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Article: Oncología torácica en Archivos de Bronconeumología 2008.

de Cos-Escuín, Julio Sánchez

2009 Volume 45 Suppl 1, Page(s) 35–38

Abstract: The articles on thoracic oncology published in this journal during the year 2008 are briefly commented on. As regards the epidemiology, it is noted that the standardised incidence rate of lung cancer in males is starting to decline, and there is another ... ...

Title translation	Thoracic oncology in Archivos de Bronconeumología 2008.
Abstract	The articles on thoracic oncology published in this journal during the year 2008 are briefly commented on. As regards the epidemiology, it is noted that the standardised incidence rate of lung cancer in males is starting to decline, and there is another study that analysed links between two common diseases, COPD and lung cancer. Other works have focused on aspects such as diagnosis, staging or prognosis, and analysing the value of positron emission tomography in the assessment of a solitary pulmonary nodule, the effectiveness of aspiration transbronchial needle aspiration in mediastinal staging, the prognostic significance of the over-expression and amplification of c-erbB-2 in patients with small cell carcinoma. As regards treatment, other authors analysed the survival of patients with N2 lung cancer detected during or after lung resection surgery. The new therapeutic technique of ablation of lung tumours by radiofrequency in the early stages is the subject of two publications that describe its basis, indications, contraindications and first results. Lastly, the communication skills needed to inform patients, surgery of lung metastases, and the presentation of an unusual case of carcinoid tumour were the subjects of other articles.
MeSH term(s)	Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Lung Neoplasms/etiology ; Lung Neoplasms/therapy ; Periodicals as Topic ; Publishing
Language	Spanish
Publishing date	2009
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	733126-5
ISSN	0300-2896
ISSN	0300-2896
DOI	10.1016/S0300-2896(09)70270-4
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Article ; Online: Aspectos claves de la Neumología y la Cirugía Torácica sometidos a debate en la era COVID-19.

Jiménez-Ruiz, Carlos A / Valido Morales, Agustin / Perez Chica, Gerardo / Urrutia Landa, Isabel / Rodriguez Portal, Jose Antonio / Arnedillo Muñoz, Aurelio / Cózar Bernal, Fernando / Peces-Barba, Germán / Diego Roza, Carmen / Solano Reina, Segismundo / Rodriguez Suarez, Pedro / Garcia Rio, Francisco / Salas Llinas, Ernest / Garcia Clemente, Marta María / Valencia Gallardo, Jose Manuel / Rodriguez Nieto, María Jesús / Martin de Carpi, Teresa / Sánchez de Cos Escuin, Julio / Estrada Trigueros, Graciliano /

Godoy Mayoral, Raúl / Barbeta Sánchez, Enric / Fernández Villar, Alberto / Ros Lucas, Jose Antonio / Martinez Moragón, Eva / Tomás López, Laura

Open respiratory archives

2021 Volume 3, Issue 4, Page(s) 100123

Title translation	Key Pulmonology and Thoracic Surgery Issues under Discussion in the COVID-19 Era.
Language	Spanish
Publishing date	2021-08-18
Publishing country	Spain
Document type	Journal Article
ISSN	2659-6636
ISSN (online)	2659-6636
DOI	10.1016/j.opresp.2021.100123
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Article ; Online: New Immunotherapy and Lung Cancer.

Sánchez de Cos Escuín, Julio

Archivos de bronconeumologia

2017 Volume 53, Issue 12, Page(s) 682–687

Abstract: Recent research on the relationship between the immune system and cancer has revealed the molecular mechanisms by which cancer cells co-opt certain T cell receptors which block the cytotoxic response to defend themselves from the antitumor immune attack. ...

Title translation	Nueva inmunoterapia y cáncer de pulmón.
Abstract	Recent research on the relationship between the immune system and cancer has revealed the molecular mechanisms by which cancer cells co-opt certain T cell receptors which block the cytotoxic response to defend themselves from the antitumor immune attack. These findings have helped identify specific targets (T cell receptors or their corresponding ligands) for the design of monoclonal antibodies that can unlock the immune response. These drugs, known as immune checkpoint inhibitors, have shown efficacy in metastatic melanoma and kidney cancer, and have been successfully tested in non-small cell lung cancer in recent trials. Immune checkpoint inhibitors were included in clinical practice as a second-line option after an initial chemotherapy (CT) regimen, and in the last year positive results have been reported from randomized trials in which they were compared in first line with standard CT. Responses have been surprising and durable, but less than 20%-25% in unselected patients, so it is essential that factors predicting efficacy be identified. One such biomarker is PD-L1, but the different methods used to detect it have produced mixed results. This non-systematic review discusses the results of the latest trials, the possibilities of incorporating these drugs in first-line regimens, the criteria for patient selection, adverse effects, and the prospects of combinations with conventional treatment modalities, such as CT, radiation therapy, and antiangiogenic agents.
MeSH term(s)	Abatacept/therapeutic use ; Antibodies, Monoclonal/economics ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; CTLA-4 Antigen/antagonists & inhibitors ; CTLA-4 Antigen/immunology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/therapy ; Carcinoma, Small Cell/drug therapy ; Carcinoma, Small Cell/immunology ; Carcinoma, Small Cell/therapy ; Clinical Trials, Phase III as Topic ; Combined Modality Therapy ; Cost-Benefit Analysis ; Forecasting ; Humans ; Immunologic Surveillance ; Immunotherapy/economics ; Immunotherapy/methods ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Lung Neoplasms/therapy ; Molecular Targeted Therapy/economics ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Radiotherapy, Adjuvant ; Randomized Controlled Trials as Topic ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes, Cytotoxic/immunology ; Therapies, Investigational
Chemical Substances	Antibodies, Monoclonal ; B7-H1 Antigen ; CD274 protein, human ; CTLA-4 Antigen ; CTLA4 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell ; Abatacept (7D0YB67S97)
Language	Spanish
Publishing date	2017-12
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2017.06.016
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Article ; Online: Prognostic Factors in Stage I Lung Cancer.

Sánchez de Cos-Escuín, Julio

Archivos de bronconeumologia

2015 Volume 51, Issue 9, Page(s) 427–428

MeSH term(s)	Humans ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Neoplasm Staging ; Prognosis ; Survival Rate
Language	Spanish
Publishing date	2015-09
Publishing country	Spain
Document type	Editorial
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2015.06.002
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Article ; Online: Diagnosis and treatment of neuroendocrine lung tumors.

Sánchez de Cos Escuín, Julio

Archivos de bronconeumologia

2014 Volume 50, Issue 9, Page(s) 392–396

Abstract: Pulmonary neuroendocrine tumors (PNT) encompass a broad spectrum of tumors including typical carcinoid (TC) and atypical (AC) tumors, large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC). Although no variety can be considered ... ...

Abstract	Pulmonary neuroendocrine tumors (PNT) encompass a broad spectrum of tumors including typical carcinoid (TC) and atypical (AC) tumors, large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC). Although no variety can be considered benign, AC and TC have a much lower metastatic potential, are usually diagnosed in early stages, and most are candidates for surgical treatment. Several chemotherapy (CT) regimens are available in the case of recurrence or in advanced stages, although scientific evidence is insufficient. LCNEC, which is currently classified alongside large-cell carcinomas, have molecular features, biological behavior and CT sensitivity profile closely resembling SCLC. Pathological diagnosis is often difficult, despite the availability of immunohistochemical techniques, and surgical specimens may be necessary. The diagnostic tests used are similar to those used in other lung tumors, with some differences in the optimal tracer in positron emission tomography. The new TNM classification is useful for staging these tumors. Carcinoid syndrome, very rare in PNT, may cause symptoms that are difficult to control and requires special therapy with somatostatin analogs and other drugs. Overall, with the exception of SCLC, new trials are needed to provide a response to the many questions arising with regard to the best treatment in each lineage and each stage.
MeSH term(s)	Carcinoid Tumor/diagnosis ; Carcinoid Tumor/therapy ; Carcinoma, Large Cell/diagnosis ; Carcinoma, Large Cell/therapy ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/therapy
Language	Spanish
Publishing date	2014-09
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2014.02.004
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Article ; Online: Estadificación y pronóstico molecular del cáncer de pulmón.

Sánchez de Cos Escuín, Julio

Archivos de bronconeumologia

2011 Volume 47, Issue 11, Page(s) 539–540

Title translation	Molecular staging and prognosis in lung cancer.
MeSH term(s)	Biomarkers, Tumor/analysis ; Chemotherapy, Adjuvant ; Gene Expression Profiling ; Humans ; Lung Neoplasms/chemistry ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Molecular Diagnostic Techniques ; Molecular Targeted Therapy ; Neoplasm Staging ; Patient Selection ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	Spanish
Publishing date	2011-11
Publishing country	Spain
Document type	Editorial
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2011.06.014
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Article ; Online: El cáncer de pulmón en España. Epidemiología, supervivencia y tratamiento actuales.

Escuín, Julio Sánchez De Cos

Archivos de bronconeumologia

2009 Volume 45, Issue 7, Page(s) 341–348

Abstract: In 2005, 19 115 people died of lung cancer in Spain. In spite of the increase since 1950 in absolute mortality rates, the adjusted rate for men has declined. The incidence among women is lower in Spain than in other countries but it has increased (with a ...

Title translation	Lung cancer in Spain. Current epidemiology, survival, and treatment.
Abstract	In 2005, 19 115 people died of lung cancer in Spain. In spite of the increase since 1950 in absolute mortality rates, the adjusted rate for men has declined. The incidence among women is lower in Spain than in other countries but it has increased (with a ratio of 1 woman for every 8.5 men). More than 50% of the patients are over 70 years of age. While the proportion of adenocarcinomas relative to other histological types has increased worldwide, squamous cell carcinoma still predominates in Spain (ranging from 24%-50.5%). The number of patients treated by surgical resection has not increased (14.8% in Spain in 2003). Operative mortality is 6.8%. Between 25% and 50% of patients receive only palliative medication. Absolute overall survival in patients with lung cancer is under 10% in many countries. The 5-year survival rate among patients treated surgically has increased slightly, with stage IA rates ranging from 58.3% to 68.5% and stage IIIA from 28.3% to 35.8%.
MeSH term(s)	Adenocarcinoma/epidemiology ; Adenocarcinoma/mortality ; Adenocarcinoma/therapy ; Age Distribution ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/epidemiology ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/therapy ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/therapy ; Comorbidity ; Drug Utilization ; Europe/epidemiology ; Female ; Humans ; Incidence ; Lung Neoplasms/epidemiology ; Lung Neoplasms/mortality ; Lung Neoplasms/therapy ; Male ; Mass Screening ; Mortality/trends ; Palliative Care ; Pneumonectomy/mortality ; Pneumonectomy/utilization ; Sex Distribution ; Spain/epidemiology ; Survival Rate ; United States/epidemiology ; Waiting Lists
Chemical Substances	Antineoplastic Agents
Language	Spanish
Publishing date	2009-07
Publishing country	Spain
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2008.06.005
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Article ; Online: Biological Marker Analysis as Part of the CIBERES-RTIC Cancer-SEPAR Strategic Project on Lung Cancer.

Monsó, Eduard / Montuenga, Luis M / Sánchez de Cos, Julio / Villena, Cristina

Archivos de bronconeumologia

2015 Volume 51, Issue 9, Page(s) 462–467

Abstract: The aim of the Clinical and Molecular Staging of Stage I-IIp Lung Cancer Project is to identify molecular variables that improve the prognostic and predictive accuracy of TMN classification in stage I/IIp non-small cell lung cancer (NSCLC). Clinical data ...

Abstract	The aim of the Clinical and Molecular Staging of Stage I-IIp Lung Cancer Project is to identify molecular variables that improve the prognostic and predictive accuracy of TMN classification in stage I/IIp non-small cell lung cancer (NSCLC). Clinical data and lung tissue, tumor and blood samples will be collected from 3 patient cohorts created for this purpose. The prognostic protein signature will be validated from these samples, and micro-RNA, ALK, Ros1, Pdl-1, and TKT, TKTL1 y G6PD expression will be analyzed. Tissue inflammatory markers and stromal cell markers will also be analyzed. Methylation of p16, DAPK, RASSF1a, APC and CDH13 genes in the tissue samples will be determined, and inflammatory markers in peripheral blood will also be analyzed. Variables that improve the prognostic and predictive accuracy of TNM in NSCLC by molecular staging may be identified from this extensive analytical panel.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/classification ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cohort Studies ; Humans ; Lung Neoplasms/classification ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Neoplasm Staging ; Research Design
Language	Spanish
Publishing date	2015-09
Publishing country	Spain
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2014.11.010
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Article ; Online: Tumor-associated metabolic and inflammatory responses in early stage non-small cell lung cancer: Local patterns and prognostic significance.

Millares, Laura / Barreiro, Esther / Cortes, Roldan / Martinez-Romero, Anabel / Balcells, Cristina / Cascante, Marta / Enguita, Ana Belen / Alvarez, Carlos / Rami-Porta, Ramón / Sánchez de Cos, Julio / Seijo, Luis / Monsó, Eduard

Lung cancer (Amsterdam, Netherlands)

2018 Volume 122, Page(s) 124–130

Abstract: Introduction: Non-small cell lung cancer (NSCLC) patients diagnosed in early stage and surgically-treated have five-year mortality rate >20%. The identification of biomarkers able to predict progression and death may help to identify patients needing ... ...

Abstract	Introduction: Non-small cell lung cancer (NSCLC) patients diagnosed in early stage and surgically-treated have five-year mortality rate >20%. The identification of biomarkers able to predict progression and death may help to identify patients needing closer follow-up. Methods: A retrospective cohort of early-stage surgically-treated NSCLC patients enrolled in the International Association for the Study of Lung Cancer (IASLC) Staging Project was created, and tissue Microarrays (TMAs) were constructed with tumor and non-tumor lung tissue. Pentose phosphate pathway (PPP) proteins (transketolase [TKT] and transketolase-like 1 [TKTL1]), inflammatory markers (cyclooxygenase-2 [COX-2], tumor necrosis factor alpha [TNF-α], interleukin 1 beta [IL1β], nuclear factor kappa-light-chain-enhancer of activated B cells [NFκB]-p65 and antigen Ki-67), and programmed death-ligand 1 (PDL1) were measured by immunohistochemistry. Results: NSCLC patients with adenocarcinoma (ADC) or squamous cell carcinoma (SCC) were included in the study (n = 199). TKT and TKTL1 were significantly higher in ADC than in non-tumor tissue (p < 0.001). Higher values were also observed in NSCLC for all the inflammatory markers, with figures >30% above those of non-tumor tissue (p < 0.001). PDL1 analysis showed a higher percentage of positivity in ADC than in non-tumor tissue (p < 0.001). Multivariate Cox proportional hazards modeling confirmed that high IL1β level in tumor tissue was independently associated with 3-year mortality in NSCLC [HR = 2.05, 95% CI (1.1-3.7), p = 0.019], a relationship driven by ADC subtype. Conclusion: This study confirms an increase in metabolic activity and an inflammatory response in tumor tissue of early stage NSCLC, and a significant relationship between high levels of IL1β in the tumor and poor prognosis in ADC.
MeSH term(s)	Aged ; Biomarkers, Tumor/metabolism ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/mortality ; Cohort Studies ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Inflammation Mediators/metabolism ; Lung Neoplasms/diagnosis ; Lung Neoplasms/immunology ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Signal Transduction ; Survival Analysis ; Tissue Array Analysis ; Transketolase/metabolism
Chemical Substances	Biomarkers, Tumor ; Inflammation Mediators ; TKTL1 protein, human (EC 2.2.1.1) ; Transketolase (EC 2.2.1.1)
Language	English
Publishing date	2018-06-10
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2018.06.015
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Article ; Online: Recommendations of the Spanish Society of Pneumology and Thoracic Surgery on the diagnosis and treatment of non-small-cell lung cancer.

Álvarez, Felipe Villar / Trueba, Ignacio Muguruza / Sanchis, José Belda / López-Rodó, Laureano Molins / Rodríguez Suárez, Pedro Miguel / de Cos Escuín, Julio Sánchez / Barreiro, Esther / Henar Borrego Pintado, M / Vicente, Carlos Disdier / Aldeyturriaga, Javier Flandes / Gámez García, Pablo / Garrido López, Pilar / León Atance, Pablo / Izquierdo Elena, José Miguel / Novoa Valentín, Nuria M / Rivas de Andrés, Juan José / Crespo, Íñigo Royo / Velázquez, Ángel Salvatierra / Seijo Maceiras, Luis M /

Reina, Segismundo Solano / Bujanda, David Aguiar / Ávila Martínez, Régulo J / de Granda Orive, José Ignacio / Martínez, Eva de Higes / Gude, Vicente Díaz-Hellín / Flor, Raúl Embún / Freixinet Gilart, Jorge L / García Jiménez, María Dolores / Alarza, Fátima Hermoso / Sarmiento, Samuel Hernández / Honguero Martínez, Antonio Francisco / Jiménez Ruiz, Carlos A / Sanz, Iker López / Mariscal de Alba, Andrea / Martínez Vallina, Primitivo / Menal Muñoz, Patricia / Pérez, Laura Mezquita / Olmedo García, María Eugenia / Rombolá, Carlos A / Arregui, Íñigo San Miguel / Somiedo Gutiérrez, María Del Valle / Triviño Ramírez, Ana Isabel / Trujillo Reyes, Joan Carles / Vallejo, Carmen / Lozano, Paz Vaquero / Simó, Gonzalo Varela / Zulueta, Javier J

Archivos de bronconeumologia

2016 Volume 52 Suppl 1, Page(s) 2–62

Title translation	Recomendaciones SEPAR de diagnóstico y tratamiento del cáncer de pulmón de células no pequeñas.
Language	Spanish
Publishing date	2016-05
Publishing country	Spain
Document type	Journal Article
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/S0300-2896(16)30198-3
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