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Article ; Online: Magnetic Targeting of 5-Fluorouracil-Loaded Liposome-Nanogels for In Vivo Breast Cancer Therapy and the Cytotoxic Effects on Liver and Kidney.

Ulker, Damla / Ozyurt, Rumeysa / Erkasap, Nilufer / Butun, Vural

2022 Volume 23, Issue 8, Page(s) 289

Abstract: In our previous paper, we demonstrated the ex vivo studies of non-toxic liposome-nanogel systems by which the long-term drug release could be provided from hybrid systems for the 5-fluorouracil (5-FU) drug molecule. The aim of this study was the in vivo ... ...

Abstract	In our previous paper, we demonstrated the ex vivo studies of non-toxic liposome-nanogel systems by which the long-term drug release could be provided from hybrid systems for the 5-fluorouracil (5-FU) drug molecule. The aim of this study was the in vivo magnetic targeting of 5-FU-loaded Fe
MeSH term(s)	Mice ; Animals ; Fluorouracil ; Nanogels ; Liposomes/pharmacology ; Caspase 3 ; Caspase 9 ; Tumor Suppressor Protein p53/pharmacology ; Antineoplastic Agents/therapeutic use ; Nanoparticles ; Liver ; Kidney ; Magnetic Phenomena ; RNA, Messenger/pharmacology ; Drug Delivery Systems ; Drug Carriers/pharmacology ; Cell Line, Tumor
Chemical Substances	Fluorouracil (U3P01618RT) ; polyethylene glycol polyethyleneimine nanogel ; Nanogels ; Liposomes ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; Tumor Suppressor Protein p53 ; Antineoplastic Agents ; RNA, Messenger ; Drug Carriers
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-022-02438-y
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Article ; Online: The Effect of Antioxidant Astaxanthin on Intestinal Ischemia Reperfusion Damage in Rats.

Yilmaz, Arda Sakir / Badak, Bartu / Erkasap, Nilufer / Ozkurt, Mete / Colak, Ertugrul

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2023 Volume 36, Issue 1, Page(s) 2182930

Abstract: Background: Mesenteric ischemia is a frequently encountered disease in surgical clinics, difficult to diagnose, and very mortal if not treated. Our study investigated the effects of astaxanthin, which is known to have potent antioxidant properties and ... ...

Abstract	Background: Mesenteric ischemia is a frequently encountered disease in surgical clinics, difficult to diagnose, and very mortal if not treated. Our study investigated the effects of astaxanthin, which is known to have potent antioxidant properties and is also known to have anti-inflammatory effects on ischemia-reperfusion (I/R) injury. Methods: A total of 32 healthy Wistar albino female rats were used in our study. Subjects were randomized and equally divided into 4 groups; control (laparotomy group only), I/R (transient mesenteric ischemia group only), astaxanthin 1 mg/kg and 10 mg/kg doses. The transient ischemia time was 60 minutes and the reperfusion time was 120 minutes. Tissue samples were taken from intracardiac blood and terminal ileum after reperfusion. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) from blood samples, interleukin-1 (IL-1), IL-6, tumor necrosis factor-α (TNFα), Caspase-3, P53 tests from terminal ileum were studied. Tissue samples were also taken for histopathological evaluation. Results: At the end of the study, both doses of astaxanthin were found to significantly reduce MDA level, CAT, and SOD enzymatic activity, whereas higher doses of astaxanthin significantly reduced MDA level, CAT, and SOD enzyme activities. In addition, cytokines such as TNFα, IL-1 and IL-6 were found to be reduced at both doses of astaxanthin, but only significantly inhibited at higher doses. We observed that inhibition of apoptosis reduced caspase-3 activity and P53 and deoxyribonucleic acid (DNA) fragmentation. Conclusion: Astaxanthin, a potent antioxidant, and anti-inflammatory, significantly reduces ischemia and reperfusion injury, especially when used at a dose of 10 mg/kg. These data need to be confirmed by larger animal series and clinical studies.
MeSH term(s)	Humans ; Rats ; Animals ; Antioxidants/therapeutic use ; Rats, Wistar ; Caspase 3/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Mesenteric Ischemia ; Interleukin-6 ; Tumor Suppressor Protein p53/therapeutic use ; Ischemia ; Reperfusion Injury/drug therapy ; Reperfusion Injury/etiology ; Reperfusion Injury/prevention & control ; Interleukin-1/therapeutic use ; Superoxide Dismutase/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Malondialdehyde
Chemical Substances	Antioxidants ; Caspase 3 (EC 3.4.22.-) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; astaxanthine (8XPW32PR7I) ; Tumor Suppressor Protein p53 ; Interleukin-1 ; Superoxide Dismutase (EC 1.15.1.1) ; Anti-Inflammatory Agents ; Malondialdehyde (4Y8F71G49Q)
Language	English
Publishing date	2023-03-05
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941939.2023.2182930
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Article ; Online: Investigation of the Anti-inflammatory Effects of Astaxanthin on Liver Tissue in Lipopolysaccharide-induced Sepsis in Rats

Nurdan Çobaner / Birgül Yelken / Nilufer Erkasap / Mete Özkurt / Ezgi Bektur

Türk Yoğun Bakim Derneği Dergisi, Vol 20, Iss 2, Pp 79-

2022 Volume 85

Abstract: Objective:Corticosteroids are one of the treatment methods used to prevent inflammation in sepsis. This study aimed to determine the anti-inflammatory activity of astaxanthin in sepsis and compare it with dexamethasone.Materials and Methods:After ... ...

Abstract	Objective:Corticosteroids are one of the treatment methods used to prevent inflammation in sepsis. This study aimed to determine the anti-inflammatory activity of astaxanthin in sepsis and compare it with dexamethasone.Materials and Methods:After approval of the local ethics committee, 40 Sprague-Dawley male rats were randomly assigned to the control group (n=8), lipopolysaccharide group (n=8), astaxanthin group (n=8), astaxanthin + lipopolysaccharide group (n=8) and dexamethasone + lipopolysaccharide group (n=8). On day 1, these groups were given dimethyl sulfoxide, Salmonella typhimurium lipopolysaccharide, astaxanthin dissolved in dimethyl sulfoxide, astaxanthin and lipopolysaccharide and dexamethasone and lipopolysaccharide, respectively. After 24 hours, rats underwent laparotomy, and liver and blood samples were taken. GraphPad Prism 6 was used for statistical analysis. P values less than 0.05 were considered significant.Results:Nuclear factor-kappa B levels in both treatment groups significantly decreased when compared with the lipopolysaccharide group. Apoptotic cells and reaction severity decreased significantly in the treatment groups compared with the lipopolysaccharide group.Conclusion:This study revealed that the use of astaxanthin had a positive effect on liver tissue undergoing treatment for sepsis. Moreover, despite some differences, measurement values were comparable when dexamethasone was administered.
Keywords	astaxanthin ; dexamethasone ; anti-inflammatory ; liver ; Medicine ; R ; Internal medicine ; RC31-1245 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Subject code	630
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
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Article ; Online: Targeting of Notch, IL-1, and leptin has therapeutic potential in xenograft colorectal cancer.

Özyurt, Rumeysa / Erkasap, Nilüfer / Özkurt, Mete / Erkasap, Serdar / Dimas, Konstantinos / Çakir Gündoğdu, Ayşe / Ulukaya, Engin

Turkish journal of biology = Turk biyoloji dergisi

2023 Volume 47, Issue 4, Page(s) 290–300

Abstract: Background/aim: Colorectal cancer (CRC) is a fatal malignancy type and its occurence still needs to be explored mechanistically. Notch, IL-1, and leptin crosstalk is reported to play a role in the proliferation, migration, and expression of ... ...

Abstract	Background/aim: Colorectal cancer (CRC) is a fatal malignancy type and its occurence still needs to be explored mechanistically. Notch, IL-1, and leptin crosstalk is reported to play a role in the proliferation, migration, and expression of proangiogenic molecules. In this study, we aimed to investigate the effect of inhibition of Notch, IL-1, and leptin on CRC. Materials and methods: To generate colorectal cancer tumor xenografts, 1 × 10 Results: There is an intact Notch, IL-1, and leptin signaling axis, and in vivo antagonism of Notch, IL-1, and leptin affects mRNA and protein expression of inflammatory and angiogenic molecules. Conclusion: Present data suggest that targeting Notch, IL-1, and leptin may be possesses therapeutic potential in CRC.
Language	English
Publishing date	2023-08-10
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2046470-8
ISSN	1303-6092 ; 1303-6092
ISSN (online)	1303-6092
ISSN	1303-6092
DOI	10.55730/1300-0152.2663
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Article: Role of Notch, IL-1 and leptin expression in colorectal cancer.

Erkasap, Nilufer / Ozyurt, Rumeysa / Ozkurt, Mete / Erkasap, Serdar / Yasar, Fatih / Ihtiyar, Enver / Ciftci, Evrim / Canaz, Funda / Colak, Ertugrul

Experimental and therapeutic medicine

2021 Volume 21, Issue 6, Page(s) 600

Abstract: An increasing number of studies have shown that angiogenesis has an important role in the progression of cancer. The growth of a new network of blood vessels is crucial for tumor growth and metastasis, which is promoted by several proangiogenic factors. ... ...

Abstract	An increasing number of studies have shown that angiogenesis has an important role in the progression of cancer. The growth of a new network of blood vessels is crucial for tumor growth and metastasis, which is promoted by several proangiogenic factors. Leptin, an essential adipokine that is secreted from fat tissue, is one of these pro-angiogenic factors. It has been shown that the inhibition of leptin-induced angiogenesis resulted in decreased levels of vascular endothelial growth factor (VEGF)/VEGFR2, hypoxia inducible factor (HIF) 1α, NF-κB, IL-1 and Notch and reduced the tumor growth in breast cancer. Leptin induces angiogenesis in breast cancer either by upregulating VEGFR2 in endothelial cells or by increasing VEGF/VEGFR2 expression through the Notch, IL-1 and leptin crosstalk outcome (NILCO) pathway. NILCO is a novel mechanism that interacts with proinflammatory and proangiogenic signals, which are critical for cell proliferation and angiogenesis in cancer. Several studies have shown that components of NILCO may affect human cancer incidence and progression. However, to the best of our knowledge, the interactions between Notch, IL-1 and leptin in human colorectal cancer have not been yet studied at the molecular level. The aim of the present study was to investigate the expression levels of genes related to the NILCO pathway in human colorectal cancer specimens. The current results demonstrated that leptin, leptin receptor (ObR) b, Notch-1, Notch-4, IL-1α, IL-1β, IL-1R, IL-6, JAK-2, STAT-1, STAT-3, VEGFA, VEGFR1, VEGFR2, TNF-α and NF-κB mRNA expression levels in the cancer tissue were increased compared with the normal tissue. No significant changes in the mRNA expression levels of Jagged-1, HIF-1α and TNF receptor 1 were observed. Western blotting revealed that the protein expression levels of IκB were increased in the cancer tissue compared with normal tissue, whereas HIF-1α and phosphorylated STAT-1 levels were decreased. IL-6 and VEGFA plasma concentrations were statistically raised and the leptin plasma concentration was also raised, although significantly, patients with cancer compared with control individuals. Together, the present findings indicated that Notch, IL-1 and leptin may serve a crucial role in the development of colorectal cancer.
Language	English
Publishing date	2021-04-11
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2021.10032
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Article ; Online: The role of anakinra in the modulation of intestinal cell apoptosis and inflammatory response during ischemia/reperfusion

Kandemir, Muhammed / Yaşar, Necdet Fatih / Özkurt, Mete / Özyurt, Rumeysa / Bektur Aykanat, Nuriye Ezgi / Erkasap, Nilüfer

Turkish journal of medical sciences

2021 Volume 51, Issue 4, Page(s) 2177–2184

Abstract: Background/aim: Even though interleukin-1 receptor antagonist, IL-1Ra, is used in certain inflammatory diseases, its effect on ischemia-reperfusion injury is a current research topic. We aimed to investigate the protective effects of anakinra, an IL-1Ra, ...

Abstract	Background/aim: Even though interleukin-1 receptor antagonist, IL-1Ra, is used in certain inflammatory diseases, its effect on ischemia-reperfusion injury is a current research topic. We aimed to investigate the protective effects of anakinra, an IL-1Ra, on the I/R induced intestinal injury. Materials and methods: The rat model of intestinal ischemia-reperfusion was induced. Rats were randomized into 4 groups: (group 1) control group, (group 2) I/R group, (group 3 and 4) treatment groups (50 mg/kg and 100 mg/kg, respectively). Gene expressions of caspase-3, TNF-α, IL-1α, IL-6, and apoptotic cells in tissue samples were evaluated by PCR and TUNEL methods, respectively. Plasma levels of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) were studied by the ELISA method and tissue samples were examined histopathologically as well. Results: Anakinra inhibited the expression of IL-1α, IL-6, and TNF-α and decreased the SOD, CAT, and MDA caused by ischemia- reperfusion injury in both treatment groups. Caspase-3 expression and TUNEL-positive cell number in treatment groups were also less. Histopathologically, anakinra better preserved the villous structure of the small intestine at a dose of 100 mg/kg than 50 mg/kg. Conclusion: Anakinra decreased the intestinal damage caused by ischemia-reperfusion and a dose of 100 mg/kg was found to be histopathologically more effective.
MeSH term(s)	Animals ; Antirheumatic Agents/pharmacology ; Apoptosis/drug effects ; Caspase 3/genetics ; Interleukin 1 Receptor Antagonist Protein/pharmacology ; Interleukin-6 ; Ischemia ; Malondialdehyde/blood ; Rats ; Reperfusion ; Reperfusion Injury/drug therapy ; Superoxide Dismutase/blood ; Tumor Necrosis Factor-alpha
Chemical Substances	Antirheumatic Agents ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Malondialdehyde (4Y8F71G49Q) ; Superoxide Dismutase (EC 1.15.1.1) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2021-08-30
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2008-258
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Article: SERCA in genesis of arrhythmias: what we already know and what is new?

Erkasap, Nilüfer

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology

2007 Volume 7 Suppl 1, Page(s) 43–46

Abstract: This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion translocating ATPases and pumps ... ...

Abstract	This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion translocating ATPases and pumps free cytosolic calcium into intracellular stores. Active transport of Ca2+ is achieved, according to the E1-E2 model, changing of SERCA structure by Ca2+. The affinity of Ca2+ -binding sites varies from high (E1) to low (E2). Three different SERCA genes were identified-SERCA1, SERCA2, and SERCA3. SERCA is mainly represented by the SERCA2a isoform in the heart. In heart muscle, during systole, depolarization triggers the release of Ca2+ from the sarcoplasmic reticulum (SR) and starts contraction. During diastole, muscle relaxation occurs as Ca2+ is again removed from cytosol, predominantly by accumulation into SR via the action of SERCA2a. The main regulator of SERCA2a is phospholamban and another regulator proteolipid of SERCA is sarcolipin. There are a lot of studies on the effect of decreased and/or increased SERCA activity in genesis of arrhythmia. Actually both decrease and increase of SERCA activity in the heart result in some pathological mechanisms such as heart failure and arrhythmia.
MeSH term(s)	Arrhythmias, Cardiac/physiopathology ; Calcium Signaling ; Humans ; Sarcoplasmic Reticulum/enzymology ; Sarcoplasmic Reticulum/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism
Chemical Substances	Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8)
Language	English
Publishing date	2007-07
Publishing country	Turkey
Document type	Journal Article ; Review
ZDB-ID	2278670-3
ISSN	1308-0032 ; 1302-8723
ISSN (online)	1308-0032
ISSN	1302-8723
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Article ; Online: Ceranib-2 inhibits HIF1-α gene expression and induces apoptosis in HepG2 cells

Cemile Meral / Mete Ozkurt / Rumeysa Özyurt / Abdullah Karadağ / Nılufer Erkasap

Cukurova Medical Journal, Vol 45, Iss 4, Pp 1318-

2020 Volume 1325

Abstract: Purpose: The aim of this study is to investigate the apoptotic effect of a novel anti-cancer drug, ceranib-2 and impact on HIF-1α levels on HepG2. Materials and Methods: The cell line was treated in vitro with 0,1, 1, 5, 10, 25 and 50 µM ceranib-2 for 24 ...

Abstract	Purpose: The aim of this study is to investigate the apoptotic effect of a novel anti-cancer drug, ceranib-2 and impact on HIF-1α levels on HepG2. Materials and Methods: The cell line was treated in vitro with 0,1, 1, 5, 10, 25 and 50 µM ceranib-2 for 24 and 48 hours and cell viabilitiy was determined. mRNA levels of acid ceramidase, caspase-3, caspase-8, caspase-9, Cyc1, HIF-1α and TNF-α were measured by qPCR. Results: Ceranib-2 at 10 µM concentration reduced the viability by about 58 % after 24 and 48 hours. The same dose increased mRNA level of caspase-3 and no change was detected on caspase-8 when compared to the control group after 24 hours. No difference was detected on caspase-3, but caspase-8 mRNA level increased after 48 hours with ceranib-2 at 10 µM concentration. Caspase-9 mRNA levels did not differ after 24 and 48 hours. Ceranib-2 at 10 µM concentration lowered mRNA level of Cyc1 against the control group after the 24- hour treatment. ASAH mRNA level was reduced after the 48-hour treatment with 10 µM ceranib-2. Reduction of ASAH indicated that 10 µM ceranib-2 could inhibit ceramidase after 48 hours and this may elavate ceramide concentration. TNF-α mRNA increased after 24 and 48 hours, but HIF-1α expression was low after 24 hours when compared to the control group. Conclusion: We have found that ceranib-2 induces apoptosis in HepG2, thus ceranib-2 may play an anti-cancer role at 10 µM concentration.
Keywords	hepg2 ; apoptosis ; hif-1α ; tnf-α ; ceranib ; ceranib-2 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Cukurova University
Document type	Article ; Online
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Article: Parenchymal Pressure Inconsistency in Different Brain Areas After Kaolin Injection into the Subarachnoid Space of Neonatal Rats.

Vural, Murat / Cosan, T Erhan / Uzuner, Kubilay / Erkasap, Nilufer / Cosan, Didem / Bal, Cengiz

Turkish neurosurgery

2018 Volume 28, Issue 1, Page(s) 142–148

Abstract: Aim: To describe the relationship between the parenchymal pressure changes and the development of hydrocephalus in kaolininjected neonatal rats according to cerebral regions and time intervals of developing hydrocephalus.: Material and methods: ... ...

Abstract	Aim: To describe the relationship between the parenchymal pressure changes and the development of hydrocephalus in kaolininjected neonatal rats according to cerebral regions and time intervals of developing hydrocephalus. Material and methods: Neonatal rats aged 2 to 3 days were examined in 5 groups as kaolin frontal "K-F", kaolin parietal "KP", saline frontal "SF-F", saline parietal "SF-P" and control "C", based on the injected material and injection sites. All injections were performed into the cortical subarachnoid space of the right frontal and right parietal regions. The fifth group was injection free. On the 3 < sup > rd < /sup > , 7 < sup > th < /sup > , 15 < sup > th < /sup > , 30 < sup > th < /sup > and 60 < sup > th < /sup > days after injection, parenchymal pressures (PP) of 5-7 rats from each group were measured from different regions. Results: We compared the control group with saline-injected and kaolin-injected groups and found statistically significant parenchymal pressure differences based on regional measurements. In the kaolin groups, the mean PP values were obviously higher than the saline-injected group. Within each kaolin-injected group, the pressure values were variable and inconsistent regarding the parenchymal regions. Conclusion: Hydrocephalus cannot be totally explained with existent "bulk-flow" or "hydrodynamic" theories. Although our experimental design was planned to develop hydrocephalus according to the bulk flow theory, our results were more compatible with the hydrodynamic theory. The present comments on the occurrence and pathogenesis of hydrocephalus are still open to debate and may require further comprehensive studies.
MeSH term(s)	Animals ; Animals, Newborn ; Brain/drug effects ; Brain/physiopathology ; Hydrocephalus/chemically induced ; Hydrocephalus/physiopathology ; Injections ; Kaolin/toxicity ; Male ; Parenchymal Tissue/drug effects ; Parenchymal Tissue/physiopathology ; Pressure ; Rats ; Rats, Sprague-Dawley ; Subarachnoid Space/drug effects ; Subarachnoid Space/physiopathology
Chemical Substances	Kaolin (24H4NWX5CO)
Language	English
Publishing date	2018
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1203779-5
ISSN	1019-5149
ISSN	1019-5149
DOI	10.5137/1019-5149.JTN.18072-16.1
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Article: Protective effect of chitosan treatment against acetaminophen-induced hepatotoxicity.

Ozcelik, Eda / Uslu, Sema / Erkasap, Nilufer / Karimi, Hadi

The Kaohsiung journal of medical sciences

2014 Volume 30, Issue 6, Page(s) 286–290

Abstract: Acetaminophen (APAP) is the most commonly reported toxic ingestion in the world. Severe liver injury resulting from overdose or chronic use of APAP remains a significant clinical problem. In recent years, the mechanisms underlying liver injury caused by ... ...

Abstract	Acetaminophen (APAP) is the most commonly reported toxic ingestion in the world. Severe liver injury resulting from overdose or chronic use of APAP remains a significant clinical problem. In recent years, the mechanisms underlying liver injury caused by APAP have become much better understood. We have studied the protective effect of chitosan supplementation against APAP-induced hepatotoxicity with respect to changes in the levels of total and lipid-bound sialic acid in the serum and in the liver tissue and changes in the activity of diagnostic marker enzymes, lipid peroxidation, and ceruloplasmin oxidase enzyme in normal and experimental groups of rats. During the experimental period, chitosan (200 mg/kg body weight per day) was administered to APAP + chitosan-treated rats by oral gavage. Results showed that treatment with APAP induced a significant increase in the serum alanine aminotransferase and alkaline phosphatase activities, in total and lipid-bound sialic acids levels, and in the liver lipid peroxide content. The administration of chitosan significantly prevented APAP-induced alterations in the levels of diagnostic marker enzymes, total sialic acid, lipid-bound sialic acid, and malondialdehyde in the experimental groups of rats. Furthermore, chitosan administration increased the activity of ceruloplasmin oxidase. In conclusion, our results suggest that chitosan has a protective effect on APAP-induced hepatic injury in rats. The study sheds light on the therapeutic potential of chitosan in an APAP-induced hepatotoxicity model.
MeSH term(s)	Acetaminophen/adverse effects ; Animals ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/enzymology ; Chitosan/therapeutic use ; Male ; Protective Agents/therapeutic use ; Rats, Sprague-Dawley
Chemical Substances	Protective Agents ; Acetaminophen (362O9ITL9D) ; Chitosan (9012-76-4)
Language	English
Publishing date	2014-06
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	1607-551X ; 0257-5655
ISSN	1607-551X ; 0257-5655
DOI	10.1016/j.kjms.2014.02.003
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