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  1. Article ; Online: O-Linked β-

    Dos Passos Junior, Rinaldo Rodrigues / Bomfim, Gisele Facholi / Giachini, Fernanda R / Tostes, Rita C / Lima, Victor Vitorino

    Frontiers in immunology

    2022  Volume 13, Page(s) 852115

    Abstract: ... ...

    Abstract The
    MeSH term(s) Acetylglucosamine ; Humans ; Hypertension ; Immune System/metabolism ; Protein Processing, Post-Translational ; Proteins/metabolism
    Chemical Substances Proteins ; Acetylglucosamine (V956696549)
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.852115
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  2. Article ; Online: Interleukin-10 in the Vasculature: Pathophysiological Implications.

    de Freitas, Raiany A / Lima, Victor V / Bomfim, Gisele F / Giachini, Fernanda R C

    Current vascular pharmacology

    2021  Volume 20, Issue 3, Page(s) 230–243

    Abstract: Interleukin-10 (IL-10) is an important immunomodulatory cytokine, initially characterized as an anti-inflammatory agent released by immune cells during infectious and inflammatory processes. IL-10 exhibits biological functions that extend to the ... ...

    Abstract Interleukin-10 (IL-10) is an important immunomodulatory cytokine, initially characterized as an anti-inflammatory agent released by immune cells during infectious and inflammatory processes. IL-10 exhibits biological functions that extend to the regulation of different intracellular signaling pathways directly associated with vascular function. This cytokine plays a vital role in vascular tone regulation by changing important proteins involved in vasoconstriction and vasodilation. Numerous investigations covered here have shown that therapeutic strategies inducing IL-10 exert anti-inflammatory, anti-hypertrophic, anti-hyperplastic, anti-apoptotic and antihypertensive effects. This non-systematic review summarizes the modulating effects mediated by IL-10 in vascular tissue, particularly on vascular tone, and the intracellular pathway induced by this cytokine. We also highlight the advances in IL-10 manipulation as a therapeutic target in different cardiovascular pathophysiologies, including the physiological implications in animals and humans. Finally, the review illustrates current and potential future perspectives of the potential use of IL-10 in clinical trials based on the clinical evidence.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Antihypertensive Agents ; Cytokines ; Humans ; Interleukin-10 ; Vasoconstriction
    Chemical Substances Anti-Inflammatory Agents ; Antihypertensive Agents ; Cytokines ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2021-12-24
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2192362-0
    ISSN 1875-6212 ; 1570-1611
    ISSN (online) 1875-6212
    ISSN 1570-1611
    DOI 10.2174/1570161120666211227143459
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  3. Article ; Online: Sex Differences in Molecular Mechanisms of Cardiovascular Aging.

    Dela Justina, Vanessa / Miguez, Jéssica S G / Priviero, Fernanda / Sullivan, Jennifer C / Giachini, Fernanda R / Webb, R Clinton

    Frontiers in aging

    2021  Volume 2, Page(s) 725884

    Abstract: Cardiovascular disease (CVD) is still the leading cause of illness and death in the Western world. Cardiovascular aging is a progressive modification occurring in cardiac and vascular morphology and physiology where increased endothelial dysfunction and ... ...

    Abstract Cardiovascular disease (CVD) is still the leading cause of illness and death in the Western world. Cardiovascular aging is a progressive modification occurring in cardiac and vascular morphology and physiology where increased endothelial dysfunction and arterial stiffness are observed, generally accompanied by increased systolic blood pressure and augmented pulse pressure. The effects of biological sex on cardiovascular pathophysiology have long been known. The incidence of hypertension is higher in men, and it increases in postmenopausal women. Premenopausal women are protected from CVD compared with age-matched men and this protective effect is lost with menopause, suggesting that sex-hormones influence blood pressure regulation. In parallel, the heart progressively remodels over the course of life and the pattern of cardiac remodeling also differs between the sexes. Lower autonomic tone, reduced baroreceptor response, and greater vascular function are observed in premenopausal women than men of similar age. However, postmenopausal women have stiffer arteries than their male counterparts. The biological mechanisms responsible for sex-related differences observed in cardiovascular aging are being unraveled over the last several decades. This review focuses on molecular mechanisms underlying the sex-differences of CVD in aging.
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 3076785-4
    ISSN 2673-6217 ; 2673-6217
    ISSN (online) 2673-6217
    ISSN 2673-6217
    DOI 10.3389/fragi.2021.725884
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  4. Article ; Online: Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation.

    Dela Justina, Vanessa / Giachini, Fernanda R / Sullivan, Jennifer C / Webb, R Clinton

    Journal of cardiovascular pharmacology

    2020  Volume 76, Issue 3, Page(s) 255–266

    Abstract: Toll-like receptors (TLRs) play an important role in the innate immune system, and recently, they have been shown to be involved in the regulation of blood pressure. The incidence of hypertension is higher in men, and it increases in postmenopausal women. ...

    Abstract Toll-like receptors (TLRs) play an important role in the innate immune system, and recently, they have been shown to be involved in the regulation of blood pressure. The incidence of hypertension is higher in men, and it increases in postmenopausal women. In fact, premenopausal women are protected from cardiovascular disease compared with age-matched men, and it is well established that this protective effect is lost with menopause. However, the molecular mechanisms underlying this protection in women are unknown. Whether or not it could be related to differential activation of the innate immune system remains to be elucidated. This review focuses on (1) the differences between men and women in TLR activation and (2) whether TLR activation may influence the regulation of blood pressure in a sex-dependent manner.
    MeSH term(s) Animals ; Blood Pressure ; Female ; Gene Expression Regulation ; Humans ; Hypertension/epidemiology ; Hypertension/immunology ; Hypertension/metabolism ; Hypertension/physiopathology ; Immunity, Innate ; Incidence ; Male ; Risk Assessment ; Risk Factors ; Sex Characteristics ; Sex Factors ; Signal Transduction ; Toll-Like Receptors/genetics ; Toll-Like Receptors/metabolism
    Chemical Substances Toll-Like Receptors
    Language English
    Publishing date 2020-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000000869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Vascular dysfunction beyond pathological pregnancies. An international effort addressed to fill the gaps in Latin America, Volume II.

    Escudero, Carlos / Giachini, Fernanda Regina / García-Robles, Reggie / Galaviz-Hernandez, Carlos / Damiano, Alicia E

    Frontiers in physiology

    2022  Volume 13, Page(s) 989407

    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.989407
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  6. Article ; Online: Does Na+ really play a role in Ca2+ homeostasis in hypertension?

    Giachini, Fernanda R / Tostes, Rita C

    American journal of physiology. Heart and circulatory physiology

    2010  Volume 299, Issue 3, Page(s) H602–4

    MeSH term(s) Animals ; Calcium/metabolism ; Homeostasis ; Hypertension/metabolism ; Sodium/metabolism
    Chemical Substances Sodium (9NEZ333N27) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2010-06-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00542.2010
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  7. Article ; Online: Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases.

    Gohar, Eman Y / Giachini, Fernanda R / Pollock, David M / Tostes, Rita C

    Life sciences

    2016  Volume 159, Page(s) 20–29

    Abstract: Epidemiological studies of blood pressure in men and women and in experimental animal models point to substantial sex differences in the occurrence of arterial hypertension as well as in the various manifestations of arterial hypertension, including ... ...

    Abstract Epidemiological studies of blood pressure in men and women and in experimental animal models point to substantial sex differences in the occurrence of arterial hypertension as well as in the various manifestations of arterial hypertension, including myocardial infarction, stroke, retinopathy, chronic kidney failure, as well as hypertension-associated diseases (e.g. diabetes mellitus). Increasing evidence demonstrates that the endothelin (ET) system is a major player in the genesis of sex differences in cardiovascular and renal physiology and diseases. Sex differences in the ET system have been described in the vasculature, heart and kidney of humans and experimental animals. In the current review, we briefly describe the role of the ET system in the cardiovascular and renal systems. We also update information on sex differences at different levels of the ET system including synthesis, circulating and tissue levels, receptors, signaling pathways, ET actions, and responses to antagonists in different organs that contribute to blood pressure regulation. Knowledge of the mechanisms underlying sex differences in arterial hypertension can impact therapeutic strategies. Sex-targeted and/or sex-tailored approaches may improve treatment of cardiovascular and renal diseases.
    MeSH term(s) Cardiovascular Diseases/physiopathology ; Endothelins/physiology ; Female ; Humans ; Kidney Diseases/physiopathology ; Male ; Sex Characteristics ; Sex Chromosomes
    Chemical Substances Endothelins
    Language English
    Publishing date 2016-08-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2016.02.093
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  8. Article ; Online: The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field.

    Blanco-Castañeda, Ricardo / Galaviz-Hernández, Carlos / Souto, Paula C S / Lima, Victor Vitorino / Giachini, Fernanda R / Escudero, Carlos / Damiano, Alicia E / Barragán-Zúñiga, L Jazel / Martínez-Aguilar, Gerardo / Sosa-Macías, Martha

    Expert review of clinical pharmacology

    2020  Volume 13, Issue 3, Page(s) 247–263

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Animals ; Female ; Fetus/physiology ; Gene Expression Regulation/drug effects ; Humans ; Maternal-Fetal Exchange/physiology ; Placenta/enzymology ; Placenta/metabolism ; Pregnancy ; Xenobiotics/adverse effects ; Xenobiotics/pharmacokinetics
    Chemical Substances Xenobiotics
    Language English
    Publishing date 2020-03-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2020.1733412
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  9. Article ; Online: Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women.

    Macías-Salas, Alejo / Sosa-Macías, Martha / Barragán-Zúñiga, Laura Jazel / Blanco-Castañeda, Ricardo / Damiano, Alicia / Garcia-Robles, Reggie / Ayala-Ramírez, Paola / Bueno-Sánchez, Julio / Giachini, Fernanda Regina / Escudero, Carlos / Galaviz-Hernández, Carlos

    Placenta

    2023  Volume 135, Page(s) 1–6

    MeSH term(s) Humans ; Female ; Pregnancy ; Case-Control Studies ; Pregnant Women ; Latin America ; Pre-Eclampsia/genetics ; Polymorphism, Single Nucleotide ; Placenta ; Vascular Endothelial Growth Factor A/genetics
    Chemical Substances Vascular Endothelial Growth Factor A ; VEGFA protein, human
    Language English
    Publishing date 2023-03-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2023.02.010
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    Zs.A 1578: Show issues Location:
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  10. Article ; Online: Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation.

    Wynne, Brandi M / Labazi, Hicham / Lima, Victor V / Carneiro, Fernando S / Webb, R Clinton / Tostes, Rita C / Giachini, Fernanda R

    Canadian journal of physiology and pharmacology

    2018  Volume 96, Issue 8, Page(s) 719–727

    Abstract: The endothelium is crucial for the maintenance of vascular tone by releasing several vasoactive substances, including nitric oxide (NO). Systemic mean arterial pressure is primarily regulated by the resistance vasculature, which has been shown to exhibit ...

    Abstract The endothelium is crucial for the maintenance of vascular tone by releasing several vasoactive substances, including nitric oxide (NO). Systemic mean arterial pressure is primarily regulated by the resistance vasculature, which has been shown to exhibit increased vascular reactivity, and decreased vasorelaxation during hypertension. Here, we aimed to determine the mechanism for mesenteric artery vasorelaxation of the stroke-prone spontaneously hypertensive rat (SHRSP). We hypothesized that endothelial NO synthase (eNOS) is upregulated in SHRSP vessels, increasing NO production to compensate for the endothelial dysfunction. Concentration-response curves to acetylcholine (ACh) were performed in second-order mesenteric arteries; we observed decreased relaxation responses to ACh (maximum effect elicited by the agonist) as compared with Wistar-Kyoto (WKY) controls. Vessels from SHRSP incubated with N
    MeSH term(s) Acetylcholine/pharmacology ; Animals ; Arginase/antagonists & inhibitors ; Arginase/metabolism ; Arginine/pharmacology ; Blood Pressure ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Endothelium, Vascular/physiopathology ; Enzyme Activation ; Male ; Mesenteric Arteries/pathology ; Mesenteric Arteries/physiopathology ; NF-kappa B/metabolism ; Neurons/drug effects ; Neurons/enzymology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Inbred SHR ; Stroke/pathology ; Stroke/physiopathology ; Substrate Specificity/drug effects ; Systole ; Vasodilation/drug effects
    Chemical Substances NF-kappa B ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Arginase (EC 3.5.3.1) ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2018-02-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2017-0477
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