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  1. Article ; Online: Special Issue

    Urnov, Fyodor

    The CRISPR journal

    2023  Volume 6, Issue 6, Page(s) 488

    MeSH term(s) Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; CRISPR-Cas Systems/genetics ; Gene Editing
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3017891-5
    ISSN 2573-1602 ; 2573-1599
    ISSN (online) 2573-1602
    ISSN 2573-1599
    DOI 10.1089/crispr.2023.29166.cfp2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Special Issue

    Urnov, Fyodor

    The CRISPR journal

    2023  Volume 6, Issue 5, Page(s) 404

    MeSH term(s) Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; CRISPR-Cas Systems/genetics ; Gene Editing
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3017891-5
    ISSN 2573-1602 ; 2573-1599
    ISSN (online) 2573-1602
    ISSN 2573-1599
    DOI 10.1089/crispr.2023.29166.cfp
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An ode to gene edits that prevent deafness.

    Urnov, Fyodor

    Nature

    2020  Volume 553, Issue 7687, Page(s) 162–163

    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-017-08645-z
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    Zs.MO 244: Show issues

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  4. Article ; Online: CRISPR-Cas9 can cause chromothripsis.

    Urnov, Fyodor D

    Nature genetics

    2021  Volume 53, Issue 6, Page(s) 768–769

    MeSH term(s) CRISPR-Cas Systems/genetics ; Chromothripsis ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Gene Editing ; Humans
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-021-00881-4
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  5. Article ; Online: Imagine CRISPR cures.

    Urnov, Fyodor D

    Molecular therapy : the journal of the American Society of Gene Therapy

    2021  Volume 29, Issue 11, Page(s) 3103–3106

    MeSH term(s) Animals ; CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Editing/methods ; Genetic Therapy/methods ; Humans
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2021.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5640: Show issues Location:
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  6. Article ; Online: SARS-Cov2 Clinical Diagnostics: Academic Scientists Take on the COVID-19 Pandemic.

    Urnov, Fyodor

    Med (New York, N.Y.)

    2020  Volume 1, Issue 1, Page(s) 11–13

    Abstract: In this issue ... ...

    Abstract In this issue of
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Pandemics ; RNA, Viral ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2 ; Safety-net Providers
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-06
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2020.06.002
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  7. Article ; Online: The Cas9 Hammer-and Sickle: A Challenge for Genome Editors.

    Urnov, Fyodor D

    The CRISPR journal

    2021  Volume 4, Issue 1, Page(s) 6–13

    Abstract: Genome editing using CRISPR-Cas9 has produced a functional cure for a small number of patients with sickle cell disease and beta-thalassemia. Rather than repairing the causative mutation, this striking outcome was attained by the knockout of a lineage- ... ...

    Abstract Genome editing using CRISPR-Cas9 has produced a functional cure for a small number of patients with sickle cell disease and beta-thalassemia. Rather than repairing the causative mutation, this striking outcome was attained by the knockout of a lineage-specific regulatory element for a gene, BCL11A, that controls fetal hemoglobin levels: a first example of clinical success in targeting a locus initially identified in a genome-wide association study, and formal proof of the "in the age of CRISPR, the entire genome is a druggable target" notion. This remarkable development, along with advancement to the clinic of several additional editing-based approaches to the hemoglobinopathies, highlights a sense of urgency in accelerating scientific, regulatory, and public health innovation that will allow broad and equitable access to editing-based cures.
    MeSH term(s) Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/therapy ; CRISPR-Cas Systems ; Clinical Trials as Topic ; Gene Editing/methods ; Genetic Therapy ; Genome-Wide Association Study ; Hemoglobinopathies/genetics ; Humans ; Mutation ; United States ; United States Food and Drug Administration ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
    Language English
    Publishing date 2021-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3017891-5
    ISSN 2573-1602 ; 2573-1599
    ISSN (online) 2573-1602
    ISSN 2573-1599
    DOI 10.1089/crispr.2021.29120.fur
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An ode to gene edits that prevent deafness.

    Urnov, Fyodor

    Nature

    2018  Volume 553, Issue 7687, Page(s) 162–163

    MeSH term(s) Deafness ; Gene Editing ; Humans
    Language English
    Publishing date 2018--11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-017-08645-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prime Time for Genome Editing?

    Urnov, Fyodor D

    The New England journal of medicine

    2020  Volume 382, Issue 5, Page(s) 481–484

    MeSH term(s) Animals ; CRISPR-Associated Protein 9 ; CRISPR-Cas Systems ; Gene Editing/history ; Gene Editing/methods ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/therapy ; History, 21st Century ; Humans ; Mammals ; Mutation
    Chemical Substances CRISPR-Associated Protein 9 (EC 3.1.-)
    Language English
    Publishing date 2020-01-29
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr1914271
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  10. Article ; Online: SARS-Cov2 Clinical Diagnostics

    Urnov, Fyodor

    Med ; ISSN 2666-6340

    Academic Scientists Take on the COVID-19 Pandemic

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.medj.2020.06.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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