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Article: From face-to-face to online: Teachers' perceived experiences in online distance teaching during the Covid-19 pandemic.

Sidi, Yael / Shamir-Inbal, Tamar / Eshet-Alkalai, Yoram

2023 Volume 201, Page(s) 104831

Abstract: The urgent shift to online distance teaching and learning during the Covid-19 pandemic presented teachers with unique pedagogical, technological, and psychological challenges. The aim of this study was to map the main positive and negative experiences of ...

Abstract	The urgent shift to online distance teaching and learning during the Covid-19 pandemic presented teachers with unique pedagogical, technological, and psychological challenges. The aim of this study was to map the main positive and negative experiences of teachers during this transition, as well as to examine intra- and interpersonal factors that affected teachers' ability to cope effectively with the challenges of online distance teaching. We used a mixed-method approach that combined qualitative (interviews) and quantitative (questionnaires) analyses. The interviews were analyzed using a grounded theory approach, specifically a bottom-up analysis, which led to the identification of five primary categories reflecting teachers' main concerns in online distance teaching (i.e., social, emotional, cognitive, pedagogical, and system support. The two most prominent categories were pedagogy and emotions, illustrating their centrality in teachers' experiences. A regression analysis of the questionnaires' data revealed that the two main variables which predicted both positive and negative experiences in online distance teaching were self-efficacy and teachers' attitudes towards technology integration in teaching. Findings of this study allow formulation of guidelines to promote factors related to positive experiences in online distance teaching.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2017194-8
ISSN	1873-782X ; 0360-1315
ISSN (online)	1873-782X
ISSN	0360-1315
DOI	10.1016/j.compedu.2023.104831
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Teacher prototypes in technology-enhanced instruction in elementary school second language acquisition

Esti Schwartz / Tamar Shamir-Inbal / Ina Blau

Computers and Education Open, Vol 5, Iss , Pp 100155- (2023)

Comparing routine and emergency learning in different cultures

2023

Abstract: Over the past decade, learning cultures worldwide have been affected differently by the rapid spread of educational technology. During emergency distance learning, teachers had to adapt themselves to a new mode of learning. The purpose of this study was ... ...

Abstract	Over the past decade, learning cultures worldwide have been affected differently by the rapid spread of educational technology. During emergency distance learning, teachers had to adapt themselves to a new mode of learning. The purpose of this study was to compare technology-integrated instructional strategies and teacher prototypes in three learning cultures during routine and emergency learning based on the Five Spaces for Design in Education framework (Weiner et al., 2020). The participants were 31 teachers from three regions - Eastern Europe, Western Europe, and Northern America, all integrating the same adaptive digital learning environment in second language instruction. Participants' interviews were coded according to a three level tier of instructional strategies (n = 938) denoting the student's place in the learning process and level of independence, as well as a categorization of four teacher prototypes representing the degree of teacher centrality in the classroom (n = 764): sage, facilitator, guide, and partner. Chi-square tests highlighted the differences in instructional strategies and teacher centrality between the learning cultures in the three regions. The findings of the teacher prototype analysis showed a similar distribution of prototypes among the three regions, both in routine learning and emergency times. Regarding instructional strategies, each culture showed a unique tendency to specific strategies, while in the transition to emergency learning there was a convergence to strategies with the medium level of teacher control over students and a certain degree of student independence.
Keywords	Educational technology ; Emergency remote teaching – ERT ; Distance learning ; Learning culture ; Five Spaces for Design in Education framework ; Teacher prototypes framework ; Electronic computers. Computer science ; QA75.5-76.95 ; Theory and practice of education ; LB5-3640
Subject code	370
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differential silencing of STAT3 isoforms leads to changes in STAT3 activation.

Shamir, Inbal / Tsarfaty, Ilan / Paret, Gidi / Nevo-Caspi, Yael

Oncotarget

2023 Volume 14, Page(s) 366–376

Abstract: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in multiple fundamental biological processes and a key player in cancer development and progression. STAT3 is activated upon tyrosine phosphorylation and is ... ...

Abstract	Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in multiple fundamental biological processes and a key player in cancer development and progression. STAT3 is activated upon tyrosine phosphorylation and is constitutively active in various malignancies; therefore, the expression of pSTAT3 has been recognized as a predictor of poor survival. STAT3 encodes two alternatively-spliced STAT3 isoforms: the full-length STAT3α isoform and the truncated STAT3β isoform. These isoforms have been suggested as the reason for the occasionally observed opposing roles of STAT3 in cancer: an oncogene, on one hand, and a tumor suppressor on the other. To investigate their roles in aggressive breast cancer, we separately silenced each isoform and found that they affect each other's activation, impacting cell viability, cytokine expression, and migration. Silencing specific isoforms can lead to a more favorable balance of activated STAT3 proteins in the cell. Distinguishing between the two isoforms and their active forms is crucial for STAT3-related cancer diagnosis and therapy.
MeSH term(s)	Humans ; Female ; STAT3 Transcription Factor/metabolism ; Protein Isoforms/metabolism ; Breast Neoplasms/pathology ; Gene Expression Regulation ; Cytokines/metabolism ; Phosphorylation
Chemical Substances	STAT3 Transcription Factor ; Protein Isoforms ; Cytokines ; STAT3 protein, human
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28412
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Article ; Online: Recurrence rates following ileo-colic resection in pediatric patients with Crohn's disease.

Dreznik, Yael / Samuk, Inbal / Shouval, Dror S / Paran, Maya / Matar, Manar / Shamir, Raanan / Totah, Moussa / Kravarusic, Dragan

Pediatric surgery international

2023 Volume 39, Issue 1, Page(s) 83

Abstract: Background: Ileo-colic resection (ICR) is an important therapeutic option for Crohn's disease (CD) patients. There are limited updated data of clinical and endoscopic post-operative recurrence (POR) in pediatric patients with CD for the long run. We ... ...

Abstract	Background: Ileo-colic resection (ICR) is an important therapeutic option for Crohn's disease (CD) patients. There are limited updated data of clinical and endoscopic post-operative recurrence (POR) in pediatric patients with CD for the long run. We aimed to determine recurrence rates following ICR over an extended period of time and asses its risk factors. Methods: This is a single-center retrospective review of 35 patients with CD between the ages of 6 and 17.9 years who required ICR between 2003 and 2021 at Schneider Children Medical Center of Israel. Medical charts were reviewed at different time-points post-ICR. Results: Clinical recurrence following ICR was demonstrated in only 11.4% and 28.6% (n = 4, n = 10) in the first two and five years-much lower rates than what was reported so far. We found no specific risk factor that correlated with clinical recurrence, although patients that were treated with early prophylaxis of anti-TNF medications following ICR tend to have less recurrence. Conclusions: We found lower POR following ICR, especially in the first years after surgery-which can be attributed to close surveillance and early medical treatment. Such surveillance seems to improve recurrence rates in the first years following ICR.
MeSH term(s)	Humans ; Child ; Adolescent ; Crohn Disease/epidemiology ; Crohn Disease/surgery ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Colic ; Retrospective Studies ; Endoscopy ; Recurrence
Chemical Substances	Tumor Necrosis Factor Inhibitors
Language	English
Publishing date	2023-01-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-022-05346-1
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Article ; Online: Biases in the SMART-DNA library preparation method associated with genomic poly dA/dT sequences.

Vardi, Oriya / Shamir, Inbal / Javasky, Elisheva / Goren, Alon / Simon, Itamar

PloS one

2017 Volume 12, Issue 2, Page(s) e0172769

Abstract: Avoiding biases in next generation sequencing (NGS) library preparation is crucial for obtaining reliable sequencing data. Recently, a new library preparation method has been introduced which has eliminated the need for the ligation step. This method, ... ...

Abstract	Avoiding biases in next generation sequencing (NGS) library preparation is crucial for obtaining reliable sequencing data. Recently, a new library preparation method has been introduced which has eliminated the need for the ligation step. This method, termed SMART (switching mechanism at the 5' end of the RNA transcript), is based on template switching reverse transcription. To date, there has been no systematic analysis of the additional biases introduced by this method. We analysed the genomic distribution of sequenced reads prepared from genomic DNA using the SMART methodology and found a strong bias toward long (≥12bp) poly dA/dT containing genomic loci. This bias is unique to the SMART-based library preparation and does not appear when libraries are prepared with conventional ligation based methods. Although this bias is obvious only when performing paired end sequencing, it affects single end sequenced samples as well. Our analysis demonstrates that sequenced reads originating from SMART-DNA libraries are heavily skewed toward genomic poly dA/dT tracts. This bias needs to be considered when deciding to use SMART based technology for library preparation.
MeSH term(s)	Gene Library ; Genome ; Genomics ; High-Throughput Nucleotide Sequencing/methods ; Poly dA-dT/genetics ; RNA/genetics ; Sequence Analysis, DNA/methods
Chemical Substances	Poly dA-dT (26966-61-0) ; RNA (63231-63-0)
Language	English
Publishing date	2017-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0172769
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Article ; Online: STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy.

Shamir, Inbal / Abutbul-Amitai, Mor / Abbas-Egbariya, Haya / Pasmanik-Chor, Metsada / Paret, Gideon / Nevo-Caspi, Yael

Journal of cellular and molecular medicine

2020 Volume 24, Issue 21, Page(s) 12864–12868

Abstract: The SARS-coronavirus 2 is the aetiologic agent COVID-19. ACE2 has been identified as a cell entry receptor for the virus. Therefore, trying to understand how the gene is controlled has become a major goal. We silenced the expression of STAT3α and STAT3β, ...

Abstract	The SARS-coronavirus 2 is the aetiologic agent COVID-19. ACE2 has been identified as a cell entry receptor for the virus. Therefore, trying to understand how the gene is controlled has become a major goal. We silenced the expression of STAT3α and STAT3β, and found that while silencing STAT3α causes an increase in ACE2 expression, silencing STAT3β causes the opposite effect. Studying the role of STAT3 in ACE2 expression will shed light on the molecular events that contribute to the progression of the disease and that the different roles of STAT3α and STAT3β in that context must be taken in consideration. Our results place STAT3 in line with additional potential therapeutic targets for treating COVID-19 patients.
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Binding Sites ; COVID-19 ; Humans ; MCF-7 Cells ; Promoter Regions, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; SARS-CoV-2/drug effects ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
Chemical Substances	Protein Isoforms ; STAT3 Transcription Factor ; STAT3 protein, human ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.15838
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Article ; Online: Biases in the SMART-DNA library preparation method associated with genomic poly dA/dT sequences.

Oriya Vardi / Inbal Shamir / Elisheva Javasky / Alon Goren / Itamar Simon

PLoS ONE, Vol 12, Iss 2, p e

2017 Volume 0172769

Abstract	Avoiding biases in next generation sequencing (NGS) library preparation is crucial for obtaining reliable sequencing data. Recently, a new library preparation method has been introduced which has eliminated the need for the ligation step. This method, termed SMART (switching mechanism at the 5' end of the RNA transcript), is based on template switching reverse transcription. To date, there has been no systematic analysis of the additional biases introduced by this method. We analysed the genomic distribution of sequenced reads prepared from genomic DNA using the SMART methodology and found a strong bias toward long (≥12bp) poly dA/dT containing genomic loci. This bias is unique to the SMART-based library preparation and does not appear when libraries are prepared with conventional ligation based methods. Although this bias is obvious only when performing paired end sequencing, it affects single end sequenced samples as well. Our analysis demonstrates that sequenced reads originating from SMART-DNA libraries are heavily skewed toward genomic poly dA/dT tracts. This bias needs to be considered when deciding to use SMART based technology for library preparation.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is fundoplication mandatory in children with neurological impairment undergoing gastrostomy?

Dreznik, Yael / Baazov, Artur / Dvir, Nadav / Seguier-Lipszyc, Emmanuelle / Zevit, Noam / Nica, Adrianna / Samuk, Inbal / Shamir, Raanan / Dlugi, Elena / Freud, Enrique / Kravarusic, Dragan

Journal of paediatrics and child health

2021 Volume 58, Issue 4, Page(s) 588–592

Abstract: Aim: Percutaneous endoscopic gastrostomy (PEG) and surgical gastrostomy (SG) are common procedures in children with neurological impairment (NI) with swallowing difficulties. Pulmonary aspirations are a major concern and performing concomitant or ... ...

Abstract	Aim: Percutaneous endoscopic gastrostomy (PEG) and surgical gastrostomy (SG) are common procedures in children with neurological impairment (NI) with swallowing difficulties. Pulmonary aspirations are a major concern and performing concomitant or delayed fundoplication is still controversial, especially among these patients. The aim of our study was to review our experience with fundoplication performed concomitantly with gastrostomy or later and to evaluate patient outcomes. Methods: This is a retrospective, cohort study including all paediatric patients who underwent SG or PEG with or without Nissen fundoplication at Schneider Children's Medical Center of Israel between the years 2007 and 2018. Patients' clinical and surgical data were recorded and analysed. Results: Between 2007 and 2018, 345 patients underwent SG or PEG. Of these, 89 patients underwent fundoplication. Of the patients who underwent PEG/SG, 158 (45.8%) were neurologically impaired. Most of the patients who underwent fundoplication (n = 69, 77.5%) were NI patients (P = 0.0001). NI patients with refractory seizures showed almost no improvement in terms of relief of gastro-oesophageal reflux disease symptoms following fundoplication (P = 0.0001) compared to NI patients without refractory seizures. Conclusion: Our findings suggest that in NI patients a concomitant fundoplication is not mandatory and is not efficacious in preventing gastro-oesophageal reflux disease in patients with refractory seizures.
MeSH term(s)	Child ; Cohort Studies ; Fundoplication/methods ; Gastroesophageal Reflux/surgery ; Gastrostomy/methods ; Humans ; Retrospective Studies
Language	English
Publishing date	2021-10-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.15767
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Article ; Online: STAT3 isoforms differentially affect ACE2 expression

Shamir, Inbal / Abutbul‐Amitai, Mor / Abbas‐Egbariya, Haya / Pasmanik‐Chor, Metsada / Paret, Gideon / Nevo‐Caspi, Yael

Journal of Cellular and Molecular Medicine ; ISSN 1582-1838 1582-4934

A potential target for COVID‐19 therapy

2020

Keywords	Molecular Medicine ; Cell Biology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/jcmm.15838
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy

Shamir, Inbal / Abutbul-Amitai, Mor / Abbas-Egbariya, Haya / Pasmanik-Chor, Metsada / Paret, Gideon / Nevo-Caspi, Yael

J. cell. mol. med

Abstract	The SARS-coronavirus 2 is the aetiologic agent COVID-19. ACE2 has been identified as a cell entry receptor for the virus. Therefore, trying to understand how the gene is controlled has become a major goal. We silenced the expression of STAT3α and STAT3ß, and found that while silencing STAT3α causes an increase in ACE2 expression, silencing STAT3ß causes the opposite effect. Studying the role of STAT3 in ACE2 expression will shed light on the molecular events that contribute to the progression of the disease and that the different roles of STAT3α and STAT3ß in that context must be taken in consideration. Our results place STAT3 in line with additional potential therapeutic targets for treating COVID-19 patients.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #780917
Database	COVID19

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