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  1. Article ; Online: The soil and the seed: The relationship between Descemet's membrane and the corneal endothelium.

    Petrela, Redion B / Patel, Sangita P

    Experimental eye research

    2022  Volume 227, Page(s) 109376

    Abstract: Descemet's membrane (DM), the basement membrane of the corneal endothelium, is formed from the extracellular matrix (ECM) secreted by corneal endothelial cells. The ECM supports the growth and function of the corneal endothelial cells. Changes to DM are ... ...

    Abstract Descemet's membrane (DM), the basement membrane of the corneal endothelium, is formed from the extracellular matrix (ECM) secreted by corneal endothelial cells. The ECM supports the growth and function of the corneal endothelial cells. Changes to DM are central to the diagnosis of the most common corneal endothelial disease, Fuchs endothelial corneal dystrophy (FECD). Changes in DM are also noted in systemic diseases such as diabetes mellitus. In FECD, the DM progressively accumulates guttae, "drop-like deposits" that disrupt the corneal endothelial cell monolayer. While the pathophysiologic changes to corneal endothelial cells in the course of FECD have been well described and reviewed, the changes to DM have received limited attention. The reciprocity of influence between the corneal endothelial cells and DM demands full attention to the latter in our search for novel treatment and preventive strategies. In this review, we discuss what is known about the formation and composition of DM and how it changes in FECD and other conditions. We review characteristics of guttae and the interplay between corneal endothelial cells and guttae, particularly as it might apply to future cell-based and genetic therapies for FECD.
    MeSH term(s) Humans ; Endothelium, Corneal ; Descemet Membrane ; Soil ; Endothelial Cells ; Fuchs' Endothelial Dystrophy
    Chemical Substances Soil
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2022.109376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis.

    Fard, Ali Mahdavi / Patel, Sangita P / Nader, Nader D

    International ophthalmology

    2023  Volume 43, Issue 11, Page(s) 4383–4393

    Abstract: Purpose: To compare the efficacy of phakic intra-ocular lenses in isolation or in combination with corneal crosslinking (CXL) and/or intra-stromal corneal ring segments (ICRS) in keratoconus.: Methods: Data extracted from the publications meeting the ...

    Abstract Purpose: To compare the efficacy of phakic intra-ocular lenses in isolation or in combination with corneal crosslinking (CXL) and/or intra-stromal corneal ring segments (ICRS) in keratoconus.
    Methods: Data extracted from the publications meeting the selection. The outcome parameters included mean pre- and post-operative uncorrected distance visual acuity, corrected distance visual acuity (CDVA), sphere and cylinder of refraction and complications. Available data analyzed with Cochrane Review Manager.
    Results: A total of 23 studies including 464 eyes were included. All the parameters showed significant improvement in all subgroups other than CDVA in ACPIOL + CXL subgroup and cylinder in PIOL + CXL subgroups. There was not a significant difference between PCPIOL and ACPIOL in the outcomes, exception was more improvement of CDVA in "ACPIOL only" than" PCPIOL only" subgroup.
    Conclusion: Both PCPIOLs and ACPIOLs are comparably safe and efficient options in management of KCN and their efficacy significantly improves when combined with CXL/ICRS.
    MeSH term(s) Humans ; Phakic Intraocular Lenses ; Photosensitizing Agents/therapeutic use ; Keratoconus/drug therapy ; Keratoconus/surgery ; Riboflavin/therapeutic use ; Collagen/pharmacology ; Collagen/therapeutic use ; Corneal Topography ; Cross-Linking Reagents/therapeutic use ; Corneal Stroma/surgery
    Chemical Substances Photosensitizing Agents ; Riboflavin (TLM2976OFR) ; Collagen (9007-34-5) ; Cross-Linking Reagents
    Language English
    Publishing date 2023-07-20
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-023-02813-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: JAK2 p.V617F detection and allele burden measurement in peripheral blood and bone marrow aspirates in patients with myeloproliferative neoplasms.

    Takahashi, Koichi / Patel, Keyur P / Kantarjian, Hagop / Luthra, Rajyalakshmi / Pierce, Sherry / Cortes, Jorge / Verstovsek, Srdan

    Blood

    2013  Volume 122, Issue 23, Page(s) 3784–3786

    Abstract: Detection of the JAK2 p.V617F mutation and measurement of its allele burden can be performed using ... However, the diagnostic accuracy of detecting the JAK2 p.V617F mutation and quantifying its allele burden in PB and BM ... been tested for JAK2 p.V617F allele burden using both PB and BM samples within 3 months ...

    Abstract Detection of the JAK2 p.V617F mutation and measurement of its allele burden can be performed using both peripheral blood (PB) and bone marrow (BM) samples from patients with myeloproliferative neoplasms (MPNs). However, the diagnostic accuracy of detecting the JAK2 p.V617F mutation and quantifying its allele burden in PB and BM samples has not been systematically compared. We retrospectively analyzed 388 patients with MPN who had been tested for JAK2 p.V617F allele burden using both PB and BM samples within 3 months of each other. The sensitivity and specificity of detecting JAK2 p.V617F in PB when compared with BM were both 100%. Furthermore, the JAK2 p.V617F allele burden measured in PB and BM were equivalent by linear regression analysis (R(2) = 0.991; P < .0001). We therefore conclude that PB is a reliable source for testing for the JAK2 p.V617F mutation and quantifying its allele burden in patients with MPN.
    MeSH term(s) Alleles ; Amino Acid Substitution ; Bone Marrow/metabolism ; Humans ; Janus Kinase 2/blood ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Linear Models ; Mutant Proteins/blood ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Mutation ; Myeloproliferative Disorders/blood ; Myeloproliferative Disorders/enzymology ; Myeloproliferative Disorders/genetics ; Polycythemia Vera/blood ; Polycythemia Vera/enzymology ; Polycythemia Vera/genetics ; Primary Myelofibrosis/blood ; Primary Myelofibrosis/enzymology ; Primary Myelofibrosis/genetics ; Reproducibility of Results ; Retrospective Studies ; Thrombocythemia, Essential/blood ; Thrombocythemia, Essential/enzymology ; Thrombocythemia, Essential/genetics
    Chemical Substances Mutant Proteins ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2013-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2013-07-515676
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  4. Article ; Online: Risk assessment of variant Creutzfeldt-Jakob disease in corneal transplantation.

    Desilets, Jeffrey / Mittal, Abhiniti / Sellick, John A / Patel, Sangita P

    American journal of ophthalmology case reports

    2023  Volume 30, Page(s) 101856

    Abstract: Purpose: While corneal transplantation is known to have a potential risk of transmission of variant Creutzfeldt-Jacob Disease (vCJD), the magnitude of this risk has not been quantified.: Observations: A case report is presented of a 73 year-old man ... ...

    Abstract Purpose: While corneal transplantation is known to have a potential risk of transmission of variant Creutzfeldt-Jacob Disease (vCJD), the magnitude of this risk has not been quantified.
    Observations: A case report is presented of a 73 year-old man with a penetrating keratoplasty graft from corneal tissue that was recalled after transplantation due to risk of vCJD because it was later discovered that the donor had traveled to the United Kingdom (UK). Probabilities of vCJD transmission were extrapolated using Creutzfeldt-Jacob Disease (CJD) mortality (incidence) rate, all-cause death rate, and rate of recovery for intended transplantation.
    Conclusions: An overestimate of the risk of transplanting a cornea infected with vCJD in 2018 was 1 in 940,000. The true risk of vCJD transmission would be even lower due to an incomplete infectivity rate. We conclude that the risk of transmission of latent vCJD by corneal transplantation from a donor who traveled to the UK from 1980 to 1996 is exceedingly low.
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2023.101856
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  5. Article: A Case Report Illustrating the Postoperative Course of Descemetorhexis without Endothelial Keratoplasty with Topical Netarsudil Therapy.

    Ploysangam, Pimpiroon / Patel, Sangita P

    Case reports in ophthalmological medicine

    2019  Volume 2019, Page(s) 6139026

    Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common indication for corneal transplantation in the United States. Recently, descemetorhexis without endothelial keratoplasty (DWEK) or Descemet's stripping only (DSO) has become an attractive ... ...

    Abstract Fuchs endothelial corneal dystrophy (FECD) is the most common indication for corneal transplantation in the United States. Recently, descemetorhexis without endothelial keratoplasty (DWEK) or Descemet's stripping only (DSO) has become an attractive alternative to corneal transplantation for these patients. DSO circumvents the challenges associated with cadaveric donor corneal transplantation by tapping into the potential of the patient's own corneal endothelium to repair defects. Outcomes have been variable with emerging knowledge on predictive factors for success. Our case describes a 51-year-old patient with visually significant confluent central guttae from FECD who underwent a successful DSO with immediate post-operative use of the Rho-associated protein kinase (ROCK) inhibitor (netarsudil). We report the preoperative and post-operative slit lamp images, specular microscopy data, and corneal topography, thickness, and densitometry data. These represent a unique data set for this new surgical treatment option for FECD. Despite a small descemetorhexis, we show the improvement in corneal thickness and opacity extends beyond the boundaries of the descemetorhexis. Early initiation of a ROCK inhibitor was a successful treatment for this patient.
    Language English
    Publishing date 2019-10-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659091-8
    ISSN 2090-6730 ; 2090-6722
    ISSN (online) 2090-6730
    ISSN 2090-6722
    DOI 10.1155/2019/6139026
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  6. Article: The bull's eye: are we off-target for corneal endothelial cell physiology?

    Patel, Sangita P

    Journal of ophthalmic & vision research

    2013  Volume 8, Issue 1, Page(s) 83–85

    Language English
    Publishing date 2013-06-25
    Publishing country India
    Document type Journal Article
    ISSN 2008-2010
    ISSN 2008-2010
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  7. Article: Prevalence and Risk Factors of Cardiac Autonomic Neuropathy in Diabetes Mellitus.

    Patel, Hiren P / Gandhi, Archana / Trivedi, Smita / Patel, Sangita

    The Journal of the Association of Physicians of India

    2020  Volume 68, Issue 5, Page(s) 54

    MeSH term(s) Autonomic Nervous System ; Autonomic Nervous System Diseases ; Diabetes Mellitus ; Diabetes Mellitus, Type 1 ; Diabetic Neuropathies ; Heart ; Humans ; Prevalence ; Risk Factors
    Language English
    Publishing date 2020-06-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
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    Zs.B 313: Show issues Location:
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  8. Article ; Online: Bilateral ocular injuries with globe perforation and retinitis sclopetaria from birdshot shotgun: A case report and review of the literature.

    Ku, Cristy A / Jeng, Franklin / Reynolds, Andrew L / Patel, Sangita P

    Trauma case reports

    2020  Volume 28, Page(s) 100329

    Language English
    Publishing date 2020-06-28
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2835433-3
    ISSN 2352-6440 ; 2352-6440
    ISSN (online) 2352-6440
    ISSN 2352-6440
    DOI 10.1016/j.tcr.2020.100329
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  9. Article ; Online: A portable, low-cost practice model for microsurgical skills training.

    Greyner-Almeida, Henry D / Mahdavi Fard, Ali / Chen, Chi / Zhao, Jiwei / Patel, Sangita P

    International ophthalmology

    2022  Volume 42, Issue 8, Page(s) 2323–2333

    Abstract: ... decrease in time required to pass the needle (P = 0.018) and significant improvement in technical scores ... P = 0.001). In the control group, there was no significant decrease in time or improvement ...

    Abstract Purpose: We describe a portable practice model for acquisition of microsurgical skills using widely available inexpensive tools and materials as a model in learning ophthalmic corneal suturing skills.
    Methods: Interested participants without prior microsurgery experience affiliated with the Jacobs School of Medicine and Biomedical Sciences with no prior microsurgical experience qualified to participate. Each participant completed written informed consent. We developed a 3-dimensional micro-stellated icosahedron model using microtubules, monofilament fishing line, jewelers' forceps, and a basic laboratory dissection microscope. We tested this model in improving microsurgical skills in a randomized, controlled intervention trial. Following a pre-assessment task of passing a microsurgical needle and performing a tie, participants were randomized to a control or an intervention (building the micro-stellated icosahedrons) group. The assessment task was repeated after two weeks. Videos of pre- and post-assessments were rated by two masked ophthalmologists. Technique scores and time to complete microsurgical tasks were analyzed to determine improvement in skills.
    Results: A total of 27 microsurgically naïve participants were recruited and randomized (14 Intervention / 13 Control). Comparing pre- and post-assessments, the intervention group showed significant decrease in time required to pass the needle (P = 0.018) and significant improvement in technical scores. (P = 0.001). In the control group, there was no significant decrease in time or improvement in technical scores.
    Conclusions: The portable inexpensive micro-stellated icosahedron skills acquisition model is an effective practice model to acquire skills necessary to perform a microsurgical tie. The similarity in dimensions between the model and the eye suggests translatability to ophthalmic surgery.
    MeSH term(s) Clinical Competence ; Humans ; Microsurgery/education ; Models, Educational ; Ophthalmology/education
    Language English
    Publishing date 2022-01-29
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-022-02229-1
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  10. Article: Comparing iStent versus CyPass with or without phacoemulsification in patients with glaucoma: a meta-analysis.

    Mahdavi Fard, Ali / Pourafkari, Leili / Patel, Sangita P / Nader, Nader D

    Therapeutic advances in chronic disease

    2019  Volume 10, Page(s) 2040622319865657

    Language English
    Publishing date 2019-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622319865657
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