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Book: Detection of SARS-CoV-2 antibodies in diagnosis and treatment of COVID-19

Simmons, Daimon P.

(Clinics in laboratory medicine ; volume 42, number 1 (March 2022))

2022

Author's details	editors Daimon P. Simmons, Peter H. Schur
Series title	Clinics in laboratory medicine ; volume 42, number 1 (March 2022)
Collection
Language	English
Size	xiii, 128 Seiten, Illustrationen
Publisher	Elsevier
Publishing place	Philadelphia, Pennsylvania
Publishing country	United States
Document type	Book
HBZ-ID	HT021367380
ISBN	978-0-323-83586-2 ; 0-323-83586-4
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Perspectives on Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 and Its Implications for Diagnostics, Biology, and Clinical Management.

Simmons, Daimon P / Schur, Peter H

Clinics in laboratory medicine

2021 Volume 42, Issue 1, Page(s) xi–xiii

Language	English
Publishing date	2021-12-21
Publishing country	United States
Document type	Editorial
ZDB-ID	604580-7
ISSN	1557-9832 ; 0272-2712
ISSN (online)	1557-9832
ISSN	0272-2712
DOI	10.1016/j.cll.2021.12.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lessons learned: A look back at the performance of nine COVID-19 serologic assays and their proposed utility.

Tolan, Nicole V / DeSimone, Mia S / Fernandes, Maria D / Lewis, Joshua E / Simmons, Daimon P / Schur, Peter H / Brigl, Manfred / Tanasijevic, Milenko J / Desjardins, Michaël / Sherman, Amy C / Baden, Lindsey R / Snyder, Marion / Melanson, Stacy Ef

Clinical biochemistry

2023 Volume 117, Page(s) 60–68

Abstract: ... TOT was observed for Moderna vaccine recipients then Pfizer (p-values < 0.0001). A sustained RS TOT ... lower RS TOT than healthy VD (p < 0.0001) at dose 2 and 4 weeks after.: Conclusions: Our data ...

Abstract	Background: Serologic assays for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been proposed to assist with the acute diagnosis of infection, support epidemiological studies, identify convalescent plasma donors, and evaluate vaccine response. Methods: We report an evaluation of nine serologic assays: Abbott (AB) and Epitope (EP) IgG and IgM, EUROIMMUN (EU) IgG and IgA, Roche anti-N (RN TOT) and anti-S (RS TOT) total antibody, and DiaSorin (DS) IgG. We evaluated 291 negative controls (NEG CTRL), 91 PCR positive (PCR POS) patients (179 samples), 126 convalescent plasma donors (CPD), 27 healthy vaccinated donors (VD), and 20 allogeneic hematopoietic stem cell transplant (HSCT) recipients (45 samples). Results: We observed good agreement with the method performance claims for specificity (93-100%) in NEG CTRL but only 85% for EU IgA. The sensitivity claims in the first 2 weeks of symptom onset was lower (26-61%) than performance claims based on > 2 weeks since PCR positivity. We observed high sensitivities (94-100%) in CPD except for AB IgM (77%), EP IgM (0%). Significantly higher RS TOT was observed for Moderna vaccine recipients then Pfizer (p-values < 0.0001). A sustained RS TOT response was observed for the five months following vaccination. HSCT recipients demonstrated significantly lower RS TOT than healthy VD (p < 0.0001) at dose 2 and 4 weeks after. Conclusions: Our data suggests against the use of anti-SARS-CoV-2 assays to aid in acute diagnosis. RN TOT and RS TOT can readily identify past-resolved infection and vaccine response in the absence of native infection. We provide an estimate of expected antibody response in healthy VD over the time course of vaccination for which to compare antibody responses in immunosuppressed patients.
MeSH term(s)	Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; Sensitivity and Specificity ; Antibodies, Viral ; Immunoglobulin G ; COVID-19 Serotherapy ; Immunoglobulin M ; Immunoglobulin A ; COVID-19 Testing
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin A
Language	English
Publishing date	2023-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2023.03.003
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Article ; Online: Hemolysis from ABO Incompatibility.

Simmons, Daimon P / Savage, William J

Hematology/oncology clinics of North America

2015 Volume 29, Issue 3, Page(s) 429–443

Abstract: ABO incompatibility of red blood cells leads to brisk complement-mediated lysis, particularly in the setting of red cell transfusion. The ABO blood group is the most clinically significant blood group because of preformed immunoglobulin M (IgM) and IgG ... ...

Abstract	ABO incompatibility of red blood cells leads to brisk complement-mediated lysis, particularly in the setting of red cell transfusion. The ABO blood group is the most clinically significant blood group because of preformed immunoglobulin M (IgM) and IgG antibodies to ABO blood group antigens (isohemagglutinins) in everyone except group AB individuals. In addition to transfusion, ABO incompatibility can cause hemolysis in hematopoietic and solid organ transplantation, hemolytic disease of the newborn, and intravenous immunoglobulin infusion. It is important to prevent ABO incompatibility when possible and to anticipate complications when ABO incompatibility is unavoidable.
MeSH term(s)	ABO Blood-Group System/immunology ; Blood Group Incompatibility/etiology ; Blood Group Incompatibility/immunology ; Blood Group Incompatibility/prevention & control ; Blood Grouping and Crossmatching/methods ; Cell Transplantation/adverse effects ; Hemolysis/immunology ; Humans ; Models, Immunological ; Tissue Transplantation/adverse effects ; Transfusion Reaction
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	93115-9
ISSN	1558-1977 ; 0889-8588
ISSN (online)	1558-1977
ISSN	0889-8588
DOI	10.1016/j.hoc.2015.01.003
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Article: Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases.

Faust, Heather J / Cheng, Tan-Yun / Korsunsky, Ilya / Watts, Gerald F M / Gal-Oz, Shani T / Trim, William / Kongthong, Kurt / Jonsson, Anna Helena / Simmons, Daimon P / Zhang, Fan / Padera, Robert / Chubinskaya, Susan / Wei, Kevin / Raychaudhuri, Soumya / Lynch, Lydia / Moody, D Branch / Brenner, Michael B

bioRxiv : the preprint server for biology

2023

Abstract: Fibroblasts play critical roles in tissue homeostasis, but in pathologic states can drive fibrosis, inflammation, and tissue destruction. In the joint synovium, fibroblasts provide homeostatic maintenance and lubrication. Little is known about what ... ...

Abstract	Fibroblasts play critical roles in tissue homeostasis, but in pathologic states can drive fibrosis, inflammation, and tissue destruction. In the joint synovium, fibroblasts provide homeostatic maintenance and lubrication. Little is known about what regulates the homeostatic functions of fibroblasts in healthy conditions. We performed RNA sequencing of healthy human synovial tissue and identified a fibroblast gene expression program characterized by enhanced fatty acid metabolism and lipid transport. We found that fat-conditioned media reproduces key aspects of the lipid-related gene signature in cultured fibroblasts. Fractionation and mass spectrometry identified cortisol in driving the healthy fibroblast phenotype, confirmed using glucocorticoid receptor gene (
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.16.540975
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Article ; Online: Impact of allele-specific anti-human leukocyte antigen class I antibodies on organ allocation.

Yeung, Melissa Y / Murakami, Naoka / Kafetzi, Maria L / Simmons, Daimon P / Wood, Isabelle / Macaskill, Peter / Towle, Matthew / DellaGatta, Jamie / Stevens, Jonathan / Comeau, Edward / Baronas, Jane / Mohsin, Nabil / Chen, Mike / Lee, Jar-How / Lane, William J / Milford, Edgar L / Guleria, Indira

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2023 Volume 23, Issue 9, Page(s) 1388–1400

Abstract: Technological advances in the field of histocompatibility have allowed us to define anti-human leukocyte antigen (HLA) antibody specificity at the allelic level. However, how allele-specific antibodies affect organ allocation is poorly studied. We ... ...

Abstract	Technological advances in the field of histocompatibility have allowed us to define anti-human leukocyte antigen (HLA) antibody specificity at the allelic level. However, how allele-specific antibodies affect organ allocation is poorly studied. We examined allelic specificities of class I HLA antibodies in 6726 consecutive serum samples from 2953 transplant candidates and evaluated their impact on the corresponding crossmatch and organ allocation. Out of 17 class I HLA antigens represented by >1 allele in the LABScreen single antigen bead assay, 12 had potential allele-specific reactivity. Taking advantage of our unbiased cohort of deceased donor-candidate testing (123,135 complement-dependent cytotoxicity crossmatches between 2014 and 2017), we estimated that the presence of allele-specific antibody detected using a single antigen bead assay (median fluorescence intensity, >3000) against only the rare allele was a poor predictor of a positive complement-dependent cytotoxicity crossmatch, with a positive predictive value of 0% to 7%, compared with 52.5% in allele-concordant class I HLA antibodies against A or B locus antigens. Further, we confirmed allele-specific reactivity using flow crossmatch in 3 scenarios: A11:01/A11:02, A68:01/A68:02, and B44:02/B44:03. Our results suggest that allele-specific antibodies may unnecessarily exclude transplant candidates (up to 10%) from organ offers by overcalling unacceptable antigens; incorporation of selective reactivity pattern in allocation may promote precision matching and more equitable allocation.
MeSH term(s)	Humans ; Isoantibodies ; Alleles ; Histocompatibility Testing/methods ; Histocompatibility Antigens Class I/genetics ; HLA Antigens/genetics ; Antigens
Chemical Substances	Isoantibodies ; Histocompatibility Antigens Class I ; HLA Antigens ; Antigens
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1016/j.ajt.2023.05.021
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Article ; Online: High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases.

Mueller, Alisa A / Sasaki, Takanori / Keegan, Joshua W / Nguyen, Jennifer P / Griffith, Alec / Horisberger, Alice M / Licata, Thomas / Fieg, Elizabeth / Cao, Ye / Elahee, Mehreen / Marks, Kathryne E / Simmons, Daimon P / Briere, Lauren C / Cobban, Laurel A / Pallais, J Carl / High, Frances A / Walker, Melissa A / Linnoila, Jenny J / Sparks, Jeffrey A /

Holers, V Michael / Costenbader, Karen H / Sweetser, David A / Krier, Joel B / Loscalzo, Joseph / Lederer, James A / Rao, Deepak A

The Journal of clinical investigation

2023 Volume 133, Issue 24

MeSH term(s)	Humans ; Immunophenotyping ; Autoimmune Diseases/diagnosis ; Autoimmunity
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI169619
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Article ; Online: A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.

Donado, Carlos A / Cao, Anh B / Simmons, Daimon P / Croker, Ben A / Brennan, Patrick J / Brenner, Michael B

Cell reports

2020 Volume 31, Issue 1, Page(s) 107466

Abstract: Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation. Here we describe an ... ...

Abstract	Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation. Here we describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β. Following cognate interactions with TLR-primed bone marrow-derived dendritic cells (BMDCs), iNKT cells rapidly translocate intracellular Fas ligand to the surface to engage Fas on BMDCs. Fas ligation activates a caspase-8-dependent signaling cascade in BMDCs that drives IL-1β release largely independent of inflammasomes. The apoptotic program initiated by Fas ligation rapidly transitions into a pyroptosis-like form of cell death mediated by gasdermin D. Together, our findings support a two-cell model for IL-1β secretion that may supersede inflammasome activation when cytosolic triggers fail.
MeSH term(s)	Animals ; Apoptosis ; Caspase 1/metabolism ; Caspase 8/metabolism ; Dendritic Cells/metabolism ; Female ; Humans ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Interleukin-1beta/physiology ; Male ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Natural Killer T-Cells/metabolism ; Pyroptosis ; Receptors, Death Domain/metabolism ; Signal Transduction
Chemical Substances	IL1B protein, human ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; Receptors, Death Domain ; CASP8 protein, human (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2020-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2020.03.030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

Carlos A. Donado / Anh B. Cao / Daimon P. Simmons / Ben A. Croker / Patrick J. Brennan / Michael B. Brenner

Cell Reports, Vol 31, Iss 1, Pp - (2020)

2020

Abstract: Summary: Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation. Here we describe an ... ...

Abstract	Summary: Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation. Here we describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β. Following cognate interactions with TLR-primed bone marrow-derived dendritic cells (BMDCs), iNKT cells rapidly translocate intracellular Fas ligand to the surface to engage Fas on BMDCs. Fas ligation activates a caspase-8-dependent signaling cascade in BMDCs that drives IL-1β release largely independent of inflammasomes. The apoptotic program initiated by Fas ligation rapidly transitions into a pyroptosis-like form of cell death mediated by gasdermin D. Together, our findings support a two-cell model for IL-1β secretion that may supersede inflammasome activation when cytosolic triggers fail. : How the immune system triggers IL-1β release during infection with inflammasome-evasive microbes is largely unknown. Donado et al. describe an alternative, caspase-8-dependent IL-1β secretion pathway where a second cell, the invariant natural killer T (iNKT) cell, can provide antigen-presenting cells with cell-extrinsic IL-1β release signals through FasL. Keywords: interleukin-1, inflammasome, cell death, Fas, Fas ligand, NKT cell, caspase, gasdermin, apoptosis, pyroptosis
Keywords	Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validation and Implementation of an Ordering Alert to Improve the Efficiency of Monoclonal Gammopathy Evaluation.

Uljon, Sacha N / Simmons, Daimon P / Rudolf, Joseph W / Baron, Jason M / Dutta, Sayon / McEvoy, Dustin S / Murali, Mandakolathur / Dighe, Anand S

American journal of clinical pathology

2019 Volume 153, Issue 3, Page(s) 396–406

Abstract: Objectives: To evaluate the use of a provider ordering alert to improve laboratory efficiency and reduce costs.: Methods: We conducted a retrospective study to assess the use of an institutional reflex panel for monoclonal gammopathy evaluation. We ... ...

Abstract	Objectives: To evaluate the use of a provider ordering alert to improve laboratory efficiency and reduce costs. Methods: We conducted a retrospective study to assess the use of an institutional reflex panel for monoclonal gammopathy evaluation. We then created a clinical decision support (CDS) alert to educate and encourage providers to change their less-efficient orders to the reflex panel. Results: Our retrospective analysis demonstrated that an institutional reflex panel could be safely substituted for a less-efficient and higher-cost panel. The implemented CDS alert resulted in 79% of providers changing their high-cost order panel to an order panel based on the reflex algorithm. Conclusions: The validated decision support alert demonstrated high levels of provider acceptance and directly led to operational and cost savings within the laboratory. Furthermore, these studies highlight the value of laboratory involvement with CDS efforts to provide agile and targeted provider ordering assistance.
MeSH term(s)	Cost Savings ; Decision Support Systems, Clinical/economics ; Efficiency ; Humans ; Medical Order Entry Systems ; Paraproteinemias/diagnosis ; Practice Patterns, Physicians'/economics ; Retrospective Studies
Language	English
Publishing date	2019-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqz180
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