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  1. Article: Evacuation of Non-ST Elevation Myocardial Infarction in West Africa: 19 Hours of Lessons Learned in Prolonged Casualty Care and En Route Care.

    Speicher, Matthew V / McGowan, Joel / Pruett, Sean / Shurden, Jaimie / Bianchi, William D / Kibler, Aaron

    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

    2023  Volume 23, Issue 1, Page(s) 114–116

    Abstract: Trauma casualty care has historically been the cornerstone of special operations military medical training. A recent case of myocardial infarction at a remote base of operations in Africa highlights the importance of foundational medical knowledge and ... ...

    Abstract Trauma casualty care has historically been the cornerstone of special operations military medical training. A recent case of myocardial infarction at a remote base of operations in Africa highlights the importance of foundational medical knowledge and training. A 54-year-old government contractor supporting operations in the AFRICOM area of responsibility (AOR) presented to the Role 1 medic with substernal chest pain with onset during exercise. Abnormal rhythm strips concerning for ischemia were obtained from his monitors. A MEDEVAC to a Role 2 facility was arranged and executed. At the Role 2 a non-ST-elevation myocardial infarction (NSTEMI) was diagnosed. The patient was emergently evacuated on a lengthy flight to a civilian Role 4 treatment facility for definitive care. He was found to have a 99% occlusion of the left anterior descending (LAD) coronary artery, as well as a 75% occlusion of the posterior coronary artery and a chronic 100% occlusion of the circumflex artery. The LAD and posterior arteries were stented, and the patient made a favorable recovery. This case highlights the importance of preparedness for medical emergencies and care of medically critical patients in remote and austere locations.
    MeSH term(s) Male ; Humans ; Middle Aged ; Non-ST Elevated Myocardial Infarction/surgery ; Electrocardiography ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Coronary Vessels ; Africa, Western ; Coronary Angiography
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3006517-3
    ISSN 1553-9768
    ISSN 1553-9768
    DOI 10.55460/JIDF-CWE7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7196: Show issues Location:
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  2. Article ; Online: Illogical Critiques of the Pressure Natriuresis Theory of Chronic Hypertension.

    Lohmeier, Thomas E / Pruett, William Andrew

    American journal of hypertension

    2016  Volume 29, Issue 12, Page(s) 1332–1334

    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpw076
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2329: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Comparative effectiveness of oral prostacyclin pathway drugs on hospitalization in patients with pulmonary hypertension in the United States: a retrospective database analysis.

    McConnell, John W / Tsang, Yuen / Pruett, Janis / Iii, William Drake

    Pulmonary circulation

    2020  Volume 10, Issue 4, Page(s) 2045894020911831

    Abstract: Two oral medications targeting the prostacyclin pathway are available to treat pulmonary arterial hypertension in the United States: oral treprostinil and selexipag. We compared real-world hospitalization in patients receiving these medications. A ... ...

    Abstract Two oral medications targeting the prostacyclin pathway are available to treat pulmonary arterial hypertension in the United States: oral treprostinil and selexipag. We compared real-world hospitalization in patients receiving these medications. A retrospective administrative claims study was conducted using the Optum® Clinformatics® Data Mart database. Patients with pulmonary hypertension were identified using diagnostic codes. Cohort inclusion required age ≥ 18 years, first oral treprostinil or selexipag prescription between 1 January 2015 and 30 September 2017 (index date), and continuous enrollment in the prior ≥6 months. Patients who switched index drug were excluded. Follow-up was from index date until the first of end of index drug exposure, end of continuous enrollment, death, or 31 December 2017. Multivariable Cox proportional hazard and Poisson regression were used to compare risk and rate, respectively, of hospitalization associated with oral treprostinil vs. selexipag, adjusting for potential confounders. The study cohort included 99 patients receiving oral treprostinil and 123 receiving selexipag. Mean age was 61 years, and most patients were females (71%). Compared with oral treprostinil, selexipag was associated with a 46% lower risk of all-cause hospitalization (hazard ratio 0.54, 95% confidence interval 0.31, 0.92;
    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1177/2045894020911831
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  5. Article ; Online: Use of Computer Simulations to Understand Female Physiology: Where's the Data?

    Hester, Robert L / Pruett, William A

    Physiology (Bethesda, Md.)

    2015  Volume 30, Issue 6, Page(s) 404–405

    MeSH term(s) Animals ; Biomedical Research/methods ; Computer Simulation ; Female ; Health Status Disparities ; Humans ; Male ; Models, Animal ; Models, Biological ; Physiology/methods ; Sex Factors
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00021.2015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2164: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation.

    Pruett, Lauren J / Kenny, Hannah L / Swift, William M / Catallo, Katarina J / Apsel, Zoe R / Salopek, Lisa S / Scumpia, Philip O / Cottler, Patrick S / Griffin, Donald R / Daniero, James J

    NPJ Regenerative medicine

    2023  Volume 8, Issue 1, Page(s) 10

    Abstract: Biomaterial-enabled de novo formation of non-fibrotic tissue in situ would provide an important tool to physicians. One example application, glottic insufficiency, is a debilitating laryngeal disorder wherein vocal folds do not fully close, resulting in ... ...

    Abstract Biomaterial-enabled de novo formation of non-fibrotic tissue in situ would provide an important tool to physicians. One example application, glottic insufficiency, is a debilitating laryngeal disorder wherein vocal folds do not fully close, resulting in difficulty speaking and swallowing. Preferred management of glottic insufficiency includes bulking of vocal folds via injectable fillers, however, the current options have associated drawbacks including inflammation, accelerated resorption, and foreign body response. We developed a novel iteration of microporous annealed particle (MAP) scaffold designed to provide persistent augmentation. Following a 14-month study of vocal fold augmentation using a rabbit vocal paralysis model, most MAP scaffolds were replaced with tissue de novo that matched the mixture of fibrotic and non-fibrotic collagens of the contralateral vocal tissue. Further, persistent tissue augmentation in MAP-treated rabbits was observed via MRI and via superior vocal function at 14 months relative to the clinical standard.
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2057-3995
    ISSN (online) 2057-3995
    DOI 10.1038/s41536-023-00281-8
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  7. Article: Parathyroid hormone secretion by multiple distinct cell populations, a time dynamic mathematical model.

    Pruett, William A / Hester, Robert L

    Physiological reports

    2014  Volume 2, Issue 2, Page(s) e00231

    Abstract: The acute response of parathyroid hormone to perturbations in serum ionized calcium ([Ca(2+)]) is physiologically complex, and poorly understood. The literature provides numerous observations of quantitative and qualitative descriptions of parathyroid ... ...

    Abstract The acute response of parathyroid hormone to perturbations in serum ionized calcium ([Ca(2+)]) is physiologically complex, and poorly understood. The literature provides numerous observations of quantitative and qualitative descriptions of parathyroid hormone (PTH) dynamics. We present a physiologically based mathematical model of PTH secretion constructed from mechanisms suggested in the literature, and validated against complex [Ca(2+)] clamping protocols from human data. The model is based on two assumptions. The first is that secretion is a fraction of cellular reserves, with the fraction being determined by the kinetics of [Ca(2+)] with its receptor. The second is that there are multiple distinct populations of parathyroid cells, with different secretory parameters. The steady state and transient PTH secretion responses of the model are in agreement with human experimental PTH responses to different hypocalcemia and hypercalcemia stimuli. This mathematical model suggests that a population of secreting cells is responsible for the PTH secretory dynamics observed experimentally.
    Language English
    Publishing date 2014-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X
    ISSN 2051-817X
    DOI 10.1002/phy2.231
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  8. Article: RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity.

    Singh, Shivendra / Fang, Jie / Jin, Hongjian / Van de Velde, Lee-Ann / Wu, Qiong / Cortes, Andrew / Morton, Christopher L / Woolard, Mary A / Quarni, Waise / Steele, Jacob A / Connelly, Jon P / He, Liusheng / Thorne, Rebecca / Turner, Gregory / Confer, Thomas / Johnson, Melissa / Caufield, William V / Freeman, Burgess B / Lockey, Timothy /
    Pruett-Miller, Shondra M / Wang, Ruoning / Davidoff, Andrew M / Thomas, Paul G / Yang, Jun

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The cellular plasticity of neuroblastoma is defined by a mixture of two major cell states, adrenergic (ADRN) and mesenchymal (MES), which may contribute to therapy resistance. However, how neuroblastoma cells switch cellular states during therapy remains ...

    Abstract The cellular plasticity of neuroblastoma is defined by a mixture of two major cell states, adrenergic (ADRN) and mesenchymal (MES), which may contribute to therapy resistance. However, how neuroblastoma cells switch cellular states during therapy remains largely unknown and how to eradicate neuroblastoma regardless of their cell states is a clinical challenge. To better understand the lineage switch of neuroblastoma in chemoresistance, we comprehensively defined the transcriptomic and epigenetic map of ADRN and MES types of neuroblastomas using human and murine models treated with indisulam, a selective RBM39 degrader. We showed that cancer cells not only undergo a bidirectional switch between ADRN and MES states, but also acquire additional cellular states, reminiscent of the developmental pliancy of neural crest cells. The lineage alterations are coupled with epigenetic reprogramming and dependency switch of lineage-specific transcription factors, epigenetic modifiers and targetable kinases. Through targeting RNA splicing, indisulam induces an inflammatory tumor microenvironment and enhances anticancer activity of natural killer cells. The combination of indisulam with anti-GD2 immunotherapy results in a durable, complete response in high-risk transgenic neuroblastoma models, providing an innovative, rational therapeutic approach to eradicate tumor cells regardless of their potential to switch cell states.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.21.586157
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  9. Article ; Online: Accumulation of senescence observed in spinocerebellar ataxia type 7 mouse model.

    Miller, William / Pruett, Charles Lewis Humphrey / Stone, William / Eide, Cindy / Riddle, Megan / Popp, Courtney / Yousefzadeh, Matthew / Lees, Christopher / Seelig, Davis / Thompson, Elizabeth / Orr, Harry / Niedernhofer, Laura / Tolar, Jakub

    PloS one

    2022  Volume 17, Issue 10, Page(s) e0275580

    Abstract: Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease caused by a trinucleotide CAG repeat. SCA7 predominantly causes a loss of photoreceptors in the retina and Purkinje cells of the cerebellum. Severe infantile-onset SCA7 also causes renal ...

    Abstract Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease caused by a trinucleotide CAG repeat. SCA7 predominantly causes a loss of photoreceptors in the retina and Purkinje cells of the cerebellum. Severe infantile-onset SCA7 also causes renal and cardiac irregularities. Previous reports have shown that SCA7 results in increased susceptibility to DNA damage. Since DNA damage can lead to accumulation of senescent cells, we hypothesized that SCA7 causes an accumulation of senescent cells over the course of disease. A 140-CAG repeat SCA7 mouse model was evaluated for signs of disease-specific involvement in the kidney, heart, and cerebellum, tissues that are commonly affected in the infantile form. We found evidence of significant renal abnormality that coincided with an accumulation of senescent cells in the kidneys of SCA7140Q/5Q mice, based on histology findings in addition to RT-qPCR for the cell cycle inhibitors p16Ink4a and p21Cip1 and senescence-associated ß-galactosidase (SA-ßgal) staining, respectively. The Purkinje layer in the cerebellum of SCA7140Q/5Q mice also displayed SA-ßgal+ cells. These novel findings offer evidence that senescent cells accumulate in affected tissues and may possibly contribute to SCA7's specific phenotype.
    MeSH term(s) Animals ; Ataxin-7/genetics ; Disease Models, Animal ; Galactosidases ; Mice ; Nerve Tissue Proteins/genetics ; Spinocerebellar Ataxias/genetics ; Spinocerebellar Ataxias/pathology ; Trinucleotide Repeats
    Chemical Substances Ataxin-7 ; Nerve Tissue Proteins ; Galactosidases (EC 3.2.1.-)
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0275580
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  10. Article ; Online: Comparison of the performance of a clinical classification tree versus clinical gestalt in predicting sepsis with extended-spectrum beta-lactamase-producing gram-negative rods.

    Smith, Hayden L / Elfeki, Mohamed A / Lowry, Dana / Sabates, Rebecca / Ropte, Molly / Sittig, Katherine R / Finch, Stephanie / Braun, Kristina / Pruett, William / Wasson, Aaron / Fischman, Kenna / Peterson, Jennifer / Rosa, Rossana

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2022  Volume 2, Issue 1, Page(s) e35

    Abstract: A clinical decision tree was developed using point-of-care characteristics to identify patients with culture-proven sepsis due to extended-spectrum β-lactamase- ... ...

    Abstract A clinical decision tree was developed using point-of-care characteristics to identify patients with culture-proven sepsis due to extended-spectrum β-lactamase-producing
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2021.253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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