Article: Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptide-expressing metaplasia lesions.
World journal of gastrointestinal oncology
2021 Volume 13, Issue 11, Page(s) 1741–1754
Abstract: ... Xiaoyu granules (YWXY) in SPEM lesions.: Methods: Gastric mucosa biopsies were collected from chronic ...
Abstract | Background: Spasmolytic polypeptide-expressing metaplasia (SPEM) is a potential preneoplastic lesion. Aim: To elucidate the microRNA (miR)-7-mediated preventive and inhibitive effects of Yiwei Xiaoyu granules (YWXY) in SPEM lesions. Methods: Gastric mucosa biopsies were collected from chronic atrophic gastritis patients and healthy people with signed informed consent. YWXY was administered to the mice with induced SPEM by tamoxifen, and the gastric mucosa was harvested on the tenth day of the experiment. Then immunohistochemistry and immunofluorescence were performed to validate the SPEM, lesions and the potential mechanism was investigated. RNA transcripts were detected with reverse transcription-quantitative polymerase chain reaction. Results: The expression of miR-7 was downregulated in the SPEM lesions, and expression of trefoil factor 2 (TFF2) and clusterin was high in the human gastric mucosa. Conclusion: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa. YWXY is able to inhibit the cell proliferation and restore the expression of miR-7 by mediating TFF2 in the SPEM mouse model. |
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Language | English |
Publishing date | 2021-10-15 |
Publishing country | China |
Document type | Journal Article |
ZDB-ID | 2573696-6 |
ISSN | 1948-5204 |
ISSN | 1948-5204 |
DOI | 10.4251/wjgo.v13.i11.1741 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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