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  1. Article ; Online: SCARF1: a multifaceted, yet largely understudied, scavenger receptor.

    Patten, Daniel A

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2018  Volume 67, Issue 8, Page(s) 627–632

    Abstract: Background: As is a prerequisite of belonging to the scavenger receptor super family, SCARF1 (scavenger receptor class F, member 1) is known to play a key role in the binding and endocytosis of a wide range of endogenous and exogenous ligands.: ... ...

    Abstract Background: As is a prerequisite of belonging to the scavenger receptor super family, SCARF1 (scavenger receptor class F, member 1) is known to play a key role in the binding and endocytosis of a wide range of endogenous and exogenous ligands.
    Findings: Unlike most scavenger receptors, SCARF1 is an essential protein, as SCARF1-deficient mice exhibit a severe resting phenotype in which they develop systemic lupus erythematosus (SLE)-like disease, thus highlighting the importance of SCARF1-mediated clearance of apoptotic host cells in homeostasis. In addition, a number of other roles in homeostasis and disease pathology have also been suggested, including roles in both innate and adaptive immunity; however, the majority of these studies have utilised transfected cell lines engineered to ectopically express SCARF1 and very few have utilised in vivo or ex vivo approaches.
    Conclusion: This review summarises our current knowledge on SCARF1 biology and reflects on future directions for research on this multifaceted, yet largely understudied, scavenger receptor.
    MeSH term(s) Adaptive Immunity ; Animals ; Apoptosis ; Cell Adhesion Molecules/metabolism ; Humans ; Immunity, Innate ; Lipoproteins, LDL/metabolism ; Scavenger Receptors, Class F/immunology ; Scavenger Receptors, Class F/metabolism
    Chemical Substances Cell Adhesion Molecules ; Lipoproteins, LDL ; SCARF1 protein, human ; Scavenger Receptors, Class F
    Language English
    Publishing date 2018-05-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-018-1154-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Erratum to: Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer.

    Patten, Daniel A / Wilkinson, Alex L / O'Keeffe, Ayla / Shetty, Shishir

    Seminars in liver disease

    2021  Volume 42, Issue 1, Page(s) e1

    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/s-0041-1739050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Role of Stabilin-1 in Lymphocyte Trafficking and Macrophage Scavenging in the Liver Microenvironment.

    Patten, Daniel A / Shetty, Shishir

    Biomolecules

    2019  Volume 9, Issue 7

    Abstract: Chronic liver diseases are a major global health burden, and cases of these conditions continue to rise in many countries. A diverse range of insults can lead to chronic liver disease, but they are all characterised by the infiltration and accumulation ... ...

    Abstract Chronic liver diseases are a major global health burden, and cases of these conditions continue to rise in many countries. A diverse range of insults can lead to chronic liver disease, but they are all characterised by the infiltration and accumulation of immune cells within liver tissue and, if progressive, can lead to tissue fibrosis and cirrhosis. In this review, we focus on the role of stabilin-1 in two key processes that contribute to liver disease, namely, the recruitment of lymphocytes into liver tissue and the response of macrophages to tissue injury. Stabilin-1 is constitutively expressed on the sinusoidal endothelium of the liver and contributes to the homeostatic scavenging function of these cells. Epithelial damage in the context of chronic liver disease leads to the upregulation of stabilin-1 at sites of tissue injury, specifically at sites of immune cell recruitment and on subpopulations of hepatic macrophages. Functionally, stabilin-1 has been shown to mediate transendothelial migration of lymphocyte subsets in the setting of pro-inflammatory-activated human liver endothelium. In experimental models of liver fibrosis, stabilin-1 promotes the uptake of products of chronic oxidative stress by a subset of hepatic macrophages and suppresses their release of pro-inflammatory mediators that regulate tissue remodelling. These studies highlight the active contribution that scavenger receptors such as stabilin-1 can make in regulating chronic inflammation and tissue fibrosis, and their potential as novel therapeutic targets for these conditions.
    MeSH term(s) Animals ; Humans ; Liver/metabolism ; Liver Diseases/metabolism ; Lymphocytes/metabolism ; Macrophages/metabolism ; Receptors, Lymphocyte Homing/metabolism
    Chemical Substances Receptors, Lymphocyte Homing
    Language English
    Publishing date 2019-07-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom9070283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chronic liver disease: scavenger hunt for novel therapies.

    Patten, Daniel A / Shetty, Shishir

    Lancet (London, England)

    2018  Volume 391, Issue 10116, Page(s) 104–105

    MeSH term(s) Chronic Disease ; Humans ; Liver Diseases/etiology ; Liver Diseases/pathology ; Liver Diseases/therapy
    Language English
    Publishing date 2018--13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(17)32671-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Expression of E-cadherin by CD8

    Davies, Scott P / Ronca, Vincenzo / Wootton, Grace E / Krajewska, Natalia M / Bozward, Amber G / Fiancette, Rémi / Patten, Daniel A / Yankouskaya, Katharina / Reynolds, Gary M / Pat, Sofia / Osei-Bordom, Daniel C / Richardson, Naomi / Grover, Liam M / Weston, Christopher J / Oo, Ye H

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 853

    Abstract: The presence of ... ...

    Abstract The presence of CD8
    MeSH term(s) Humans ; Bile Ducts/metabolism ; Liver Cirrhosis, Biliary/pathology ; CD8-Positive T-Lymphocytes/metabolism ; Epithelial Cells/metabolism ; Cadherins/metabolism
    Chemical Substances Cadherins
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44910-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exciton delocalization in a fully synthetic DNA-templated bacteriochlorin dimer.

    Mass, Olga A / Watt, Devan R / Patten, Lance K / Pensack, Ryan D / Lee, Jeunghoon / Turner, Daniel B / Yurke, Bernard / Knowlton, William B

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 41, Page(s) 28437–28451

    Abstract: A bacteriochlorophyll ...

    Abstract A bacteriochlorophyll
    MeSH term(s) Light-Harvesting Protein Complexes/chemistry ; Computing Methodologies ; Quantum Theory ; Photosynthetic Reaction Center Complex Proteins/chemistry ; DNA
    Chemical Substances Light-Harvesting Protein Complexes ; bacteriochlorin ; Photosynthetic Reaction Center Complex Proteins ; DNA (9007-49-2)
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp01634j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer.

    Patten, Daniel A / Wilkinson, Alex L / O'Keeffe, Ayla / Shetty, Shishir

    Seminars in liver disease

    2021  Volume 42, Issue 1, Page(s) 61–76

    Abstract: The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-conserved receptors which are known to play key roles in host homeostasis, the most prominent of which is the clearance of unwanted endogenous macromolecules, ... ...

    Abstract The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-conserved receptors which are known to play key roles in host homeostasis, the most prominent of which is the clearance of unwanted endogenous macromolecules, such as oxidized low-density lipoproteins, from the systemic circulation. Members of this family have also been well characterized in their binding and internalization of a vast range of exogenous antigens and, consequently, are generally considered to be pattern recognition receptors, thus contributing to innate immunity. Several studies have implicated scavenger receptors in the pathophysiology of several inflammatory diseases, such as Alzheimer's and atherosclerosis. Hepatic resident cellular populations express a diverse complement of scavenger receptors in keeping with the liver's homeostatic functions, but there is gathering interest in the contribution of these receptors to hepatic inflammation and its complications. Here, we review the expression of scavenger receptors in the liver, their functionality in liver homeostasis, and their role in inflammatory liver disease and cancer.
    MeSH term(s) Atherosclerosis/etiology ; Hepatitis ; Humans ; Inflammation ; Neoplasms ; Receptors, Scavenger/metabolism
    Chemical Substances Receptors, Scavenger
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/s-0041-1733876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking.

    Patten, Daniel A / Shetty, Shishir

    Frontiers in immunology

    2018  Volume 9, Page(s) 2904

    Abstract: Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature. Consequently, ... ...

    Abstract Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature. Consequently, scavenger receptors are known to play important roles in host homeostasis, with common endogenous ligands including apoptotic cells, and modified low density lipoproteins (LDLs); additionally, scavenger receptors are key regulators of inflammatory diseases, such as atherosclerosis. Also, as a consequence of their affinity for a wide range of microbial products, their role in innate immunity is also being increasingly studied. However, in this review, a secondary function of a number of endothelial-expressed scavenger receptors is discussed. There is increasing evidence that some endothelial-expressed scavenger receptors are able to directly bind leukocyte-expressed ligands and subsequently act as adhesion molecules in the trafficking of leukocytes in lymphatic and vascular tissues. Here, we cover the current literature on this alternative role for endothelial-expressed scavenger receptors and also speculate on their therapeutic potential.
    MeSH term(s) Apoptosis/immunology ; Atherosclerosis/immunology ; Atherosclerosis/metabolism ; Cell Movement/immunology ; Homeostasis/immunology ; Humans ; Leukocytes/cytology ; Leukocytes/immunology ; Leukocytes/metabolism ; Ligands ; Lipoproteins, LDL/immunology ; Lipoproteins, LDL/metabolism ; Protein Transport/immunology ; Receptors, Scavenger/immunology ; Receptors, Scavenger/metabolism
    Chemical Substances Ligands ; Lipoproteins, LDL ; Receptors, Scavenger
    Language English
    Publishing date 2018-12-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tumour-associated macrophages in hepatocellular carcinoma: Pressing the metabolic switch to prevent T cell responses.

    O'Rourke, Joanne M / Patten, Daniel A / Shetty, Shishir

    Journal of hepatology

    2019  Volume 71, Issue 2, Page(s) 243–245

    MeSH term(s) B7-H1 Antigen ; Carcinoma, Hepatocellular ; Humans ; Immune Privilege ; Liver Neoplasms ; Macrophages ; Monocytes ; Phosphofructokinase-2 ; T-Lymphocytes
    Chemical Substances B7-H1 Antigen ; PFKFB3 protein, human (EC 2.7.1.105) ; Phosphofructokinase-2 (EC 2.7.1.105)
    Language English
    Publishing date 2019-06-14
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2019.05.019
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  10. Article ; Online: Covid-19: Use social media to maximise vaccine confidence and uptake.

    Patten, Daniel / Green, Adelle / Bown, Daniel / Russell, Craig

    BMJ (Clinical research ed.)

    2021  Volume 372, Page(s) n225

    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; Cultural Competency ; Ethnic Groups/psychology ; Humans ; Information Dissemination/methods ; Intersectoral Collaboration ; Mass Vaccination/organization & administration ; Mass Vaccination/psychology ; Minority Groups/psychology ; Patient Acceptance of Health Care/psychology ; SARS-CoV-2/immunology ; Social Media ; Societies, Medical/organization & administration ; Societies, Scientific/organization & administration ; Socioeconomic Factors ; Trust ; United Kingdom/epidemiology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n225
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