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  1. Article ; Online: Effects of PCSK9 inhibitors on platelet function.

    Räber, Lorenz / Ueki, Yasushi

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2023  Volume 18, Issue 15, Page(s) 1215–1217

    MeSH term(s) Humans ; Anticholesteremic Agents ; Hemostasis ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; PCSK9 Inhibitors
    Chemical Substances Anticholesteremic Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; PCSK9 Inhibitors
    Language English
    Publishing date 2023-03-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-E-23-00005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  2. Article ; Online: In search of the pleiotropic effects of PCSK9 inhibitors.

    Räber, Lorenz / Ueki, Yasushi

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2022  Volume 18, Issue 8, Page(s) e609–e610

    MeSH term(s) Anticholesteremic Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cholesterol, LDL ; Humans ; PCSK9 Inhibitors ; Proprotein Convertase 9
    Chemical Substances Anticholesteremic Agents ; Cholesterol, LDL ; PCSK9 Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2022-10-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-E-22-00032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  3. Article ; Online: Frequency and outcomes of periprocedural myocardial infarction in patients with chronic coronary syndromes undergoing percutaneous coronary intervention.

    Ueki, Yasushi / Räber, Lorenz

    Current opinion in cardiology

    2022  Volume 37, Issue 6, Page(s) 488–494

    Abstract: Purpose of review: Various definitions of periprocedural myocardial infarction (MI) have been proposed by academic groups and professional societies differing in terms of biomarker thresholds and ancillary criteria for myocardial ischemia. The incidence ...

    Abstract Purpose of review: Various definitions of periprocedural myocardial infarction (MI) have been proposed by academic groups and professional societies differing in terms of biomarker thresholds and ancillary criteria for myocardial ischemia. The incidence and clinical significance of periprocedural MI substantially varies according to the definitions applied. In this review, we summarize available clinical data on the frequency and outcomes of periprocedural MI according to various MI definitions in patients undergoing percutaneous coronary intervention (PCI).
    Recent findings: Numerous clinical studies and meta-analyses have investigated the incidence and prognostic relevance of periprocedural MI following PCI. The incidence of periprocedural MI was higher when defined by universal definition of myocardial infarction (UDMI), which applies a lower biomarker threshold with broader ancillary criteria compared with the Society for Cardiovascular Angiography and Intervention (SCAI) and academic research consortium (ARC)-2. The prognostic impact of periprocedural MI defined by SCAI and ARC-2 on mortality was consistently greater compared with the UDMI definition.
    Summary: Among chronic coronary syndrome patients undergoing PCI, the frequency and prognostic value of periprocedural MI varies considerably based on definitions. Periprocedural MI defined by the ARC-2 and SCAI occurred 3-6 times less frequently and were prognostically more relevant as compared with the UDMI. Clinically relevant definitions should be used in daily practice and clinical trials.
    MeSH term(s) Biomarkers ; Coronary Artery Disease/complications ; Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Myocardial Infarction/surgery ; Percutaneous Coronary Intervention/adverse effects ; Risk Factors ; Syndrome ; Treatment Outcome
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000000995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2556: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention.

    Ueki, Yasushi / Kuwahara, Koichiro

    Journal of cardiology

    2022  Volume 81, Issue 4, Page(s) 364–372

    Abstract: Percutaneous coronary intervention (PCI) in addition to guideline-directed medical therapy reduces the risk of spontaneous myocardial infarction (MI), urgent revascularization, and improves angina status; however, PCI is associated with an increased risk ...

    Abstract Percutaneous coronary intervention (PCI) in addition to guideline-directed medical therapy reduces the risk of spontaneous myocardial infarction (MI), urgent revascularization, and improves angina status; however, PCI is associated with an increased risk of periprocedural myocardial injury and MI. Numerous studies have investigated the mechanisms, predictors, and therapeutic strategies for periprocedural MI. Various definitions of periprocedural MI have been proposed by academic groups and professional societies requiring different cardiac biomarker thresholds and ancillary criteria for myocardial ischemia. The frequency and clinical significance of periprocedural MI substantially varies according to the definitions applied. In daily practice, accurate diagnosis of clinically-relevant periprocedural MI is essential because it may have a substantial impact on subsequent patient management. In the clinical trial setting, only clinically relevant periprocedural MI definitions should be applied as a clinical endpoint in order to avoid obscuring meaningful outcomes. In this review, we aim to summarize the mechanisms, predictors, frequency, and prognostic impact of periprocedural MI in patients undergoing PCI and to provide the current perspective on this issue.
    MeSH term(s) Humans ; Percutaneous Coronary Intervention/adverse effects ; Myocardial Infarction/etiology ; Myocardial Infarction/therapy ; Myocardial Infarction/diagnosis ; Coronary Artery Disease/complications ; Myocardial Ischemia/complications ; Angina Pectoris ; Treatment Outcome ; Risk Factors
    Language English
    Publishing date 2022-11-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2022.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1794: Show issues Location:
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  5. Article ; Online: Prognostic Impact of Stent Expansion Indices Following IVUS-Guided PCI: When Lumen Is Not Enough.

    Räber, Lorenz / Ueki, Yasushi

    JACC. Cardiovascular interventions

    2021  Volume 14, Issue 15, Page(s) 1651–1654

    MeSH term(s) Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Drug-Eluting Stents ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Prognosis ; Stents ; Treatment Outcome ; Ultrasonography, Interventional
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2021.06.012
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    Zs.A 6669: Show issues Location:
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  6. Article ; Online: Outcomes of Intravascular Ultrasound-Guided Percutaneous Coronary Intervention in the United States.

    Räber, Lorenz / Ueki, Yasushi

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 16, Page(s) 1891–1893

    MeSH term(s) Drug-Eluting Stents ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Stents ; Treatment Outcome ; Ultrasonography, Interventional ; United States
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.06.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bioresorbable Scaffolds: Unfulfilled Prophecies.

    Räber, Lorenz / Ueki, Yasushi

    Circulation

    2019  Volume 140, Issue 23, Page(s) 1917–1920

    MeSH term(s) Absorbable Implants ; Coronary Artery Disease ; Everolimus ; Humans ; Prospective Studies ; Stents
    Chemical Substances Everolimus (9HW64Q8G6G)
    Language English
    Publishing date 2019-09-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.043773
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    Ui IV Zs.60: Show issues Location:
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  8. Article ; Online: Understanding the Bioresorbable Vascular Scaffold Achilles Heel: Insights From ABSORB Japan Serial Intracoronary Imaging.

    Räber, Lorenz / Ueki, Yasushi

    JACC. Cardiovascular interventions

    2019  Volume 13, Issue 1, Page(s) 128–131

    MeSH term(s) Absorbable Implants ; Coronary Vessels ; Drug-Eluting Stents ; Everolimus ; Japan ; Treatment Outcome
    Chemical Substances Everolimus (9HW64Q8G6G)
    Language English
    Publishing date 2019-12-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2019.10.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6669: Show issues Location:
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  9. Article: A Strategic Translational Research System for Drug Discovery in Tottori University.

    Endo, Yusuke / Yoshida, Tsutomu / Washijima, Ichiro / Ueki, Masaru / Kikuchi, Noriyoshi / Takenaka, Atsushi / Kawata, Yasushi

    Yonago acta medica

    2023  Volume 66, Issue 4, Page(s) 394–403

    Abstract: The probability of successful drug discovery is declining, and research and development costs are increasing. To solve these problems, pharmaceutical companies tend to in-license seeds from venture companies and academia. Therefore, academia's role in ... ...

    Abstract The probability of successful drug discovery is declining, and research and development costs are increasing. To solve these problems, pharmaceutical companies tend to in-license seeds from venture companies and academia. Therefore, academia's role in drug discovery is extremely important. Tottori University started a "Next-Generation Research Support Project (Strategic Research Support Project)" in 2020, developing a translational research system to promote drug discovery. In this project, we established a research and development infrastructure, such as seed registration, construction of drug research and development support, and research fund allocation. The registered seed were converted into project, and the project implemented this research and development system, and evaluated and verified its results. Twenty-two seeds were converted into projects and portfolios were constructed. Research funds were allocated to eight prioritized projects. Each project raised the research and development stages. From the overall portfolio, one project with the Japan Agency for Medical Research and Development (AMED) Drug Discovery Booster Project, and three projects with Seeds A of the AMED Translational Research Strategic Promotion Program were adopted. Additionally, a new low-molecular weight chaperone drug against GM1-gangliosidosis was out-licensed to an overseas pharmaceutical company. The strength of this system was the strategic allocation of research funds and the accompanying support that leveraged internal and external resources with the PM and researchers at its core. This system achieved certain results in promoting drug discovery; however, resource optimization of specialized personnel needs to be strengthened in the future. In this report, we summarized the efforts of translational research in Japan and around the world. In addition, the translational research efforts of Japanese academia and Tottori University were compared and the current status was summarized.
    Language English
    Publishing date 2023-10-06
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 840719-8
    ISSN 1346-8049 ; 0513-5710
    ISSN (online) 1346-8049
    ISSN 0513-5710
    DOI 10.33160/yam.2023.11.001
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    Zs.A 268: Show issues Location:
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  10. Article ; Online: Coronary embolism due to possible thrombosis of prosthetic aortic valve - the role of optical coherence tomography: case report.

    Kavaliauskaite, Raminta / Otsuka, Tatsuhiko / Ueki, Yasushi / Räber, Lorenz

    European heart journal. Case reports

    2021  Volume 5, Issue 7, Page(s) ytab115

    Abstract: Background: Coronary embolism is an important non-atherosclerotic cause of acute myocardial infarction (AMI) that requires an individualized diagnostic and therapeutic approach. Although certain angiographic criteria exist that render an embolic origin ... ...

    Abstract Background: Coronary embolism is an important non-atherosclerotic cause of acute myocardial infarction (AMI) that requires an individualized diagnostic and therapeutic approach. Although certain angiographic criteria exist that render an embolic origin likely, uncertainty remains. Optical coherence tomography (OCT) is a high-resolution intracoronary imaging technology that enables visualization of thrombus and the underlying coronary vessel wall, which may be helpful to distinguish between an atherosclerotic and non-atherosclerotic origin of AMI.
    Case summary: A 50-year-old male was admitted with ongoing chest pain. Eleven years ago, he underwent implantation of a mechanical aortic valve prosthesis due to degenerated bicuspid valve with normal coronaries on preoperative angiography. The electrocardiogram showed anterior ST-segment elevation. Emergent angiography revealed total occlusion of the proximal left anterior descending artery (LAD). Thrombus was aspirated along with administration of intravenous glycoprotein IIbIIIa inhibitor. Except the apical part of the LAD showing distal embolization, coronary flow was completely re-established with no evidence of significant atherosclerosis. Stents were not implanted on the basis of the OCT finding, which demonstrated at the site of occlusion a normal vessel wall without atherosclerosis that could explain an erosion or plaque rupture event. Transoesophageal echocardiography confirmed a floating structure in the left ventricular outflow tract, suggesting that an embolus originating from the prosthetic aortic valve obstructed the LAD. The international normalized ratio 2 days prior to presentation measured 1.9.
    Discussion: This case illustrates the utility of OCT to rule out the atherosclerotic aetiology of myocardial infarction and to avoid unnecessary stenting.
    Language English
    Publishing date 2021-07-30
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab115
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