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  1. Article ; Online: BAFF receptor polymorphisms and deficiency in humans.

    Sevdali, Eirini / Block Saldana, Violeta / Speletas, Matthaios / Eibel, Hermann

    Current opinion in immunology

    2021  Volume 71, Page(s) 103–110

    Abstract: The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including survival, protein synthesis, and ... ...

    Abstract The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including survival, protein synthesis, and metabolic fitness. In humans, BAFFR deficiency interrupts B cell development at the transition from immature to mature B cells and causes B lymphopenia, hypogammaglobulinemia, and impaired humoral immune responses. Polymorphisms in TNFRSF13C gene affecting BAFFR oligomerization and signaling have been described in patients with immunodeficiency, autoimmunity and B cell lymphomas. Despite a uniform expression pattern of BAFFR in peripheral mature B cells, depletion of BAFF with neutralizing antibodies in patients with systemic lupus erythematosus does not affect the survival of switched memory B cells. These findings imply a distinct dependency of mature B cell subsets on BAFF/BAFFR interaction and highlight the contribution of BAFFR-derived signals in peripheral B cell development and homeostasis.
    MeSH term(s) B-Cell Activating Factor/immunology ; B-Cell Activation Factor Receptor/deficiency ; B-Cell Activation Factor Receptor/genetics ; B-Cell Activation Factor Receptor/immunology ; B-Lymphocytes/immunology ; Homeostasis/immunology ; Humans ; Polymorphism, Genetic/genetics
    Chemical Substances B-Cell Activating Factor ; B-Cell Activation Factor Receptor ; TNFRSF13C protein, human ; TNFSF13B protein, human
    Language English
    Publishing date 2021-07-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2021.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
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    Zs.MG 13: Show issues

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  2. Article ; Online: TNFRSF13B/TACI

    Tsiouma, Georgia K / Skoulakis, Charalampos E / Lachanas, Vasileios A / Sevdali, Eirini G / Tsinti, Gerasimina N / Florou, Zoi A / Petinaki, Efthymia A / Speletas, Matthaios G

    American journal of rhinology & allergy

    2022  Volume 37, Issue 1, Page(s) 74–77

    Abstract: Background: The pathogenesis of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) remains still inconclusive. Recent studies identified an increased expression of BAFF (a B cell-activating factor) and its receptor TACI (Transmembrane Activator and cAML ... ...

    Abstract Background: The pathogenesis of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) remains still inconclusive. Recent studies identified an increased expression of BAFF (a B cell-activating factor) and its receptor TACI (Transmembrane Activator and cAML Interactor) in nasal polyp samples, while
    Objective: The aim of our study was to evaluate the possible contribution of
    Methods: Forty-four (44) patients with CRSwNP (male/female: 33/11, mean age: 52.5 years, range: 16-83) were analyzed for
    Results: No pathogenic
    Conclusion: TNFRSF13B/TACI
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.1177/19458924221134731
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2542: Show issues Location:
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  3. Article ; Online: Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis.

    Zachou, Kalliopi / Arvaniti, Pinelopi / Lyberopoulou, Aggeliki / Sevdali, Eirini / Speletas, Matthaios / Ioannou, Maria / Koukoulis, George K / Renaudineau, Yves / Dalekos, George N

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 42, Issue 6, Page(s) 1355–1368

    Abstract: Background and aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in AIH peripheral lymphocytes at ... ...

    Abstract Background and aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in AIH peripheral lymphocytes at diagnosis and remission.
    Methods: Ten AIH patients at diagnosis (time-point 1; AIH-tp1), 8/10 following biochemical response (time-point 2; AIH-tp2), 9 primary biliary cholangitis (PBC) and 10 healthy controls (HC) were investigated. Peripheral CD19(+) and CD4(+) cells were isolated. Global DNA methylation (5
    Results: Reduced TET1 and increased DNMT3A mRNA levels characterized CD19(+) and CD4(+)-lymphocytes from AIH-tp1 compared to HC and PBC, respectively, without affecting global DNA 5
    Conclusion: Altered TET1 and DNMT3A expressions, characterize peripheral lymphocytes in AIH. DNMT3A was associated with disease activity and decreased following remission. Gene DNA methylation modifications affect immunological pathways that may play an important role in AIH pathogenesis.
    MeSH term(s) CD4-Positive T-Lymphocytes ; DNA Methylation ; Hepatitis, Autoimmune/diagnosis ; Humans ; Liver Cirrhosis, Biliary/complications ; Mixed Function Oxygenases/genetics ; Proto-Oncogene Proteins/genetics ; RNA, Messenger
    Chemical Substances Proto-Oncogene Proteins ; RNA, Messenger ; Mixed Function Oxygenases (EC 1.-) ; TET1 protein, human (EC 1.-)
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15176
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
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  4. Article ; Online: CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses.

    Block, Violeta / Sevdali, Eirini / Recher, Mike / Abolhassani, Hassan / Hammarstrom, Lennart / Smulski, Cristian R / Baronio, Manuela / Plebani, Alessandro / Proietti, Michele / Speletas, Matthaios / Warnatz, Klaus / Voll, Reinhard E / Lougaris, Vassilios / Schneider, Pascal / Eibel, Hermann

    Journal of clinical immunology

    2022  Volume 43, Issue 2, Page(s) 391–405

    Abstract: Purpose: Binding of the B cell activating factor (BAFF) to its receptor (BAFFR) activates in mature B cells many essential pro-survival functions. Null mutations in the BAFFR gene result in complete BAFFR deficiency and cause a block in B cell ... ...

    Abstract Purpose: Binding of the B cell activating factor (BAFF) to its receptor (BAFFR) activates in mature B cells many essential pro-survival functions. Null mutations in the BAFFR gene result in complete BAFFR deficiency and cause a block in B cell development at the transition from immature to mature B cells leading therefore to B lymphopenia and hypogammaglobulinemia. In addition to complete BAFFR deficiency, single nucleotide variants encoding BAFFR missense mutations were found in patients suffering from common variable immunodeficiency (CVID), autoimmunity, or B cell lymphomas. As it remained unclear to which extent such variants disturb the activity of BAFFR, we performed genetic association studies and developed a cellular system that allows the unbiased analysis of BAFFR variants regarding oligomerization, signaling, and ectodomain shedding.
    Methods: In addition to genetic association studies, the BAFFR variants P21R, A52T, G64V, DUP92-95, P146S, and H159Y were expressed by lentiviral gene transfer in DG-75 Burkitt's lymphoma cells and analyzed for their impacts on BAFFR function.
    Results: Binding of BAFF to BAFFR was affected by P21R and A52T. Spontaneous oligomerization of BAFFR was disturbed by P21R, A52T, G64V, and P146S. BAFF-dependent activation of NF-κB2 was reduced by P21R and P146S, while interactions between BAFFR and the B cell antigen receptor component CD79B and AKT phosphorylation were impaired by P21R, A52T, G64V, and DUP92-95. P21R, G64V, and DUP92-95 interfered with phosphorylation of ERK1/2, while BAFF-induced shedding of the BAFFR ectodomain was only impaired by P21R.
    Conclusion: Although all variants change BAFFR function and have the potential to contribute as modifiers to the development of primary antibody deficiencies, autoimmunity, and lymphoma, P21R is the only variant that was found to correlate positively with CVID.
    MeSH term(s) Humans ; B-Cell Activating Factor/genetics ; B-Cell Activating Factor/metabolism ; B-Cell Activation Factor Receptor/genetics ; B-Cell Activation Factor Receptor/metabolism ; B-Lymphocytes ; Common Variable Immunodeficiency/genetics ; Common Variable Immunodeficiency/metabolism ; Ligands ; Signal Transduction
    Chemical Substances B-Cell Activating Factor ; B-Cell Activation Factor Receptor ; Ligands ; TNFRSF13C protein, human
    Language English
    Publishing date 2022-10-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01378-3
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    Zs.A 1640: Show issues Location:
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  5. Article ; Online: Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.

    Smulski, Cristian R / Zhang, Luyao / Burek, Malte / Teixidó Rubio, Ariadna / Briem, Jana-Susann / Sica, Mauricio P / Sevdali, Eirini / Vigolo, Michele / Willen, Laure / Odermatt, Patricia / Istanbullu, Duygu / Herr, Stephanie / Cavallari, Marco / Hess, Henry / Rizzi, Marta / Eibel, Hermann / Schneider, Pascal

    Cell reports

    2022  Volume 38, Issue 13, Page(s) 110583

    Abstract: In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency ( ... ...

    Abstract In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations.
    MeSH term(s) B-Lymphocytes ; Cell Proliferation ; Common Variable Immunodeficiency/genetics ; Common Variable Immunodeficiency/metabolism ; Humans ; Ligands ; Transmembrane Activator and CAML Interactor Protein/genetics ; Transmembrane Activator and CAML Interactor Protein/metabolism
    Chemical Substances Ligands ; Transmembrane Activator and CAML Interactor Protein
    Language English
    Publishing date 2022-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.110583
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  6. Article ; Online: BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.

    Sevdali, Eirini / Block, Violeta / Lataretu, Marie / Li, Huiying / Smulski, Cristian R / Briem, Jana-Susann / Heitz, Yannic / Fischer, Beate / Ramirez, Neftali-Jose / Grimbacher, Bodo / Jäck, Hans-Martin / Voll, Reinhard E / Hölzer, Martin / Schneider, Pascal / Eibel, Hermann

    Cell reports

    2022  Volume 39, Issue 13, Page(s) 111019

    Abstract: Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without ... ...

    Abstract Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without BAFF. Here, we show that BAFF activates PI3K/AKT only in naive B cells and changes the expression of genes regulating migration, proliferation, growth, and survival. BAFF-induced PI3K/AKT activation requires direct interactions between BAFFR and the B cell antigen receptor (BCR) components CD79A and CD79B and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also as an intrinsic factor for B cell survival.
    MeSH term(s) B-Cell Activating Factor/immunology ; B-Cell Activating Factor/metabolism ; B-Cell Activation Factor Receptor/immunology ; B-Cell Activation Factor Receptor/metabolism ; Humans ; Memory B Cells/immunology ; Memory B Cells/metabolism ; Phosphatidylinositol 3-Kinases/immunology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/immunology ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Antigen, B-Cell/immunology ; Receptors, Antigen, B-Cell/metabolism
    Chemical Substances B-Cell Activating Factor ; B-Cell Activation Factor Receptor ; Receptors, Antigen, B-Cell ; TNFRSF13C protein, human ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111019
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  7. Article ; Online: TACI Mutations in Primary Antibody Deficiencies: A Nationwide Study in Greece.

    Kakkas, Ioannis / Tsinti, Gerasimina / Kalala, Fani / Farmaki, Evangelia / Kourakli, Alexandra / Kapousouzi, Androniki / Dimou, Maria / Kalaitzidou, Vassiliki / Sevdali, Eirini / Peristeri, Athanasia-Marina / Tsiouma, Georgia / Patiou, Peristera / Papadimitriou, Eleni / Vassilakopoulos, Theodoros P / Panayiotidis, Panayiotis / Kioumi, Anna / Symeonidis, Argiris / Speletas, Matthaios

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 8

    Abstract: Background and ... ...

    Abstract Background and objectives
    MeSH term(s) B-Lymphocytes ; Female ; Greece/epidemiology ; Humans ; Male ; Mutation ; Primary Immunodeficiency Diseases ; Transmembrane Activator and CAML Interactor Protein
    Chemical Substances TNFRSF13B protein, human ; Transmembrane Activator and CAML Interactor Protein
    Language English
    Publishing date 2021-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57080827
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  8. Article ; Online: SIAE

    Sevdali, Eirini / Tsitsami, Elena / Tsinti, Maria / Farmaki, Evangelia / Papadopoulou-Alataki, Efimia / Germenis, Anastasios E / Speletas, Matthaios

    Journal of immunology research

    2017  Volume 2017, Page(s) 1514294

    Abstract: Sialic acid acetylesterase (SIAE) deficiency was suggested to lower the levels of ligands for sialic acid-binding immunoglobulin-like receptors, decreasing the threshold for B-cell activation. In humans, studies of rare heterozygous loss-of-function ... ...

    Abstract Sialic acid acetylesterase (SIAE) deficiency was suggested to lower the levels of ligands for sialic acid-binding immunoglobulin-like receptors, decreasing the threshold for B-cell activation. In humans, studies of rare heterozygous loss-of-function mutations in
    Language English
    Publishing date 2017
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2017/1514294
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  9. Article: BAFF/APRIL System Is Functional in B-Cell Acute Lymphoblastic Leukemia in a Disease Subtype Manner.

    Sevdali, Eirini / Katsantoni, Eleni / Smulski, Cristian R / Moschovi, Maria / Palassopoulou, Maria / Kolokotsa, Eleni-Nefeli / Argentou, Nikoletta / Giannakoulas, Nikolaos / Adamaki, Maria / Vassilopoulos, Georgios / Polychronopoulou, Sophia / Germenis, Anastasios E / Eibel, Hermann / Speletas, Matthaios

    Frontiers in oncology

    2019  Volume 9, Page(s) 594

    Abstract: BAFF, APRIL and their receptors regulate the survival, maturation and homeostasis of mature B-cells. Despite the lack of a functional role of BAFF/APRIL system during normal early B-cell development, previous studies indicated a contribution of these ... ...

    Abstract BAFF, APRIL and their receptors regulate the survival, maturation and homeostasis of mature B-cells. Despite the lack of a functional role of BAFF/APRIL system during normal early B-cell development, previous studies indicated a contribution of these molecules in the pathogenesis of B-lineage acute lymphoblastic leukemia (B-ALL). Here, we evaluated the expression of this system in B-ALL and its involvement in spontaneous and drug-induced apoptosis of B-lymphoblasts, taking into consideration the distinct disease subtypes. We found that BAFFR is the most predominant aberrantly expressed receptor in B-ALL and that its expression, along with BCMA and APRIL, positively correlates with the maturation stage of B-lymphoblasts. Moreover, the binding of the E2A-PBX1 chimeric protein to the
    Language English
    Publishing date 2019-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.00594
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  10. Article ; Online: TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis.

    Ntellas, Panagiotis / Dardiotis, Efthimios / Sevdali, Eirini / Siokas, Vasileios / Aloizou, Athina-Maria / Tsinti, Gerasimina / Germenis, Anastasios E / Hadjigeorgiou, Georgios M / Eibel, Hermann / Speletas, Matthaios

    Multiple sclerosis and related disorders

    2019  Volume 37, Page(s) 101422

    Abstract: Recent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently, several molecules participating in B cell survival and proliferation, including B-cell activating factor (BAFF), have recently been analyzed in MS patients. BAFF ... ...

    Abstract Recent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently, several molecules participating in B cell survival and proliferation, including B-cell activating factor (BAFF), have recently been analyzed in MS patients. BAFF mediates its function through binding to three receptors; among them, its interaction with the BAFF receptor (BAFFR) is crucial in mediating its survival function. Interestingly, two common polymorphisms of the TNFRSF13C gene, encoding BAFFR, P21R (rs77874543) and H159Y (rs61756766), have been reported to affect BAFFR assembly and signaling. In order to evaluate the possible contribution of BAFFR in MS pathogenesis and/or phenotype, we analyzed both TNFRSF13C/BAFFR polymorphisms in 486 MS patients in relation to their disease severity, their disability status and the age of disease onset and duration. As control group, we used allele frequencies extracted from the Exome Aggregation Consortium (ExAC) Browser. Interestingly, we found a higher prevalence of the H159Y polymorphism in MS patients, suggesting that enhanced BAFFR-signaling might contribute to the disease pathogenesis.
    MeSH term(s) Adult ; Age of Onset ; B-Cell Activating Factor/genetics ; B-Cell Activating Factor/immunology ; B-Cell Activation Factor Receptor/genetics ; B-Lymphocytes/immunology ; Female ; Humans ; Male ; Multiple Sclerosis/genetics ; Multiple Sclerosis/metabolism ; Polymorphism, Genetic/genetics ; Signal Transduction/genetics
    Chemical Substances B-Cell Activating Factor ; B-Cell Activation Factor Receptor ; TNFRSF13C protein, human ; TNFSF13B protein, human
    Language English
    Publishing date 2019-09-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2019.101422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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