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  1. Article ; Online: Renin-angiotensin system and SARS-CoV-2 infection: there is a before and after.

    Kuster, Gabriela M

    European heart journal

    2020  Volume 41, Issue 22, Page(s) 2128–2129

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Renin-Angiotensin System ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa451
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    Zs.A 1563: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  2. Article ; Online: A 'decoy' function of the 3'-untranslated region adds a new dimension to gene regulation in cardiac disease.

    Bernasconi, Riccardo / Kuster, Gabriela M

    European heart journal

    2021  Volume 42, Issue 36, Page(s) 3800–3802

    MeSH term(s) 3' Untranslated Regions/genetics ; Binding Sites ; Heart Diseases/genetics ; Humans ; Transfection
    Chemical Substances 3' Untranslated Regions
    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
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  4. Article ; Online: Renin–angiotensin system and SARS-CoV-2 infection

    Kuster, Gabriela M

    European Heart Journal

    there is a before and after

    2020  Volume 41, Issue 22, Page(s) 2128–2129

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa451
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 1563: Show issues Location:
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  5. Article ; Online: Switching antihypertensive therapy in times of COVID-19: why we should wait for the evidence.

    Kuster, Gabriela M / Osswald, Stefan

    European heart journal

    2020  Volume 41, Issue 19, Page(s) 1857

    MeSH term(s) Antihypertensive Agents ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Hypertension ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Antihypertensive Agents
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Relation of cyclosporine blood levels to adverse effects on lipoproteins

    Kuster, Gabriela M.

    1996  

    Author's details vorgelegt von Gabriela M. Kuster
    Language English
    Size S. 1479 - 1483 : graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 1996
    Note Aus: Transplantation ; 57,10.1994
    HBZ-ID HT007565100
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    97 E 1400 order for loan Magazin

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  7. Article ; Online: TNF-α protects from exacerbated myocarditis and cardiac death by suppressing expansion of activated heart-reactive CD4+ T cells.

    Rolski, Filip / Tkacz, Karolina / Węglarczyk, Kazimierz / Kwiatkowski, Grzegorz / Pelczar, Paweł / Jaźwa-Kusior, Agnieszka / Bar, Anna / Kuster, Gabriela M / Chłopicki, Stefan / Siedlar, Maciej / Kania, Gabriela / Błyszczuk, Przemysław

    Cardiovascular research

    2024  Volume 120, Issue 1, Page(s) 82–94

    Abstract: Aims: Tumour necrosis factor α (TNF-α) represents a classical pro-inflammatory cytokine, and its increased levels positively correlate with the severity of many cardiovascular diseases. Surprisingly, some heart failure patients receiving high doses of ... ...

    Abstract Aims: Tumour necrosis factor α (TNF-α) represents a classical pro-inflammatory cytokine, and its increased levels positively correlate with the severity of many cardiovascular diseases. Surprisingly, some heart failure patients receiving high doses of anti-TNF-α antibodies showed serious health worsening. This work aimed to examine the role of TNF-α signalling on the development and progression of myocarditis and heart-specific autoimmunity.
    Methods and results: Mice with genetic deletion of TNF-α (Tnf+/- and Tnf-/-) and littermate controls (Tnf+/+) were used to study myocarditis in the inducible and the transgenic T cell receptor (TCRM) models. Tnf+/- and Tnf-/- mice immunized with α-myosin heavy chain peptide (αMyHC) showed reduced myocarditis incidence, but the susceptible animals developed extensive inflammation in the heart. In the TCRM model, defective TNF-α production was associated with increased mortality at a young age due to cardiomyopathy and cardiac fibrosis. We could confirm that TNF-α as well as the secretome of antigen-activated heart-reactive effector CD4+ T (Teff) cells effectively activated the adhesive properties of cardiac microvascular endothelial cells (cMVECs). Our data suggested that TNF-α produced by endothelial in addition to Teff cells promoted leucocyte adhesion to activated cMVECs. Analysis of CD4+ T lymphocytes from both models of myocarditis showed a strongly increased fraction of Teff cells in hearts, spleens, and in the blood of Tnf+/- and Tnf-/- mice. Indeed, antigen-activated Tnf-/- Teff cells showed prolonged long-term survival and TNF-α cytokine-induced cell death of heart-reactive Teff.
    Conclusion: TNF-α signalling promotes myocarditis development by activating cardiac endothelial cells. However, in the case of established disease, TNF-α protects from exacerbating cardiac inflammation by inducing activation-induced cell death of heart-reactive Teff. These data might explain the lack of success of standard anti-TNF-α therapy in heart failure patients and open perspectives for T cell-targeted approaches.
    MeSH term(s) Animals ; Mice ; Autoimmune Diseases ; CD4-Positive T-Lymphocytes ; Cytokines/metabolism ; Death ; Endothelial Cells/pathology ; Heart Failure/metabolism ; Inflammation/metabolism ; Myocarditis/metabolism ; Myocardium/metabolism ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Cytokines ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Chronic heart failure: advances in pharmacological treatment and future perspectives.

    Kuster, Gabriela M / Pfister, Otmar

    Swiss medical weekly

    2019  Volume 149, Page(s) w20036

    Abstract: Besides noticeable progress in device therapy during the past decade, more recent advances in the management of chronic heart failure have led to exciting new pharmacological options. Among these, the combined angiotensin II receptor/neprilysin inhibitor ...

    Abstract Besides noticeable progress in device therapy during the past decade, more recent advances in the management of chronic heart failure have led to exciting new pharmacological options. Among these, the combined angiotensin II receptor/neprilysin inhibitor (ARNI) valsartan/sacubitril has already proven highly effective in heart failure with reduced ejection fraction (HFrEF), and convincing data are available regarding the cardioprotective effects of sodium-glucose-co-transporter 2 (SGLT2) inhibitors. These two treatments have earned a class I and a class II recommendation, respectively, in the European Society of Cardiology guidelines for the diagnosis and treatment of heart failure. Whereas progress with respect to heart failure with preserved ejection fraction (HFpEF) is still slow, both ARNIs and SGLT2 inhibitors hold great promise for this condition as well, and large clinical trials are currently ongoing. In addition, new diagnostic algorithms have recently been developed to improve the diagnostic accuracy for HFpEF, which will ultimately aid the search for effective therapies in future clinical trials. In this review article, these most recent advances in the diagnosis and pharmacological management of HFrEF and HFpEF are highlighted, and set-backs as well as opportunities for future developments (e.g., tafamidis for the treatment of transthyretin amyloid cardiomyopathy) are discussed.
    MeSH term(s) Aminobutyrates/pharmacology ; Aminobutyrates/therapeutic use ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Drug Combinations ; Heart Failure/drug therapy ; Humans ; Neprilysin/pharmacology ; Neprilysin/therapeutic use ; Stroke Volume ; Tetrazoles/pharmacology ; Tetrazoles/therapeutic use
    Chemical Substances Aminobutyrates ; Angiotensin Receptor Antagonists ; Drug Combinations ; Tetrazoles ; Neprilysin (EC 3.4.24.11) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
    Language English
    Publishing date 2019-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2019.20036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Switching antihypertensive therapy in times of COVID-19

    Kuster, Gabriela M / Osswald, Stefan

    European Heart Journal

    why we should wait for the evidence

    2020  Volume 41, Issue 19, Page(s) 1857–1857

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa335
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
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