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Article: SCFE: clinical aspects, diagnosis, and classification.

Millis, M B

2017 Volume 11, Issue 2, Page(s) 93–98

Abstract: Purpose: This article seeks to improve treatment outcomes in slipped capital femoral epiphysis (SCFE) by outlining advances in diagnosis, understanding of pathomechanics, and mechanically-based classification.: Methods: Review of clinical experience ... ...

Abstract	Purpose: This article seeks to improve treatment outcomes in slipped capital femoral epiphysis (SCFE) by outlining advances in diagnosis, understanding of pathomechanics, and mechanically-based classification. Methods: Review of clinical experience with SCFE at our high-volume centre, interaction with other clinical experts, and literature review has allowed a current perspective to be articulated. Results: SCFE remains an important clinical problem, with late diagnosis still frequent. Improved understanding of the ubiquity of femoroacetabular impingement has guided current classification and treatment protocols. Conclusion: SCFE is an important clinical problem, with high historical rates of impaired hip function both in childhood and adulthood. Great opportunities exist for improved outcomes following earliest possible clinical diagnosis, modern imaging, and mechanically-based classification of involved hips to allow optimal treatment.
Language	English
Publishing date	2017-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2279410-4
ISSN	1863-2548 ; 1863-2521
ISSN (online)	1863-2548
ISSN	1863-2521
DOI	10.1302/1863-2548-11-170025
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Article ; Online: Chemical Potential of a Flexible Polymer Liquid in a Coarse-Grained Representation.

Dinpajooh, M / Millis, J / Donley, J P / Guenza, M G

The journal of physical chemistry. B

2023 Volume 128, Issue 5, Page(s) 1275–1288

Abstract: While the excess chemical potential is the key quantity in determining phase diagrams, its direct computation for high-density liquids of long polymer chains has posed a significant challenge. Computationally, the excess chemical potential is calculated ... ...

Abstract	While the excess chemical potential is the key quantity in determining phase diagrams, its direct computation for high-density liquids of long polymer chains has posed a significant challenge. Computationally, the excess chemical potential is calculated using the Widom insertion method, which involves monitoring the change in internal energy as one incrementally introduces individual molecules into the liquid. However, when dealing with dense polymer liquids, inserting long chains requires generating trial configurations with a bias that favors those at low energy on a unit-by-unit basis: a procedure that becomes more challenging as the number of units increases. Thus, calculating the excess chemical potential of dense polymer liquids using this method becomes computationally intractable as the chain length exceeds
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c06795
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Article ; Online: Predicting seizure clustering in the epilepsy monitoring unit: A multivariable analysis.

Maliekal, Leya / Zutshi, Deepti / Millis, Scott / Basha, Maysaa M

Epilepsy & behavior : E&B

2023 Volume 147, Page(s) 109433

Abstract: Introduction: Seizure clustering, is the most frequently reported adverse event in epilepsy monitoring unit (EMU) safety studies which, can also potentiate other adverse events, such as falls, status epilepticus, and increased length of stay. The ... ...

Abstract	Introduction: Seizure clustering, is the most frequently reported adverse event in epilepsy monitoring unit (EMU) safety studies which, can also potentiate other adverse events, such as falls, status epilepticus, and increased length of stay. The purpose of this study is to determine variables associated with increased risk of seizure clustering among patients admitted to the EMU. Methods: A retrospective review of patients admitted to the EMU over a two-year period was completed. Data collected included patient demographics, types of epilepsy, seizure frequency, anti-seizure medications (ASMs) and hospital and EMU course including incidence of seizure clustering. Results: Two hundred seven patients were included in our study; of these, ninety patients experienced two or more seizures in a 24-hour period (24SC), and 68 patients experienced two or more seizures in a 4-hour period (4SC). Logistic regression analysis associated the absence of long-acting ASM with increased clustering within the 4SC group (p = 0.038). For every additional ASM taken by a patient at home, the odds of seizure clustering increased by 81% in the 4SC group (p = 0.009) and by 61% in the 24SC group (p = 0.022). In addition, patients with a diagnosis of temporal lobe epilepsy had some association with clustering in the 24SC group (p = 0.061). Conclusion: Our data showed that long-acting ASMs can be protective against seizure clustering. Furthermore, patients with temporal lobe epilepsy, and those on increased numbers of ASMs, were more likely to experience seizure clustering when undergoing medication withdrawal during an EMU evaluation.
MeSH term(s)	Humans ; Epilepsy, Temporal Lobe ; Electroencephalography ; Epilepsy/diagnosis ; Epilepsy/drug therapy ; Epilepsy/epidemiology ; Status Epilepticus ; Retrospective Studies ; Cluster Analysis
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2023.109433
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Article: Adhesion-based capture stabilizes nascent microvilli at epithelial cell junctions.

Cencer, Caroline S / Silverman, Jennifer B / Meenderink, Leslie M / Krystofiak, Evan S / Millis, Bryan A / Tyska, Matthew J

bioRxiv : the preprint server for biology

2023

Abstract: Differentiated transporting epithelial cells present an extensive apical array of microvilli - a "brush border" - where neighboring microvilli are linked together by intermicrovillar adhesion complexes (IMACs) composed of protocadherins CDHR2 and CDHR5. ... ...

Abstract	Differentiated transporting epithelial cells present an extensive apical array of microvilli - a "brush border" - where neighboring microvilli are linked together by intermicrovillar adhesion complexes (IMACs) composed of protocadherins CDHR2 and CDHR5. Although loss-of-function studies provide strong evidence that IMAC function is needed to build a mature brush border, how the IMAC contributes to the stabilization and accumulation of nascent microvilli remains unclear. We found that, early in differentiation, the apical surface exhibits a marginal accumulation of microvilli, characterized by higher packing density relative to medial regions of the surface. While medial microvilli are highly dynamic and sample multiple orientations over time, marginal protrusions exhibit constrained motion and maintain a vertical orientation. Unexpectedly, we found that marginal microvilli span the junctional space and contact protrusions on neighboring cells, mediated by complexes of CDHR2/CDHR5. FRAP analysis indicated that these
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.08.531705
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Article ; Online: Adhesion-based capture stabilizes nascent microvilli at epithelial cell junctions.

Cencer, Caroline S / Silverman, Jennifer B / Meenderink, Leslie M / Krystofiak, Evan S / Millis, Bryan A / Tyska, Matthew J

Developmental cell

2023 Volume 58, Issue 20, Page(s) 2048–2062.e7

Abstract: To maximize solute transport, epithelial cells build an apical "brush border," where thousands of microvilli are linked to their neighbors by protocadherin-containing intermicrovillar adhesion complexes (IMACs). Previous studies established that the IMAC ...

Abstract	To maximize solute transport, epithelial cells build an apical "brush border," where thousands of microvilli are linked to their neighbors by protocadherin-containing intermicrovillar adhesion complexes (IMACs). Previous studies established that the IMAC is needed to build a mature brush border, but how this complex contributes to the accumulation of new microvilli during differentiation remains unclear. We found that early in differentiation, mouse, human, and porcine epithelial cells exhibit a marginal accumulation of microvilli, which span junctions and interact with protrusions on neighboring cells using IMAC protocadherins. These transjunctional IMACs are highly stable and reinforced by tension across junctions. Finally, long-term live imaging showed that the accumulation of microvilli at cell margins consistently leads to accumulation in medial regions. Thus, nascent microvilli are stabilized by a marginal capture mechanism that depends on the formation of transjunctional IMACs. These results may offer insights into how apical specializations are assembled in diverse epithelial systems.
MeSH term(s)	Humans ; Animals ; Mice ; Swine ; Microvilli/metabolism ; Epithelial Cells/metabolism
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2023.09.001
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Protocol and validity testing of femoroacetabular posterior translation with dynamic hip ultrasonography.

Le, Hung M / d'Hemecourt, Pierre A / Jackson, Sarah S / Whitney, Kristin E / Miller, Patricia E / Millis, Michael B / Wuerz, Thomas H / Kiapour, Ata M / Lewis, Cara L / Stracciolini, Andrea

Skeletal radiology

2024

Abstract: Objective: To describe femoroacetabular posterior translation (FAPT) using dynamic hip ultrasonography (DHUS), and to determine the inter- and intra-rater reliability of hip ultrasound measurements of FAPT.: Materials and methods: The study design ... ...

Abstract	Objective: To describe femoroacetabular posterior translation (FAPT) using dynamic hip ultrasonography (DHUS), and to determine the inter- and intra-rater reliability of hip ultrasound measurements of FAPT. Materials and methods: The study design was a feasibility study of 13 healthy young adults (26 hips) using test-retest analysis. The data was collected prospectively over a 2-week time period. Three DHUS measurements (posterior neutral (PN), flexion, adduction, and internal rotation (PFADIR), and stand and load (PStand) were measured by four independent raters (2 senior who divided the cohort, 1 intermediate, 1 junior) at two time points for bilateral hips of each participant. Reliability was assessed by calculating the intraclass correlation coefficient (ICC) along with 95% confidence intervals (CIs) for each rater and across all raters. Results: A total of 468 US scans were completed. The mean age of the cohort was 25.7 years (SD 5.1 years) and 54% were female. The inter-rater reliability was excellent for PFADIR (ICC 0.85 95% CI 0.76-0.91), good for PN (ICC 0.69 95% CI 0.5-0.81), and good for PStand (ICC 0.72 95% CI 0.55-0.83). The intra-rater reliability for all raters was good for PFADIR (ICC 0.60 95% CI 0.44-0.73), fair for PN (ICC 0.42 95% CI 0.21-0.59), and fair for PStand (ICC 0.42 95% CI 0.22-0.59). Conclusion: This is the first study to present a protocol using dynamic ultrasonography to measure FAPT. DHUS measure for FAPT was shown to be reliable across raters with varying levels of ultrasound experience.
Language	English
Publishing date	2024-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-024-04560-3
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Book ; Online: Trigonal Symmetry Breaking and its Electronic Effects in Two-Dimensional Dihalides and Trihalides

Georgescu, Alexandru B. / Millis, Andrew J. / Rondinelli, James M.

2021

Abstract: ... metal (M) site in two-dimensional van der Waals MX$_2$ dihalides and MX$_3$ trihalides. The trigonal ...

Abstract	We study the consequences of the approximately trigonal ($D_{3d}$) point symmetry of the transition metal (M) site in two-dimensional van der Waals MX$_2$ dihalides and MX$_3$ trihalides. The trigonal symmetry leads to a 2-2-1 orbital splitting of the transition metal $d$ shell, which may be tuned by the interlayer distance, and changes in the ligand-ligand bond lengths. Orbital order coupled to various lower symmetry lattice modes may lift the remaining orbital degeneracies, and we explain how these may support unique electronic states using ZrI$_2$ and CuCl$_2$ as examples, and offer a brief overview of possible electronic configurations in this class of materials. By building and analysing Wannier models adapted to the appropriate symmetry we examine how the interplay among trigonal symmetry, electronic correlation effects, and $p$-$d$ orbital charge transfer leads to insulating, orbitally polarized magnetic and/or orbital-selective Mott states. Our work establishes a rigorous framework to understand, control, and tune the electronic states in low-dimensional correlated halides. Our analysis shows that trigonal symmetry and its breaking is a key feature of the 2D halides that needs to be accounted for in search of novel electronic states in materials ranging from CrI$_3$ to $\alpha$-RuCl$_3$.
Keywords	Condensed Matter - Strongly Correlated Electrons ; Condensed Matter - Materials Science
Subject code	539
Publishing date	2021-10-09
Publishing country	us
Document type	Book ; Online
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Article: Periacetabular osteotomy to treat residual dysplasia in adolescents and young adults: indications, complications, results.

Millis, M B / McClincy, M

Journal of children's orthopaedics

2018 Volume 12, Issue 4, Page(s) 349–357

Abstract: Purpose: Discuss current indications, techniques, complications and results of periacetabular osteotomy (PAO) to treat the adolescent and young adult with symptomatic acetabular dysplasia or the rare minimally symptomatic patient with dysplasia with a ... ...

Abstract	Purpose: Discuss current indications, techniques, complications and results of periacetabular osteotomy (PAO) to treat the adolescent and young adult with symptomatic acetabular dysplasia or the rare minimally symptomatic patient with dysplasia with a guarded prognosis without PAO surgery. Methods: Review of clinical experience with PAO at our and other high-volume centres. Results: At a mean follow-up of 18 years after PAO, more than 75% of hips are preserved. At 30-year follow-up, longest term reported series notes survival of one-third of hips. Conclusion: Both middle- and long-term results suggest efficacy of PAO in improving function and prognosis in most symptomatic adolescent and young adult patients with spherically congruous pre-arthritic dysplastic hips.
Language	English
Publishing date	2018-08-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2279410-4
ISSN	1863-2548 ; 1863-2521
ISSN (online)	1863-2548
ISSN	1863-2521
DOI	10.1302/1863-2548.12.180068
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Article ; Online: Rasch analysis of fatigue severity scale in patients with epilepsy.

Syed, Maryam Jamil / Millis, Scott R / Marawar, Rohit / Basha, Maysaa M / Zutshi, Deepti

Epilepsy & behavior : E&B

2022 Volume 130, Page(s) 108688

Abstract: Objective: To utilize the Rasch model to validate and assess the psychometric properties of the Fatigue Severity Scale (FSS) in patients with epilepsy.: Methods: A total of 307 patients (age > 18 years) with a confirmed diagnosis of epilepsy were ... ...

Abstract	Objective: To utilize the Rasch model to validate and assess the psychometric properties of the Fatigue Severity Scale (FSS) in patients with epilepsy. Methods: A total of 307 patients (age > 18 years) with a confirmed diagnosis of epilepsy were consented to participate. Exclusion criteria included patients with psychogenic nonepileptic events, cognitive disabilities, and patients who did not speak/understand English. The nine-step FSS was programmed into software administered to patients on electronic tablets, and patient responses were auto-scored. The Rasch rating scale model (RSM) was used to evaluate the unidimensionality, reliability, and targeting of the FSS. To assess unidimensionality, we examined infit and outfit mean squares. We also assessed unidimensionality of the FSS using a principal component analysis of Rasch residuals, where residuals are understood as the difference between observed and expected data values. We evaluated the internal consistency of person and item performance by examining separation reliability estimates and separation ratio. Differential Item Functioning (DIF) was calculated for gender. Results: There was mixed evidence regarding the extent to which the FSS fit the Rasch model. Outfit values ranged from 0.52 to 2.72 and infit values were 0.60 to 2.18, strongly suggesting the presence of misfitting items: Item 1 ("My motivation is lower when I am fatigued") and Item 2 ("Exercise brings on my fatigue"). Significance: The nine-item FSS showed fair psychometric properties in this sample of patients with epilepsy. Our study provides unique, supportive information for the use of a modified version of the FSS, omitting the first two items, in patients with epilepsy. Given the prevalence of fatigue and other neuropsychiatric comorbidities of epilepsy, having a validated fatigue scale can aid healthcare providers to identify moderate-to-severe fatigue levels in patients with epilepsy and address the plausible risk factors.
MeSH term(s)	Adult ; Epilepsy/complications ; Epilepsy/diagnosis ; Fatigue/diagnosis ; Fatigue/epidemiology ; Fatigue/etiology ; Humans ; Middle Aged ; Reproducibility of Results ; Severity of Illness Index ; Surveys and Questionnaires
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2022.108688
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Article ; Online: Phonon-induced disorder in dynamics of optically pumped metals from nonlinear electron-phonon coupling.

Sous, John / Kloss, Benedikt / Kennes, Dante M / Reichman, David R / Millis, Andrew J

Nature communications

2021 Volume 12, Issue 1, Page(s) 5803

Abstract: The non-equilibrium dynamics of matter excited by light may produce electronic phases, such as laser-induced high-transition-temperature superconductivity, that do not exist in equilibrium. Here we simulate the dynamics of a metal driven at initial time ... ...

Abstract	The non-equilibrium dynamics of matter excited by light may produce electronic phases, such as laser-induced high-transition-temperature superconductivity, that do not exist in equilibrium. Here we simulate the dynamics of a metal driven at initial time by a spatially uniform pump that excites dipole-active vibrational modes which couple nonlinearly to electrons. We provide evidence for rapid loss of spatial coherence, leading to emergent effective disorder in the dynamics, which arises in a system unitarily evolving under a translation-invariant Hamiltonian, and dominates the electronic behavior as the system evolves towards a correlated electron-phonon long-time state, possibly explaining why transient superconductivity is not observed. Our framework provides a basis within which to understand correlation dynamics in current pump-probe experiments of vibrationally coupled electrons, highlight the importance of the evolution of phase coherence, and demonstrate that pumped electron-phonon systems provide a means of realizing dynamically induced disorder in translation-invariant systems.
Language	English
Publishing date	2021-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-26030-3
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