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Article: Diabetes, COVID-19 and Mucormycosis: Unanswered Questions!

Rastogi, Ashu / Jude, Edward B

Indian journal of endocrinology and metabolism

2021 Volume 25, Issue 3, Page(s) 191–192

Language	English
Publishing date	2021-10-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2600211-5
ISSN	2230-9500 ; 2230-8210
ISSN (online)	2230-9500
ISSN	2230-8210
DOI	10.4103/ijem.ijem_284_21
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Article: Triple challenge of diabetes, COVID-19, and mucormycosis.

Rastogi, Ashu / Khamesra, Anshu

International journal of diabetes in developing countries

2021 Volume 42, Issue 1, Page(s) 171–172

Language	English
Publishing date	2021-08-13
Publishing country	India
Document type	Journal Article
ZDB-ID	2263351-0
ISSN	1998-3832 ; 0973-3930
ISSN (online)	1998-3832
ISSN	0973-3930
DOI	10.1007/s13410-021-00991-z
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Article ; Online: Second Malignancy Masquerading as Recurrence of Neuroendocrine Tumor.

Chakraborty, Ananda Mohan / Bhardwaj, Neha / Rastogi, Ashu / Bhadada, Sanjay Kumar

JCEM case reports

2024 Volume 2, Issue 2, Page(s) luad127

Abstract: Neuroendocrine tumors (NETs) may mimic many endocrine syndromes, including Cushing syndrome (CS) secondary to ectopic ACTH secretion. Radiotherapy (RT) is often used as adjuvant therapy for such persistent or recurrent NETs. However, RT may predispose a ... ...

Abstract	Neuroendocrine tumors (NETs) may mimic many endocrine syndromes, including Cushing syndrome (CS) secondary to ectopic ACTH secretion. Radiotherapy (RT) is often used as adjuvant therapy for such persistent or recurrent NETs. However, RT may predispose a susceptible person to a second malignancy. Here, we reported the story of a 37-year-old male, who presented with progressive weight loss, bone pain, and shortness of breath in the emergency department. He was diagnosed with CS secondary to a carcinoid tumor in the bronchopulmonary tree a decade previous and underwent total bilateral adrenalectomy. He also underwent lobectomy, and subsequent RT for a primary NET and was in clinical remission. His presenting symptoms were considered a recurrence of pulmonary NETs. However, the biopsy suggested high-grade mucoepidermoid carcinoma (MEC). MEC of the lung is a rare tumor with a prevalence of <1% of all lung malignancies. MEC of the lung after RT for bronchial NET-causing ectopic CS has not yet been reported in the literature. The present patient did not survive despite achieving remission of CS and primary tumor because of the aggressive second malignancy attributed to RT, which was given for the primary tumor.
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luad127
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Article ; Online: Understanding the diabetes self-care behaviour in rural areas: Perspective of patients with type 2 diabetes mellitus and healthcare professionals.

Gupta, Saurabh Kumar / Lakshmi, P V M / Chakrapani, Venkatesan / Rastogi, Ashu / Kaur, Manmeet

PloS one

2024 Volume 19, Issue 2, Page(s) e0297132

Abstract: Background: Diabetes self-care behaviour plays a crucial role in managing the diabetes effectively and preventing complications. Patients with type 2 diabetes mellitus (T2DM) and health care professionals (HCPs) of rural areas often face unique ... ...

Abstract	Background: Diabetes self-care behaviour plays a crucial role in managing the diabetes effectively and preventing complications. Patients with type 2 diabetes mellitus (T2DM) and health care professionals (HCPs) of rural areas often face unique challenges when it comes to diabetes self-care practices (SCPs). Therefore, this study aim to explore the perspectives of patients with T2DM and HCPs on diabetes SCPs. Methods: Eight focus group discussions (FGDs) among individuals with T2DM and In-depth interviews (IDIs) with 15 HCPs were conducted in rural areas of Punjab, North India. Capability, Opportunity, Motivation, and Behaviour model (COM-B) was employed for thematic framework analyses. Results: The study participants perceived that a limited understanding of diabetes mellitus (DM), beliefs in alternative therapies, drug side effects, attitudes towards DM (psychological capability), comorbidities (physical capability), family support (social opportunity), financial and time constraints, and weather conditions (physical opportunity) contributed to lack of DM SCPs. Physicians' guidance and support were motivating them to adhere to SCPs, especially when aligned with their sense of self-efficacy (reflective motivation). HCPs constraints in providing patient-centred care are due to training limitations (psychological capability) and a lack of essential resources (physical opportunities). Participants expressed need for comprehensive diabetes care (automatic motivation) through structured diabetes education intervention to improve diabetes SCPs. Conclusions: The study findings indicate that various factors influence diabetes SCPs from the perspectives of both patients with T2DM and HCPs and emphasizes the need for a multi-faceted approach to improve diabetes SCPs in rural areas. Implementing a structured diabetes self-care intervention strategy in rural areas may help for preventing and mitigating the impact of diabetes-related complications in rural areas.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/therapy ; Diabetes Mellitus, Type 2/psychology ; Self Care ; Motivation ; Health Personnel/psychology ; Attitude of Health Personnel ; Qualitative Research
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297132
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Article ; Online: Development and evaluation of self-care intervention to improve self-care practices among people living with type 2 diabetes mellitus

Manmeet Kaur / Ashu Rastogi

BMJ Open, Vol 11, Iss

a mixed-methods study protocol

2021 Volume 7

Abstract: Introduction The management of diabetes mellitus (DM) depends on medication adherence, self-care and regular follow-up to prevent complications and premature mortality. This study aims to develop and implement the behavioural change theory and model ... ...

Abstract	Introduction The management of diabetes mellitus (DM) depends on medication adherence, self-care and regular follow-up to prevent complications and premature mortality. This study aims to develop and implement the behavioural change theory and model based diabetes self-care intervention package to improve self-care practices among people living with type 2 DM.Methods and analysis An exploratory sequential mixed-method study design wherein, quantitative follows qualitative will be used to develop, implement and evaluate the effect of diabetes self-care intervention package among people living with type 2 diabetes. The qualitative research method will be used to identify barriers and facilitators for self-care practices among people living with type 2 DM and will also provide the basis for the development of the diabetes self-care intervention package. The quasi-experimental with control study design will be used to evaluate the developed intervention package among 220 randomly selected people living with type 2 diabetes in both intervention and control arms. Baseline, follow-ups and endline data will be collected using same prevalidated and structured questionnaire for each self-care activity. Difference-in-difference analysis will be used to measure for changes in the proportion of people living with type 2 DM doing different component of self-care practices, preintervention and postintervention in both arms.Ethics and dissemination Permission for conducting the study has been taken from Institutional Ethical Committee of PGIMER, Chandigarh (Ref no. NK/4538/PhD/226, Dated 18.08.18). The findings of the trial will be disseminated through publication in peer-reviewed journals.Trial registration number CTRI/2018/10/016108; Pre-results.
Keywords	Medicine ; R
Subject code	650
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
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Article ; Online: A paradigm shift for cardiovascular outcome evaluation in diabetes: Major adverse cardiovascular events (MACE) to major adverse vascular events (MAVE).

Rastogi, Ashu / Sudhayakumar, Anand / Schaper, Nicolaas C / Jude, Edward B

Diabetes & metabolic syndrome

2023 Volume 17, Issue 11, Page(s) 102875

Abstract: Background and aims: Drugs for diabetes are required to demonstrate cardiovascular safety through CV outcome trials (CVOT). The pre-defined end-points for cardiovascular outcome studies may not be sufficient to capture all clinically relevant ... ...

Abstract	Background and aims: Drugs for diabetes are required to demonstrate cardiovascular safety through CV outcome trials (CVOT). The pre-defined end-points for cardiovascular outcome studies may not be sufficient to capture all clinically relevant atherosclerotic cardio vascular disease (ASCVD) events particularly peripheral arterial disease (PAD). Methods: We planned a scoping review and searched database to identify CVOT conducted in population with diabetes measuring lower limb events due to PAD as the primary outcome measure. We also searched CVOT for reported differential cardiovascular outcomes in population with PAD. Results: We identified that CV outcomes are measured as 3 point major adverse cardiovascular outcomes (3P-MACE) that includes nonfatal MI and nonfatal stroke or 4P-MACE that included additional unstable angina which is further expanded to 5P-MACE by the inclusion of hospitalization for heart failure (HHF). These CV end points are captured as surrogate for CV mortality based on the biological plausibility of relation between the surrogate and final outcome from pathophysiological studies. We found the prevalence of PAD is no lesser than other CV events in people with diabetes. Moreover, PAD contributes to the significant morbidity associated with diabetes as a surrogate for mortality. However, none of the CVOT with anti-diabetic drugs include PAD events as primary outcome measure despite the inclusion of 6-25 % participants with PAD in major CVOT. PAD outcomes are objectively measurable with tibial arterial waveforms and clinical end-point as lower extremity amputation. PAD outcomes do improve with treatment including intensive glycemic control and novel oral anticoagulants. We suggest the inclusion of PAD to MACE as a pre-specified outcome for a comprehensive capture of major adverse vascular event in future studies for people with diabetes. Conclusions: MACE should be expanded to include PAD event as major adverse vascular event in cardiovascular outcome studies since PAD is clinically relevant and objectively measurable in diabetes.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/therapeutic use ; Risk Factors ; Atherosclerosis/drug therapy ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/epidemiology ; Outcome Assessment, Health Care ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/chemically induced
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2023-10-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2023.102875
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Article: Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts.

Kulkarni, Sudhir A / Deshpande, Supreet K / Rastogi, Ashu

Frontiers in endocrinology

2022 Volume 13, Page(s) 926129

Abstract: Aims/objectives: Wound healing in people with diabetes is delayed secondary to impaired nitric oxide generation, advanced glycation end products (AGE), and poor migration of epithelial cells. We developed a novel topical esmolol hydrochloride (Galnobax) ...

Abstract	Aims/objectives: Wound healing in people with diabetes is delayed secondary to impaired nitric oxide generation, advanced glycation end products (AGE), and poor migration of epithelial cells. We developed a novel topical esmolol hydrochloride (Galnobax) and assessed its efficacy for wound healing in streptozocin-induced diabetic hairless rat. Methods: All experiments were performed at an animal laboratory and tertiary-care research facility. Results: Esmolol inhibited the formation of sorbitol by 59% in erythrocytes in comparison to glucose-induced sorbitol levels. AGE generation in bovine serum albumin was reduced at 1 mM esmolol concentrations (2.6 ± 1.7) compared with control ( Conclusions: Topical esmolol hydrochloride is a novel, safe, and effective treatment modality that acts through pleotropic mechanisms to hasten wound healing in diabetes.
MeSH term(s)	Aldehyde Reductase/antagonists & inhibitors ; Animals ; Diabetes Complications/drug therapy ; Diabetes Mellitus/drug therapy ; Endothelial Cells ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Glucose/pharmacology ; Glycation End Products, Advanced/drug effects ; Glycation End Products, Advanced/metabolism ; Humans ; Hydroxyproline/pharmacology ; Nitric Oxide/pharmacology ; Propanolamines ; Rats ; Sorbitol/pharmacology ; Streptozocin ; Swine ; Swine, Miniature ; Wound Healing/drug effects
Chemical Substances	Glycation End Products, Advanced ; Propanolamines ; Nitric Oxide (31C4KY9ESH) ; Sorbitol (506T60A25R) ; Streptozocin (5W494URQ81) ; Aldehyde Reductase (EC 1.1.1.21) ; Glucose (IY9XDZ35W2) ; esmolol (MDY902UXSR) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.926129
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Article ; Online: Early and Intensive Glycemic Control for Diabetic Foot Ulcer Healing: A Prospective Observational Nested Cohort Study.

Dutta, Aditya / Bhansali, Anil / Rastogi, Ashu

The international journal of lower extremity wounds

2021 Volume 22, Issue 3, Page(s) 578–587

Abstract: We aimed to assess the effect of glycemic control on diabetic foot ulcer (DFU) healing. A prospective nested cohort study was employed of individuals with poorly controlled diabetes (glycated hemoglobin [ ... ...

Abstract	We aimed to assess the effect of glycemic control on diabetic foot ulcer (DFU) healing. A prospective nested cohort study was employed of individuals with poorly controlled diabetes (glycated hemoglobin [HbA
MeSH term(s)	Humans ; Diabetic Foot/diagnosis ; Diabetic Foot/therapy ; Cohort Studies ; Prospective Studies ; Glycemic Control ; Blood Glucose ; Diabetes Mellitus
Chemical Substances	Blood Glucose
Language	English
Publishing date	2021-07-19
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2171119-7
ISSN	1552-6941 ; 1534-7346
ISSN (online)	1552-6941
ISSN	1534-7346
DOI	10.1177/15347346211033458
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Article ; Online: Urinary exosomal miRNA-663a shows variable expression in diabetic kidney disease patients with or without proteinuria.

Sinha, Nisha / Puri, Veena / Kumar, Vivek / Nada, Ritambhra / Rastogi, Ashu / Jha, Vivekanand / Puri, Sanjeev

Scientific reports

2023 Volume 13, Issue 1, Page(s) 4516

Abstract: Heterogeneity in the Diabetic Kidney Disease (DKD) diagnosis makes its rational therapeutics challenging. Although albuminuria characterizes DKD, reports also indicate its prevalence among non-proteinuric. Recent understanding of disease progression has ... ...

Abstract	Heterogeneity in the Diabetic Kidney Disease (DKD) diagnosis makes its rational therapeutics challenging. Although albuminuria characterizes DKD, reports also indicate its prevalence among non-proteinuric. Recent understanding of disease progression has thus inclined the focus on proximal tubular cell damage besides the glomeruli. A non-invasive approach exploiting exosomal miRNA derived from human kidney proximal tubular cell line was, hence, targeted. Upon miRNA profiling, three miRNAs, namely, hsa-miR-155-5p, hsa-miR-28-3p, and hsa-miR-425-5p were found to be significantly upregulated, while hsa-miR-663a was downregulated under diabetic conditions. Among these, hsa-miR-663a downregulation was more pronounced in non-proteinuric than proteinuric DKD subjects and was thus selected for the bioinformatics study. Ingenuity Pathway Analysis (IPA) narrowed on to IL-8 signaling and inflammatory response as the most enriched 'canonical pathway' and 'disease pathway' respectively, during DKD. Further, the putative gene network generated from these enriched pathways revealed experimentally induced diabetes, renal tubular injury, and decreased levels of albumin as part of mapping under 'disease and function'. Genes target predictions and annotations by IPA reiterated miR-663a's role in the pathogenesis of DKD following tubular injury. Overall, the observations might offer an indirect reflection of the underlying mechanism between patients who develop proteinuria and non-proteinuria.
MeSH term(s)	Humans ; Cell Line ; Diabetes Mellitus ; Diabetic Nephropathies/metabolism ; Kidney/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Signal Transduction
Chemical Substances	MicroRNAs ; MIRN633 microRNA, human
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-26558-4
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Article ; Online: Region-wise severity analysis of diabetic plantar foot thermograms.

Sharma, Naveen / Mirza, Sarfaraj / Rastogi, Ashu / Singh, Satbir / Mahapatra, Prasant K

Biomedizinische Technik. Biomedical engineering

2023 Volume 68, Issue 6, Page(s) 607–615

Abstract: Objectives: Diabetic foot ulcers (DFU) can be avoided if symptoms of diabetic foot complications are detected early and treated promptly. Early detection requires regular examination, which might be limited for many reasons. To identify affected or ... ...

Abstract	Objectives: Diabetic foot ulcers (DFU) can be avoided if symptoms of diabetic foot complications are detected early and treated promptly. Early detection requires regular examination, which might be limited for many reasons. To identify affected or potentially affected regions in the diabetic plantar foot, the region-wise severity of the plantar foot must be known. Methods: A novel thermal diabetic foot dataset of 104 subjects was developed that is suitable for Indian healthcare conditions. The entire plantar foot thermogram is divided into three parts, i.e., forefoot, midfoot, and hindfoot. The division of plantar foot is based on the prevalence of foot ulcers and the load on the foot. To classify the severity levels, conventional machine learning (CML) techniques like logistic regression, decision tree, KNN, SVM, random forest, etc., and convolutional neural networks (CNN), such as EfficientNetB1, VGG-16, VGG-19, AlexNet, InceptionV3, etc., were applied and compared for robust outcomes. Results: The study successfully developed a thermal diabetic foot dataset, allowing for effective classification of diabetic foot ulcer severity using the CML and CNN techniques. The comparison of different methods revealed variations in performance, with certain approaches outperforming others. Conclusions: The region-based severity analysis offers valuable insights for targeted interventions and preventive measures, contributing to a comprehensive assessment of diabetic foot ulcer severity. Further research and development in these techniques can enhance the detection and management of diabetic foot complications, ultimately improving patient outcomes.
MeSH term(s)	Humans ; Diabetic Foot/diagnosis ; Diabetic Foot/etiology ; Pressure ; Foot ; Thermography ; Machine Learning ; Diabetes Mellitus
Language	English
Publishing date	2023-06-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120817-2
ISSN	1862-278X ; 0013-5585
ISSN (online)	1862-278X
ISSN	0013-5585
DOI	10.1515/bmt-2022-0376
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