K/BET (bromodomain and extra-terminal domain proteins) alone or combined with antiviral therapies is beneficial in mitigating SARS-CoV-2 and its variants of concern (VOCs).
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ISSN 2768-0622
    ISSN (online) 2768-0622
    DOI 10.1002/ctd2.66
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  10. Article ; Online: The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.

    Rothan, Hussin A / Byrareddy, Siddappa N

    Journal of autoimmunity

    2020  Volume 109, Page(s) 102433

    Abstract: Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market ...

    Abstract Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of COVID-19. Person-to-person transmission of COVID-19 infection led to the isolation of patients that were subsequently administered a variety of treatments. Extensive measures to reduce person-to-person transmission of COVID-19 have been implemented to control the current outbreak. Special attention and efforts to protect or reduce transmission should be applied in susceptible populations including children, health care providers, and elderly people. In this review, we highlights the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease.
    MeSH term(s) Animals ; Betacoronavirus/classification ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Humans ; Pandemics/prevention & control ; Phylogeny ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Public Health ; SARS-CoV-2 ; Zoonoses/epidemiology ; Zoonoses/virology
    Keywords covid19
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2020.102433
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