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Article ; Online: SCOR: A secure international informatics infrastructure to investigate COVID-19.

Raisaro, J L / Marino, Francesco / Troncoso-Pastoriza, Juan / Beau-Lejdstrom, Raphaelle / Bellazzi, Riccardo / Murphy, Robert / Bernstam, Elmer V / Wang, Henry / Bucalo, Mauro / Chen, Yong / Gottlieb, Assaf / Harmanci, Arif / Kim, Miran / Kim, Yejin / Klann, Jeffrey / Klersy, Catherine / Malin, Bradley A / Méan, Marie / Prasser, Fabian /

Scudeller, Luigia / Torkamani, Ali / Vaucher, Julien / Puppala, Mamta / Wong, Stephen T C / Frenkel-Morgenstern, Milana / Xu, Hua / Musa, Baba Maiyaki / Habib, Abdulrazaq G / Cohen, Trevor / Wilcox, Adam / Salihu, Hamisu M / Sofia, Heidi / Jiang, Xiaoqian / Hubaux, J P

Journal of the American Medical Informatics Association : JAMIA

2020 Volume 27, Issue 11, Page(s) 1721–1726

Abstract: Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still lacks a ... ...

Abstract	Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still lacks a secure and privacy-preserving infrastructure to support auditable data sharing and facilitate automated and legally compliant federated analysis on an international scale. Existing health informatics systems do not incorporate the latest progress in modern security and federated machine learning algorithms, which are poised to offer solutions. An international group of passionate researchers came together with a joint mission to solve the problem with our finest models and tools. The SCOR Consortium has developed a ready-to-deploy secure infrastructure using world-class privacy and security technologies to reconcile the privacy/utility conflicts. We hope our effort will make a change and accelerate research in future pandemics with broad and diverse samples on an international scale.
MeSH term(s)	Biomedical Research ; COVID-19 ; Computer Security ; Coronavirus Infections ; Humans ; Information Dissemination/ethics ; Internationality ; Machine Learning ; Pandemics ; Pneumonia, Viral ; Privacy
Keywords	covid19
Language	English
Publishing date	2020-09-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1205156-1
ISSN	1527-974X ; 1067-5027
ISSN (online)	1527-974X
ISSN	1067-5027
DOI	10.1093/jamia/ocaa172
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Article ; Online: SCOR

Raisaro, J.L. / Marino, F. / Troncoso-Pastoriza, J. / Beau-Lejdstrom, R. / Bellazzi, R. / Murphy, R. / Bernstam, E.V. / Wang, H. / Bucalo, M. / Chen, Y. / Gottlieb, A. / Harmanci, A. / Kim, M. / Kim, Y. / Klann, J. / Klersy, C. / Malin, B.A. / Méan, M. / Prasser, F. /

Scudeller, L. / Torkamani, A. / Vaucher, J. / Puppala, M. / Wong, STC / Frenkel-Morgenstern, M. / Xu, H. / Musa, B.M. / Habib, A.G. / Cohen, T. / Wilcox, A. / Salihu, H.M. / Sofia, H. / Jiang, X. / Hubaux, J.P.

Journal of the American Medical Informatics Association

A secure international informatics infrastructure to investigate COVID-19.

2020

Abstract	Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still lacks a secure and privacy-preserving infrastructure to support auditable data sharing and facilitate automated and legally compliant federated analysis on an international scale. Existing health informatics systems do not incorporate the latest progress in modern security and federated machine learning algorithms, which are poised to offer solutions. An international group of passionate researchers came together with a joint mission to solve the problem with our finest models and tools. The SCOR Consortium has developed a ready-to-deploy secure infrastructure using world-class privacy and security technologies to reconcile the privacy/utility conflicts. We hope our effort will make a change and accelerate research in future pandemics with broad and diverse samples on an international scale.
Keywords	COVID-19 ; federated learning ; healthcare privacy ; international consortium ; secure data analysis ; covid19
Subject code	005
Language	English
Publishing date	2020-07-10
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: SCOR: A secure international informatics infrastructure to investigate COVID-19

J Am Med Inform Assoc

Abstract	Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still lacks a secure and privacy-preserving infrastructure to support auditable data sharing and facilitate automated and legally compliant federated analysis on an international scale. Existing health informatics systems do not incorporate the latest progress in modern security and federated machine learning algorithms, which are poised to offer solutions. An international group of passionate researchers came together with a joint mission to solve the problem with our finest models and tools. The SCOR Consortium has developed a ready-to-deploy secure infrastructure using world-class privacy and security technologies to reconcile the privacy/utility conflicts. We hope our effort will make a change and accelerate research in future pandemics with broad and diverse samples on an international scale.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #759959
Database	COVID19

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Article ; Online: SCOR

Journal of the American Medical Informatics Association ; ISSN 1067-5027 1527-974X

A secure international informatics infrastructure to investigate COVID-19

2020

Abstract: Abstract Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still ... ...

Abstract	Abstract Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still lacks a secure and privacy-preserving infrastructure to support auditable data sharing and facilitate automated and legally compliant federated analysis on an international scale. Existing health informatics systems do not incorporate the latest progress in modern security and federated machine learning algorithms, which are poised to offer solutions. An international group of passionate researchers came together with a joint mission to solve the problem with our finest models and tools. The SCOR Consortium has developed a ready-to-deploy secure infrastructure using world-class privacy and security technologies to reconcile the privacy/utility conflicts. We hope our effort will make a change and accelerate research in future pandemics with broad and diverse samples on an international scale.
Keywords	Health Informatics ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
DOI	10.1093/jamia/ocaa172
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SCOR

A secure international informatics infrastructure to investigate COVID-19

2020

Abstract	Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still lacks a secure and privacy-preserving infrastructure to support auditable data sharing and facilitate automated and legally compliant federated analysis on an international scale. Existing health informatics systems do not incorporate the latest progress in modern security and federated machine learning algorithms, which are poised to offer solutions. An international group of passionate researchers came together with a joint mission to solve the problem with our finest models and tools. The SCOR Consortium has developed a ready-to-deploy secure infrastructure using world-class privacy and security technologies to reconcile the privacy/utility conflicts. We hope our effort will make a change and accelerate research in future pandemics with broad and diverse samples on an international scale.
Keywords	covid19
Subject code	005
Language	??????
Publisher	Oxford University Press
Publishing country	kr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High-dose erythropoietin in patients with acute myocardial infarction: a pilot, randomised, placebo-controlled study.

Ferrario, Maurizio / Arbustini, Eloisa / Massa, Margherita / Rosti, Vittorio / Marziliano, Nicola / Raineri, Claudia / Campanelli, Rita / Bertoletti, Alessandra / De Ferrari, Gaetano Maria / Klersy, Catherine / Angoli, Luigi / Bramucci, Ezio / Marinoni, Barbara / Ferlini, Marco / Moretti, Enza / Raisaro, Arturo / Repetto, Alessandra / Schwartz, Peter J / Tavazzi, Luigi

International journal of cardiology

2011 Volume 147, Issue 1, Page(s) 124–131

Abstract: Background: Mortality and morbidity after acute myocardial infarction (AMI) remain high even when myocardial reperfusion is successful. Erythropoietin (EPO) protects against experimental MI.: Methods: The aim of this single-centre study was to ... ...

Abstract	Background: Mortality and morbidity after acute myocardial infarction (AMI) remain high even when myocardial reperfusion is successful. Erythropoietin (EPO) protects against experimental MI. Methods: The aim of this single-centre study was to investigate the effects of short-term high-dose erythropoietin on peripheral blood cells (PBCs) and infarct size in 30 patients with a first uncomplicated AMI undergoing percutaneous coronary intervention (PCI) who were randomly assigned to treatment with EPO (33 × 10(3)IU before PCI, and 24 and 48 h after admission), or placebo. We considered short-term CD34+ cell mobilisation, quantitative PBC gene expression in the apoptotic, angiogenic and inflammatory pathways, and enzymatically estimated infarct size. Echocardiographic and cardiac magnetic resonance studies were performed in the acute phase and six months later. Results: CD34+ cell mobilisation 72 h after admission was greater in the EPO-treated patient group (93 cells/μl [36-217] vs 22 cells/μl [6-51]; p = 0.002), who also showed higher expression of the anti-apoptotic AKT and NFkB, the pro-angiogenic VEGFR-2, and the EPO-R genes, and lower expression of the pro-apoptotic CASP3 and TP53 and pro-inflammatory IL12a genes. Moreover, they showed smaller infarct size (30% reduction in CK-MB release; p = 0.025), and a favourable pattern of left ventricular remodelling. Conclusions: Short-term high-dose EPO administration in patients with AMI treated by PCI and standard anti-platelet therapy increases the levels of circulating CD34+ cells, shifts PBC gene expression towards anti-apoptotic, pro-angiogenic and anti-inflammatory pathways, and decreases infarct size. The clinical relevance of these results needs to be confirmed in specifically tailored trials.
MeSH term(s)	Adult ; Aged ; Double-Blind Method ; Drug Administration Schedule ; Erythropoietin/administration & dosage ; Erythropoietin/blood ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Pilot Projects ; Receptors, Erythropoietin/biosynthesis ; Receptors, Erythropoietin/blood
Chemical Substances	Receptors, Erythropoietin ; Erythropoietin (11096-26-7)
Language	English
Publishing date	2011-02-17
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2009.10.028
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Article ; Online: Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: insights from the START Study

De Luca, Leonardo / Temporelli, Pier Luigi / Gulizia, Michele Massimo / Gonzini, Lucio / Ammaturo, Tiziana Anita / Tedesco, Luigi / Pede, Silvia / Oliva, Fabrizio / Gabrielli, Domenico / Colivicchi, Furio / Averna, Maurizio R. / Maggioni, A.P. / Lucci, D. / Lorimer, A. / Orsini, G. / Gonzini, L. / Fabbri, G. / Priami, P. / Maras, P. /

Ramani, F. / Falcone, C. / Passarelli, I. / Mauri, S. / Calabrò, P. / Bianchi, R. / Di Palma, G. / Mascia, F. / Vetrano, A. / Fusco, A. / Proia, E. / Colivicchi, F. / Aiello, A. / Tomai, F. / Licitra, R. / Petrolini, A. / Bosco, B. / Magliari, F. / Callerame, M. / Mazzella, T. / Lettica, G.V. / Coco, G. / Incao, F. / Marinacci, L. / D'Addario, S. / Tartaglione, S.N. / Ubaldi, S. / Sanchez, F.A. / Costa, P. / Manca, G. / Failla, M. / Scherillo, M. / Procaccini, V. / Formigli, D. / Senni, M. / Luminita, E.M. / Bonomo, P. / Mossa, C. / Corda, S. / Colavita, A.R. / Trevisonno, G. / Vizzari, G. / Cosentino, N. / Formaro, C. / Paolillo, C. / Nalin, I.L. / De Rosa, F.M. / Fontana, F. / Fuscaldo, G.F. / Passamonti, E. / Bertella, E. / Calvaruso, E.V. / Varani, E. / Tani, F. / Cicchitelli, G. / Gabrielli, D. / Paoloni, P. / Marziali, A. / Campo, G. / Tebaldi, M. / Biscaglia, S. / Biase, M Di / Brunetti, N.D. / Gallotta, A.M. / Mattei, L. / Marini, R. / Balsemin, F. / Urbano, M.D. / Naio, R. / Vicinelli, P. / Arena, G. / Mazzini, M. / Gigli, N. / Miserrafiti, B. / Monopoli, A. / Mortara, A. / Delfino, P. / Chioffi, M.M. / Mariño, P. / Gravellone, M. / Barbieri, L. / Ledda, A. / Geraci, G. / Carmina, M.G. / Raisaro, A.E. / Di Giacomo, C. / Somaschini, A. / Fasano, M.L. / Sannazzaro, M. / Arcieri, R. / Pantaleoni, M. / Leuzzi, C. / Gorlato, G. / Greco, G. / Chiera, A. / Ammaturo, T.A. / Malanchini, G. / Del Corral, M.P. / Tedesco, L. / Pede, S. / Urso, L.G. / Piscione, F. / Galasso, G. / Provasoli, S. / Fattore, L. / Lucca, G. / Cresti, A. / Cardillo, A. / Fera, M.S. / Vennettilli, F. / Gaudio, C. / Paravati, V. / Caldarola, P. / Locuratolo, N. / Verlato, R. / De Conti, F. / Turiano, G. / Preti, G. / Moretti, L. / Silenzi, S. / Colonna, G. / Picciolo, A. / Nicosia, A. / Cascone, C. / Di Sciascio, G. / Mangiacapra, F. / Russo, A. / Mastroianno, S. / Esposito, G. / Cosmi, F. / D'Orazio, S. / Costantini, C. / Lanari, A. / De Rosa, P. / Esposito, L. / Bilato, C. / Valle, C Dalla / Ceresa, M. / Colombo, E. / Pennisi, V. / Casciola, G. / Driussi, M. / Bisceglia, T. / Scalvini, S. / Rivadossi, F. / Volpe, M. / Comito, F. / Scorzoni, D. / Grimoldi, P. / Lagioia, R. / Santoro, D. / De Cesare, N. / Comotti, T. / Poli, A. / Martina, P. / Musolino, M.F. / Multari, E.I. / Bilardo, G. / Scalchi, G. / Olivieri, C. / Caranci, F. / Pavan, D. / Ganci, G. / Mariani, A. / Falchetti, E. / Lanzillo, T. / Caccavale, A. / Bongo, A.S. / Rizzi, A. / Favilli, R. / Maffei, S. / Mallardo, M. / Fulgione, C. / Bordin, F. / Bonmassari, R. / Battaia, E. / Puzzo, A. / Vianello, G. / D'Arpino, A. / Romei, M. / Pajes, G. / Petronzelli, S. / Ghezzi, F. / Brigido, S. / Pignatelli, L. / Brscic, E. / Sori, P. / Russo, M. / Biancolillo, E. / Ignone, G. / De Giorgio, N.A. / Campaniello, C. / Ponticelli, P. / Margonato, A. / Gerosa, S. / Cutaia, A. / Casalicchio, C. / Bartolomucci, F. / Larosa, C. / Spadafina, T. / Putignano, A. / De Cristofaro, R. / Bernardi, L. / Sommariva, L. / Celestini, A. / Bertucci, C.M. / Marchetti, M. / Grisolia, E Franceschini / Ammendolea, C. / Carini, M. / Scipione, P. / Politano, M. / Rubino, G. / Reina, C. / Peccerillo, N. / Paloscia, L. / D'Alleva, A. / Petacchi, R. / Pignalosa, M. / Lucchetti, D. / Di Palma, F. / La Mastra, R.A. / Amico, A.F. / Filippis, M De / Fontanella, B. / Zanini, G. / Casolo, G. / Del Meglio, J. / Parato, V.M. / Genovesi, E. / D'Alimonte, A. / Miglioranza, A. / Alessandri, N. / Moscariello, F. / Mauro, C. / Sasso, A. / Caso, P. / Petrillo, C. / Napoletano, C. / Paparoni, S.R. / Bernardo, V. / Serdoz, R. / Rotunno, R. / Oppo, I. / Aloisio, A. / Aurelio, A. / Licciardello, G. / Cassaniti, L. / Gulizia, M.M. / Francese, G.M. / Marcassa, C. / Temporelli, P.L. / Villani, R. / Zorzoli, F. / Mileto, F. / Vecchis, M De / Scolozzi, D. / Lupi, G. / Caruso, D. / Rebulla, E. / La Fata, B. / Anselmi, M. / Girardi, P. / Borruso, E. / Ferrantelli, G. / Sassone, B. / Bressan, S. / Capriolo, M. / Pelissero, E. / Piancastelli, M. / Gobbi, M. / Cocco, F. / Bruno, M.G. / Berti, S. / Lo Surdo, G. / Tanzi, P. / De Rosa, R. / Vilei, E. / De Iaco, M.R. / Grassi, G. / Zanella, C. / Marullo, L. / Alfano, G. / Pelaggi, P. / Talarico, R. / Tuccillo, B. / Irace, L. / Proietti, F. / Di Croce, G. / Di Lorenzo, L. / Zarrilli, A. / Bongini, M. / Ranise, A. / Aprile, A. / Fornengo, C. / Capogrosso, V. / Tranghese, A. / Golia, B. / Marziano, A. / Roncon, L. / Picariello, C. / Bagni, E. / Leci, E. / Gregorio, G. / Gatto, F. / Piemonte, F. / Gervasio, F. / Navazio, A. / Guerri, E. / Belmonte, E. / Marino, F. / Di Belardino, N. / Di Nuzzo, M.R. / Epifani, M. / Comolatti, G. / Conconi, B. / Benea, D. / Casu, G. / Merella, P. / Ammirati, M.A. / Corrado, V.M. / Spagnolo, D. / Caico, S.I. / Bonizzato, S. / Margheri, M. / Corrado, L. / Antonicelli, R. / Ferrigno, C. / Merlino, A. / Nassiacos, D. / Antonelli, A. / Marchese, A. / Uguccioni, M. / Villella, A. / Bechi, S. / Lo Bianco, F. / Bedogni, F. / Negro, L. / Donato, L. / Statile, D. / Cassin, M. / Fedele, F. / Granatelli, A. / Calcagno, S. / Politi, A. / Pani., A.

Nutrition, Metabolism and Cardiovascular Diseases. 2023 Aug. 07

2023

Abstract: Elevated triglyceride (TG) levels seem to identify subjects at increased cardiovascular risk, independent of LDL-C levels. We sought to evaluate the predictive role of hypertriglyceridemia, defined as TG levels ≥150 mg/dl, in very high risk (VHR) ... ...

Abstract	Elevated triglyceride (TG) levels seem to identify subjects at increased cardiovascular risk, independent of LDL-C levels. We sought to evaluate the predictive role of hypertriglyceridemia, defined as TG levels ≥150 mg/dl, in very high risk (VHR) patients with chronic coronary syndromes (CCS) treated with statins. Using the data from the STable Coronary Artery Diseases RegisTry (START) study, an Italian nationwide registry, we assessed the association between the TG levels and baseline clinical characteristics, pharmacological treatment and major adverse cardio-cerebrovascular events (MACCE) at 1 year in a large cohort of statin-treated patients at VHR. Of the 4751 consecutive patients with CCS enrolled in the registry and classified as VHR, 2652 (55.8%) had TG values available (mean 120.6±54.9) and were treated with at least a statin at baseline: 2019 (76.1%) with TG <150 and 633 (23.9%) with TG ≥150 mg/dl. At 1 year from enrolment, MACCE occurred in 168 (6.3%) patients, without differences between the two groups of TG (5.9 vs 7.6%; p=0.14). At multivariable analysis, hypertriglyceridemia did not result as independent predictor of the MACCE (hazard ratio: 1.16; 95% confidence intervals: 0.82-1.64; p=0.42). In the present large, nationwide cohort of consecutive CCS patients at VHR with statin-controlled LDL-C levels, hypertriglyceridemia was present in around 24% of cases and did not result as predictor of MACCE at 1 year. Further studies with a longer follow-up and larger sample size are needed to better define the prognostic role of TG levels when intensive LDL lowering therapies are used.
Keywords	coronary vessels ; hazard ratio ; hypertriglyceridemia ; metabolism ; nutrition ; risk ; sample size ; triacylglycerols ; LDL-C ; management ; treatment ; statin ; ezetimibe
Language	English
Dates of publication	2023-0807
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.07.036
Database	NAL-Catalogue (AGRICOLA)

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Article: Ventricular septal rupture after myocardial infarction: diagnosis by two-dimensional and pulsed Doppler echocardiography.

Recusani, F / Raisaro, A / Sgalambro, A / Tronconi, L / Venco, A / Salerno, J / Ardissino, D

The American journal of cardiology

1984 Volume 54, Issue 3, Page(s) 277–281

Abstract: Rupture of the ventricular septum in the acute phase of myocardial infarction (MI) requires prompt recognition for correct management. The 2-dimensional and pulsed Doppler echocardiographic findings are reported from 11 patients with ventricular septal ( ... ...

Abstract	Rupture of the ventricular septum in the acute phase of myocardial infarction (MI) requires prompt recognition for correct management. The 2-dimensional and pulsed Doppler echocardiographic findings are reported from 11 patients with ventricular septal (VS) rupture. VS rupture was confirmed by cardiac catheterization in 9 patients, surgery in 4 patients and necropsy examination in 3 patients. Two-dimensional echocardiography (echo) directly visualized the rupture in 7 patients and assessed the size and location of an associated aneurysm in 10. In all patients, M-mode pulsed Doppler echo allowed detection of the left-to-right shunting due to VS rupture, but failed to indicate the rupture site. M-mode pulsed Doppler echo was reliable for detecting VS rupture after MI. Conversely, 2-dimensional echo was less effective in the direct visualization of the rupture, but provided anatomic and functional information that was useful in medical and surgical management. Thus, the techniques are complementary and should be used in combination for the assessment of VS rupture in acute MI.
MeSH term(s)	Adult ; Aged ; Echocardiography ; Female ; Heart Aneurysm/diagnosis ; Heart Aneurysm/etiology ; Heart Rupture/diagnosis ; Heart Rupture/etiology ; Heart Septum ; Heart Ventricles ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications
Language	English
Publishing date	1984-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/0002-9149(84)90182-6
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Article: A new method for quantitation of mitral regurgitation based on color flow Doppler imaging of flow convergence proximal to regurgitant orifice.

Bargiggia, G S / Tronconi, L / Sahn, D J / Recusani, F / Raisaro, A / De Servi, S / Valdes-Cruz, L M / Montemartini, C

Circulation

1991 Volume 84, Issue 4, Page(s) 1481–1489

Abstract: Background: Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric ... ...

Abstract	Background: Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric hemispheric isovelocity surfaces centered at the orifice. The flow rate is constant across all isovelocity surfaces and equals the flow rate through the orifice. For any isovelocity surface the flow rate (Q) is given by: Q = 2 pi r2 Vr, where 2 pi r2 is the area of the hemisphere and Vr is the velocity at the radial distance (r) from the orifice. Methods and results: We studied 52 consecutive patients with mitral regurgitation (mean age, 49 years; age range, 21-66 years) verified by left ventricular angiography using color flow mapping. The FCR r was measured as the distance between the first aliasing limit--at a Nyquist limit obtained by zero-shifting the velocity cutoff to 38 cm/sec--and the regurgitant orifice. Seven patients without evidence of an FCR had only grade 1+ mitral regurgitation angiographically. There was a significant relation between the Doppler-derived maximal instantaneous regurgitant flow rate and the angiographic degree of mitral regurgitation in the other patients (rs = 0.91, p less than 0.001). The regurgitant flow rate by Doppler also correlated with the angiographic regurgitant volume (r = 0.93, SEE = 123 ml/sec) in the 15 patients in normal sinus rhythm and without other regurgitant lesions in whom it could be measured. The correlation between regurgitant jet area within the left atrium and the angiographic grade was only fair (rs = 0.75, p less than 0.001). Conclusions: Color flow Doppler provides new velocity information about the proximal FCR in patients with mitral regurgitation. According to the continuity principle, the maximal instantaneous regurgitant flow rate, obtained with the FCR method, may provide a quantitative estimate of the severity of mitral regurgitation, which is relatively independent of technical factors.
MeSH term(s)	Angiocardiography ; Blood Flow Velocity/physiology ; Cardiac Catheterization ; Coronary Circulation/physiology ; Echocardiography, Doppler ; Female ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve Insufficiency/diagnostic imaging
Language	English
Publishing date	1991-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/01.cir.84.4.1481
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Color Doppler diagnosis of mechanical prosthetic mitral regurgitation: usefulness of the flow convergence region proximal to the regurgitant orifice.

Bargiggia, G S / Tronconi, L / Raisaro, A / Recusani, F / Ragni, T / Valdes-Cruz, L M / Sahn, D J / Montemartini, C

American heart journal

1990 Volume 120, Issue 5, Page(s) 1137–1142

Abstract: In prosthetic or paravalvular prosthetic mitral regurgitation, transthoracic color Doppler flow mapping can sometimes fail to detect the regurgitant jet within the left atrium because of the shadowing by the prosthetic valve. To overcome this limitation, ...

Abstract	In prosthetic or paravalvular prosthetic mitral regurgitation, transthoracic color Doppler flow mapping can sometimes fail to detect the regurgitant jet within the left atrium because of the shadowing by the prosthetic valve. To overcome this limitation, we assessed the utility of color Doppler visualization of the flow convergence region (FCR) proximal to the regurgitant orifice in 20 consecutive patients with mechanical prosthetic mitral regurgitation documented by surgery and cardiac catheterization (13 of 20 patients). In addition, we studied 33 patients with normally functioning mitral prostheses. Doppler studies were performed in the apical, subcostal, and parasternal long-axis views. An FCR was detected in 95% (19 of 20) of patients with prosthetic mitral regurgitation. A jet area in the left atrium was detected in 60% (12 of 20) of patients. In 18 of 19 patients with Doppler-detected FCR, the site of the leak was correctly identified by observing the location of the FCR. A trivial jet area was detected in eight patients with a normally functioning mitral prosthesis; in none was an FCR identified. Thus color Doppler visualization of the FCR proximal to the regurgitant orifice is superior to the jet area in the diagnosis of mechanical prosthetic mitral regurgitation. Moreover, FCR permits localization of the site of the leak with good accuracy.
MeSH term(s)	Adult ; Aged ; Echocardiography, Doppler ; Female ; Heart Valve Prosthesis ; Humans ; Male ; Middle Aged ; Mitral Valve ; Prosthesis Failure
Language	English
Publishing date	1990-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/0002-8703(90)90127-j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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