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Article ; Online: Analysis of the Correlation/Agreement of Maternal-fetal Doppler Parameters in Normal and Growth-Restricted Fetuses.

Pinsuti, Ederlei Munhoz / Bruns, Rafael Frederico / Kulak Júnior, Jaime / Carvalho, Newton Sérgio / Nascimento, Dênis José / Zamarian, Ana Cristina Perez / Araújo Júnior, Edward

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

2022 Volume 44, Issue 2, Page(s) 118–124

Abstract: Objective: To assess the degree of correlation/agreement of maternal-fetal Doppler parameters between normal and growth-restricted fetuses (fetal growth restriction [FGR]).: Methods: The present observational and retrospective study included 274 ... ...

Title translation	Análise da correlação/concordância dos parâmetros Doppler materno-fetal em fetos normais e com restrição do crescimento.
Abstract	Objective: To assess the degree of correlation/agreement of maternal-fetal Doppler parameters between normal and growth-restricted fetuses (fetal growth restriction [FGR]). Methods: The present observational and retrospective study included 274 singleton pregnancies. The following maternal-fetal Doppler parameters were assessed: uterine artery (UAt), umbilical artery (UA), middle cerebral artery (MCA), cerebroplacental ratio (CPR), and umbilical-cerebral ratio (U/C). The assessment of FGR was based on the Figueiras and Gratacós9 criteria. Spearman correlation coefficients were estimated to assess the correlation between resistance (RI) and pulsatility (PI) indices of Doppler parameters. The agreement between two Doppler parameters was assessed by the Kappa coefficient. Results: In total, 502 Doppler examinations were included, and FGR was observed in 19 out of 274 fetuses. A strong correlation was observed between RI and PI of UAt, UA, and MCA in all of the samples ( Conclusion: Strong correlation was observed among RI and PI UAt, UA, and MCA Doppler examinations in the present study; however, weak agreement was observed between U/C and CPR in the normal and FGR fetuses. In SGA, U/C and CPR demonstrated moderate agreement.
MeSH term(s)	Female ; Fetal Growth Retardation/diagnostic imaging ; Fetus/blood supply ; Fetus/diagnostic imaging ; Gestational Age ; Humans ; Middle Cerebral Artery/diagnostic imaging ; Pregnancy ; Pulsatile Flow ; Retrospective Studies ; Ultrasonography, Doppler ; Ultrasonography, Prenatal ; Umbilical Arteries/diagnostic imaging
Language	English
Publishing date	2022-02-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0041-1741453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association between decreased ovarian reserve and poor oocyte quality.

Scantamburlo, Viviane Margareth / Linsingen, Renate von / Centa, Lidio Jair Ribas / Toso, Kahisa Fontana Dal / Scaraboto, Debora / Araujo Júnior, Edward / Kulak Junior, Jaime

Obstetrics & gynecology science

2021 Volume 64, Issue 6, Page(s) 532–539

Abstract: Objective: To analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young women undergoing controlled ovarian stimulation (COS).: Methods: This retrospective study included 49 patients classified as having DOR ... ...

Abstract	Objective: To analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young women undergoing controlled ovarian stimulation (COS). Methods: This retrospective study included 49 patients classified as having DOR based on anti-Müllerian hormone (AMH) levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocytes were analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilized gonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. The Student's t test or Mann-Whitney test was used to compare the groups. Spearman's coefficients were estimated to verify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate the association between patient- and oocyte-related variables, logistic regression models were adjusted. Results: Women with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DOR according to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according to AFC had an increased risk of abnormally shaped oocytes (P=0.035). Conclusion: This study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes in young women who underwent COS.
Language	English
Publishing date	2021-10-19
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2814367-X
ISSN	2287-8580 ; 2287-8572
ISSN (online)	2287-8580
ISSN	2287-8572
DOI	10.5468/ogs.20168
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Article ; Online: Estrogen and progesterone receptors in endometriosis.

Guimarães Ferreira, Luiz R / Cavalcanti, Teresa / Zomer, Monica / Kondo, William / Araujo Júnior, Edward / Kulak Junior, Jaime

Minerva obstetrics and gynecology

2021 Volume 74, Issue 4, Page(s) 330–336

Abstract: Background: This study aims to identify the presence of estrogen and progesterone hormone receptors in endometriosis implants and to determine whether hormone treatment influences the receptors in these implants.: Methods: Cross-sectional study with ... ...

Abstract	Background: This study aims to identify the presence of estrogen and progesterone hormone receptors in endometriosis implants and to determine whether hormone treatment influences the receptors in these implants. Methods: Cross-sectional study with historical data collection. The analysis was conducted on 156 endometriosis implants from 67 patients undergoing endometriosis laparoscopy. The patients were divided into two groups: one group underwent hormone treatment (N.=20) and another group did not receive hormone treatment (N.=47) prior to surgery. Women of reproductive age with clinical pain and/or infertility who were diagnosed with endometriosis and underwent surgery were included. The specimens were analyzed after the estrogen and progesterone hormone receptors underwent immunohistochemistry. Results: All analyzed topographies presented estrogen and progesterone hormone receptors. Progesterone hormone receptor expression was considerably superior to estrogen receptor expression (P<0.001). Conclusions: Hormone receptors are present in endometriosis implants on the ovarian fossae, uterosacral ligaments, sac fundus, and ovaries. Progesterone receptors predominate in implants, regardless of hormonal treatment.
MeSH term(s)	Cross-Sectional Studies ; Endometriosis/surgery ; Female ; Hormone Replacement Therapy ; Humans ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism
Chemical Substances	Receptors, Estrogen ; Receptors, Progesterone
Language	English
Publishing date	2021-09-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062815-5
ISSN	2724-6450
ISSN (online)	2724-6450
DOI	10.23736/S2724-606X.21.04888-0
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Article: Analysis of the Correlation/Agreement of Maternal–fetal Doppler Parameters in Normal and Growth-Restricted Fetuses

Pinsuti, Ederlei Munhoz / Bruns, Rafael Frederico / Kulak Júnior, Jaime / Carvalho, Newton Sérgio / Nascimento, Dênis José / Zamarian, Ana Cristina Perez / Araújo Júnior, Edward

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics

2022 Volume 44, Issue 02, Page(s) 118–124

Abstract: Objective: To assess the degree of correlation/agreement of maternal–fetal Doppler parameters between normal and growth-restricted fetuses (fetal growth restriction [FGR]).: Methods: The present observational and retrospective study included 274 ... ...

Abstract	Objective: To assess the degree of correlation/agreement of maternal–fetal Doppler parameters between normal and growth-restricted fetuses (fetal growth restriction [FGR]). Methods: The present observational and retrospective study included 274 singleton pregnancies. The following maternal–fetal Doppler parameters were assessed: uterine artery (UAt), umbilical artery (UA), middle cerebral artery (MCA), cerebroplacental ratio (CPR), and umbilical–cerebral ratio (U/C). The assessment of FGR was based on the Figueiras and Gratacós9 criteria. Spearman correlation coefficients were estimated to assess the correlation between resistance (RI) and pulsatility (PI) indices of Doppler parameters. The agreement between two Doppler parameters was assessed by the Kappa coefficient. Results: In total, 502 Doppler examinations were included, and FGR was observed in 19 out of 274 fetuses. A strong correlation was observed between RI and PI of UAt, UA, and MCA in all of the samples ( p < 0.001). Of the 502 Doppler examinations, there was agreement between U/C and CPR percentiles for 480 (95.6%) and disagreement for 22 (4.4%), with Kappa coefficient of 0.26, thereby corresponding to weak agreement. Of the 68 cases with estimated fetal weight ≤ 9 th percentile (small for gestational age [SGA]), there was agreement between U/C > 1.0 and CPR < 5 th percentile in 61 (88.4%) and disagreement in 7 (5.8%) with Kappa coefficient of 0.49, thereby corresponding to moderate agreement. Conclusion: Strong correlation was observed among RI and PI UAt, UA, and MCA Doppler examinations in the present study; however, weak agreement was observed between U/C and CPR in the normal and FGR fetuses. In SGA, U/C and CPR demonstrated moderate agreement.
Keywords	fetal growth restriction ; doppler ; cerebroplacental ratio ; agreement ; correlation ; restrição do crescimento fetal ; doppler ; relação cérebro-placentária ; concordância ; correlação
Language	English
Publishing date	2022-02-01
Publisher	Thieme Revinter Publicações Ltda.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0041-1741453
Database	Thieme publisher's database

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Article ; Online: Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review.

Dias, Rejane Camila Alvarenga / Kulak Junior, Jaime / Ferreira da Costa, Eloise Haydeê / Nisihara, Renato Mitsunori

International journal of rheumatic diseases

2019 Volume 22, Issue 11, Page(s) 1961–1971

Abstract: Introduction: Fibromyalgia (FM) symptoms worsen in a significant portion of patients with the onset of menopause. Some patients report that their symptoms begin after menopause, suggesting a relationship between these entities. Sleep disturbance is a ... ...

Abstract	Introduction: Fibromyalgia (FM) symptoms worsen in a significant portion of patients with the onset of menopause. Some patients report that their symptoms begin after menopause, suggesting a relationship between these entities. Sleep disturbance is a common condition in FM and menopause, and it is associated with chronic pain. Methods/objectives: Several electronic databases were searched, from the first available year to April 2018 to evaluate the publications that assessed the effects of menopause and sleep disturbance on the appearance or worsening of FM and the role of hormone therapy for these patients. Results: The results are summarized in three tables. The objective sleep patterns of FM patients included high sleep latency, frequent arousals and intrusion of alpha wave sleep and NREM (non-rapid eye movement) sleep in delta sleep. Poor sleep during menopause is more frequent in late perimenopause and surgical menopause, and may be related to vasomotor symptoms or not. Hormone therapy exerted a positive effect on subjective sleep quality of symptomatic menopausal women. Studies have shown a high association between FM and early and surgical menopause. Raloxifene exerted a positive effect on pain and sleep in FM patients; however one study that analyzed the effects of transdermal estrogen therapy found no improvement in subjective and objective parameters of pain. Conclusion: Further studies are needed to elucidate the nature of the association between menopause, sleep and persistent pain syndromes, such as FM, showing the role of hormone therapy in prospective placebo-controlled trials.
MeSH term(s)	Estrogen Replacement Therapy ; Female ; Fibromyalgia/diagnosis ; Fibromyalgia/drug therapy ; Fibromyalgia/epidemiology ; Fibromyalgia/physiopathology ; Humans ; Menopause/drug effects ; Prognosis ; Risk Assessment ; Risk Factors ; Sleep/drug effects ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/drug therapy ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/physiopathology
Language	English
Publishing date	2019-10-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.13713
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Article ; Online: Initial evaluation in the climacteric.

Baccaro, Luiz Francisco Cintra / Paiva, Lúcia Helena Simões da Costa / Nasser, Elizabeth Jeha / Valadares, Ana Lúcia Ribeiro / Silva, Célia Regina da / Nahas, Eliana Aguiar Petri / Kulak Junior, Jaime / Rodrigues, Márcio Alexandre Hipólito / Albernaz, Marco Aurélio / Wender, Maria Celeste Osório / Mendes, Maria Célia / Dardes, Rita de Cassia de Maio / Strufaldi, Rodolfo / Bocardo, Rogerio Cesar / Pompei, Luciano de Melo

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

2022 Volume 44, Issue 5, Page(s) 548–556

MeSH term(s)	Climacteric ; Humans ; Menopause
Language	English
Publishing date	2022-06-13
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0042-1750282
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Article ; Online: Genitourinary Syndrome of Menopause.

Valadares, Ana Lúcia Ribeiro / Kulak Junior, Jaime / Paiva, Lúcia Helena Simões da Costa / Nasser, Elizabeth Jeha / Silva, Célia Regina da / Nahas, Eliana Aguiar Petri / Baccaro, Luiz Francisco Cintra / Rodrigues, Márcio Alexandre Hipólito / Albernaz, Marco Aurélio / Wender, Maria Celeste Osório / Mendes, Maria Célia / Dardes, Rita de Cassia de Maio / Strufaldi, Rodolfo / Bocardo, Rogerio Cesar / Pompei, Luciano de Melo

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

2022 Volume 44, Issue 3, Page(s) 319–324

MeSH term(s)	Female ; Female Urogenital Diseases/diagnosis ; Humans ; Menopause ; Syndrome ; Vagina
Language	English
Publishing date	2022-05-16
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0042-1748463
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Article ; Online: Bone disease after transplantation: osteoporosis and fractures risk.

Kulak, Carolina A M / Borba, Victoria Z C / Kulak Júnior, Jaime / Custódio, Melani Ribeiro

Arquivos brasileiros de endocrinologia e metabologia

2014 Volume 58, Issue 5, Page(s) 484–492

Abstract: Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post ... ...

Abstract	Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pathogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.
MeSH term(s)	Bone Diseases/etiology ; Bone Diseases/prevention & control ; Bone Marrow Transplantation/adverse effects ; Bone Resorption/etiology ; Calcium/blood ; Diphosphonates/therapeutic use ; Heart Transplantation/adverse effects ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Liver Transplantation/adverse effects ; Lung Transplantation/adverse effects ; Osteoporotic Fractures/etiology ; Transplantation/adverse effects ; Vitamin D/therapeutic use
Chemical Substances	Diphosphonates ; Immunosuppressive Agents ; Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2014-08-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	603919-4
ISSN	1677-9487 ; 0004-2730
ISSN (online)	1677-9487
ISSN	0004-2730
DOI	10.1590/0004-2730000003343
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Article ; Online: SERMs in the prevention and treatment of postmenopausal osteoporosis: an update.

Kulak Júnior, Jaime / Kulak, Carolina Aguiar Moreira / Taylor, Hugh S

Arquivos brasileiros de endocrinologia e metabologia

2010 Volume 54, Issue 2, Page(s) 200–205

Abstract: Selective estrogen receptor modulators (SERMs) have the ability to bind the estrogen receptor (ER) and are known to confer ER agonist or antagonist effects depending on the target tissue. A number of newer SERMs, including bazedoxifene, lasofoxifene and ... ...

Abstract	Selective estrogen receptor modulators (SERMs) have the ability to bind the estrogen receptor (ER) and are known to confer ER agonist or antagonist effects depending on the target tissue. A number of newer SERMs, including bazedoxifene, lasofoxifene and ospemifene, are currently under clinical development for the prevention and treatment of postmenopausal osteoporosis and for other indications. Although the possibility of developing a single agent that has all of the desired characteristics of an ideal SERM seems to be unlikely, progress in the clinical development of SERMs targeted to the ER suggests that these newer compounds may have attributes that represent an improvement relative to existing SERMs. A new approach to menopausal therapy is the tissue selective estrogen complex or the pairing of a selective estrogen receptor modulator with estrogens. Further investigation will help to clarify relative benefits/risks of novel SERMs in development within specific indications.
MeSH term(s)	Female ; Humans ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/prevention & control ; Selective Estrogen Receptor Modulators/administration & dosage ; Selective Estrogen Receptor Modulators/therapeutic use
Chemical Substances	Selective Estrogen Receptor Modulators
Language	English
Publishing date	2010-05-14
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	603919-4
ISSN	1677-9487 ; 0004-2730
ISSN (online)	1677-9487
ISSN	0004-2730
DOI	10.1590/s0004-27302010000200016
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Article ; Online: Safety, Efficacy and Patient Acceptability of Bazedoxifene Acetate in the Management of Postmenopausal Osteoporosis

Tayane Muniz Fighera / Carolina Aguiar Moreira Kulak / Jaime Kulak Júnior

Clinical Medicine Insights : Women's Health, Vol 2012, Iss 5, Pp 9-

2012 Volume 16

Keywords	Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2012-03-01T00:00:00Z
Publisher	Libertas Academica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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