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  1. Article: Effect of Al Content on the Wear Evolution of Ti

    Fan, Guanghui / Zhang, Jingjie / Zhang, Peirong / Du, Jin / Xu, Chonghai / Yi, Mingdong / Zhang, Guoqing

    Micromachines

    2023  Volume 14, Issue 6

    Abstract: ... ...

    Abstract Ti
    Language English
    Publishing date 2023-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14061228
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  2. Article ; Online: Detection of DNA translocations in a nanopore series circuit using a current clamp.

    Zheng, Fei / Tao, Yi / Xu, Wei / Sha, Jingjie

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 15, Page(s) 10440–10446

    Abstract: The advancement of nanopore sensing technology over the past 20 years has been impressive, particularly in the field of nucleic acid sequencing, which has already been used in commercial diagnostic tests. A traditional configuration of nanopore sensing ... ...

    Abstract The advancement of nanopore sensing technology over the past 20 years has been impressive, particularly in the field of nucleic acid sequencing, which has already been used in commercial diagnostic tests. A traditional configuration of nanopore sensing records the current through a single nanopore using a voltage clamp, which hits a bottleneck in expanding its functions, while integrating several nanopores to build a nanopore circuit may be an effective solution. Here, we report a new strategy combining a nanopore series circuit and a current clamp to record the current signal and the voltage signal of DNA translocation through a nanopore simultaneously, which could increase the fidelity of event analysis. We observed a capacitor-like charging and discharging behavior in the voltage signals and proposed a detailed microscopic mechanism to elucidate it. Our strategy could benefit the development of nanopore technology and contribute to understanding the working principles of the units in a nanopore circuit system.
    MeSH term(s) Nanopores ; DNA/analysis ; Base Sequence
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp04530c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MC design and FIB preparation of a YSZ biochemical material microstructure.

    Wang, Xintian / Cui, Hao / Chen, Zhaoqiang / Wang, Li / Chen, Jun / Yi, Mingdong / Xiao, Guangchun / Zhang, Jingjie / Chen, Hui / Xu, Chonghai

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 147, Page(s) 106152

    Abstract: Aiming at the difficulty of traditional machining of ... ...

    Abstract Aiming at the difficulty of traditional machining of Y
    Language English
    Publishing date 2023-09-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2023.106152
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  4. Article ; Online: Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

    Jingjie Yi / Omid Tavana / Huan Li / Donglai Wang / Richard J. Baer / Wei Gu

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 17

    Abstract: The clinical success of restoring P53 for cancer therapy has been limited due to toxicity. Here, the authors identify USP2 as an upstream regulator of VPRBP-mediated degradation of p53 and PD-L1 and demonstrate the efficacy of combining USP2 inhibitor ... ...

    Abstract The clinical success of restoring P53 for cancer therapy has been limited due to toxicity. Here, the authors identify USP2 as an upstream regulator of VPRBP-mediated degradation of p53 and PD-L1 and demonstrate the efficacy of combining USP2 inhibitor and PD-L1/PD-1 immune checkpoint blockade in cancers.
    Keywords Science ; Q
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Study on spatial-temporal characteristics and influencing factors of urban environmental resource efficiency in the Yangtze River Basin of China

    Jingjie Li / Junli Ding / Yi Zhang / Shanwei Li

    Frontiers in Environmental Science, Vol

    2022  Volume 10

    Abstract: There is a close relationship between environmental resource efficiency and the high-quality development of the river basin economy. Improving urban environmental resource efficiency is of great significance to the high-quality development of the river ... ...

    Abstract There is a close relationship between environmental resource efficiency and the high-quality development of the river basin economy. Improving urban environmental resource efficiency is of great significance to the high-quality development of the river basin. Based on the environmental panel data of cities in the Yangtze River Basin from 2004 to 2020, this paper applies the DEA-Malmquist index model to explore the static characteristics and dynamic changes in the overall environmental resource efficiency of cities in the Yangtze River Basin. Then, the spatial and temporal aspects of the environment are discussed by combining the kernel density function method. The Tobit regression model is used to analyze the factors affecting the environmental resource efficiency of cities in the Yangtze River Basin and its importance. Finally, the grey prediction model is utilized to predict the undesirable output data of cities in the Yangtze River Basin from 2023 to 2025. The results show that the overall urban environmental resource efficiency level in the Yangtze River Basin is high. However, the number of cities that achieve DEA efficiency is less than that of non-DEA efficient cities. The Total Factor Productivity (TFP) of cities shows a “high-low-high” trend, and the technical efficiency change (Effch) and pure technical efficiency change (Pech) have an improvement trend. Industrial structure, regional factors, and openness are positively correlated with environmental resource efficiency, during the economic scale and environmental governance level negatively moderate environmental resource efficiency. The forecast results show that the undesired output of cities in the Yangtze River Basin has been somewhat controlled.
    Keywords Yangtze river basin ; urban environmental resource efficiency ; DEA Malmquist model ; tobit regression model ; Kernel density estimation method ; grey prediction model ; Environmental sciences ; GE1-350
    Subject code 550
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: CircRNA mmu_circ_0000021 regulates microvascular function via the miR-143-3p/NPY axis and intracellular calcium following ischemia/reperfusion injury.

    Xiong, Jingjie / Hu, Yisen / Liu, Yi / Zeng, Xiaocong

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 315

    Abstract: Cardiac ischemia-reperfusion (I/R) is associated with a high rate of complications. Restoring microvascular function is crucial for cardiac repair. However, the molecular mechanisms by which the circRNAs repairs microvascular dysfunction are unknown. ... ...

    Abstract Cardiac ischemia-reperfusion (I/R) is associated with a high rate of complications. Restoring microvascular function is crucial for cardiac repair. However, the molecular mechanisms by which the circRNAs repairs microvascular dysfunction are unknown. High-throughput RNA sequencing and quantitative real-time PCR (qRT-PCR) were used to measures circRNA levels in cardiac tissue samples. We found a total of 80 up-regulated and 54 down-regulated differentially expressed circRNAs, of which mmu_circ_0000021 were consistent with bioinformatics predictions. Next, mmu_circ_0000021 knockdown and overexpression were performed to indicate the functional role of mmu_circ_0000021. The interaction of mmu_circ_0000021, miR-143-3p and NPY were evaluated using dual-luciferase assays, RNA pull-down assays and RNA immunoprecipitation (RIP). Immunohistochemistry, transmission electron microscopy, and immunofluorescence were used to determine the presence of leukocytes and changes in microvascular morphology and function. Mechanistically, mmu_circ_0000021 involved in regulating microvascular dysfunction via miR-143-3p by targeting NPY. However, the contraction of microvascular spasm caused by NPY is related to calmodulin. By regulating NPY, Circular RNA (circRNA) further affects microvascular spasm, regulates microcirculation disorders, and restores cardiac function. Our findings highlight a novel role for mmu_circ_0000021 by regulating microvascular function following I/R injury.
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01108-z
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  7. Article: Addition of Nano CaF

    Zhang, Wenhao / Chen, Zhaoqiang / Tian, Congfeng / Wu, Jun / Xiao, Guangchun / Guo, Niansheng / Yi, Mingdong / Zhang, Jingjie / Xu, Chonghai

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 15

    Abstract: The addition of ... ...

    Abstract The addition of CaF
    Language English
    Publishing date 2022-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15155430
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  8. Article: Overexpression of Activating Transcription Factor 3 Alleviates Cardiac Microvascular Ischemia/Reperfusion Injury in Rats.

    Liu, Yi / Hu, Yisen / Xiong, Jingjie / Zeng, Xiaocong

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 598959

    Abstract: Activating transcription factor 3 (ATF3) has been confirmed to be responsive to oxidative stress and to negatively regulate the activity of Toll-like receptor 4 (TLR4). However, the effect of ATF3 on cardiac microvascular ischemia/reperfusion (I/R) ... ...

    Abstract Activating transcription factor 3 (ATF3) has been confirmed to be responsive to oxidative stress and to negatively regulate the activity of Toll-like receptor 4 (TLR4). However, the effect of ATF3 on cardiac microvascular ischemia/reperfusion (I/R) injury remains unknown. The GEO2R online tool was employed to obtain differentially expressed genes GSE4105 and GSE122020, in two rat I/R injury microarray datasets. We established a rat myocardial I/R model
    Language English
    Publishing date 2021-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.598959
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  9. Article ; Online: Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.

    Yi, Jingjie / Tavana, Omid / Li, Huan / Wang, Donglai / Baer, Richard J / Gu, Wei

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1941

    Abstract: Since Mdm2 (Mouse double minute 2) inhibitors show serious toxicity in clinic studies, different approaches to achieve therapeutic reactivation of p53-mediated tumor suppression in cancers need to be explored. Here, we identify the USP2 (ubiquitin ... ...

    Abstract Since Mdm2 (Mouse double minute 2) inhibitors show serious toxicity in clinic studies, different approaches to achieve therapeutic reactivation of p53-mediated tumor suppression in cancers need to be explored. Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as an important pathway for p53 regulation. Like Mdm2, VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis also regulates PD-L1 (programmed death-ligand 1) expression. Strikingly, the combination of a small-molecule USP2 inhibitor and anti-PD1 monoclonal antibody leads to complete regression of the tumors expressing wild-type p53. In contrast to Mdm2, knockout of Usp2 in mice has no obvious effect in normal tissues. Moreover, no obvious toxicity is observed upon the USP2 inhibitor treatment in vivo as Mdm2-mediated regulation of p53 remains intact. Our study reveals a promising strategy for p53-based therapy by circumventing the toxicity issue.
    MeSH term(s) Mice ; Animals ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Proto-Oncogene Proteins c-mdm2/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Carrier Proteins ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/metabolism ; Protein Serine-Threonine Kinases/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; CD274 protein, human ; B7-H1 Antigen ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Carrier Proteins ; Usp2 protein, mouse (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; VprBP protein, mouse (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37617-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of interface layer on the enhancement of thermal conductivity of SiC-Water nanofluids: Molecular dynamics simulation.

    Zhu, Yandong / Chen, Hui / Zhang, Jingjie / Xiao, Guangchun / Yi, Mingdong / Chen, Zhaoqiang / Xu, Chonghai

    Journal of molecular graphics & modelling

    2023  Volume 127, Page(s) 108696

    Abstract: To investigate the impact of interfacial layer effects on the thermal conductivity of nanofluids and the microscopic mechanisms of enhanced thermal conductivity, this study employed non-equilibrium molecular dynamics to compute the thermal conductivity, ... ...

    Abstract To investigate the impact of interfacial layer effects on the thermal conductivity of nanofluids and the microscopic mechanisms of enhanced thermal conductivity, this study employed non-equilibrium molecular dynamics to compute the thermal conductivity, number density, radial distribution function, and mean square displacement distribution of SiC nanofluids. The impact of nanoparticle volume fraction and particle size parameters on the thermal conductivity of nanofluids and the structure of interfacial adsorption layers was discussed. The simulation calculation results show that the coefficient of thermal conductivity of nanofluid is positively related to the volume fraction of nanoparticles, increasing from 0.6529 W/(m·K) to 0.8159 W/(m·K), and the enhancement of thermal conductivity by the volume fraction can be up to 33.97 %. The thermal conductivity is inversely correlated with the change in particle size, and the maximum improvement in thermal conductivity by particle size can reach up to 12.05 %. The simulated results of the thermal conductivity of nanofluid are almost consistent with the predicted results of the Yu&Choi model, and the error is controlled within 5 %. Simultaneously, the thickness of the interfacial adsorption layer decreases with an increase in particle size. This reduction arises due to larger particles having a smaller specific surface area, resulting in fewer particle surfaces covered by the interface layer. Moreover, the impact of particle size on the arrangement and affinity of molecules within the interface layer contributes to this decrease. Overall, interface layer effects exhibit a dual impact on the thermal conduction of nanofluids. The structured formation and high-density distribution of the adsorption layer contribute to enhanced heat transfer, while thermal resistance between nanoparticle surfaces and the fluid restricts heat transmission.
    MeSH term(s) Molecular Dynamics Simulation ; Thermal Conductivity ; Adsorption ; Hot Temperature ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2023.108696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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